My opinion is completely uninformed, as I don't combine uppers and downers, but I'm willing to bet almost anything other than a beta blocker will dull the amphetamines. Alprazolam (xanax) sure as Hell ruins it for me, personally. A lot of people like to drink some with them or combine with an opiate or something, but personally I find anything like that just ruins the amphetamine feeling for me. Don't know about a beta blocker, since those are a bit unique. Could work I suppose.Honestly though, it doesn't seem like a very good idea to push on if you really *need* to do that. Far be it from me to call anybody reckless or unsafe (what a joke that would be), but maybe amphetamines just aren't your thing if the paranoia and anxiety are that severe for you?