Nootropics make the blood/brain barrier more permeable, as well as oxygenationg it, no known side effects, it's been a well established method of potentiating MDxx for years. I have not tried but will soon.
You don't "feel" nootropics hitting you, they just make your brain more efficient like oxygen caffiene and nicotine do, but for longer periods than the latter two.
That's not necessarily true.. Many different Nootropics work in many different ways..
When you think about the brain, and are considering nootropics, you have to consider a lot of ways that can increase your brain's ability to store, process, and recall information
A few ways that exist are:
Increase of Cerebral blood flow - More blood flow equates to increased oxygenation, which is required for energy formation from the powerhouse of our cells, mitochondria. More blood flow also increases nutrient and protein availability in order to express brain relevant genes and help in the conversion of precursor nutrients into relevant molecules that are required for optimal brain processing.
Increasing the amount of antioxidants present in the brain - When parts of your brain are very active then generate large quantities of reactive oxygen species (ROS) which go on to damage cellular proteins, cell membranes, etc. Antioxidants act to "mop up" these ROS and prevent their eventual "brain fog" causing properties.
Increasing the amount of Neural branching - Neurons receive signals through their dendrites, which are like the arms of a tree. The more interconnections between neurons, the more dendrites there will be, and the more information the system can hold (more connections between concepts are able to be formed).
Improving the metabolic health of neurons - Neurons, as cells, are required to produce large amounts of ATP (the energy molecule of the cell). More ATP means that they can fire more times without getting as exhausted.
There are a lot more complex things going on with nootropics other than the permeability of the BBB... also, I don't think that's how Piracetam works either..
