I have not noticed any side effects but others surely have noted some. My friend I tripped with threw up and then she was fine, which also happens to certain people on LSD and other psychedelics. Some other people reported "bad" effects but did not detail them so I am skeptical. I would probably do 450ug if you have a small amount and can't risk wasting it. It's been pretty well used at this point with only a few negative reports but many many glowing experiences. It is LSD-like. It's a psychedelic drug so you can't reliably compare it to another psychedelic as they are all different and even the same substance can produce a totally different experience. A bad trip is always possible as with all psychs. Most people report it takes about 2+ hours to come up, which is what I experienced, It is definitely real (it's been lab tested) and all coming from the same source. I am pretty confident in saying any AL-LAD out there right now is the from the same synthesis, especially if it's the labeled blotter. My source has spread it to the ends of the internet. You can tell it's AL-LAD by the long come-up time, the gigglyness, and the fact it says AL-LAD on the blotter (just kidding). You have to hit the right dose and then it gets really visual. This dose is different for everyone. Your duration sounds right. I think it's like i speculated before, some are just much more sensitive then others. Some people say 150ug is too much, others say they don't feel anything at 300ug. If you are a tripper just drop 450ug and hold on as you surely shouldn't need anymore than that.