Silk Road forums
Discussion => Drug safety => Topic started by: hubbabubba on June 26, 2012, 11:28 pm
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Hi, I read somewhere that it was a bad idea to mix ecstasy and speed because of a toxic reaction, is this true?
Thank you
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Yeah you can but you will have a bangin come down from it.
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Hi Limetless, thanks for the quick response and advice.
I think I will try to avoid mixing them as there is nothing worse than a bad comedown, even the memory of it makes me feel queasy :o
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neurotoxicity from MDMA is doubled when mixed with any form of amphetamine. MDMA is a serotonin antagonist and the neurotoxicity is achieved by your body trying to replace the empty serotonin deposits with dopmaine. This creates free radicals, hence the neurotoxicity. Amphetamines are a dopamine antagonist, and you are just dumping more dopamine into those empty serotonin deposits. The comedown will be horrific to say the least. Be smart and keep your drugs for seperate days. unless, ketamine and mdma were on the list for the evening.
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neurotoxicity from MDMA is doubled when mixed with any form of amphetamine. MDMA is a serotonin antagonist and the neurotoxicity is achieved by your body trying to replace the empty serotonin deposits with dopmaine. This creates free radicals, hence the neurotoxicity. Amphetamines are a dopamine antagonist, and you are just dumping more dopamine into those empty serotonin deposits. The comedown will be horrific to say the least. Be smart and keep your drugs for seperate days. unless, ketamine and mdma were on the list for the evening.
MDMA is an Amphetamine.
MDMA a Serotonin ANTagonist? lol, that guy is trolling :) funny arguing tho.
im surprised at how pretentious you can sound. i know that MDMA is a amphetamine/phenathylamine and i meant mixing it with any other amphetamine. MDMA is a serotonin AGONIST that also releases dopamine and one more neurotransmitter. regular amphetamines or methamphetamine work mostly on dopamine, but also effect serotonin.
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I might sound pretentious, but doesn't change the fact that most of what you wrote is either wrong or purely hypothetical and you state it as it is a proven fact.
If you wanna state facts then watch out for your syntax.
Amphetamine (singular, points to the substance, not the group) and MDMA is one of the most common combos in the party-drug-scene. I do have extensive experience with it myself and I read into couple of studies regarding brain recovery after long-term use.
So I accept sounding pretentious in favor of making false claims.
Now I am out, nothing good ever came out of these discussions. thanks for the downboat :)
just because it is a common combo to use, does not make it safe. Speedballs were common until everybody realized you die from the mix. if your only justification is that it is a common party drug, then you can justify just about any wanton drug abuse. also, go to erowid and research the detrimental effects of mixing meth and amphetamine.
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if you want to view it that way, then all illegal drugs are not safe. The dose is in the poison, and most drugs can be enjoyed responsibly. It depends on self control more then anything. go to the M.A.P.S website and read their research pages. they are the only ones conducting legal MDMA studies, and will prove to you through mounds of empirical evidence that it can be used safely. also, in regards to the attack on my syntax. I'm not at work, where i have to meticulously proofread everything, and enjoy not having to when i come home and surf the web. i speak well enough to get my point across, and don't find the need to make my Sr forum banter pass through publication.
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I'm just wondering if he used the word "syntax" either on purpose, or subconsciously!
I think Cedric Bixler has used that word a bit! right??
:)
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I never said it's safe. I said your claims are incorrect. Neither MDMA nor Amphetamine are safe. Much less the combination of both. Stay away from all phenethylamines.
mdma is definitely safe for most people when taken under the right circumstances. do some research before spreading misinformation. anything can be unsafe if taken in excess.
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MD is one of the safest drugs there is. ???
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Beyond issues of purity, the other most common reason for negative drug side effects is very likely drug interactions. Literally drugs can piggyback on each other in what is known as a synergistic reaction, producing an overdose.
Even with regular over the counter drugs, many people die every year from the affects of drug interactions, especially in hospital surgery, even with trained staff on call. So, it's not exactly like mixing cola and vodka.
You should only ingest 1 substance at a time unless you're sure drug interaction is unlikely. You don't need to get paranoid, but if you're taking two completely new little white pills you should be reading the label on both. Often they will say something like: don't take this drug with SSRIs or something similar, so if you were taking something similar to zoloft, citalopram or some new prozac, then it is going to be a problem e.g. super headaches or mood swings. But don't worry about your orange juice so much.
As it is, mixing two amphetamine class drugs could produce overly speedy side effects unless you study the pharmacology of both drugs. Since that isn't trivial, it is best to avoid the idea entirely and take 1 at a time. Besides which, MDMA and regular amphetamine don't exactly have the same effects on a person anyway. You want to be ecstatically pleased and friendly, but also concentrate intensely? Amphetamine is a work drug, not a pleasure drug, I don't really get why you'd want to mix the two.
IMHO, alcohol is often a very complex drug and although I don't have the numbers, I would agree that mixing alcohol and anything else is not a great idea. I don't suggest you stop drinking beer or something at a party, but you ought to be reaching for the becks instead of the bud when you take an tablet.
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I never said it's safe. I said your claims are incorrect. Neither MDMA nor Amphetamine are safe. Much less the combination of both. Stay away from all phenethylamines.
mdma is definitely safe for most people when taken under the right circumstances. do some research before spreading misinformation. anything can be unsafe if taken in excess.
Ditto. MDMA (taken all by its lonesome at 100mg - 200mg a dose per 5 - 8 hours) is safer than aspirin. Seriously, more people have ODed on aspirin than MDMA. People have actually tried to suicide by taking too much MDMA, and, uh, it didn't work very well... If anything MDMA saves lives in those cases :D
There was even a guy who took 40,000 + MDMA tablets in nine years.
http://www.guardian.co.uk/society/2006/apr/04/drugsandalcohol.drugs1
I mean, given the not infrequent lack of actual MDMA and abundance of complete shit in some of these tablets on the street, it's a wonder he's alive at all. He should have died from the side affects alone of all the other junk in the street E pills by taking 12 Ecstasy tablets per day, every day, never mind the actual MDMA!!
As it is, he suffers from some bad memory problems, but is quite alive.
Protip: if you take 12 tablets per day, everyday, of anything in your medicine cabinet, expect to die.
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if you want to view it that way, then all illegal drugs are not safe. The dose is in the poison, and most drugs can be enjoyed responsibly. It depends on self control more then anything. go to the M.A.P.S website and read their research pages. they are the only ones conducting legal MDMA studies, and will prove to you through mounds of empirical evidence that it can be used safely. also, in regards to the attack on my syntax. I'm not at work, where i have to meticulously proofread everything, and enjoy not having to when i come home and surf the web. i speak well enough to get my point across, and don't find the need to make my Sr forum banter pass through publication.
Why do you 'explain' the technical stuff if you can't be bothered to get the details right? What's the point? How should anyone know what you mean? Guessing?
Advice: Take a dosage of 100mg or 1000mg something like that, and it will or will not affect Dopamin or Serotonin, either one. Don't add another drug that toys with whatever mdma acts on or doesn't act on, could be dangerous, or not. Oh and it's neurotoxic! But completely safe. Trust me. And add some Ketamin!
You see were this is going?! If you want to show off your elite knowledge then at least do it properly. I am fine with that, appreciate it even. I am not fine with trying to show off with elite chem knowledge, getting the most basic shit wrong and then whining like a 5 year old when pointed out.
I don't care if you know shit better than me, or if you know more than me or if you have the longer penis than me. All I care about is the correct answer and decent advice that's not misleading. Is this so hard to understand? It's not all about you and your ego. Get over it.
And this kids, is why I usually don't bother answering here... :)
I think there were many Freudian slips in that long drawn out comment. You think you are intellectually inadequate, and apparently have a small penis. it is funny how you are telling me to explain things properly, but you don't disprove my logic, and bring up dick sizes.... let me guess you are one of the many children who are plaguing this website. im done here, and im glad respected members backed me up on this. Thank you limitless and pine
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I'm just wondering if he used the word "syntax" either on purpose, or subconsciously!
I think Cedric Bixler has used that word a bit! right??
:)
I'm glad you know who cedric is! i also love your Gumby icon; karma points for being awesome(that includes limitless and pine).
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I don't know what you are trying to achieve here. I'm sorry if I stepped on your huge ego. No idea why you keep pushing it, so I removed all my posts.
marsvolta12's statement's ARE ALL CORRECT. PLEASE FOLLOW HIS ADVICE!
please leave me alone now? thank you.
the circlejerk may continue...
when did i ever "push you" to remove your post? can you please provide some proof? my huge ego? you are just being ridiculous now... you are making unsubstantiated claims that seem to be fueled by a Napoleon complex. i give advice to help people. If that makes me have a huge ego, then i am guilty as charged. I don't get where all this animosity comes from..
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I tend to avoid drug cocktails other than (any drug) + cannabis. There are so many complex contra-indications that it is always better safe than sorry.
There are some drugs, such as MDMA whose use necessitates a basic understanding of their impact on the brain and therefore reasonable steps to negate any possible negative long-term impact. I am a firm believer in the value of pre and post-loading before rolling as well as taking breaks of at least 6 weeks between rolls. I would never mix MDMA with other drugs.
Having said that, I did once take MDMA and Viagra together and it was fucking insane. My partner's vag was so sore in the morning it hurt her to pee.
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In the early clubbing days we didnt know what was in them (pills) and probably 20 on might still be a mix of mdma plus the rest of amphet family in there, which we now recognise thru experience and taking significant of each elements to know how to recognise them which would otherwise have just been a Mitsi or other...
so we all question what we're actually taking in, but you dont have much choice if its in pill form, otherwise a bit of speed gives you legs.
Enjoy
TWM
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I tend to avoid drug cocktails other than (any drug) + cannabis. There are so many complex contra-indications that it is always better safe than sorry.
There are some drugs, such as MDMA whose use necessitates a basic understanding of their impact on the brain and therefore reasonable steps to negate any possible negative long-term impact. I am a firm believer in the value of pre and post-loading before rolling as well as taking breaks of at least 6 weeks between rolls. I would never mix MDMA with other drugs.
Having said that, I did once take MDMA and Viagra together and it was fucking insane. My partner's vag was so sore in the morning it hurt her to pee.
Lol I'm basically the opposite. Once I get going I'm on it. Is there a buffet? So much the better! ;)
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I've experimented with mixing them, it's not the healthiest thing to do and your heart gets beating pretty fast, it can be a little uncomfortable at times. But it's pretty fun, I enjoy mixing drugs. Do it carefully though, better to take too little amphetamine and just ride out the roll and try again next time than take too much.
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^ pretty much this, I'd add a couple things though. And not that horrible of a comedown, why should it be? PM if you want my personal experience or make a new thread and let this die.
@muslix: any advice or are you pissed off again ;D :P ;D
i'm not pissed off, never was. Said that in the first post (read the quotes) already, the circlejerking troll threads are bad for me, I tend to get involved and then it goes on forever, so I'm avoiding them. Read mars' posts, all offtopic. pointless.
There's like 5 people here who claim to know it all, why do you need me?
Or can't marsvolta12 be bothered again to share his knowledge? lol. And trolling in Drug Safety backed up by mods (as if this meant anything) is well, I better say nothing about that. Be proud of yourself.
off topic.... i answered his question. you are making no sense....
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i have mixed them and like lim and a few others have said bad bad comedown you feel like you want to die, but it was a great night, i love mixing drugs and will even mix 3-4 different ones at times plus weed on top, some combos go and some dont, love mixing mdma ;)
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i have mixed them and like lim and a few others have said bad bad comedown you feel like you want to die, but it was a great night, i love mixing drugs and will even mix 3-4 different ones at times plus weed on top, some combos go and some dont, love mixing mdma ;)
I used to love smoking weed with stims but these days I prefer to wait until I'm starting to comedown and enjoy the mix of stims on their own.
i have the same problem. when i was younger my heart would take it, and i wouldn't mind the monstrous rise in blood pressure, but now i feel like i might keel over. for the comedown it does work wonders
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i have mixed them and like lim and a few others have said bad bad comedown you feel like you want to die, but it was a great night, i love mixing drugs and will even mix 3-4 different ones at times plus weed on top, some combos go and some dont, love mixing mdma ;)
I used to love smoking weed with stims but these days I prefer to wait until I'm starting to comedown and enjoy the mix of stims on their own.
i have the same problem. when i was younger my heart would take it, and i wouldn't mind the monstrous rise in blood pressure, but now i feel like i might keel over. for the comedown it does work wonders
see i smoke almost all day long everyday so doing any drug would feel odd without weed let alone a trip,
it might be the difference between a good and bad trip for me, im very much looking forward to my dmt experience after all the research and videos i have watched on the subject, im mentally ready :)
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Mixed it many times - personally I've found that takin amphetamine can stop you monging out in al all-body gurn in the corner if you've hit the mandy hard...
Don't expect to sleep easy afterwards though - and the comedown is harder and longer
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It's all about moderation and rotation. I mixed some really good mdma with some really good meth. I finally understand what "suicide Tuesdays" meant. I tried to kill myself because of it. Granted, that i didn't have anything for the crash and nothing to supplement. (I didn't have the right vitamins or any drugs to ease the comdedown.)
So i can't stress this enough. Moderation (because if you use moderation you'll be able to get high more times, and not have as bad of a crash.) and rotation. (Since you rotated substances and saved one for another day. You get to get high another day and have something to look forward to.)
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Wondering if the OP tried this, I think we'd all appreciate an update to see how it went.
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honestly, who gives a shit.
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It's all about moderation and rotation. I mixed some really good mdma with some really good meth. I finally understand what "suicide Tuesdays" meant. I tried to kill myself because of it. Granted, that i didn't have anything for the crash and nothing to supplement. (I didn't have the right vitamins or any drugs to ease the comdedown.)
So i can't stress this enough. Moderation (because if you use moderation you'll be able to get high more times, and not have as bad of a crash.) and rotation. (Since you rotated substances and saved one for another day. You get to get high another day and have something to look forward to.)
The same thing happened to me, but without the trying to kill myself part. That is why I'm so vehement about not mixing them.
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^ pretty much this, I'd add a couple things though. And not that horrible of a comedown, why should it be? PM if you want my personal experience or make a new thread and let this die.
@muslix: any advice or are you pissed off again ;D :P ;D
i'm not pissed off, never was. Said that in the first post (read the quotes) already, the circlejerking troll threads are bad for me, I tend to get involved and then it goes on forever, so I'm avoiding them. Read mars' posts, all offtopic. pointless.
There's like 5 people here who claim to know it all, why do you need me?
Or can't marsvolta12 be bothered again to share his knowledge? lol. And trolling in Drug Safety backed up by mods (as if this meant anything) is well, I better say nothing about that. Be proud of yourself.
off topic.... i answered his question. you are making no sense....
Marsvolta12 & Marsprotege could be the next Thomson & Thompson going undercover. Great disguise guys. _X_
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it does add Neurotoxicity but i enjoy doing it with small amounts of amphetamine to keep me off the couch ;)