Quote from: 328502E on February 16, 2013, 07:49 amQuote from: valakki on February 14, 2013, 06:08 pmLook . You can have a positive experience with ssri and mdma combo but its not worth the risk. Both drugs work by inhibiting serotonin reuptake. That means you will have a shit load serotonin between your neurons because it cant be reabsorbed. This can lead to serotonin poisoning called serotonin syndrome.  I understand you are trying to help, but it helps to have a real understanding of how the brain works in this scenario. MDMA doesn't make you roll by simply inhibiting serotonin reuptake. Otherwise, SSRI's would make you roll. MDMA actually takes the reuptake inhibitors and reverses them, spitting out 5ht from the pre-synaptic neuron into the synapse. It also causes the release of 5ht from vesicles into the cytoplasm, so there is 5ht to spit out into the synapse. Adding an SSRI into the mix doesn't make it more intense. Why? Because all the reuptake pumps are already bound to MDMA (well, depending on your dose, of course...). What does this mean? The SSRI will haev to compete with MDMA to bind to the pumps. And when the SSRI is successful (I believe some SSRIs actually have a higher affinity for it than does MDMA), the MDMA ceases to function is a reuptake reverser. Which is why people on SSRI's can't roll; the SSRI inhibits MDMAs mechanism of action. You're leaving out the part about there being a dozen different kinds of serotonin each with its own affinity for dozens of different areas of the brain, not to mention the hundreds or thousands of neurotransmitter cascades that only PhD researchers know about -- and even then, you're leaving out the ones we still haven't discovered yet. We don't understand the brain. We have a child's inkling of how we work, but little more.To boil it down *that* far is as misleading as it is informative. Granted, you do have the facts more or less correct... just... inaccurate.