This is useful in the 5 percent of cases where you know the package was intercepted ahead of time. You can throw away the mailbox key, never visit that post office again, and you'll be safe because they won't know who are or where to find you. In the other 95% of cases, you won't have a clue that it was intercepted until you're standing in the post office with the package in your hand and a guy with a badge steps out from behind the counter (or pulls you over a few blocks away).
IMO, a residential address is safer because you can passively receive the package and choose when to pull it out of the box. LE isn't going to wait around for hours or days, and at all hours of the night, for you to pick up a small amount. They will either knock on your door and see if you accept it, or not deliver it at all (in which case, it will join the ranks of the infamous missing packages). To that end, it's best not to be home when the mail is delivered.
The reason you give for using a residential address sounds like it is a good reason for using a PMB obtained with a fake ID. If you order a package to a residential address LE doesn't need to wait around for days or hours, they know where you live already. They will either knock on your door and see if you accept it, or they will just raid you anyway because they already know a package with illegal drugs was sent to you and they can probably get a warrant to search your house based on that alone. In the case of a fake ID box, they have no door to knock on and no home to raid until they identify you picking up the package and follow you back to wherever you live or ID your car. And in cases where they are not going to do anything at all, wouldn't it be better for them to not do anything against a fake name and address that isn't linkable to you, than for them to do nothing against your real name and address (other than make a note of it).
Although you may only be tipped of to an interception in advance 5% of the time (I can think of a few examples of this happening, although I agree it is rare overall. Two general themes: tracking let it slip, or everybody who ordered from the vendor starts getting CDed at once), you might learn that a vendor you worked with has been arrested 50% of the time. It is much more common for someone to learn a vendor they worked with has been arrested than it is for someone to learn that a package they had has been intercepted. Or maybe the vendor simply disappears. Maybe this is more common on tighter community oriented forums where everybody talks regularly with each other, and you notice an unexplained absence of a vendor and nobody knows what happened to them (until you check for drug busts in the area they shipped from and piece together what happened. Note that this happened with enelysion, in the case of Joot we learned about it from the court documents very shortly after TFM went down, etc). Then you need to consider some vendors are probably keeping customer shipping information to aide them in plea bargaining. Or maybe the busted vendor even had outgoing package addresses recorded (enelysion did) and your address in on a list. No interception to you has happened yet, but packages to that address are probably way more likely to be intercepted in the future!
And better not order from an asshole who will blackmail you with your real address.
People have proposed using various light sensitive devices that can warn you when the package has been opened. They might be worth it for large orders, but it's also possible for LE to x-ray the package, discover that it contains such a device, and open it in a dark room to field test the drugs. They are also known to use needle-sized poking devices to sample the contents, which leave a hole so small that it probably wouldn't set off the device. To protect against that, you would have to fortify it with a hard internal package, which again isn't worth it for small amounts, when simply mailing the drugs in an envelope is much safer.
Vacuum seal the device with the drugs and have it detect the presence of oxygen then. I would be less worried about LE x-raying the package and finding it has some obscure electronic device in it and more worried about LE x-raying the package and finding that it has some pills or powdery substances wrapped up inside of it.