I definitely without any doubt think that NMDA antagonists such as ketamine do a far superior job of mimicking the effects of schizophrenia. On ketamine binges I have heard voices in my head, had delusional thoughts, the works. LSD has never induced an effect in me that seems at all comparable to schizophrenia. I believe that loss of brain tissue does not mean that it is a progressive disease unless the amount of tissue continues to lessen over time. I think in at least a quarter of cases schizophrenics only experience a single episode in their life and have no further disturbances related to the disease. I can find several dozen citations in support of either arguement though, so who knows. http://earlypsychosis.medicine.dal.ca/index.php/2012/12/schizophrenia-is-not-a-progressive-brain-disease/ This study seems to conclude that decreased brain tissue in schizophrenics is correlative but not causative. http://www.madinamerica.com/2012/11/22141/