As someone who has both used and been around users of both meth and amphetamine, I can say with 100% certainty that meth is 10000000000X more destructive and addictive than amphetamine is. I really must think that anyone who disagrees either has no idea what they are talking about or is in total denial. I guess I should assume that everyone is different, but I have seen enough meth users and amphetamine users that I can see the general trend. Plus I used amphetamine almost daily for a few months and don't feel at all addicted to it nor do I get strong cravings for it ever (although I sure wouldn't mind having some ). I smoked meth 12 times and still get strong cravings for it 7 years later. Plus the people on amphetamine I hung out with were generally nice normal people. Most of the meth users I hung out with were thieving selfish fucktards who would steal from their own mothers to get more meth. Of course not all meth users can't be trusted at all. Hell, maybe even the majority of them. but if I had the choice between hanging out with regular meth users or regular amphetamine users I would pick regular amphetamine users in a heart beat. IMO and IME amphetamine is like a soft drug compared to meth. Yeah that is a bunch of bullshit but whatever Pretty sure it is actually a direct result of meths pharmaceutical effect of decreased salvation and increased vasoconstriction, but whatever Snort NaCL. Now snort NA. Then take a breath of Cl. Seriously. https://www.erowid.org/chemicals/amphetamines/amphetamines_health.shtml Stress & Oxidative Damage: Methamphetamine causes stress to the body and mind and causes an increase in oxidative stress in blood and tissues. At very high doses and frequencies of use, organ damage and premature aging may occur. Frequency: common. Certainty: some evidence. Neurotoxicity (Methamphetamine): At high doses, methamphetamine causes damage to dopamine and serotonin neurons in the brain [Seiden 1976, Thompson 2004]. Long term use may lead to noticeable neurological and behavioral problems. This effect is well documented with methamphetamine in mice and now largely confirmed in humans; behavioral/clinical effects of this damage is not well documented in humans [Hanson 2004]. Frequency: unknown. Certainty: link established in rodents, exact nature unclear in humans. Neurotoxicity (D/L-Amphetamine): Neurotoxicity with D/L amphetamine (most of what is prescribed as medications) is not as well documented, but at very high doses and frequencies, neurotoxicity does occur in mice and rats. [Jonsson 1982] Frequency: unknown. Certainty: unknown.