Ask a Drug Expert Physician about Drugs & Health

[DoctorX]

Hello,
I am a Spanish Family Physician working in fields like risk reduction associated to drug use, club drugs, new synthetic drugs, cannabis therapeutic and steroids since 1999. I would like to contribute to this forum offering professional advice in topics related to drug use and health: pharmacological interactions, risks of drug use in particular conditions (specific diseases, problems of health…), contraindications, adverse effects and toxicity, risk reduction measures…
This advice cannot replace a complete face-to-face medical evaluation, but I know how difficult can be to talk frankly about these things. You can see my CV on my personal web-page http://www.doctorcaudevilla.com/
You can also use PM for personal questions or video-conference in my web (available only in Spanish).
I will try to answer all your questions (if I know the answers) but I have limited time
DoctorX

Please look over and follow these guidelines before posting:

1) Have a look into the thread or use the search engine. It is possible your question has been     asked and answered already.

2) Try to be as descriptive as possible, the more accurate your information (age, gender, health problems, prescription/illegal drug use...) the more specific my answer will be.

3) Information in this thread is general advice, but it can't replace a personal, medical evaluation. Health problems must be evaluated in person. No responsibility is assumed by misunderstanding of this information.

4) Answering questions entails dedicating time and personal effort. Consider supporting this service with a donation

(10/10/13) Continuing this thread from old SR forum

(03/05/13) Please only use PM and PGP for personal questions. Most of the questions can be answered in general forum and can be useful to other people

[Rastaman Vibration]

Doc! So good to see you here. Glad you could join us! I look forward to reading this thread

[V]

Yes, again my sincere thanks for responding and bringing your expertize back to Silk Road.

V

[MrTerrific]

In the far future (about a year from now), I plan on using MDMA to engage in a sexual encounter with a very close friend. We'll be using it together. Is that something that you would recommend? What dangers should i look out for? what can I do to limit risks, or make the experience the best it can be?

[DoctorX]

If you are using moderate-normal dosages (not higher than 120-140 mg, 1.5-2 mg/kg), you both have experience with the substance and are in a general good health, there should not be excessive risks in a physical point of view. Having sex is no more risky than dancing in a rave (in a cardiovascular point of view), so adding MDMA does not imply many differences. General rules of risk reduction for MDMA are applicable.

There are different opinions about sex on MDMA, probably it is a question of personal preferences. Most people prefer sex 3-4 hours after MDMA intake. In that moment the important mental effects are diminishing but persist well being and tactile enhancement. MDMA difficults penile erection in many men, and 3-4 hours after this effect is less noticeable, at least for most people. It can be interesting to forget about penile erection and explore other aspects of sexuality. Retarded ejaculation is another frequent issue (this can be an adventage or disadventage, depending on persons and situations).  As I say, many people prefer sex after MDMA but, nevertheless, other prefer it during the peak experience.

Another aspect is psychological reactions and changes in communication with other persons. Depending on your personal implication with that person it is possible that your  thoughts about your partner arne different than usual (deeper, clearer, more emotional...). It is possible that he/she experiments the same. The consequences of this kind of situations can be very possitive, negative or neutral, depending on many factors. But taking in consideration MDMA psychological effects is also a risk reduction measure.

Look for an adequate, intimate space, be free of preocupations...a good set and settting, in definitive, is the best you can do. And leave some space for improvisation and do not expect too much of it.

[Pillows]

Hi Dr. X!

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course 

[cleansober]

Whose got the Karma? I have none. I was going to give X his first - in honor of the demise of SR 1.


DoctorX,

This whole thing reminds me of the health care system in the States.  Computers could not keep up with the demand or the system put in place was poorly designed resulting in the overload.

In your first post here you tackle the subject of MDMA and sex.  What about the need for known purity levels and the "rejecting" BAD stuff?  I'm smoking some weed that must have been soaked in animal poison but since I'm almost done I might as well finish it. It causes less eating not more.  A diet pill in the form of weed.  What is the market for my new product line?  I'd say biggest.  Who knows the side effects at this time and good luck trying to get the ingredients.

All this solidarity stuff is bull crap.  A vendor has the text copy of every address he ever shipped to, he gets ten years less in jail, does he give up the addresses?

CS

Doc, do you do anything online in English or Spanish like a google hangout? Also do you give online drug related advice in English or in any language for that matter?  We could have an online encounter group. 

[leadsingersdisease]

Hey Doc,

You rock!

Peace x

[Quizitix]

Welcome Doc!

Nice to see you have joined these forums, your information is invaluable

[NotACop]

Hey Doctor!

I am mostly not serious -but for you, because I love you so much... I will be somewhat serious.
(If anyone else is reading this: then please commit more felonies and report your felonies, your whereabouts and your name here on this website.)

I'm talking about Cranial Electrotherapy Stimulation specifically targeting any known pleasure centers of the brain.

A lot of the drugs that people do somewhat stimulate the pleasure centers of the brain. How can I stimulate these centers using some legal, yet external device? I know for example that I can buy a Fisher Wallace Cranial Stimulator. I KNOW FOR A FACT THAT THIS DOES NOT DO WHAT I AM LOOKING FOR IT TO DO.

But say hypothetically that I wanted to modify one to do this. The effects would have to be the following:

1) It would stimulate something in my brain that would be pleasurable
2) I would be able to remember the experience.
3) Besides neuron connections (via memory) there would be no known long term side effects

What part of the brain would I be looking  to stimulate? Do you know of anyone doing this experimentation (preferably non-invasive).

Thank you doctor. As a sign of good faith - please once again post your bitcoin wallet somewhere because I owe you at least 10 dollars.

[DoctorX]

Hi Dr. X!

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course 

Detoxification with opioids (descending dosages of methadone, codeine or buprenorphine) is the simplest and less umconfortable way for heroin/opiate withdrawal. If, for any reason, these drugs are not used, clonidine could be an option. You can find dosages in page 28 (table 10) of this guide:

http://www.pnsd.msssi.gob.es/en/Categoria2/publica/pdf/GuiaClinicaOpiaceos.pdf

Clonidine acts on abdominal pain,  shivering, muscular cramps and other physical symptoms but it is not very useful for anxiety and insomnia. Short time use of benzodiacepines like chlorazepate or midazolam (oral) can help.

L-acetyl-carnitine acts on pain in methadone detoxification. According to my professional experience it is useful for other opiates detoxification, too

www.ncbi.nlm.nih.gov/pubmed/18978503‎

General measures: good hydration, soft meals, resting...are useful, too.

[parabol]

Hello, I have a question about micro dosing LSD, I know is unknown territory but please let me know if this is a wrong line of thought.

Average trip 200ug needs at least 14 days for you to restore tolerance. But with less amount wouldn't you also need less time for that? So if I take 10ug that's 5% then I would need only 5% of the restoring time, that is 0.75 days. According to this logic only 1 day after that dosage will be more than plenty to recuperate and don't build tolerance. And if you take even lower amount, let's say 5ug or 2.5% that's 0.375 days of recovery time, so if you take it at the morning, for example 8:00 AM, next morning at the same hour you will be more than recovered, so you could take 5ug all week. This will require testing and I guess is variable to each individual.

I'm very interested in this and help is much appreciated.

[Druggie]

I am prescribed dexedrine and ritalin.

Would it be a good idea to combine the two drugs to counteract amphetamine neurotoxicity?

[DoctorX]

Whose got the Karma? I have none. I was going to give X his first - in honor of the demise of SR 1.


DoctorX,

This whole thing reminds me of the health care system in the States.  Computers could not keep up with the demand or the system put in place was poorly designed resulting in the overload.

In your first post here you tackle the subject of MDMA and sex.  What about the need for known purity levels and the "rejecting" BAD stuff?  I'm smoking some weed that must have been soaked in animal poison but since I'm almost done I might as well finish it. It causes less eating not more.  A diet pill in the form of weed.  What is the market for my new product line?  I'd say biggest.  Who knows the side effects at this time and good luck trying to get the ingredients.

All this solidarity stuff is bull crap.  A vendor has the text copy of every address he ever shipped to, he gets ten years less in jail, does he give up the addresses?

CS

Doc, do you do anything online in English or Spanish like a google hangout? Also do you give online drug related advice in English or in any language for that matter?  We could have an online encounter group.

Knowing purity and composition of drugs is basic.  One of the problems of illegality of certain substances is the lack of sanitary controls on products. Sometimes (for example, cocaine and levamisol), risks from adulterants are higher than those of the pure drug. In other cases it is almost impossible to find the pure substance (main composition of speed is not amphetamine, but caffeine).
Markets as SR are not perfect but at least allow a relative control on big frauds. In some countries drug testing services are available, making possible a more strict control on adulterants. In Spain I work with the Drug Testing Service of the NGO Energy Control (www.energcontrol.org). We have a project to make an International Drug Testing Service but lack of funds is limiting its development.
I have a videoconference service in my web, and I could use Google Hangout if necessary

[DoctorX]

Hey Doctor!

I am mostly not serious -but for you, because I love you so much... I will be somewhat serious.
(If anyone else is reading this: then please commit more felonies and report your felonies, your whereabouts and your name here on this website.)

I'm talking about Cranial Electrotherapy Stimulation specifically targeting any known pleasure centers of the brain.

A lot of the drugs that people do somewhat stimulate the pleasure centers of the brain. How can I stimulate these centers using some legal, yet external device? I know for example that I can buy a Fisher Wallace Cranial Stimulator. I KNOW FOR A FACT THAT THIS DOES NOT DO WHAT I AM LOOKING FOR IT TO DO.

But say hypothetically that I wanted to modify one to do this. The effects would have to be the following:

1) It would stimulate something in my brain that would be pleasurable
2) I would be able to remember the experience.
3) Besides neuron connections (via memory) there would be no known long term side effects

What part of the brain would I be looking  to stimulate? Do you know of anyone doing this experimentation (preferably non-invasive).

Thank you doctor. As a sign of good faith - please once again post your bitcoin wallet somewhere because I owe you at least 10 dollars.

First of all...I love you too
Theoretically, you would have to point to your mesocortical-limbic dopaminergic way, in the ventral part of the mesencephalon. Unfortunatelly there is no way to predict what would happen to you. All the data about "pleasure centers of the brain" and its relation with drug are hypothesis based in animal models, specifically on rats. All experimentations are invasive, in laboratory conditions and using electrodes to activate that areas in rats. It is a very interesting hypothesis but only that, theoretical speculation. As far as I know there is no way to replicate these experiments on humans with transcraneal devices
You can find my BTC address in my signature. Thx

[DoctorX]

Hello, I have a question about micro dosing LSD, I know is unknown territory but please let me know if this is a wrong line of thought.

Average trip 200ug needs at least 14 days for you to restore tolerance. But with less amount wouldn't you also need less time for that? So if I take 10ug that's 5% then I would need only 5% of the restoring time, that is 0.75 days. According to this logic only 1 day after that dosage will be more than plenty to recuperate and don't build tolerance. And if you take even lower amount, let's say 5ug or 2.5% that's 0.375 days of recovery time, so if you take it at the morning, for example 8:00 AM, next morning at the same hour you will be more than recovered, so you could take 5ug all week. This will require testing and I guess is variable to each individual.

I'm very interested in this and help is much appreciated.

Tolerance depends on chemical characteristics and way of metabolism of each drug. Also, to develop tolerance it is neccesary a minimun dosage and frequency of administration. Tolerance to LSD develops quickly (for most people it is very difficult to use LSD 2 or 3 consecutive days) and also disappears quickly. There are no validated studies to know specifically the time of tolerance duration, but it osciles between 5-10 days.
In theory, reducing dosages would reduce time of tolerance. But LSD threshold is 20-30 mg, so, dosages lower than that would make virtually no psychological effects. And daily administration of very low dosages could have neurochemical effects that affect tolerance development even without psychological effects. So I think reality is much comlex than your reasoning on this issue, it is not a question of a linear dosage-response relation, there are many factors that have influence on that.

[DoctorX]

I am prescribed dexedrine and ritalin.

Would it be a good idea to combine the two drugs to counteract amphetamine neurotoxicity?

Neurotoxicity of dextroamphetamine is only manifested at very high dosages in some animal models. Dosages used in human prescritpion are under neurotoxic levels. Methylphenidate (ritalin) neurotoxic potential is even lower, insignificant.
http://www.ncbi.nlm.nih.gov/pubmed/9365033
http://www.ncbi.nlm.nih.gov/pubmed/22289608
www.ncbi.nlm.nih.gov/pubmed/2440058
 So neurotoxicity should not be a matter of concern, supposing oral route and prescription dosage. Combining both will have no effect in neurotoxicity (as it is unlikely that it exists) and would increase adverse effects.

[bobby421]

Hello Doctor X,

This is great to have your knowledge on this forum.

I have big trouble finding information on 2c-B. I saw post where you say it may be harmless, on erowid/bluelight, the health info is very incomplete and this molecule is classified as RC.
 
I also saw that his 2c cousins seems way more powerfull/dangerous.

Do you have any explanation/articles/research on this topic, in order to understand why 2c-b may be less harmfull than MDMA ou others 2C or the nasti nbome.

Thanks doc

[DoctorX]

Hello Doctor X,

This is great to have your knowledge on this forum.

I have big trouble finding information on 2c-B. I saw post where you say it may be harmless, on erowid/bluelight, the health info is very incomplete and this molecule is classified as RC.
 
I also saw that his 2c cousins seems way more powerfull/dangerous.

Do you have any explanation/articles/research on this topic, in order to understand why 2c-b may be less harmfull than MDMA ou others 2C or the nasti nbome.

Thanks doc

In general, Research Chemicals (RCs) are substances recently sythethized with little or nonexistent data in humans. Strictly, 2C-B should be considered a RC, as there are almost no data on humans, but 2C-B was synthetized in late 70s and been widely used by dozens of  thousands of persons over 30 years. Comparision with other "real RCs" as bromo-dragonfly or NBOMEs would be exaggerated. There is much more information on 2C-B than on these new substances.

2C-B has appeared as a substitute of MDMA when this is not available in several countries. There can be anxiety problems (mostly in people who take 2C-B thinking it is MDMA), but there are no data of long-term effects, physical damage to any organ or other important short or long term effects. There are only 2 reports of toxicity associated to 2C-B, that must be considered as anecdotical.

http://www.ncbi.nlm.nih.gov/pubmed/21036198
http://www.ncbi.nlm.nih.gov/pubmed/20445431

2C-B is the 2C-X most used, and experience is a point when considering risks. Its moleculal structure (an unique atom of bromine) seems similar to other prescription drugs and there is a lack of bizarre molecular structures that suggest harms. In fact 2C-B is a minimal modification of mescaline.

The long time of 2C-B use (more than 30 years) and the lack of reports on toxicity are the main arguments to consider this substance relatively safe (or at least safer than others). Mild psychedelic effects are aggreable for most people, although it is important to be cautious with dosages, frequences, setting of use, drug combinations...as any other substance.

It is not auto-propaganda, but my investigation team is the unique who has published data of 2C-B in humans:
http://www.slideshare.net/fernandocaudevilla/2cb#!

[LOL]

hello dr. fernando,
thanks for everything you do for this community. i can say that you are one of the biggest assets these forums have.

it's very hard to find solid information regarding marijuana studies that have been performed under controlled situations. thus, the advice one finds is both unfounded and tends to be contradicting. so, my question, whether it's from your personal opinion or  from solid evidence, how negative of an effect does marijuana have for memory? i smoke a small amount everyday, maybe 2-3 hits from a pipe vaporizer. if i wanted to reduce the negative effects it has over memory, is it enough if i considerably cut down on frequency/amount, or does it require a full stop from smoking?

[DoctorX]

hello dr. fernando,
thanks for everything you do for this community. i can say that you are one of the biggest assets these forums have.

it's very hard to find solid information regarding marijuana studies that have been performed under controlled situations. thus, the advice one finds is both unfounded and tends to be contradicting. so, my question, whether it's from your personal opinion or  from solid evidence, how negative of an effect does marijuana have for memory? i smoke a small amount everyday, maybe 2-3 hits from a pipe vaporizer. if i wanted to reduce the negative effects it has over memory, is it enough if i considerably cut down on frequency/amount, or does it require a full stop from smoking?

The most noticeable neurocognitive effect from cannabis is a subtle alteration of short time memory (memory used, for example, to remember and learn new data). This effect depends on cannabis dosage, frequency and individual characteristics (some people are very susceptible to this even with low doses, other don’t feel it even with high dosages). It is reversible after a few weeks of complete abstinence. There are no other “cognitive declines” associated to cannabis use.

Two high quality studies (meta-analysis) support this idea, so it is not a question of personal opinion, but scientific evidence
http://www.ncbi.nlm.nih.gov/pubmed/12901774
http://www.ncbi.nlm.nih.gov/pubmed/22731735

This kind of studies distinguishes between heavy smokers/light smokers/non smokers. They don't considerate situations like yours. In general, impact on memory is moderate and depending on dosage. 2-3 hits on a vaporizer seems a moderate quantity, effect in theory should be very little. It is also important consider aspects as potency of cannabis and your occupation (student or person who needs concentration and memory). In this last case it should be important to smoke after (and not before) studying.

[Dread Pirate Roberts]

Thread has been stickied. Many thanks to you Doctor X for all your contributions, you are an asset to the profession, the community and everyone who has dedicated their lives to helping others.

[weed dude]

Thread has been stickied. Many thanks to you Doctor X for all your contributions, you are an asset to the profession, the community and everyone who has dedicated their lives to helping others.

+1

[TorXic]

Great you are still up DoctorX!

I thought you will stop after the seize, but you just moved!

Thanks for your work!

[LOL]

gracias doctor

[kissthemoon]

Hi Doc,

First of all, great that you help other people like you do

A while ago I insufflated about 500 mg cocaine in the coarse of an evening, it was the first time I used coke. Nearing the end of the evening I had an constant runny nose which was pretty annoying. I cleaned my nose with saline, but nevertheless by the time I went to bed my nose was totally clogged up.
The next morning when I blew my nose, all of the mucus was red coloured. For about a week afterwards there was blood in my mucus, it became less and less till finally no blood at all after a week and the mucus was colourless again.

Clearly this is a sign that my nose didn't like what I put up there, but I'm not sure how harmfull it is. Is such a reaction 'normal' for coke use? Could another coke experiment be conducted without a risk on permanent damage, or is coke a nono for my nose?

Best regards,

[stonedapetheory]

Hi Doc,

First of all, great that you help other people like you do

A while ago I insufflated about 500 mg cocaine in the coarse of an evening, it was the first time I used coke. Nearing the end of the evening I had an constant runny nose which was pretty annoying. I cleaned my nose with saline, but nevertheless by the time I went to bed my nose was totally clogged up.
The next morning when I blew my nose, all of the mucus was red coloured. For about a week afterwards there was blood in my mucus, it became less and less till finally no blood at all after a week and the mucus was colourless again.

Clearly this is a sign that my nose didn't like what I put up there, but I'm not sure how harmfull it is. Is such a reaction 'normal' for coke use? Could another coke experiment be conducted without a risk on permanent damage, or is coke a nono for my nose?

Best regards,

powder fucks up teh nose. every kind..

[DoctorX]

Hi Doc,

First of all, great that you help other people like you do

A while ago I insufflated about 500 mg cocaine in the coarse of an evening, it was the first time I used coke. Nearing the end of the evening I had an constant runny nose which was pretty annoying. I cleaned my nose with saline, but nevertheless by the time I went to bed my nose was totally clogged up.
The next morning when I blew my nose, all of the mucus was red coloured. For about a week afterwards there was blood in my mucus, it became less and less till finally no blood at all after a week and the mucus was colourless again.

Clearly this is a sign that my nose didn't like what I put up there, but I'm not sure how harmfull it is. Is such a reaction 'normal' for coke use? Could another coke experiment be conducted without a risk on permanent damage, or is coke a nono for my nose?

Best regards,

Intranasal damage is a common problem of drugs used by this route of administration. Dosage, frequency and technique of use are important factors that have influence in severity. Cocaine itself (and impurities associated) can irritate nasal tissues and make it bleeding. Half a gram seems a quite elevated dosage for a newbie. It is recommendable to pulverize the substance to a very thin dust before sniffing. Do not use always the same nostril for sniffing, but alternate both. Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better. Saline irrigation can be used several days (better using a syringe). If you are experimenting again I suggest to follow these advices, and diminishing dosages also.

[DoctorX]

Hi DoctorX,

Regarding buprenorphine and alcohol being co-administered:

Have you ever experienced or heard of people on approx. 4MG of buprenorphine blacking out for an extended period of time after 2-3 rapidly consumed alcoholic beverages?

Black-outs or amnesic episodes are not common adverse effects of buprenorphine. They are not even mentioned as a rare possibility in technical sheet of the product. But alcohol itself by itself without necessity of other factors. Drinking too quickly (and/or high graduaton beverages) can facilitate this.

[composer]

Hi Dr.,

I looked through this thread for mentions of heart rate/vascular system, but couldn't find anything, so I thought I'd ask a few questions on the topic.

Marijuana is sort of famous for increasing heart rate - some websites talk about it effecting an increase of 40 bpm, while others mention an increase of 50% over resting heart rate. Personally, my heart rate goes from a resting rate of 70 bpm, to about 120 bpm (as if I'm jogging), and I have measured it to go as fast as 156 bpm, which is about 80% the maximum heart rate for my age group. This >120 bpm heart rate can persist for an hour, sometimes two. Of course, if I were running a marathon, this would be considered normal and safe, but all of this is when I am at rest and not exerting myself at all. Is such an elevated heart rate for such a long time dangerous to the body when it's not accompanied/caused by physical activity? Would this become risky as I age and the heart and blood vessels deteriorate, and maximum heart rate lowers to 130? Finally, I read that smoking tobacco products increases risk of abdominal anyeurism at later ages (60+) - does smoking marijuana increase the chance of anyeurism (abdominal or otherwise) like tobacco?

[DoctorX]

Cannabis increases heart rate by a different mechanism than stimulants. The main effect is relaxation of veins and arteries. This effect lowers blood pressure. To compensate this and mantaining blood flow heart beats more quickly. As a general idea this is less risky than cardiovascular effect of stimulants. There are some cases of cardiovascular damage induced by cannabis, but are anecdotal and uncommon. The main risk is fainting if you get up quickly or make exercise. So if you feel dizzy, lie down to avoid hurting if you fall as a result of loss of consciousness.
The increase you report is important and long-lasting. Probably it is constitutional (I mean, you are particularly susceptible to that effect) or related with cannabis potency (you should try another variety or use less quantity). It is theoretically possible that cannabis use could trigger an asymptomatic arrhitmia and maybe it should be interesting to have an electrocardiography test to rule out this possibility.
In aged persons who are regular users of cannabis, in general this effect diminishes on time, as adaptative mechanisms of body change.
There are no data about cannabis and aneurysms. Studies are difficult because most smokers of cannabis are also smokers of tobacco and results are difficult to interpret. In my opinion and according to mechanisms of action of cannabis, the causal relation is unlikely

[stonedapetheory]

Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better.

you are the best!

[cleansober]

Cannabis increases heart rate by a different mechanism than stimulants. The main effect is relaxation of veins and arteries. This effect lowers blood pressure. To compensate this and mantaining blood flow heart beats more quickly.

X,

Would you recommend someone exercise after using weed to take advantage of the higher heart rate even though there is a relaxation of the veins and arteries?  Revving up a car while stationary is bad for the pistons and rings, is revving up the heart for no good reason a potential health issue?

C

[DoctorX]

Cannabis increases heart rate by a different mechanism than stimulants. The main effect is relaxation of veins and arteries. This effect lowers blood pressure. To compensate this and mantaining blood flow heart beats more quickly.

X,

Would you recommend someone exercise after using weed to take advantage of the higher heart rate even though there is a relaxation of the veins and arteries?  Revving up a car while stationary is bad for the pistons and rings, is revving up the heart for no good reason a potential health issue?

C

Vascular relaxation induced by cannabis can lead to hypotension, dizziness and syncope. Physical exercise, quick changes of position, to stand up very quicky will enhance the possibility of these problems. So physical exercise in not reccomended after using weed.

[stonedapetheory]

Hi Doctor X

You are doing a huge favor to the community. I just want to ask you: How are you? Are you doing alright?

Are you planning to write a book about your experiences up here? If so.. When? I wanna read a book about the truth and not fake drug stories written to scare little children!!

Is there any other thread where you write? Do you have the old sr thread saved? In case the forums go down... If you are planning to write a book there a re a lot of good quotes up there!!

The drug addicts are on your side! If you need some help I think everyone on this forum will be ready to help you!
You believe in heaven? If so.. you will go there when you die!!
Have a good life and sorry for the drugged up loved up message!
Peace!!

[DoctorX]

Hi Doctor X

You are doing a huge favor to the community. I just want to ask you: How are you? Are you doing alright?

Are you planning to write a book about your experiences up here? If so.. When? I wanna read a book about the truth and not fake drug stories written to scare little children!!

Is there any other thread where you write? Do you have the old sr thread saved? In case the forums go down... If you are planning to write a book there a re a lot of good quotes up there!!

The drug addicts are on your side! If you need some help I think everyone on this forum will be ready to help you!
You believe in heaven? If so.. you will go there when you die!!
Have a good life and sorry for the drugged up loved up message!
Peace!!

Thx for message...   I´m fine,thx!!!
I don`t think my English is good enough to write a book, although it would be interesting. I have saved part of the old thread but not finished yet. Anyway I think I have read there are some back-ups of the old forum.
Peace and love.

[Cornelius23]

You could write it in Spanish. The help you provide extends far beyond national and language boundaries. Let others do the translations

[chewbacca]

Hi DoctorX!
Great thread!!! I wish every doctor was like you...
I am thinking about trying dissociatives...what should be the safest option...PCP, ketamine or methoxetamine?

[Sweetheart]

sub

[Professor Chaos]

Hello Doctor, It is great to see you here again,

Since discovering Silk Road and similar sites, I've enjoyed trying out new chemicals with my wife and a handful of close friends. My wife is on the anti-depressant wellbutrin and  this seems to mute the effects of a lot of things, some more so than others.  For example while MDMA has little effect on her, she finds bk-MDMA very enjoyable, 4-FMA seemed to work well for her but 6-APB did little if anything. 25i had a fairly noticeable effect for her at 1mg but 3 hits of LSD did nothing. Opiates seem to work very well as does marijuana.

Is there any way to sort of predict based on the medication she takes, what chemicals might work better for her? I've read a little on wikipedia and such how different areas of the brain are affected by different chemicals, but its difficult to make sense of it all in regards to knowing what chemicals will be unaffected by wellbutrin.  Are there any dangers to be aware of, or specific chemicals that should be avoided?

Thanks for everything :-)

[cocoanatta]

Hello Doc, I was considering preparing Ayahuasca for therapeutic and entheogenic purposes, and I wanted to know if you had any experience with this preperation and how it compares to other psychedelics such as LSD and Mushrooms. I am going to take 6g of mimosa to 2g of syrian rue and sit around a camp fire. What subjective cognitive effects should I expect?

[DoctorX]

Hi DoctorX!
Great thread!!! I wish every doctor was like you...
I am thinking about trying dissociatives...what should be the safest option...PCP, ketamine or methoxetamine?

Ketamine is a well known drug, widely used in therapy during 50 years. Recreative use of ketamine has, more or less, 15-20 years. In the last 5 years there have been a lot of scientific reports talking about bladder and urinary problems in ketamine users. It was an unknown problem until 2005 (more or less), and has been detected after 15-20 years of recreative, intranasal use. In general, it only affects to intensive users. Ketamine dependence is another problem with this drug.
http://www.ncbi.nlm.nih.gov/pubmed/21155941
PCP was used in medicine from 1920 to 1950 and it was finished then because of its adverse side effects, such as hallucinations, mania, delirium, and disorientation. In fact ketamine has its substitute, because it has less adverse effects. PCP has been linked to neurotoxicity in animals, but it is not probably extrapolable to humans. PCP can be lethal in overdose, this event is much less likely with ketamine.
Methoxetamine is a very new substance. We don´t know anything about its pharmacological properties and toxicity in humans, although there are reports of problems linked to its use:
http://www.ncbi.nlm.nih.gov/pubmed/23111916
http://www.ncbi.nlm.nih.gov/pubmed/22578175
http://www.ncbi.nlm.nih.gov/pubmed/22205276
http://www.ncbi.nlm.nih.gov/pubmed/23349353
Considering overall risks and benefits, probably ketamine is the safest, most pleasurable and less risky of all dissociatives, although it has it own problems associated indeed.

[Nunya]

Hello Doc,

Does opioid tolerance last a lifetime?  More specifically if someone was regularly taking opioids for years, developed a high tolerance, but was able to withdraw and stay off for several years - would the tolerance remain?  Or would it return more quickly than in someone who never had a tolerance?

Thank you.

[DoctorX]

Alright Doc, I have a question or two for you.

I took about 300 milligrams of oxycodone a day for about 5 years (by the way, it was the best 5 years of my life, work, family etc.), but then of course the big crack down began (pill mills etc) making it extremely difficult to obtain easily, so I had to stop as I did not feel like driving around to 300 pharmacies a day trying to fill my legally obtained prescription. Anyways it has now been about 3 years since I stopped taking them regularly, but to this day I feel as if it is my first day off of them, absolute no energy, tired constantly, no interest in anything, my gut is all screwed up, its total crap.  Now not to long before SR got shut down I finally had access to the things that made me feel normal again (coke, adderall, oxy's etc.).  I really believe that I am of the sorts that just do better with proper dosing of drugs, I spent my whole life with the mantra "better living through modern chemistry", but in today's age it is getting more and more difficult to self medicate properly and I am paying the price dearly for it (Job, family etc).  Do you think that my brain balance will ever return to normal without drugs?  Would any sort of doctor see it my way (that maybe there are some people that can benefit from certain drugs deemed evil?).  Is it impossible or ridiculous to say that I can function better with these drugs?  I think my lifetime would show that it is and today's governmental interference is wrecking my life.

Tolerance is one of the most important characteristics of many psychoactives. It is necessary to increase dosages to feel the same effect. So, some people take dosages that would be lethal for non-tolerant people. It is possible that some works are better done on drugs, but adverse effects and long time effects (including dependence risk) should also be considered. I´m not sure that necessity of high-doses of stimulants or opioids to do daily activities is a "better living", although I am not judging your life or decissions.  Tolerance diminishes on time, but psychological factors are also important. I am sorry but your question and situation is one of these that is difficult to assess only by Internet. It should be necessary personal and long-time contact to be able to help you

[DoctorX]

Hello Doctor, It is great to see you here again,

Since discovering Silk Road and similar sites, I've enjoyed trying out new chemicals with my wife and a handful of close friends. My wife is on the anti-depressant wellbutrin and  this seems to mute the effects of a lot of things, some more so than others.  For example while MDMA has little effect on her, she finds bk-MDMA very enjoyable, 4-FMA seemed to work well for her but 6-APB did little if anything. 25i had a fairly noticeable effect for her at 1mg but 3 hits of LSD did nothing. Opiates seem to work very well as does marijuana.

Is there any way to sort of predict based on the medication she takes, what chemicals might work better for her? I've read a little on wikipedia and such how different areas of the brain are affected by different chemicals, but its difficult to make sense of it all in regards to knowing what chemicals will be unaffected by wellbutrin.  Are there any dangers to be aware of, or specific chemicals that should be avoided?

Thanks for everything :-)

Bupropion can cause seizures in susceptible persons, and also diminishes threshold for seizures. So combination with stimulants (cocaine, amphetamine, amphetamine derivatives and others) should be contraindicated
Risks of 6-APB, 4-FMC or 25i to humans are unknown. There is a lack of data about its mechanism of action, pharmacological properties, acute and long-time risks...substances as cannabis or opiates are much safer in this way, as their possible harms are predictable. This is valid for the substances alone and for combination with bupropion. It is not possible to predict problems or interactions from molecular structures, action of areas of the brain or other theoretical speculations.
Another important item to take into account is the reason why she is taking antidepressants. Sometimes this cause can be affected by drug use, and so it is not reccomended. It is not only a question of pharmacological interactions but considering the whole person.

[Sir William Wonka]

Quick question about pharmacies in Spain.

While in Madrid I had the flue and could not get codeine from the pharmacy.  They just gave me sudafed.  Have the laws regrding over the counter codeine changed recently?

[theproblemsk]

MY sister is an heroin addict .. how do i make her stop using these fucking opiates??

[DoctorX]

Hello Doc, I was considering preparing Ayahuasca for therapeutic and entheogenic purposes, and I wanted to know if you had any experience with this preperation and how it compares to other psychedelics such as LSD and Mushrooms. I am going to take 6g of mimosa to 2g of syrian rue and sit around a camp fire. What subjective cognitive effects should I expect?

Composition and effects of ayahuasca depends on many factors: kind of plant, method of extraction, preservation...concentrations of DMT and MAOIs are very different depending on these factors
http://catbull.com/alamut/Bibliothek/various%20alkaloid%20profiles%20in%20aya%20decoction.pdf
Effects are different to psychedelics as LSD or mushrooms. Spiritual revelations are more common, as contact with spiritual dimensions and extra dimensional beings ("power animals"). Physical effects (nausea, vomiting, diarrhea) are common too.
http://www.erowid.org/chemicals/ayahuasca/ayahuasca_effects.shtml
It is important that, as with any other psychedelic effects are mediated by set and setting. Motivations, context of use, expectations, beleifs, intentions...are factors that have influence in subjective effects. There are people who report important and deep psychological changes after ayahuasca use. In many cases these changes are positive for persons, in other integration of experience is more difficult and it may appear emotional and psychological distress. Clasically, presence and advice of a "shaman" is adviced for ayahuasca use,  if you are using ayahuasca in a classical-ritual context this may be convenient.

[DoctorX]

Hello Doc,

Does opioid tolerance last a lifetime?  More specifically if someone was regularly taking opioids for years, developed a high tolerance, but was able to withdraw and stay off for several years - would the tolerance remain?  Or would it return more quickly than in someone who never had a tolerance?

Thank you.

Tolerance does not last a lifetime. Depending of family of substances it lasts more or less time. For opiates, it is necessary weeks or months to significantly reduce tolerance. In some months tolerance diminish practically to levels of people who never had used substance. In persons with story of tolerance it is typical that it develops more quickly when re-using opiates.

[DoctorX]

Quick question about pharmacies in Spain.

While in Madrid I had the flue and could not get codeine from the pharmacy.  They just gave me sudafed.  Have the laws regrding over the counter codeine changed recently?

In Spain opiates can be purchased in any pharmacy, but most of them need a Narcotic Medical Prescription. Codeine and tramadol need a ordinary prescription, but sometimes they are sold over-the-counter. This depends on your luck with the pharmacist. If you are an old lady you will have no problems to get codeine or tramadol OTC. If you look like younger, long-haired, clubber or something suspicious to the pharmacist's eyes you will need the medical prescription.

[Druggie]

DoctorX,

1.   I am prescribed Dexedrine for ADHD (15mg daily). I am concerned about potential neurotoxicity. I have read that co-administration of methylphenidate with methamphetamine reduces/reverses methamphetamine neurotoxicity (see: http://jpet.aspetjournals.org/content/304/3/1181.full and http://www.sciencedirect.com/science/article/pii/000689939090467P), so I am considering taking Dexedrine and Ritalin at the same time. Is this a safe combination if both drugs are taken at a relatively low dosage?

2.  Are there any effective ways to reduce amphetamine tolerance?

3. My uncle suffers from brain damage caused by chronic methamphetamine abuse. Are there any drugs or supplements you can recommend that can help repair his brain?

Thank you!

[DoctorX]

MY sister is an heroin addict .. how do i make her stop using these fucking opiates??

Some people quit opiates by themselves. Other need medical and/or psychological help. There are some drugs that make the process of detoxification easier or long-term treatments to avoid relapse. But quitting opiates or any other drug is always a personal decision. There is no way that you can make her quitting opiates. It does not mean that you can't help her.  She will not change until she feels opiate use is a problem for her. It is common that opiate addicts do not realize this, so, in a first step you can try to help her to realize of the real and particular problems that opiates have in her concrete case. Once she is conscious of this, changes will be much easier.

[DoctorX]

DoctorX,

1.   I am prescribed Dexedrine for ADHD (15mg daily). I am concerned about potential neurotoxicity. I have read that co-administration of methylphenidate with methamphetamine reduces/reverses methamphetamine neurotoxicity (see: http://jpet.aspetjournals.org/content/304/3/1181.full and http://www.sciencedirect.com/science/article/pii/000689939090467P), so I am considering taking Dexedrine and Ritalin at the same time. Is this a safe combination if both drugs are taken at a relatively low dosage?

2.  Are there any effective ways to reduce amphetamine tolerance?

3. My uncle suffers from brain damage caused by chronic methamphetamine abuse. Are there any drugs or supplements you can recommend that can help repair his brain?

Thank you!

1. Dextroamphetamine does not produce neurotoxicity in dosages used in human therapeutics. Maximum dosage of dextroamphetamine used in humans is 60 mg daily, your dosage is far beyond that. Your links are studies on methamphetamine (pharmacologically different to dextroamphetamine). One is a cellular study, the other is an animal study on rats, with a dosage of injected 100 mg/kg.  You can't compare the effects of 15 mg of dextroamphetamine oral with 6 gr of injected meth.So there are no data to be concerned about dextroamphetamine toxicity at your dosage.  There are no studies about dexedrine and ritalin combination, and it is not a combination used in human clinic, because both of them have similar effects. Probably the combination is safe at low dosages but will have more adverse effects and, probably, no more efficacy than normal dosages of each one separated.

2. In people using amphetamines by oral route and prescribed dosages, tolerance is not a usual problem. In recreative users the only way to avoid tolerance is to separate dosages and frequencies of use.

3. It should be necessary to know the exact nature of this problem, its repercussion and clinical manifestations (symptoms) to recommend drugs or supplements.

[stranger]

hello DoctorX,

is cooking a crack from cocaine and then using the same ROA (snorting) safer? I reckon that it will remove impuirities, and all that remains in the form of crack is pure coke. This is the method I'm referring to if you don't aware of the process: [clearnet only link. will give you error when trying to view in tor] http://www.drugs-forum.com/forum/showthread.php?t=34254

thanks a lot, i'm a big fan of your posts, been reading them all and will contribute once bitcoin price drops (now it's too expensive to be buying any!)

[freaksmontana69]

Hello DoctorX,

I wand to try DMT and wanted to ask you as a first timer what is the dosage i should use and what type of DMT should i use, and if there is any side effects?

Thank You

[DoctorX]

hello DoctorX,

is cooking a crack from cocaine and then using the same ROA (snorting) safer? I reckon that it will remove impuirities, and all that remains in the form of crack is pure coke. This is the method I'm referring to if you don't aware of the process: [clearnet only link. will give you error when trying to view in tor] http://www.drugs-forum.com/forum/showthread.php?t=34254

thanks a lot, i'm a big fan of your posts, been reading them all and will contribute once bitcoin price drops (now it's too expensive to be buying any!)

Most common adulterants in cocaine ( local anaesthetics as lidocaine, procaine, benzocaine..., levamisol, phenacetine...) are present in cocaine as salts. Converting to crack or salt will transform this substances the same way as cocaine, and they will remain in the final product. It is possible that caffeine, if present, could be removed in this way.

[DoctorX]

Hello DoctorX,

I wand to try DMT and wanted to ask you as a first timer what is the dosage i should use and what type of DMT should i use, and if there is any side effects?

Thank You

DMT is a strong psychedelic characterized by intense visuals and deep psychedelic effects. DMT is not active by oral route (unless you use another drug, a mono-amino-oxidase inhibitor), so it has to be smoked, injected  or snorted. Smoked route is the most usual and safe. A typical DMT dosage is 15-60 mg. DMT is smoked in successive breaths until the user is not able (or does not want) to take another hit. To avoid risks of accidents it is recommended not to do this alone.
DMT is a unique substance. It can be synthesized in laboratory or appear naturally in some plants (as beverage containing ayahuasca). Synthetic DMT makes much easier to measure dosages. There are different derivatives with different properties. 5-MeO-DMT is similar in effects to DMT but much more potent (5-10 mg smoked is enough to have full effects). 4-AcO-DMT is a derivative of DMT active by oral route and effects last during 3-5 hours.
Risks are related with psychological stress in persons unable to integrate the experience, psychotic reactions or other mental health problems (usually in genetically predisposed persons), fear,  accidents (dropped pipe, knocking things over, falling)

[orbital]

Hello, DoctorX:
I have been following you in the old forum. Very nice to see you here.
I have been using heroin daily for three years. I quitted by myself using codeine two months ago. Most symptoms of abstinence have disappeared but I still have terrible sweating, fever and strong pain in all my body that lasts all the night. Benzos are not useful. My doctor says it is normal signs of abstinence, I do not think he pays me attention. What can I do?   

[freaksmontana69]

Hello DoctorX,

I wand to try DMT and wanted to ask you as a first timer what is the dosage i should use and what type of DMT should i use, and if there is any side effects?

Thank You

DMT is a strong psychedelic characterized by intense visuals and deep psychedelic effects. DMT is not active by oral route (unless you use another drug, a mono-amino-oxidase inhibitor), so it has to be smoked, injected  or snorted. Smoked route is the most usual and safe. A typical DMT dosage is 15-60 mg. DMT is smoked in successive breaths until the user is not able (or does not want) to take another hit. To avoid risks of accidents it is recommended not to do this alone.
DMT is a unique substance. It can be synthesized in laboratory or appear naturally in some plants (as beverage containing ayahuasca). Synthetic DMT makes much easier to measure dosages. There are different derivatives with different properties. 5-MeO-DMT is similar in effects to DMT but much more potent (5-10 mg smoked is enough to have full effects). 4-AcO-DMT is a derivative of DMT active by oral route and effects last during 3-5 hours.
Risks are related with psychological stress in persons unable to integrate the experience, psychotic reactions or other mental health problems (usually in genetically predisposed persons), fear,  accidents (dropped pipe, knocking things over, falling)

thanks a lot for the information DoctorX

[Druggie]

DoctorX,

Thank you for your answer to my previous questions.

What makes you believe that dextroamphetamine is not neurotoxic at therapeutic dosages?

[DoctorX]

Hello, DoctorX:
I have been following you in the old forum. Very nice to see you here.
I have been using heroin daily for three years. I quitted by myself using codeine two months ago. Most symptoms of abstinence have disappeared but I still have terrible sweating, fever and strong pain in all my body that lasts all the night. Benzos are not useful. My doctor says it is normal signs of abstinence, I do not think he pays me attention. What can I do?

Fever and profuse sweating are definetly no symptoms of opioid abstinence. If they are only present in the night, and also strong pain (particularly in the bones) that could be a symptom of some other diseases. I suggest to do a simple blood test (complete blood pannel) to rule out the possibility of some haematologic diseases.

[wetdog]

Hi Dr. X!

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course 

Detoxification with opioids (descending dosages of methadone, codeine or buprenorphine) is the simplest and less umconfortable way for heroin/opiate withdrawal. If, for any reason, these drugs are not used, clonidine could be an option. You can find dosages in page 28 (table 10) of this guide:

http://www.pnsd.msssi.gob.es/en/Categoria2/publica/pdf/GuiaClinicaOpiaceos.pdf

Clonidine acts on abdominal pain,  shivering, muscular cramps and other physical symptoms but it is not very useful for anxiety and insomnia. Short time use of benzodiacepines like chlorazepate or midazolam (oral) can help.

L-acetyl-carnitine acts on pain in methadone detoxification. According to my professional experience it is useful for other opiates detoxification, too

www.ncbi.nlm.nih.gov/pubmed/18978503‎

General measures: good hydration, soft meals, resting...are useful, too.

Do you know if there are links to these topics in English?
I have used opiates for years & would like to attempt quitting, but i need to stock up with some other drugs to make it possible.

[Cornelius23]

Do you know if there are links to these topics in English?

If DoctorX doesn't know of any you might be able to paste the text into Google Translate.

[DoctorX]

DoctorX,

Thank you for your answer to my previous questions.

What makes you believe that dextroamphetamine is not neurotoxic at therapeutic dosages?

Dosages of dextroamphetamine that produce neurotoxicity are much higher than those used in human therapeutics. In animal experiments dosages are between 20-60 mg/kg injected. That would be 1.2-3.6 gr of injected d-amphetamine for humans.  In animals, these dosages produce neurotoxicity but also death caused by hyperthermia of most specimens. These effects are not seen in humans.
http://www.sciencedirect.com/science/article/pii/S0006899398008464
http://www.nature.com/npp/journal/v30/n11/full/1300771a.html
In science, proofs must be shown in positive. There are no data to suppose that d-amphetamine is neurotoxic at therapeutic dosages. Human dosages are 1000 times lower than neurotoxic dosages. There are no data also long time d-amphetamine exposure causes neurotoxic damage, and amphetamines have been widely used and studied for over a century. 

[DoctorX]

Hi Dr. X!

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course 

Detoxification with opioids (descending dosages of methadone, codeine or buprenorphine) is the simplest and less umconfortable way for heroin/opiate withdrawal. If, for any reason, these drugs are not used, clonidine could be an option. You can find dosages in page 28 (table 10) of this guide:

http://www.pnsd.msssi.gob.es/en/Categoria2/publica/pdf/GuiaClinicaOpiaceos.pdf

Clonidine acts on abdominal pain,  shivering, muscular cramps and other physical symptoms but it is not very useful for anxiety and insomnia. Short time use of benzodiacepines like chlorazepate or midazolam (oral) can help.

L-acetyl-carnitine acts on pain in methadone detoxification. According to my professional experience it is useful for other opiates detoxification, too

www.ncbi.nlm.nih.gov/pubmed/18978503‎

General measures: good hydration, soft meals, resting...are useful, too.

Do you know if there are links to these topics in English?
I have used opiates for years & would like to attempt quitting, but i need to stock up with some other drugs to make it possible.

Chapter 4 of this guideline covers buprenorphine detoxification:
http://buprenorphine.samhsa.gov/Bup_Guidelines.pdf
If available, it is desirable to have professional assessment while quitting opiates. Things in real life are more complicated than following a guideline. But it is true also that some people are able to quit opiates by themselves.

[Sir William Wonka]

Hello, DoctorX:
I have been following you in the old forum. Very nice to see you here.
I have been using heroin daily for three years. I quitted by myself using codeine two months ago. Most symptoms of abstinence have disappeared but I still have terrible sweating, fever and strong pain in all my body that lasts all the night. Benzos are not useful. My doctor says it is normal signs of abstinence, I do not think he pays me attention. What can I do?

Fever and profuse sweating are definetly no symptoms of opioid abstinence. If they are only present in the night, and also strong pain (particularly in the bones) that could be a symptom of some other diseases. I suggest to do a simple blood test (complete blood pannel) to rule out the possibility of some haematologic diseases.

or HIV... Get tested

[Steve Jobs]

You are the Greatest Doctor Ever!

[rebirth]

How can I use ketamine as antidepressant?

[mdmazing]

Hey DoctorX!

I haven't ever actually asked you a question before, but I've been following your thread here and on the old SR forums for information-purposes. But, now its time to ask!

I've been on methadone for 1.25 Years now, and I've been on a steady dosage of 20mg every 24 hours (oral dose). However, I was buying it illegally the entire time, as the local methadone clinics have a waiting list that aren't worthwhile to me.

2 days ago, my "source" sold it off on me, so now I'm left to be sick for the next 6-7 days. I have access to the following pills, but I'm not quite sure if they are worthwhile for someone who is methadone sick. (I know 20mg is not much, but its not comfortable being sick from it for a week).

The pills are: Zytram XL 400mg aka Tramadol Hydrochloride 400mg

[DoctorX]

How can I use ketamine as antidepressant?

Recent studies show that ketamine has strong antidepressant properties. Typical dosage is 0.5 mg/kg intravenous in infussion in 30-40 minutes; oral route seems also effective at that dosage (0.5 mg/kg). The effect is fast and strong but not lasting in time, it disappears in hours or days and further dosages do not reply this effect. With actual knowledge, Ketamin may prove useful in a select group of patients but current medical knowledge looks to other treatments as the first line against depression
http://www.ncbi.nlm.nih.gov/pubmed/23661785
http://www.ncbi.nlm.nih.gov/pubmed/23805864
http://www.ncbi.nlm.nih.gov/pubmed/23825857
http://www.ncbi.nlm.nih.gov/pubmed/23893490

[DoctorX]

Hey DoctorX!

I haven't ever actually asked you a question before, but I've been following your thread here and on the old SR forums for information-purposes. But, now its time to ask!

I've been on methadone for 1.25 Years now, and I've been on a steady dosage of 20mg every 24 hours (oral dose). However, I was buying it illegally the entire time, as the local methadone clinics have a waiting list that aren't worthwhile to me.

2 days ago, my "source" sold it off on me, so now I'm left to be sick for the next 6-7 days. I have access to the following pills, but I'm not quite sure if they are worthwhile for someone who is methadone sick. (I know 20mg is not much, but its not comfortable being sick from it for a week).

The pills are: Zytram XL 400mg aka Tramadol Hydrochloride 400mg

I do not think that sustained release tramadol will be very effective for your symptoms. Tramadol is a weak μ-opioid receptor agonist, a serotonin releaser and a reuptake inhibitor of norepinephrine. It has some opioid properties but not acting as a strong opioid. Anyway, 20 mg of methadone is not too much, it can be uncomfortable, but not too hard.

[ProEvo]

I just want to say it is great to have a professional doctor among our community. Your knowledge will certainly help many people in these forums. Thank you for all the time you put in to helping us here, it is very much appreciated

[stranger]

Most common adulterants in cocaine ( local anaesthetics as lidocaine, procaine, benzocaine..., levamisol, phenacetine...) are present in cocaine as salts. Converting to crack or salt will transform this substances the same way as cocaine, and they will remain in the final product. It is possible that caffeine, if present, could be removed in this way.

thank you a lot Doctor!

are those adulterants the same dangerous in the transformed form? and what about smoking? maybe their vaporizing tempterature is higher than cocaine so you could do crack and smoke just cocaine without some of the adulterants?

thank you again

[cleansober]

FC,

Tramadol is a weak μ-opioid receptor agonist, a serotonin releaser and a reuptake inhibitor of norepinephrine. It has some opioid properties but not acting as a strong opioid.

I love it when you talk this way.  Do you think scientists will eventually discover a genetic link to dependance/addiction for many other drugs as already has been done for nicotine addiction?  "Source:https://class.coursera.org/drugsandbrain-2012-001/class/index", a rather complicated look at how drugs affect the brain that points to several genes on chromosomes 15 as having some relationship to nicotine dependance.


Often recreational users describe weed as their "medicine", do you think this is a valid description of cannabis or merely an excuse or rationalization to auto-consume?

For many folks including myself who have seen our suppliers suddenly disappear we come to a crossroads of sorts; we can quit, or seek out other sources.  I feel like a baby whining about cannabis when it is reportedly nonaddictive while others are kicking known addictive substances, but nevertheless, I'm still having trouble just saying no to weed.  My initial 28 gram purchase supposedly was for making edibles but the one attempt failed so I auto-consumed via smoking the remaining 20 grams over the course of one or two months. When I say auto-consumed I mean four or five smoking sessions per day.  Perhaps the sudden availability of seemingly endless weed after years of none or small doses made me like a person rescued from the desert dieing from thirst who drinks water to excess.  Of course the difference being weed consumption is hardly a life and death matter.  When I go out for drinks and see the cost at the end of the session, I can't help but think weed is much cheaper and more fun even if it is outlawed by nearly every government with the minor exception of Uruguay, where coincidentally I'm planning to move, or possibly Colorado or Washington state, where recreational weed is now in the process of available through legal channels.

Just curious if any of your followers would be interested in teaming up on a one-way video conference where you took up specific drugs in a more detailed manner?  If each person chipped in for your time, do you think 5-10 questioners online would be a workable approach?  Questions could asked in advance or use text based chat features to maintain anonymity. 

Has anyone watched the National Geographic show Drugs Inc. which highlights the troubles many users and dealers have keeping up the lifestyle?  I'm on a binge viewing pattern lately and it seems there are many users who would like to gain true control, as compared to the reflex statement, sure I have control, but find it impossible for whatever reasons.

Cleansober

[palmergbl]

How can I use ketamine as antidepressant?

That might be interesting for you- I recently found some video on ketamine in depression treatment.
(Clearnet:) https://www.bbrfoundation.org/meet-the-scientist-august-2013
I guess it is now mainly used to treat suicidality connected with depression and treatment-resistant depression, plus he discusses some alternative ketamine derivate drugs.

[DoctorX]

Most common adulterants in cocaine ( local anaesthetics as lidocaine, procaine, benzocaine..., levamisol, phenacetine...) are present in cocaine as salts. Converting to crack or salt will transform this substances the same way as cocaine, and they will remain in the final product. It is possible that caffeine, if present, could be removed in this way.

thank you a lot Doctor!

are those adulterants the same dangerous in the transformed form? and what about smoking? maybe their vaporizing tempterature is higher than cocaine so you could do crack and smoke just cocaine without some of the adulterants?

thank you again

Fusion and boiling point of caine derivatives (cocaine, lidocaine, benzocaine...) are quite similar. There are data of levamisole toxicity in crack cocaine smokers. So it does not seem that it should work.
Anyway, from a risk reduction perspective, smoking crack implies more risks than intranasal cocaine. So it does not seem very logic to change the route only to avoid adulterants; it is possible that this problem could be partially avoided but other risks of crack cocaine (dependence potential, organic and psychiatric harms...) would be much higher.

[DoctorX]

FC,

Tramadol is a weak μ-opioid receptor agonist, a serotonin releaser and a reuptake inhibitor of norepinephrine. It has some opioid properties but not acting as a strong opioid.

I love it when you talk this way.  Do you think scientists will eventually discover a genetic link to dependance/addiction for many other drugs as already has been done for nicotine addiction?  "Source:https://class.coursera.org/drugsandbrain-2012-001/class/index", a rather complicated look at how drugs affect the brain that points to several genes on chromosomes 15 as having some relationship to nicotine dependance.


Often recreational users describe weed as their "medicine", do you think this is a valid description of cannabis or merely an excuse or rationalization to auto-consume?

For many folks including myself who have seen our suppliers suddenly disappear we come to a crossroads of sorts; we can quit, or seek out other sources.  I feel like a baby whining about cannabis when it is reportedly nonaddictive while others are kicking known addictive substances, but nevertheless, I'm still having trouble just saying no to weed.  My initial 28 gram purchase supposedly was for making edibles but the one attempt failed so I auto-consumed via smoking the remaining 20 grams over the course of one or two months. When I say auto-consumed I mean four or five smoking sessions per day.  Perhaps the sudden availability of seemingly endless weed after years of none or small doses made me like a person rescued from the desert dieing from thirst who drinks water to excess.  Of course the difference being weed consumption is hardly a life and death matter.  When I go out for drinks and see the cost at the end of the session, I can't help but think weed is much cheaper and more fun even if it is outlawed by nearly every government with the minor exception of Uruguay, where coincidentally I'm planning to move, or possibly Colorado or Washington state, where recreational weed is now in the process of available through legal channels.

Just curious if any of your followers would be interested in teaming up on a one-way video conference where you took up specific drugs in a more detailed manner?  If each person chipped in for your time, do you think 5-10 questioners online would be a workable approach?  Questions could asked in advance or use text based chat features to maintain anonymity. 

Has anyone watched the National Geographic show Drugs Inc. which highlights the troubles many users and dealers have keeping up the lifestyle?  I'm on a binge viewing pattern lately and it seems there are many users who would like to gain true control, as compared to the reflex statement, sure I have control, but find it impossible for whatever reasons.

Cleansober

The role of genetics in human diseases is, in general, less important than people think. Several morphological characteristics are genetically determined. For most diseases, there is a genetic predisposition but there exist also environmental factors that condition the fact that an illness appear and its severity. Genetic diseases are rare and none of them is psychological. So characteristics of personality (impulsivity, shyness, addictive behaviours…) have a hereditary component that implies a certain tendency, modulated by education, motivation, determination, personal decisions and life-experience. It is questionable if "drug addiction" is a medical disease, a psychological problem or a way of living. So a direct causal relation with genetics is even more arguable.

Therapeutic use of cannabis should only be considered diseases in which efficacy has been proved. Recreational use should be a valid reason by itself, but different to therapeutic.

[StringerBell]

Just wanna say i missed you and your intelligent and adequate answers! I am truly and sincerely happy of seeing you here once again!
May you always have the sun in your face and wind in your hair or something like that 

Much Love Stringer 

[onister]

Should MDMA and amphetamines be avoided during lactation? Is it strictly forbidden or risks are acceptable?
Thank you in advance

[DreaMTrip]

Hey doc, love what you're doing here!
What are the risks of the use of cannabis regarding schizophrenia? I have 3 members of my family who have/had schizophrenia. Although I take LSD and DMT more than weed, what are the chances of cannabis use activating a predisposed schizophrenic psychosis? As said, 2 members of my family have both been admitted to hospital after cannabis use has activated a schizophrenic psychosis, so how should I go about this? Stop smoking weed altogether or is it safe enough?
Not sure if you'll have time to reply or if this is your area of knowledge, but it would be useful to know.
Thanks
~DMT

[Morpheus]

One question I do have, which i'm not sure can easily be quantified due to differences in peoples size, tolerance and general mental health, but roughly what amount of LSD is needed to loose ones identity. In this I am referring to what people commonly call 'loosing your mind'. Changing personality permanently.

[DoctorX]

Should MDMA and amphetamines be avoided during lactation? Is it strictly forbidden or risks are acceptable?
Thank you in advance

The relation between MDMA and lactation is not clear. As far as I know, there are no published studies on this particular issue. Available data on amphetamine show that "In dosages prescribed for medical indications, some evidence indicates that amphetamine might not affect nursing infants adversely.". On the other hand, data from methamphetamine show that meth is secreted to breast milk and it should be avoided.
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~LJwPas:1
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~LJwPas:2
In my opinion, it is basic to avoid use that can be harmful to third persons. A person can asume risks for himself but not for others, even less a baby. So there would be three options: 1) Wait to finish lactation and then use MDMA or amphs  2) Interrupt natural lactation (use artificial milk) and use MDMA or amohs  3) Collect enough milk for 3-4 days (using a breast-pump), keep it in the fridge and use it during the following days to MDMA or amphs use

[cleansober]

All X's drug crazed followers,

It is possible to read more detailed articles on X's site.  Use a web page translator such as, http://translate.google.com/ then put in www.doctorcaudevilla.com and most of it is pretty understandable, at least to English, for me. 

Peace All,

CS
 

[Sir William Wonka]

Should MDMA and amphetamines be avoided during lactation? Is it strictly forbidden or risks are acceptable?
Thank you in advance

The relation between MDMA and lactation is not clear. As far as I know, there are no published studies on this particular issue. Available data on amphetamine show that "In dosages prescribed for medical indications, some evidence indicates that amphetamine might not affect nursing infants adversely.". On the other hand, data from methamphetamine show that meth is secreted to breast milk and it should be avoided.
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~LJwPas:1
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~LJwPas:2
In my opinion, it is basic to avoid use that can be harmful to third persons. A person can asume risks for himself but not for others, even less a baby. So there would be three options: 1) Wait to finish lactation and then use MDMA or amphs  2) Interrupt natural lactation (use artificial milk) and use MDMA or amohs  3) Collect enough milk for 3-4 days (using a breast-pump), keep it in the fridge and use it during the following days to MDMA or amphs use

VERY important information doc +++

[OzFreelancer]

Just want to chime in my public appreciation for DoctorX's work here.  And to let the world know that the previous DPR gave me quite the interview in which he praised the good doctor's works with gusto. Show him some love with your karma powers.

[Sir William Wonka]

Yea doctorx the guy with night sweats was Dxed with leukemia.  Keep up the good work.  you re one of the important members of our beloved community

[DoctorX]

Hey doc, love what you're doing here!
What are the risks of the use of cannabis regarding schizophrenia? I have 3 members of my family who have/had schizophrenia. Although I take LSD and DMT more than weed, what are the chances of cannabis use activating a predisposed schizophrenic psychosis? As said, 2 members of my family have both been admitted to hospital after cannabis use has activated a schizophrenic psychosis, so how should I go about this? Stop smoking weed altogether or is it safe enough?
Not sure if you'll have time to reply or if this is your area of knowledge, but it would be useful to know.
Thanks
~DMT

There are some studies linking use of cannabis and after development of schizophrenia, particularly in teenagers.

One important point in this subject is that, the fact that two things are correlated or linked does not mind that one is the cause of the other. I will try to explain with an example. I read some time ago a study saying that "people who read the composition of the food  have less problems of obesity". Probably,  who read labels and get information about what they are eating, are more concerned about their health and have better dietary habits. But the fact of reading a label won´t keep you thinner

This is a very important idea,and it is forgotten many times talking about drugs. In the model we explain schizophrenia actually, there is a susceptible or pre-morbid personality and there are "stressing factors" that trigger the disease. Known factors developing schizophrenia are divorce of parents, military service or sentimental break-up. Use of psychedelics can also trigger an schizophrenia, but only in susceptible, pre-morbid personalities. Think that use of cannabis has grown all over the world in the last 20 years and incidence of schizophrenia remains stable, around 1%.

In this sense, familiar antecedents of schizophrenia is clearly an accepted risk factor for developing this disease. Your risk is probably increased in relation with other persons. This does not mean that it will definetly appear, but risk is increased. This depend on many factors (age, personality ,previous response to other drugs...). In people with familiar antecedents of schizophrenia psychedelic use is not recommended. There can be exceptions, but, as a general information by Internet is all I can say.

[DreaMTrip]

Hey doc, love what you're doing here!
What are the risks of the use of cannabis regarding schizophrenia? I have 3 members of my family who have/had schizophrenia. Although I take LSD and DMT more than weed, what are the chances of cannabis use activating a predisposed schizophrenic psychosis? As said, 2 members of my family have both been admitted to hospital after cannabis use has activated a schizophrenic psychosis, so how should I go about this? Stop smoking weed altogether or is it safe enough?
Not sure if you'll have time to reply or if this is your area of knowledge, but it would be useful to know.
Thanks
~DMT

There are some studies linking use of cannabis and after development of schizophrenia, particularly in teenagers.

One important point in this subject is that, the fact that two things are correlated or linked does not mind that one is the cause of the other. I will try to explain with an example. I read some time ago a study saying that "people who read the composition of the food  have less problems of obesity". Probably,  who read labels and get information about what they are eating, are more concerned about their health and have better dietary habits. But the fact of reading a label won´t keep you thinner

This is a very important idea,and it is forgotten many times talking about drugs. In the model we explain schizophrenia actually, there is a susceptible or pre-morbid personality and there are "stressing factors" that trigger the disease. Known factors developing schizophrenia are divorce of parents, military service or sentimental break-up. Use of psychedelics can also trigger an schizophrenia, but only in susceptible, pre-morbid personalities. Think that use of cannabis has grown all over the world in the last 20 years and incidence of schizophrenia remains stable, around 1%.

In this sense, familiar antecedents of schizophrenia is clearly an accepted risk factor for developing this disease. Your risk is probably increased in relation with other persons. This does not mean that it will definetly appear, but risk is increased. This depend on many factors (age, personality ,previous response to other drugs...). In people with familiar antecedents of schizophrenia psychedelic use is not recommended. There can be exceptions, but, as a general information by Internet is all I can say.

Thank you, your knowledge and advice seems to be much greater than what I can receive round here. Unless I am suffering from something I am unable to find the risks with a doctor. Thank you for your answer, I have just reached 50 posts so will give you +1.
If I ever get any spare coins, I will be sure to give you a little donation for your help in the community
All the best,
~DMT

[Cornelius23]

Yea doctorx the guy with night sweats was Dxed with leukemia.  Keep up the good work.  you re one of the important members of our beloved community

And his doctor thought his symptoms were just normal signs of heroin abstinence. DoctorX has probably saved someone's life via this forum. That is bloody wonderful.

I've been making it my habit to donate a small percentage of all my Dark Web purchases to DoctorX and I urge everyone else to do likewise.

[mdmazing]

Hey Docx!

A close friend of mine recently purchased cocaine (which, in our geographical location, is complete SHIT aka 10-20% tops) and, he IV's it.

The problem: I know for a FACT that the dealer cuts with lidocaine and dextrose (e.g. 1.0G substance = 0.2G Cocaine + .4G lidocaine + .4G dextrose -- about correct numbers). I've been trying to convince him that its DANGEROUS to iv this "substance" but he refuses to agree, and continues making purchases.

I witnessed his last shot (he usually does a 300-400mg shot each time) and he claimed to "have a weezey stomach aka butterflies, and lips numb and tingly, and bellringer) but I am convinced the bell-ringer isnt really the cocaine one.. doesn't make sense. I read that lidocains overdose is easily done at 50-100mg ? But he's been doing this for two weeks and hasnt died nor does he felt once that he had to go to the ER.

Im 100% certain of that substance calculation I mentioned.. Any input?

[DoctorX]

One question I do have, which i'm not sure can easily be quantified due to differences in peoples size, tolerance and general mental health, but roughly what amount of LSD is needed to loose ones identity. In this I am referring to what people commonly call 'loosing your mind'. Changing personality permanently.

Ego disolution experiences are not the consequence of a particular dosage. These kind of experiences happens or not. Large dosages (>300-400 ug) facilitate this but are not a guarantee of this effect. And changes of personality are the consequence of the integration of LSD experiences, so these changes depend on many factors and not only on dosage

[DoctorX]

Yea doctorx the guy with night sweats was Dxed with leukemia.  Keep up the good work.  you re one of the important members of our beloved community

Yes...I read it yesterday in general forum. Hope everything goes well... Thx for support!

[DoctorX]

Hey Docx!

A close friend of mine recently purchased cocaine (which, in our geographical location, is complete SHIT aka 10-20% tops) and, he IV's it.

The problem: I know for a FACT that the dealer cuts with lidocaine and dextrose (e.g. 1.0G substance = 0.2G Cocaine + .4G lidocaine + .4G dextrose -- about correct numbers). I've been trying to convince him that its DANGEROUS to iv this "substance" but he refuses to agree, and continues making purchases.

I witnessed his last shot (he usually does a 300-400mg shot each time) and he claimed to "have a weezey stomach aka butterflies, and lips numb and tingly, and bellringer) but I am convinced the bell-ringer isnt really the cocaine one.. doesn't make sense. I read that lidocains overdose is easily done at 50-100mg ? But he's been doing this for two weeks and hasnt died nor does he felt once that he had to go to the ER.

Im 100% certain of that substance calculation I mentioned.. Any input?

Lidocaine can be used in human therapeutics as an antiarritmic up to a dosage of 300 mg. Toxicity appears at rank of 7 mg/kg (560 mg for an average weight of 80 kg). In a theoretical point of view, your friends seems to be yet in a safe rank. I insist in "theoretical" because, obviously, iv is the most dangerous way for cocaine use and an intravenous mixture of cocaine and lidocaine can enhance the potential of both substances to cause cardiac problems. Probably the high dosages he uses are related to pharmacological tolerance but risks seem extremely high.

[mpx-206]

hi DoctorX,
which drugs do harm the sperm quality/production?
I really want to know it.
you are a great man
thanks in advance

[bbkf]

I have an MD in the family who says that almost any "Caine" can cause serious problems with blood oxygenation and that they were taught in med school of a few instances of deaths due to OTC numb ing agents like Orajel.

Care to elaborate? Eventually I'll get the medical abstracts and share, it's somewhere either on the PC or Library.

[Sir William Wonka]

FC,

Tramadol is a weak μ-opioid receptor agonist, a serotonin releaser and a reuptake inhibitor of norepinephrine. It has some opioid properties but not acting as a strong opioid.

I love it when you talk this way.  Do you think scientists will eventually discover a genetic link to dependance/addiction for many other drugs as already has been done for nicotine addiction?  "Source:https://class.coursera.org/drugsandbrain-2012-001/class/index", a rather complicated look at how drugs affect the brain that points to several genes on chromosomes 15 as having some relationship to nicotine dependance.


Often recreational users describe weed as their "medicine", do you think this is a valid description of cannabis or merely an excuse or rationalization to auto-consume?

For many folks including myself who have seen our suppliers suddenly disappear we come to a crossroads of sorts; we can quit, or seek out other sources.  I feel like a baby whining about cannabis when it is reportedly nonaddictive while others are kicking known addictive substances, but nevertheless, I'm still having trouble just saying no to weed.  My initial 28 gram purchase supposedly was for making edibles but the one attempt failed so I auto-consumed via smoking the remaining 20 grams over the course of one or two months. When I say auto-consumed I mean four or five smoking sessions per day.  Perhaps the sudden availability of seemingly endless weed after years of none or small doses made me like a person rescued from the desert dieing from thirst who drinks water to excess.  Of course the difference being weed consumption is hardly a life and death matter.  When I go out for drinks and see the cost at the end of the session, I can't help but think weed is much cheaper and more fun even if it is outlawed by nearly every government with the minor exception of Uruguay, where coincidentally I'm planning to move, or possibly Colorado or Washington state, where recreational weed is now in the process of available through legal channels.

Just curious if any of your followers would be interested in teaming up on a one-way video conference where you took up specific drugs in a more detailed manner?  If each person chipped in for your time, do you think 5-10 questioners online would be a workable approach?  Questions could asked in advance or use text based chat features to maintain anonymity. 

Has anyone watched the National Geographic show Drugs Inc. which highlights the troubles many users and dealers have keeping up the lifestyle?  I'm on a binge viewing pattern lately and it seems there are many users who would like to gain true control, as compared to the reflex statement, sure I have control, but find it impossible for whatever reasons.

Cleansober

The role of genetics in human diseases is, in general, less important than people think. Several morphological characteristics are genetically determined. For most diseases, there is a genetic predisposition but there exist also environmental factors that condition the fact that an illness appear and its severity. Genetic diseases are rare and none of them is psychological. So characteristics of personality (impulsivity, shyness, addictive behaviours…) have a hereditary component that implies a certain tendency, modulated by education, motivation, determination, personal decisions and life-experience. It is questionable if "drug addiction" is a medical disease, a psychological problem or a way of living. So a direct causal relation with genetics is even more arguable.

Therapeutic use of cannabis should only be considered diseases in which efficacy has been proved. Recreational use should be a valid reason by itself, but different to therapeutic.

Check out TLR4 and opioids.

[DoctorX]

hi DoctorX,
which drugs do harm the sperm quality/production?
I really want to know it.
you are a great man
thanks in advance

Anabolic-androgenic steroids are substitutes of naturally occurring masculine hormones (testosterone). Used in hgh dosages or long-term (in general, more than 8-10 weeks) they can affect sperm cell production- These alterations persist, in general, several weeks.
Cannabis has also been linked to alterations in masculine hormone production, although it has only been proved in animal experimentation and not in humans. It is very unlikely that cannabis use in humans produce effects in reproductory system.

[CanIHaveSome]

Hello doc.  Does daily smoking of weed interrupt the effectiveness of a cocktail consisting of Citolipram, Seroquel, and Lamatrogine?  And if so, which one would it affect the most?

[DoctorX]

I have an MD in the family who says that almost any "Caine" can cause serious problems with blood oxygenation and that they were taught in med school of a few instances of deaths due to OTC numb ing agents like Orajel.

Care to elaborate? Eventually I'll get the medical abstracts and share, it's somewhere either on the PC or Library.

Both benzocaine and lidocaine can produce a rare condition called methemoglobinemia, in which proteins binding oxigen in blood get oxidized and cannot transport oxigen.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263062/
It is an extremely rare condition, but possible.

[fuckthishoe]

DoctorX, I would like to ask a question related to nausea that comes from Tramadol.

A while ago I took 4 Tramadol pills. 35.7Mg tramadol and around 375 MG's of APAP I believe. I took 2 at 8 am followed by 2 more at 9:30.
The whole day was calm until I arrived home where I got extremely nauseated and vomited quite a lot. Is the APAP responsible for the nausea since it was arond 1500MG's? Could the nausea be reduced by taking pure Tramadol or is the nausea coming from the Tramadol?

[StingRay]

Hi DocX, I would first like to thank you for providing such a great service.

Anyway, I was curious about etizolam.  I've been taking it recently and was wondering about the safety compared to traditional benzos.  I think it is used in a couple European countries and Japan so I think there would be some research about it.  I also read that the withdrawals are not dangerous and life threatening like traditional benzo.  I am really interested in knowing whether this is true or not so in the event I don't have stock I know if I should visit the ER.  I've been taking the stuff 1mg 2x a day.  Occasionally on days I know are going to be anxiety provoking (ie: public speaking), I take 2 mg as my initial dose. I've been doing this about a month; would this put be at risk of withdrawals (even non dangerous ones)?

Another question I had was what one should do if they are at risk of a benzo withdrawal?  I've been taking etizolam, but I have a few friends who continue to use benzo on a regular basis.  Should they admit themselves into the ER if think they will have a withdrawal? 

You may not be able to answer this question so maybe an American can chime in here.  If one has low income and cannot afford to visit the ER can they still go and receive treatment?  In America, our healthcare system is privatized (well semi-privatized because obamacare isn't full universal health care).

One final benzo question.  I have a couple careless friends who abuse benzos regularly, taking doses far exceeding the therapeutic dosage and they mix them with other benzos.  Basically, they just eat handfuls of various benzos.  My questions is, if you reduce your dose are you susceptible to benzo withdrawals?  Fortunately, they tend to abuse diazepam which has an extremely long half-life so this may be beneficial to them.

Finally, I have a couple MDMA questions.  I am currently taking Mirtazapine (7.5mg, small dose), I was wondering if this drug would prevent me from rolling?  It's seem to be some new type of anti-depressent and my doctor told me its classified as a Tricyclic anti-depressent, but claims it doesn't function like other tryclylics.  I know this stuff at the right dose will KILL a nbome trip; which I do use towards the end of the trip to aid in falling asleep.  If it is safe would I need a higher dose or would I have to discontinue for a peroid of time (not a problem because I use it for sleep).  I've looked into this for some time and can't seem to find a solid concrete answer so I would prefer advice from a medical professional. Also, is taking ginger root safe?  I've found it to do wonders at reducing/eliminating nausea.

Hopefully my post is not too long.  I just like to be thorough when it comes to this kind of stuff.

Thanks

[Sir William Wonka]

Doc,

on another thread someone asked how best to take tramadol 100ER.  I informed him there is an increased risk of seizure at 500-600mg is that the right dosage for increaased risk of having a seizure.  Please respond here and I will relay the correct info or read the thread for yourself here http://silkroad5v7dywlc.onion/index.php?topic=2099.0

thanks doc your a good man.

[TheChain]

Just want to chime in my public appreciation for DoctorX's work here.  And to let the world know that the previous DPR gave me quite the interview in which he praised the good doctor's works with gusto. Show him some love with your karma powers.

Please focus on more aspects like this if your going to report on SR. The doc is a pillar of the community. If I went to my doc with some of the questions he's answered I would get the same old 'drugs are bad' response even though I was going to do it without his consent. Real information and guidance on drugs can do wonders to put everyone out of this never ending paranoid delusion that's been instilled in society.

[Cornelius23]

I think OF already knows that DoctorX probably saved the life of someone with leukaemia whose own doctor had dismissed his symptoms as opiate withdrawal.

[TheChain]

I didn't mean any offense and to be honest I'm not familiar with the reporter myself. I just hope aspects such as these are focused on along with reduction of street dealing, quality of drugs and how these things are important in harm reduction. How SR is an example of how like minded people can get together and help each other without any violence. It ain't perfect but it is unprecedented (on this scale) so it does deserves a fresh pair of eyes so to say.

OF - I apologize if I came off a bit stereotypical in my view but I think you can agree that there's simply been to much propaganda regarding a lot of the issues that you are writing about. This misinformation is the main causes that drug legislation is in the state it is in and it's the media's role to try and change this and make some positive impact on the public perception.

It seems like you have a good reputation and DPR has given his nod of approval so I hope to read your article and not actually be pissed off for a change.

Oh and I've seen the other articles today that referenced CP, guns and hitmen and didn't really differentiate between SR and those markets, I think this is important. To the average reader it may would look like guns + drugs + hitmen + child porn = SR = TOR.

I hope you understand.

[DoctorX]

Hello doc.  Does daily smoking of weed interrupt the effectiveness of a cocktail consisting of Citolipram, Seroquel, and Lamatrogine?  And if so, which one would it affect the most?

Cannabinoids act in different receptors than citalopram, seroquel or lamotrigine. But in real life things are far more complex than neurorreceptors. If yu are taking these medications because of a mental health problem itis possible that cannabis can affect the base problem (an affective, psychologic or neuropsychiatric disorder). As a general rule, cannabis is not recommended in persons with mental health problem. The best way to enjoy the effect of drugs and to avoid drug problems is to be in a good psychological state.

[Sir William Wonka]

Doc,

I am having orthopedic surgery and have a feeling my orthopod wont meet my needs of adequate pain control.  I have a decent tolerance.  If I choose to use methadone after surgery how long would I have to wait until the general anesthetics clear my body.  Or should I just use diamorphine?

I suspect the General anesthetic will be propofol.  But I am not sure.  What else could they use for a short operation that may have a half life longer than propofols quick clearance rate.?

Mucho Gusto el doctor

[cleansober]

Doctor X says:

As a general rule, cannabis is not recommended in persons with mental health problem. The best way to enjoy the effect of drugs and to avoid drug problems is to be in a good psychological state.

The trouble is many users here, including myself, seem to think we need the drugs to get into that "good psychological state".  We are practicing medicine on ourselves to mask an assortment of mental health problems, some major, some minor.  If enough people were to take your advice, the launch of SR 2 would never happen due to the absence of mentally healthy customers.

I have to laugh when cheerleaders for psychedelics say wait until your life is in order, then take it.  By this standard I suspect I'm never doing LSD again.  There is always something left undone, something that needs work, and problems to solve.  Will all the normal people who have their life in good order please stand up now. 



We have two extremes here, society and most health professionals who say, drugs are bad don't do them, and the SR view, it's OK to do them as long as we don't harm another person.  Somewhere in the middle is responsible drug use. 

How would you describe responsible recreational drug use?  Would compulsive daily consumption of anything fall into the irresponsible use column, in your view?  You are careful to avoid judging your patients and that's why many profess their love for you, but when do you say to someone, too much, time to cut back, or god forbid, quit?

You have previously pointed out it is important to have a knowledgeable MDMA therapist if one intends on using it for helping to resolving psychological problems.  Would you say having an experienced responsible, user for any drug, to help with learning how to control the risk of addiction and dependency should be part of all recreative drug use?  A drug use teacher or guru if you will.  Many of us started using rather young, when impulsiveness was a factor, and now are attempting to change unhealthy drug use habits acquired during our days of youthful folly. 

Have you noticed any common threads in your patients who are able to gain control over their irresponsible drug usage?



CS

[DoctorX]

DoctorX, I would like to ask a question related to nausea that comes from Tramadol.

A while ago I took 4 Tramadol pills. 35.7Mg tramadol and around 375 MG's of APAP I believe. I took 2 at 8 am followed by 2 more at 9:30.
The whole day was calm until I arrived home where I got extremely nauseated and vomited quite a lot. Is the APAP responsible for the nausea since it was arond 1500MG's? Could the nausea be reduced by taking pure Tramadol or is the nausea coming from the Tramadol?

Nausea and dizziness are typical adverse effects of Tramadol. Paracetamol does not produce these adverse effects but Tramadol does. Note that in human therapeutic sometimes it is necessary to start by very low dosages (10 mg) to avoid it so 150 mg of tramadol in a single day will produce nausea with high probability

[ओ३म्]

Bupropion and Armodafinil

Doctor,

150 mg Armodafinil normally lasts about 12 hours. I'll be honest, because I spied in some other thread that you suggested that someone else NOT take it  -which is fine. As an addiction specialist you may recognize that it helps me overcome the tiredness associated with my drinking binges and otherwise staying out late on a work night. In other words, I probably won't quit taking it. I don't take it everyday and at most 1-2 times per week.

I've also been taking a low dose 150 sr of Bupropion for an unnamed yet common condition (which you could guess). What I noticed is that since I've been taking the Bupropion -that my Armodafinil has a longer lasting effect -meaning that it used to wear off within 12 hours but now it seems like it last 20 hours.

Is there a drug interaction between the two drugs? Should I quit taking Bupropion and if not Bupropion -then what?

Thank you for your advice.

[ProEvo]

Hi Doctor X,

Firstly let me just say what an honour it is to have you here. Your expert knowledge is helping many people to take drugs safely and has even saved one of this communities lives. Kudos to you Doctor

I am starting a cycle of steroid in the very near future and was just wondering could you give me some advice. I plan on using 500mg of Testosterone Enanthate per week Injecting 250mg twice a week. I am stacking this with 60mg of Anavar rising possibly to 100mg near the end. I have got Arimidex which I plan to take .25mg everyday and I am going to take 250mg of HCG twice a week. For PCT I plan on using Clomid which I will probably start about 2 weeks after my last Testosterone jab.

When should I start to the Arimidex and the HCG? I was thinking of starting it about 3 weeks in. Also where would be the best place to inject that would be less painful and most effective? Any advice on dosage and timing would be very much appreciated, this is my first ever cycle and I want to be sure on everything before I star my cycle.

Thanks Doctor X, you really are a hero. 

[DoctorX]

Hi DocX, I would first like to thank you for providing such a great service.

Anyway, I was curious about etizolam.  I've been taking it recently and was wondering about the safety compared to traditional benzos.  I think it is used in a couple European countries and Japan so I think there would be some research about it.  I also read that the withdrawals are not dangerous and life threatening like traditional benzo.  I am really interested in knowing whether this is true or not so in the event I don't have stock I know if I should visit the ER.  I've been taking the stuff 1mg 2x a day.  Occasionally on days I know are going to be anxiety provoking (ie: public speaking), I take 2 mg as my initial dose. I've been doing this about a month; would this put be at risk of withdrawals (even non dangerous ones)?

Another question I had was what one should do if they are at risk of a benzo withdrawal?  I've been taking etizolam, but I have a few friends who continue to use benzo on a regular basis.  Should they admit themselves into the ER if think they will have a withdrawal? 

You may not be able to answer this question so maybe an American can chime in here.  If one has low income and cannot afford to visit the ER can they still go and receive treatment?  In America, our healthcare system is privatized (well semi-privatized because obamacare isn't full universal health care).

One final benzo question.  I have a couple careless friends who abuse benzos regularly, taking doses far exceeding the therapeutic dosage and they mix them with other benzos.  Basically, they just eat handfuls of various benzos.  My questions is, if you reduce your dose are you susceptible to benzo withdrawals?  Fortunately, they tend to abuse diazepam which has an extremely long half-life so this may be beneficial to them.

Finally, I have a couple MDMA questions.  I am currently taking Mirtazapine (7.5mg, small dose), I was wondering if this drug would prevent me from rolling?  It's seem to be some new type of anti-depressent and my doctor told me its classified as a Tricyclic anti-depressent, but claims it doesn't function like other tryclylics.  I know this stuff at the right dose will KILL a nbome trip; which I do use towards the end of the trip to aid in falling asleep.  If it is safe would I need a higher dose or would I have to discontinue for a peroid of time (not a problem because I use it for sleep).  I've looked into this for some time and can't seem to find a solid concrete answer so I would prefer advice from a medical professional. Also, is taking ginger root safe?  I've found it to do wonders at reducing/eliminating nausea.

Hopefully my post is not too long.  I just like to be thorough when it comes to this kind of stuff.

Thanks

In a practical point of view, it is uncommon that taking 1-2 mg of etizolam during a month will lead that significative abstinence symptoms. Etizolam is based to have less dependence potential than other benzos, but data are limited and based on animal studies. Dependence and abstinence symptoms are real but are not only the result of biochemical-neuropharmacologic factors. It is important to consider psychological aspects too.

Rank of symptoms and severity of benzo dependence is very wide. In general, high dosages, intensive patterns of use and short-time duration benzos will produce more severe symptoms. For most people symptoms are only anxiety and difficulty to sleep during days-weeks. Seizures, coma or malignant neuroleptic syndrome are possible complications, but in real life are very uncommon situations that only appear in very high users who discontinue abruptly using benzos.

I´m sorry my knowledge about US sanitary system is not enough to give advice.

In people who abuse benzos, substitution with long-time benzos and gradual reduction is the usual pattern of detoxification . Diazepam is a good option.

There are no studies in humans with mirtazapine and MDMA. According to mechanism of action it is very likely that it will diminish MDMA effects. I do not reccomend to increase MDMA dosage because of possible physical side effects. I can´t also recommend you to abandon mirtazapine, but if you are exclusively using it as a sleep aid risks should be low. In this case it should not be enough quitting one day, you should need a week. Effectiveness of ginger root on MDMA nausea it is not studied but you should expect no interactions and risk of this combination is probably very low.

[DoctorX]

Doc,

on another thread someone asked how best to take tramadol 100ER.  I informed him there is an increased risk of seizure at 500-600mg is that the right dosage for increaased risk of having a seizure.  Please respond here and I will relay the correct info or read the thread for yourself here https://silkroad5v7dywlc.onion.to/index.php?topic=2099.0

thanks doc your a good man.

 You are right. Use of high dosages of tramadol in non-tolerant persons can lead to increased risk of seizures. It is an uncommon effect, although it is possible. I would not recommend that dosage, not only because of risk of  seizure but also because of adverse effects (nausea, diziness, vomiting...). In human therapeutic use it is common to start with increases of 10-20 mg daily to avoid adverse effects, so a 100 mg dosage will have probably significative adverse effects.

[WickedWords]

Hello DrX

I don't suppose you have any experience with Naltrexone do you?

Not looking for specific situation advice, just general advice on anybody (e.g. me) considering it.

Thanks.

[CoolChick]

There have been a few deaths at Electric Zoo.
http://www.nydailynews.com/new-york/queens/city-cancells-final-day-electric-zoo-dance-music-fest-deaths-concergoers-article-1.1442839


How many hits of xtacy should I take and how long should I wait till I take another?

This is a reasonable request since people are dropping dead. This is important because our friend died because she overdosed at electric zoo. Part of the problem is that MDMA is substituted for another drug or not... but the end result is that we don't feel anything and think that we've taken no drug at all-so I might take another. When the (new) drug finally takes effect -it's remarkably overpowering.

How can we solve this problem?

If one was enough but sold to me as something else, then how can I be sure that two is enough?

[justcurious]

Hi Dr. X!

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course 

Loperamide eliminates 90% without a doubt.

I will not get into it as it can be found discussed extensively on other drug forums, but essentially take about 100mg of tagamet while sipping tonic water that contains quinine (the more the better), wait an hour continuing to drink as much tonic water as possible, then take as much loperamide as you are comfortable taking. For me it was between 50-75mgs (yes this means 25-40 pills of 2mg each). I am not bull shitting. There are videos of people taking 100 pills at once. Your will experience significant relief.

Loperamide is an opiate that can cross the blood-brain barrier, but gets immediately kicked out thanks to p-glycoproteins. Thus it does not reach your opiate receptors to get your high. It is used as an anti-diarrhea for the obvious reason that any opiate constipates you as a symptom. The use of tagamet and specifically quinine (a p-glycoprotein inhibitor) will allow some loperamide to get into your brain. The large dose also overwhelms the proteins allowing some to pass.

This is a method used by many people with concrete results. You do not have to believe me, but I have used it.

If you for some reason get your hands on a large quantity of quinine or another p-glycoprotein inhibitor, DO NOT take those dosage recommendations as you will likely overdose. Loperamide is similar in strength and structure to Fentanyl if able to cross the BBB. Tonic water contains a very small amount of quinine.

[DoctorX]

Doc,

I am having orthopedic surgery and have a feeling my orthopod wont meet my needs of adequate pain control.  I have a decent tolerance.  If I choose to use methadone after surgery how long would I have to wait until the general anesthetics clear my body.  Or should I just use diamorphine?

I suspect the General anesthetic will be propofol.  But I am not sure.  What else could they use for a short operation that may have a half life longer than propofols quick clearance rate.?

Mucho Gusto el doctor

I regret your question is too general to give an adequate advice ¿what kind of surgery?¿general or local anaesthesia?¿are you a regular user of opiates?¿in which dosages? Drugs used in general anaesthesia are propofol, thiopental, etomidate, midazolam or ketamine (iv), halotane, isofluorane (respiratory). They have a quick clearance and analgesics can be used a few hours after without significant interactions. Anyway, I suggest you to consult the anaesthesiologist in order to decide the best analgesic option.

[DoctorX]

Doctor X says:

As a general rule, cannabis is not recommended in persons with mental health problem. The best way to enjoy the effect of drugs and to avoid drug problems is to be in a good psychological state.

The trouble is many users here, including myself, seem to think we need the drugs to get into that "good psychological state".  We are practicing medicine on ourselves to mask an assortment of mental health problems, some major, some minor.  If enough people were to take your advice, the launch of SR 2 would never happen due to the absence of mentally healthy customers.

I have to laugh when cheerleaders for psychedelics say wait until your life is in order, then take it.  By this standard I suspect I'm never doing LSD again.  There is always something left undone, something that needs work, and problems to solve.  Will all the normal people who have their life in good order please stand up now. 



We have two extremes here, society and most health professionals who say, drugs are bad don't do them, and the SR view, it's OK to do them as long as we don't harm another person.  Somewhere in the middle is responsible drug use. 

How would you describe responsible recreational drug use?  Would compulsive daily consumption of anything fall into the irresponsible use column, in your view?  You are careful to avoid judging your patients and that's why many profess their love for you, but when do you say to someone, too much, time to cut back, or god forbid, quit?

You have previously pointed out it is important to have a knowledgeable MDMA therapist if one intends on using it for helping to resolving psychological problems.  Would you say having an experienced responsible, user for any drug, to help with learning how to control the risk of addiction and dependency should be part of all recreative drug use?  A drug use teacher or guru if you will.  Many of us started using rather young, when impulsiveness was a factor, and now are attempting to change unhealthy drug use habits acquired during our days of youthful folly. 

Have you noticed any common threads in your patients who are able to gain control over their irresponsible drug usage?



CS

The questions you raise here are really interesting. When someone asks me a general question, answer must be general also. So, in general, mind-altering drugs are not recommended in persons with mental health problems. It is extremely difficult to distinguish what are the limits between perfect sanity, normal disconfort and severe mental health problems. For some people cannabis or other drugs can releive symptoms temporally or even help in a curative process. But the kind of advice I can offer here is general and limited. If someone is using two or three prescription psychoactive drugs I suppose that there is a significant degree of psychological discomfort.As a general rule use of psychedelics is not recommended in this cases but there can be exceptions, of course.
In my opinion, a reasonable pattern of use of drugs is the one that allows a person to live his own life as he desires, without causing harm to others and himself.
As I say, we could talk a lot about the questions you raise here. But my English is too limited and my time also. And my opinions should be only that, opinions, as valuable or not as anyone else's. So I prefer to solve technical-practical questions about health and drug use.

[DoctorX]

Bupropion and Armodafinil

Doctor,

150 mg Armodafinil normally lasts about 12 hours. I'll be honest, because I spied in some other thread that you suggested that someone else NOT take it  -which is fine. As an addiction specialist you may recognize that it helps me overcome the tiredness associated with my drinking binges and otherwise staying out late on a work night. In other words, I probably won't quit taking it. I don't take it everyday and at most 1-2 times per week.

I've also been taking a low dose 150 sr of Bupropion for an unnamed yet common condition (which you could guess). What I noticed is that since I've been taking the Bupropion -that my Armodafinil has a longer lasting effect -meaning that it used to wear off within 12 hours but now it seems like it last 20 hours.

Is there a drug interaction between the two drugs? Should I quit taking Bupropion and if not Bupropion -then what?

Thank you for your advice.

Although there are no formally described interactions between armodafinil and bupropion, both drugs have a stimulant effect (bupropion should not be used after midday in order to avoid sleep problems),so it is possible that there is an accumulative stimulant effect Data from basic science support this idea:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197159/
The decision of quitting or changing bupropion to another drug depends on the reason for this prescription. Bupropion is generally used as antideppresant or aid to quit smoking. In both cases there are pharmacological options that not interact with armodafinil, although it should be necessary a personal evaluation.

[DoctorX]

Hi Doctor X,

Firstly let me just say what an honour it is to have you here. Your expert knowledge is helping many people to take drugs safely and has even saved one of this communities lives. Kudos to you Doctor

I am starting a cycle of steroid in the very near future and was just wondering could you give me some advice. I plan on using 500mg of Testosterone Enanthate per week Injecting 250mg twice a week. I am stacking this with 60mg of Anavar rising possibly to 100mg near the end. I have got Arimidex which I plan to take .25mg everyday and I am going to take 250mg of HCG twice a week. For PCT I plan on using Clomid which I will probably start about 2 weeks after my last Testosterone jab.

When should I start to the Arimidex and the HCG? I was thinking of starting it about 3 weeks in. Also where would be the best place to inject that would be less painful and most effective? Any advice on dosage and timing would be very much appreciated, this is my first ever cycle and I want to be sure on everything before I star my cycle.

Thanks Doctor X, you really are a hero.

It is relatively simple to find reliable and accurate information about psychoactive drugs on the Internet, and there are sources (Erowid, bluelight, drugs-forum...) to put your trust in. But, in steroids, information is in general of very bad quality. You will find the classical anti-drug propaganda saying that if you touch any quantity of steroids you will be impotent and bold for ever, but on the other side you will find gym buddies proposing cycles with dosages, combinations and patterns of use that can be really harmful. I can`t offer a personalized advice on steroids through Internet, but general guidelines are:

1) If you are a novice, try first a single compound and low dosage cycle. Most gains of high dosages steroids are water retention and is lost in the following weeks. Age is a important factor. You should never use steroids before finishing natural growth (around 2 years), cycles in people over 40-45 years would need medical and analytical supervision.

2) Choose steroids  with human experience (testosterone, nandrolone, oxandrolone...) and avoid those not used in humans, very old or veterinarian

3) Use clinical trials as guidelines to plan your cycle. They can be orientative of dosages and durations with low risk. I disagree with the dosages and durations proposed in most Internet forums. Young people achieve great gains with little dosages and durations, and this diminish the risk of adverse and toxic effects. Examples of reasonable dosages are:
http://ajpendo.physiology.org/content/281/6/E1172
http://www.cnr.berkeley.edu/hellerstein-lab/pdfs/jama-ali.pdf
Take note that it is possible to have significant gains with 100 mg testosterone + 20 mg oxandrolone...much less than what you are planning. This cycle or 300 mg testosterone/6-8 weeks  should be a good starting for a novice. You will read in beefcake forums that it is not enough, but is considerably safer than megacycles you will find and, probably, as effective as these. If you feel that is not enough you can try higher dosages later but I strongly recommend to start by a simple cycle and see your body´s response
 
4) If possible, have a blood test with lipids, hepatic enzymes and complete hormonal profile, before, in the middle and 2 weeks after finishing cycle.

5) Using a dosage as those proved in science (point 3) in general it is not necessary to use antiestrogens, hepatic protectors and other complementary drugs. The efficacy and security of these substances is based in theoric models and its efficacy and security is not demonstrated in humans.

6)  The same thing happens with PCT. Low dosage cycles make it unnecessary and its efficacy in high dosages is not proved. In my opinion (and based in theory) HCG should be a better option than Clomid. Dosage for hypogonadism is 1500 UI 2 times/week

[WickedWords]

Dr

My last question was not very specific, I apologise.

What I meant to ask, was do you know how effective Naltrexone is for the treatment of a non-substance addiction? Also, are there any side-effects I should be wary of, or other drugs I should avoid taking while using it? (I am not an opioid user and so far this is the only drug I've read should be avoided when taking Naltrexone).

Also, do you know what a recommended dosage might be?

I didn't realise when I first posted that you are an addiction specialist, hence my coming back and clarifying my question.

[ProEvo]

Hi Doctor X,

Firstly let me just say what an honour it is to have you here. Your expert knowledge is helping many people to take drugs safely and has even saved one of this communities lives. Kudos to you Doctor

I am starting a cycle of steroid in the very near future and was just wondering could you give me some advice. I plan on using 500mg of Testosterone Enanthate per week Injecting 250mg twice a week. I am stacking this with 60mg of Anavar rising possibly to 100mg near the end. I have got Arimidex which I plan to take .25mg everyday and I am going to take 250mg of HCG twice a week. For PCT I plan on using Clomid which I will probably start about 2 weeks after my last Testosterone jab.

When should I start to the Arimidex and the HCG? I was thinking of starting it about 3 weeks in. Also where would be the best place to inject that would be less painful and most effective? Any advice on dosage and timing would be very much appreciated, this is my first ever cycle and I want to be sure on everything before I star my cycle.

Thanks Doctor X, you really are a hero.

It is relatively simple to find reliable and accurate information about psychoactive drugs on the Internet, and there are sources (Erowid, bluelight, drugs-forum...) to put your trust in. But, in steroids, information is in general of very bad quality. You will find the classical anti-drug propaganda saying that if you touch any quantity of steroids you will be impotent and bold for ever, but on the other side you will find gym buddies proposing cycles with dosages, combinations and patterns of use that can be really harmful. I can`t offer a personalized advice on steroids through Internet, but general guidelines are:

1) If you are a novice, try first a single compound and low dosage cycle. Most gains of high dosages steroids are water retention and is lost in the following weeks. Age is a important factor. You should never use steroids before finishing natural growth (around 2 years), cycles in people over 40-45 years would need medical and analytical supervision.

2) Choose steroids  with human experience (testosterone, nandrolone, oxandrolone...) and avoid those not used in humans, very old or veterinarian

3) Use clinical trials as guidelines to plan your cycle. They can be orientative of dosages and durations with low risk. I disagree with the dosages and durations proposed in most Internet forums. Young people achieve great gains with little dosages and durations, and this diminish the risk of adverse and toxic effects. Examples of reasonable dosages are:
http://ajpendo.physiology.org/content/281/6/E1172
http://www.cnr.berkeley.edu/hellerstein-lab/pdfs/jama-ali.pdf
Take note that it is possible to have significant gains with 100 mg testosterone + 20 mg oxandrolone...much less than what you are planning. This cycle or 300 mg testosterone/6-8 weeks  should be a good starting for a novice. You will read in beefcake forums that it is not enough, but is considerably safer than megacycles you will find and, probably, as effective as these. If you feel that is not enough you can try higher dosages later but I strongly recommend to start by a simple cycle and see your body´s response
 
4) If possible, have a blood test with lipids, hepatic enzymes and complete hormonal profile, before, in the middle and 2 weeks after finishing cycle.

5) Using a dosage as those proved in science (point 3) in general it is not necessary to use antiestrogens, hepatic protectors and other complementary drugs. The efficacy and security of these substances is based in theoric models and its efficacy and security is not demonstrated in humans.

6)  The same thing happens with PCT. Low dosage cycles make it unnecessary and its efficacy in high dosages is not proved. In my opinion (and based in theory) HCG should be a better option than Clomid. Dosage for hypogonadism is 1500 UI 2 times/week

Thank you doctor

[devildrx]

Didn't see there was a topic with questions like this so I will copy paste a thread I made in Off Topic section
(http://silkroad5v7dywlc.onion/index.php?topic=2671.0)

So the question is Doctor, how to deal with stress?

I always wanted to ask someone about this and most of the friends I have talked to about it don't have idea.

I quitted smoking weed mostly because of it. Haven't smoke even a single hit for the last 8 months. And I was smoking a lot, was the first thing I used to do when I woke up and last before I went to sleep for the last 7 years.

Basically I guess it happens to others too but most of the people don't even realise it. When I used to smoke I had a lot of anxiety, faster heart beat, noticed my breath had another, slower rhythm, some kind of weight on my chest and I didn't like to talk much. I don't remember my self being so stressed back when I wasn't smoking and that happened the last 4 years, I was hoping to overcome it but it never happened. So one day I woke up and decided to stop it cause it doesn't have anything to offer me anymore and that's what happened. But stress/anxiety happens sometimes even when I don't, and I don't know how to overcome it. Sometimes I feel like I want to get a few hits again but I don't do it. Most of the weed quality I smoked was shitty type of weed, with lots of seeds etc. But it happened with some local weed too (people that tried it said it's the best weed around the world) and different types of skunk.

I saw a lot of great weed here and I wanna try some of that stuff sometime in the future. But first I have to control this kind of feeling!

[fuckthishoe]

Currently I have a bottle of Promethazine DM (Promethazine HCL 6.25mg, DXM 15 mg,7% Alcohol per every 5mL) as well as Tramadol/APAP (37.5 mg Tramadol, 375 mg of APAP)

I was looking into taking 3 Tramadols & 20mL's of Promethazine DM.
So here's a chart of the dosages I would be taking:
Tramadol_________112.5 mg
APAP____________1125  mg                     
Promethazine._____25 mg
DXM_____________60 mg
21%_____________Alcohol???

So I'm wondering if this combination would be too strong for my liver? What are the side effects?

Should I reduce the amount of Promethazine DM I'm taking? Any other things you'd like to warn me about?

[DoctorX]

Hello DrX

I don't suppose you have any experience with Naltrexone do you?

Not looking for specific situation advice, just general advice on anybody (e.g. me) considering it.

Thanks.

I have read your subsequent message, where you clarify that you are talking about "non substance addition".
Naltrexone acts blocking opioid receptors. Many addictions have this neurological pathway and it has been studied in different conditions. Opiates and alcohol addiction are the most clear indications. Naltrexone has been studied in other compulsive behavior indications: kleptomany, pathological gambling or internet sex addiction.
These studies are preliminar, they only give information about efficacy during a few weeks, put they indicate that naltrexone could be useful in some of these behaviours. Dosages in these studies are in the rank 50-250 mg daily. There is risk of hepatotoxiciy in dosages over 300 mg and the standard dosage in opiates dependence is 50-100 mg. At that dosages adverse effects are, in general, mild. It is very important to avoid opiate usage after, during and before treatment.
In any case, I would recommend psychological support in "non substance addictions"
http://www.biologicalpsychiatryjournal.com/article/S0006-3223%2801%2901079-4/abstract
http://www.biologicalpsychiatryjournal.com/article/S0006-3223%2808%2901481-9/abstract
http://www.mayoclinicproceedings.org/article/S0025-6196%2811%2960846-X

[DoctorX]

There have been a few deaths at Electric Zoo.
http://www.nydailynews.com/new-york/queens/city-cancells-final-day-electric-zoo-dance-music-fest-deaths-concergoers-article-1.1442839


How many hits of xtacy should I take and how long should I wait till I take another?

This is a reasonable request since people are dropping dead. This is important because our friend died because she overdosed at electric zoo. Part of the problem is that MDMA is substituted for another drug or not... but the end result is that we don't feel anything and think that we've taken no drug at all-so I might take another. When the (new) drug finally takes effect -it's remarkably overpowering.

How can we solve this problem?

If one was enough but sold to me as something else, then how can I be sure that two is enough?

Reliable information on drugs and drug testing are the only ways to solve the problem.
According to clinical trials and human experience , MDMA recommended dosages are in the rank 80-120 mg followed by one or two "boosters" half a dose (40-60 mg) separated each 2-3 hours. It is very unlikely that dosages in this rank cause severe health problems if you follow common sense rules (hydration, exercise, avoiding extreme temperatures...). Higher dosages or frequencies are related to severe problems.
Some years ago, MDMA pills contained 40-80 mg. This year it is common to find pills with more than 200 mg. Using MDMA in powder without a scale increases risk of overdosing.
And of course, there is always the adulteration or fraud question. Sometimes drugs are sold as MDMA and they are not.  Drug Testing Services are the only way to avoid these problems. In the case you have not this available in your country you can use Marquis/Mecke reagents. And waiting 60-90 minutes after re-dosing. It is not very accurate but is better than nothing.

[Sir William Wonka]

Hi Doctor X,

Firstly let me just say what an honour it is to have you here. Your expert knowledge is helping many people to take drugs safely and has even saved one of this communities lives. Kudos to you Doctor

I am starting a cycle of steroid in the very near future and was just wondering could you give me some advice. I plan on using 500mg of Testosterone Enanthate per week Injecting 250mg twice a week. I am stacking this with 60mg of Anavar rising possibly to 100mg near the end. I have got Arimidex which I plan to take .25mg everyday and I am going to take 250mg of HCG twice a week. For PCT I plan on using Clomid which I will probably start about 2 weeks after my last Testosterone jab.

When should I start to the Arimidex and the HCG? I was thinking of starting it about 3 weeks in. Also where would be the best place to inject that would be less painful and most effective? Any advice on dosage and timing would be very much appreciated, this is my first ever cycle and I want to be sure on everything before I star my cycle.

Thanks Doctor X, you really are a hero.

It is relatively simple to find reliable and accurate information about psychoactive drugs on the Internet, and there are sources (Erowid, bluelight, drugs-forum...) to put your trust in. But, in steroids, information is in general of very bad quality. You will find the classical anti-drug propaganda saying that if you touch any quantity of steroids you will be impotent and bold for ever, but on the other side you will find gym buddies proposing cycles with dosages, combinations and patterns of use that can be really harmful. I can`t offer a personalized advice on steroids through Internet, but general guidelines are:

1) If you are a novice, try first a single compound and low dosage cycle. Most gains of high dosages steroids are water retention and is lost in the following weeks. Age is a important factor. You should never use steroids before finishing natural growth (around 2 years), cycles in people over 40-45 years would need medical and analytical supervision.

2) Choose steroids  with human experience (testosterone, nandrolone, oxandrolone...) and avoid those not used in humans, very old or veterinarian

3) Use clinical trials as guidelines to plan your cycle. They can be orientative of dosages and durations with low risk. I disagree with the dosages and durations proposed in most Internet forums. Young people achieve great gains with little dosages and durations, and this diminish the risk of adverse and toxic effects. Examples of reasonable dosages are:
http://ajpendo.physiology.org/content/281/6/E1172
http://www.cnr.berkeley.edu/hellerstein-lab/pdfs/jama-ali.pdf
Take note that it is possible to have significant gains with 100 mg testosterone + 20 mg oxandrolone...much less than what you are planning. This cycle or 300 mg testosterone/6-8 weeks  should be a good starting for a novice. You will read in beefcake forums that it is not enough, but is considerably safer than megacycles you will find and, probably, as effective as these. If you feel that is not enough you can try higher dosages later but I strongly recommend to start by a simple cycle and see your body´s response
 
4) If possible, have a blood test with lipids, hepatic enzymes and complete hormonal profile, before, in the middle and 2 weeks after finishing cycle.

5) Using a dosage as those proved in science (point 3) in general it is not necessary to use antiestrogens, hepatic protectors and other complementary drugs. The efficacy and security of these substances is based in theoric models and its efficacy and security is not demonstrated in humans.

6)  The same thing happens with PCT. Low dosage cycles make it unnecessary and its efficacy in high dosages is not proved. In my opinion (and based in theory) HCG should be a better option than Clomid. Dosage for hypogonadism is 1500 UI 2 times/week

Thank you doctor

Thats what ive been saying.  First cycle 500mg test isnt needed. 250-300 is more than enough for a first cycle

[DoctorX]

Hi Dr. X!

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course 

Loperamide eliminates 90% without a doubt.

I will not get into it as it can be found discussed extensively on other drug forums, but essentially take about 100mg of tagamet while sipping tonic water that contains quinine (the more the better), wait an hour continuing to drink as much tonic water as possible, then take as much loperamide as you are comfortable taking. For me it was between 50-75mgs (yes this means 25-40 pills of 2mg each). I am not bull shitting. There are videos of people taking 100 pills at once. Your will experience significant relief.

Loperamide is an opiate that can cross the blood-brain barrier, but gets immediately kicked out thanks to p-glycoproteins. Thus it does not reach your opiate receptors to get your high. It is used as an anti-diarrhea for the obvious reason that any opiate constipates you as a symptom. The use of tagamet and specifically quinine (a p-glycoprotein inhibitor) will allow some loperamide to get into your brain. The large dose also overwhelms the proteins allowing some to pass.

This is a method used by many people with concrete results. You do not have to believe me, but I have used it.

If you for some reason get your hands on a large quantity of quinine or another p-glycoprotein inhibitor, DO NOT take those dosage recommendations as you will likely overdose. Loperamide is similar in strength and structure to Fentanyl if able to cross the BBB. Tonic water contains a very small amount of quinine.

I regret there is no evidence that this method is effective and "then take as much loperamide as you are comfortable taking" does not seem a reasonable dosage...

[DoctorX]

Hey Dr,

Would there be any issues taking Propranolol during the amphetamine comedown or use (taken a little too much). I know beta Propranolol (and i think other beta-blockers) MUST not be mixed with cocaine, but what is the general consensus for amphetamine. I've heard Clonidine is generally a better option, but will Propranolol still be of some help?

Regards
Bowie

I think there is a lack of information about this topic. As you say, it is clear that cocaine and propranolol combination is very dangerous. Meth has a relatively (but not identical) way of action. But I have not been able to find cases or recommendations, even searching in the biggest reviews:
http://www.health.ny.gov/diseases/aids/harm_reduction/crystalmeth/docs/meth_literature_index.pdf
And there is no mention to problems with propranolol in the technical sheet of Desoxyn, the brand name for prescription methamphetamine.
http://www.recordatirarediseases.com/sites/default/files/USA%20DES%20PI%20Recordati%20Feb%202013%20%28w%20changes%20accepted%29.pdf
So, there are no available data to answer your question. Anyway, if using something to come down methamphetamine, benzos seem a safer option. Or trying to use a lower dosage of meth that does not make necessary using more drugs.

[WickedWords]

Thanks Doctor :-)

[DoctorX]

Didn't see there was a topic with questions like this so I will copy paste a thread I made in Off Topic section
(http://silkroad5v7dywlc.onion/index.php?topic=2671.0)

So the question is Doctor, how to deal with stress?

I always wanted to ask someone about this and most of the friends I have talked to about it don't have idea.

I quitted smoking weed mostly because of it. Haven't smoke even a single hit for the last 8 months. And I was smoking a lot, was the first thing I used to do when I woke up and last before I went to sleep for the last 7 years.

Basically I guess it happens to others too but most of the people don't even realise it. When I used to smoke I had a lot of anxiety, faster heart beat, noticed my breath had another, slower rhythm, some kind of weight on my chest and I didn't like to talk much. I don't remember my self being so stressed back when I wasn't smoking and that happened the last 4 years, I was hoping to overcome it but it never happened. So one day I woke up and decided to stop it cause it doesn't have anything to offer me anymore and that's what happened. But stress/anxiety happens sometimes even when I don't, and I don't know how to overcome it. Sometimes I feel like I want to get a few hits again but I don't do it. Most of the weed quality I smoked was shitty type of weed, with lots of seeds etc. But it happened with some local weed too (people that tried it said it's the best weed around the world) and different types of skunk.

I saw a lot of great weed here and I wanna try some of that stuff sometime in the future. But first I have to control this kind of feeling!

Cannabis has a variable effect in anxiety. For some people it reduces anxiety but for other persons it can trigger it. The effect depends on psychological factors,and the variety of cannabis is also important. Strains rich in THC are more anxiogenic than varieties rich on CBD. In your case anxiety seems to be appearing even without cannabis use. It should be necessary a personal evaluation; maybe psychological and/or pharmacological aid ( some SSRIs are very effective in this way) could help. If you feel you can´t control this feeling by yourself seek for aid. And in the meantime I do not recommend to use psychoactives that can trigger anxiety.

[DoctorX]

Currently I have a bottle of Promethazine DM (Promethazine HCL 6.25mg, DXM 15 mg,7% Alcohol per every 5mL) as well as Tramadol/APAP (37.5 mg Tramadol, 375 mg of APAP)

I was looking into taking 3 Tramadols & 20mL's of Promethazine DM.
So here's a chart of the dosages I would be taking;
Tramadol_________112.5 mg
APAP____________1125  mg                     
Promethazine._____25 mg
DXM_____________60 mg
21%_____________Alcohol???

 So I'm wondering if this combination would be too strong for my liver? What are the side effects?

Should I reduce the amount of Promethazine DM I'm taking? Any other things you'd like to warn me about?

Alcohol is an excipient in this syrup :7% alcohol in 5 ml means that you will have 7 mg of alcohol in 5 ml, 21 mg in 15 ml; that is quite a little dosage and effects and risks should be unnoticeable. On the other hand the dosage of APAP is in the limit high of the daily recommended dosage (1000 mg/day). But besides pharmacological negative effects there is a more important question (at least from my point of view)...will this combination and dosage have any pleasurable effects? In my opinion probably not. High dosages of tramadol in non-tolerant persons will probably produce adverse effects (nausea, vomiting, dizziness...) and antihistaminergic effect of promethazine will lead to an umconfortable sleepy sensation. It should be important to be in a quiet place, avoid dangerous activities and...prepare a plastic bag for vomiting

[DoctorX]

Hello,
I am a Spanish Family Physician working in fields like risk reduction associated to drug use, club drugs, new synthetic drugs, cannabis therapeutic and steroids since 1999. I would like to contribute to this forum offering professional advice in topics related to drug use and health: pharmacological interactions, risks of drug use in particular conditions (specific diseases, problems of health…), contraindications, adverse effects and toxicity, risk reduction measures…
This advice cannot replace a complete face-to-face medical evaluation, but I know how difficult can be to talk frankly about these things. You can see my CV in my personal web-page http://www.doctorcaudevilla.com/
You can also use PM for personal questions or video-conference in my web.
I will try to answer all your questions (if I know the answers) but I have limited time
DoctorX

Please look over and follow these guidelines before posting:

1) Have a look into the thread or use the search engine. It is possible your question has been     asked and answered already.

2) Try to be as descriptive as possible, the more accurate your information (age, gender, health problems, prescription/illegal drug use...) the more specific my answer will be.

3) Information in this thread is general advice, but it can't replace a personal, medical evaluation. Health problems must be evaluated in person. No responsibility is assumed by misunderstanding of this information.

4) Answering questions entails dedicating time and personal effort. Consider supporting this service with a donation

(10/10/13) Continuing this thread from old SR forum

(03/05/13) Please use only PM and PGP for personal questions. Most of the questions can be answered in general forum and can be useful to other people

[REDЯUM]

What would happen if a completely sane person took anti-psychotic medication like Seroquel or Zyprexa? Would it make them more sane?

[DoctorX]

The effect will be the same as if you take any medication that you don´t need: adverse effects.

[Naughty Dogg]

This is some great community service. Very nice thread indeed. Thank you for lending knowledge and information DocX!

[cleansober]

When does drug use become drug abuse?

[Morpheus]

What are the implications of using Testosterone with recreational LSD/DMT use? For someone with good mental health, good diet, a good gym plan and general good health, are there any problems of Testosterone and the said narcotics?

How about Finasteride (Fincar), Anastrozole (Arimidex) and/or Clomiphine combinations with LSD/DMT?

I am thinking of starting a steroid cycle of Testosterone, with Fincar, Arimidex and Clomiphine.

[DoctorX]

When does drug use become drug abuse?

"Drug abuse" is generally defined as a  maladaptive pattern of substance use leading to clinically significant impairment or distress. A pattern of use with negative consequences on personal, social, laboral, familiar life or health consequences.
It is not a quantitative definition, so limits can be difficult to define, but in general, "abuse" is defined by negative consequences.

[DoctorX]

What are the implications of using Testosterone with recreational LSD/DMT use? For someone with good mental health, good diet, a good gym plan and general good health, are there any problems of Testosterone and the said narcotics?

How about Finasteride (Fincar), Anastrozole (Arimidex) and/or Clomiphine combinations with LSD/DMT?

I am thinking of starting a steroid cycle of Testosterone, with Fincar, Arimidex and Clomiphine.

There are no described interactions between recreational tryptamines (LSD or DMT) and testosterone, finasteride, anastrazol or clomiphene. According to mechanisms of actions it is unlikely that there are clinically significant problems.
Nevertheless, psychological effects of testosterone are very different in different persons. Some people get too sexually excited, nervous, impulsive or aggressive. For these persons,  it this possible that this effect can condicionate psychedelic experience.
We talked some days ago about cycles and PCT. Feel free to ask or comment if you need additional information
silkroad5v7dywlc.onion/index.php?topic=314.msg36810#msg36810

[cleansober]

Some people get too sexually excited

By this do you mean physically aroused, psychologically excited, or both? I have enough psychological excitement, I'm looking for some physical reactions.  ha ha.

[DoctorX]

Both

[cleansober]

DoctorX, thks for the quick response.

On a different subject, could you comment on death? Do dead bodies, pre-rigor mortise, have more flexibility than when alive?  A doctor once told me that after death, but before rigor mortise, a corpse has much more range of motion joint flexibility than it does pre-death.  This was in reference to practicing hatha yoga, the ancient art of looking at women in tights. 


The doctor told a group of yoga enlightenment seekers to let our minds' and bodies' relax and this would help us reach our goal of sitting cross legged comfortably and be able to do some Kama Sutra sex positions. Of course, I'm adding the part about sex positions. Sex, drugs and yoga; that's what they say around these parts. (A joking reference to the common saying; sex, drugs and rock and roll) money could replace rock and roll given the bitcoin run up.

In a similar vein, after using cannabis I find it very easy to let my body get into mildly extreme positions, with very high levels of pleasure, no discomfort. I'm in pretty good shape, could lose a few and get better lung capacity.  For other exercise, I run in short spurts, 20 meters or so then walk a few, and another sprint of 40 meters for a total of a few hundred meters, five or six times a week.  I'm training to run a five hundred meter sprint race with my pet monkey, so far he wins every time. 

Should I be worried about cannabis induced stroke?  These yoga positions involve mostly relaxing semi-horizontal movements, no inversions.  When I look at photos of me while I'm in a position, it looks very mild, but my sense of body release is extreme.  This physical sensation is what I will miss most after I quit. My real dream is to be the oldest and only person to climb Mount Everest from a seated position.  This feat would be next to impossible to accomplish while using mota, obviously.

Quitting is really about money, or, as we know it, bitcoins.  My stash, though small, could be worth millions in the near future.  Why would I cash in my chips for a simple sensation, even if it is wonderful? I'm more greedy for money than greedy for a high.  To make money I need to stay on top of my game mentally.  Weed cause me to say stupid things, do stupid things, and smile like an idiot.  For now CS is living up to his name, strapping on the seat belt, and taking a breath of clean air.  No more constant clearing the throat or speaking with a rasp.  Started to read Princess Bride on DPR's suggestion. At first I hated reading the book, but after a few slow starts, I'm hooked.  Another thing impossible for me to do while high, read a good book.   



X,

1) Do you think I would still have these negative effects if I bought the really expensive medical grade weed?

2)  Do you treat gambling, bitcoin, and forum posting addictions too?

3) People should check out your blog for the the link to the new DPR interview.

4) Would using edibles make a significant difference in my complaints?

5)  Why do I feel like I'm standing up at an AA meeting?


As usual,

CleanSober

Colors not allowed in signatures, in case anyone is wondering.

[Hagia Sophia]

Hi Doc,

Awesome to have you here. There should be more physicians like you concerned with helping people instead of judging people.

Anyway, I have a couple of contraindication questions. I am currently taking bupropion and fluoxetine as prescribed. I have heard that mixing these with X can cause fatal serotonin syndrome, while others just say it kills the high. How dangerous is it, really? How long would I have to stop taking these in order to get them out my system enough to take X? Also, is taking ketamine with these pills dangerous?

I realize that drugs are generally a risk. Still, I'm not willing to risk death for a high.

[psilo92]

Hey Doc, i have a question for you about benzo use. im a young male in good health (i think) im on Methadone Maintenance Trearment just a little over 100mg and have been on benzos for about 4 years precribed, but recently ive been taking much more then prescribed, but i started taking rso i could sleep, it was next to impossible, and when i do i have shaking fits, not from withdrawal ill take one before bed, but all night long im like stuck in a dream thats just of me trying to sleep in my bedroom and i feel as if im awake yet cant move, then will have extreme shaking/tremor fits and it will wake up my lady and shell grab me and they stop and i wake up to actuslly trying to fall asleep again, then same dream ensues again and it repeats most of the night, i may get two hours of real sleep from 5am to 7am when i wake for MMT clinic, then come home ad may sleep at most from 9a-11a. i dont know how to stop these shaking fits other then when I do a narcotic before bed, like heroin, then ill sleep with out any tremors, and VERY large doses exceeding 60mg of midazolam (usually 15mg IV, 45 oral), 4mg of klonpin and 2mg of xanax, 20mg valium and .25 triazolam, ill still have tremors!  is this aside effect of benzo use? im guessing i shiould cut back, but the dose i just wrote above gives me some relief, the less benzos the worse it is. also ill take hydroxyzine pamoate benzos with . but one thing that actual DOES help me sleep, is .2mg clonodine, but i dont have a constant access to them. should i ween off benzos?  i feel as it will get much worse before it gets better, maybe will ask my doc to prescribe clonodine, but then how long till those effects wear off...and the other odd thing is i can go all day with out benzos and may only take at bed time for relief from tremors, but even if i dont take them at night, i dont go through s withdrawal for a day or two, which seems odd to me....any advice would be appreciated, mainly for how to make tremors stop asap, and ill deal with the coming off
that on my own, if that is the advice you think is best,  but when taken in normal amounts like 4mg klonopin, it still totally eases my anxiety, i take large doses to sleep, i wont lie sometimes during the day to get high, but mainly at night, these tremors started before increase in usage and i dont know how to make them stop but every night is like nightmare combined with sleep paralysis, also my women is not in bed in my dreams, im alone trying to fall asleep, thats how i know its some type of dream, we sleep together every night and she always stops me from shaking as fast as she can, if you can PM me any advice it would be greatly appreciated
Thank you for your dedication and help to this community, any adivce is greatly appreciated, also PM me if you need to know more and think you can help
thanks, peace!
stay safe and healthy everyone
much love
psilo

[vivalarevolution]

Hi Doc, does pot have any effects on how you act while not high? I know the question seems stupid but it'd be a good thing to know from a real doctor

[DoctorX]

Use of cannabis is not an accepted risk factor for cardiovascular or cerebrovascular disease. Tobacco is, and many cannabis smokers use tobacco at the same time than weed. So you shouldn´t be worried about a "cannabis induced stroke".
For the rest, I remind you that time is limited, and I would appreciate more concrete questions.

DoctorX, thks for the quick response.

On a different subject, could you comment on death? Do dead bodies, pre-rigor mortise, have more flexibility than when alive?  A doctor once told me that after death, but before rigor mortise, a corpse has much more range of motion joint flexibility than it does pre-death.  This was in reference to practicing hatha yoga, the ancient art of looking at women in tights. 


The doctor told a group of yoga enlightenment seekers to let our minds' and bodies' relax and this would help us reach our goal of sitting cross legged comfortably and be able to do some Kama Sutra sex positions. Of course, I'm adding the part about sex positions. Sex, drugs and yoga; that's what they say around these parts. (A joking reference to the common saying; sex, drugs and rock and roll) money could replace rock and roll given the bitcoin run up.

In a similar vein, after using cannabis I find it very easy to let my body get into mildly extreme positions, with very high levels of pleasure, no discomfort. I'm in pretty good shape, could lose a few and get better lung capacity.  For other exercise, I run in short spurts, 20 meters or so then walk a few, and another sprint of 40 meters for a total of a few hundred meters, five or six times a week.  I'm training to run a five hundred meter sprint race with my pet monkey, so far he wins every time. 

Should I be worried about cannabis induced stroke?  These yoga positions involve mostly relaxing semi-horizontal movements, no inversions.  When I look at photos of me while I'm in a position, it looks very mild, but my sense of body release is extreme.  This physical sensation is what I will miss most after I quit. My real dream is to be the oldest and only person to climb Mount Everest from a seated position.  This feat would be next to impossible to accomplish while using mota, obviously.

Quitting is really about money, or, as we know it, bitcoins.  My stash, though small, could be worth millions in the near future.  Why would I cash in my chips for a simple sensation, even if it is wonderful? I'm more greedy for money than greedy for a high.  To make money I need to stay on top of my game mentally.  Weed cause me to say stupid things, do stupid things, and smile like an idiot.  For now CS is living up to his name, strapping on the seat belt, and taking a breath of clean air.  No more constant clearing the throat or speaking with a rasp.  Started to read Princess Bride on DPR's suggestion. At first I hated reading the book, but after a few slow starts, I'm hooked.  Another thing impossible for me to do while high, read a good book.   



X,

1) Do you think I would still have these negative effects if I bought the really expensive medical grade weed?

2)  Do you treat gambling, bitcoin, and forum posting addictions too?

3) People should check out your blog for the the link to the new DPR interview.

4) Would using edibles make a significant difference in my complaints?

5)  Why do I feel like I'm standing up at an AA meeting?


As usual,

CleanSober

Colors not allowed in signatures, in case anyone is wondering.

[DoctorX]

Hi Doc,

Awesome to have you here. There should be more physicians like you concerned with helping people instead of judging people.

Anyway, I have a couple of contraindication questions. I am currently taking bupropion and fluoxetine as prescribed. I have heard that mixing these with X can cause fatal serotonin syndrome, while others just say it kills the high. How dangerous is it, really? How long would I have to stop taking these in order to get them out my system enough to take X? Also, is taking ketamine with these pills dangerous?

I realize that drugs are generally a risk. Still, I'm not willing to risk death for a high.

The possibility of a fatal serotonin syndrome mixing MDMA, bupropion and fluoxetine is more therorical than real. There are a few cases described in the world of this problem in persons taking MDMA and using antidepressants and none of  them involved these drugs. The risk is real, but probably very low (at least using usual dosages). It is more likely that, in people using these prescription drugs, MDMA effects are very diminished.
Anyway, taking MDMA while on antidepressants can be risky. Not for this problem, but for the possible effect on the underlying mental health problem. The best way to enjoy MDMA effects is to be in a good psychological state. If you are taking this drugs, maybe it is better to wait until you finish them before using MDMA or other psychedelics.

[Hagia Sophia]

[quote author=DoctorX link=topic=314.msg50551#msg50551

The possibility of a fatal serotonin syndrome mixing MDMA, bupropion and fluoxetine is more therorical than real. There are a few cases described in the world of this problem in persons taking MDMA and using antidepressants and none of  them involved these drugs. The risk is real, but probably very low (at least using usual dosages). It is more likely that, in people using these prescription drugs, MDMA effects are very diminished.
Anyway, taking MDMA while on antidepressants can be risky. Not for this problem, but for the possible effect on the underlying mental health problem. The best way to enjoy MDMA effects is to be in a good psychological state. If you are taking this drugs, maybe it is better to wait until you finish them before using MDMA or other psychedelics.
[/quote]

I appreciate the concern, but I was planning on weaning myself off the scripts anyway, with doctor's supervision of course. I've been on quite a few anti-depressants in my life and none of them have really worked. Most I've ever gotten was a really shitty withdrawal. Need to try something different. How long do you think I would have to stop taking them in order to get the full effect of MDMA? I thought I remembered reading that bupropion has an unusually long half life, which is why I asked.

[DoctorX]

Hey Doc, i have a question for you about benzo use. im a young male in good health (i think) im on Methadone Maintenance Trearment just a little over 100mg and have been on benzos for about 4 years precribed, but recently ive been taking much more then prescribed, but i started taking rso i could sleep, it was next to impossible, and when i do i have shaking fits, not from withdrawal ill take one before bed, but all night long im like stuck in a dream thats just of me trying to sleep in my bedroom and i feel as if im awake yet cant move, then will have extreme shaking/tremor fits and it will wake up my lady and shell grab me and they stop and i wake up to actuslly trying to fall asleep again, then same dream ensues again and it repeats most of the night, i may get two hours of real sleep from 5am to 7am when i wake for MMT clinic, then come home ad may sleep at most from 9a-11a. i dont know how to stop these shaking fits other then when I do a narcotic before bed, like heroin, then ill sleep with out any tremors, and VERY large doses exceeding 60mg of midazolam (usually 15mg IV, 45 oral), 4mg of klonpin and 2mg of xanax, 20mg valium and .25 triazolam, ill still have tremors!  is this aside effect of benzo use? im guessing i shiould cut back, but the dose i just wrote above gives me some relief, the less benzos the worse it is. also ill take hydroxyzine pamoate benzos with . but one thing that actual DOES help me sleep, is .2mg clonodine, but i dont have a constant access to them. should i ween off benzos?  i feel as it will get much worse before it gets better, maybe will ask my doc to prescribe clonodine, but then how long till those effects wear off...and the other odd thing is i can go all day with out benzos and may only take at bed time for relief from tremors, but even if i dont take them at night, i dont go through s withdrawal for a day or two, which seems odd to me....any advice would be appreciated, mainly for how to make tremors stop asap, and ill deal with the coming off
that on my own, if that is the advice you think is best,  but when taken in normal amounts like 4mg klonopin, it still totally eases my anxiety, i take large doses to sleep, i wont lie sometimes during the day to get high, but mainly at night, these tremors started before increase in usage and i dont know how to make them stop but every night is like nightmare combined with sleep paralysis, also my women is not in bed in my dreams, im alone trying to fall asleep, thats how i know its some type of dream, we sleep together every night and she always stops me from shaking as fast as she can, if you can PM me any advice it would be greatly appreciated
Thank you for your dedication and help to this community, any adivce is greatly appreciated, also PM me if you need to know more and think you can help
thanks, peace!
stay safe and healthy everyone
much love
psilo

Hi!
I think your case is too complicated to give you accurate information over the internet. First of all, it would be necessary to be sure about what is the cause of your tremors, and then search for the adequate, specific treatment. Your problem can be related to medication (by overdose or abrupt changes in dosages of prescription drugs), caused by a neurological or metabolic condition...Some of your symptoms (but not all) agree with a disease named "restless legs syndrome", that can be related to opiate/benzos use. Sometimes this disease is caused by low levels of iron in blood or thyroid hormones. But there are other diseases that could give similar symptoms and it is very important to know the cause before deciding a treatment. It is important to make test (a complete interview, a complete neurological exploration, blood tests...) to know what is happening and then decide the treatment. Your symptoms must be very uncomfortable. For something like this I think it is best you speak with your doctor or other health professionals. Self-medicating for these symptoms is not a good practice.

[DoctorX]

Hi Doc, does pot have any effects on how you act while not high? I know the question seems stupid but it'd be a good thing to know from a real doctor

Central Nervous System is a structure rich in lipids (fats), it has a lot of cannabinoid receptors and cannabis has a very high affinity by lipidic tissues, so I think your question is not stupid at all. Long-time, residual effects of cannabis depend a lot on pattern of use. There is evidence that regular use of cannabis can produce a selective effect in short-time memory (memory used to learn or remember new concepts). People who use cannabis regularly learn new concepts with more difficulty (and forget more easily) than no users:
http://www.cmcr.ucsd.edu/images/pdfs/Grant_2003.pdf
This effect is very dependent on pattern of use. For most occasional, non-intensive users this effect is probably unnoticeable. In daily users of cannabis this effect can have some impact, and in most heavy users is significant. There are also important inter-individual differences caused by other factors.
The effect is not neurotoxic, and reversible after a few (3-4) weeks of abstinence
http://www.ncbi.nlm.nih.gov/pubmed/22731735

[DoctorX]

[quote author=DoctorX link=topic=314.msg50551#msg50551

The possibility of a fatal serotonin syndrome mixing MDMA, bupropion and fluoxetine is more therorical than real. There are a few cases described in the world of this problem in persons taking MDMA and using antidepressants and none of  them involved these drugs. The risk is real, but probably very low (at least using usual dosages). It is more likely that, in people using these prescription drugs, MDMA effects are very diminished.
Anyway, taking MDMA while on antidepressants can be risky. Not for this problem, but for the possible effect on the underlying mental health problem. The best way to enjoy MDMA effects is to be in a good psychological state. If you are taking this drugs, maybe it is better to wait until you finish them before using MDMA or other psychedelics.

I appreciate the concern, but I was planning on weaning myself off the scripts anyway, with doctor's supervision of course. I've been on quite a few anti-depressants in my life and none of them have really worked. Most I've ever gotten was a really shitty withdrawal. Need to try something different. How long do you think I would have to stop taking them in order to get the full effect of MDMA? I thought I remembered reading that bupropion has an unusually long half life, which is why I asked.
[/quote]

For most people, 2-3 weeks of abstinence are the time necessary to revert changes induced by antidepressants.

[bodnostrokulum]

Hi Doc

In 2003 i became infected with Hep C, caused by my IV drug abuse. Since than i didnt use a syringe, even once.
Im using hard drugs very rare, im working out a lot and i live very healthy.

My questions to you are two.

Is it possible to cure myself naturaly, cause i never use interferon and simillar and i feel great ?
And the most important question - Can i transmit my virus to my son, via his mother when i impregnate her ? She is not Hep C positive and she never used narcotics .

Thank you in advance !

[37]

Hey!

I've been wondering about a combination of two drugs and if it would get me the full "stoned" experience while suppressing my appetite.

The two drugs I wanted to combine would be an appetite-suppressant (piracetam) and marijuana.

My goal is to get all the effects of marijuana without getting obsessively hungry right after.

Thanks!

[psilo92]

Hey Doc, i have a question for you about benzo use. im a young male in good health (i think) im on Methadone Maintenance Trearment just a little over 100mg and have been on benzos for about 4 years precribed, but recently ive been taking much more then prescribed, but i started taking rso i could sleep, it was next to impossible, and when i do i have shaking fits, not from withdrawal ill take one before bed, but all night long im like stuck in a dream thats just of me trying to sleep in my bedroom and i feel as if im awake yet cant move, then will have extreme shaking/tremor fits and it will wake up my lady and shell grab me and they stop and i wake up to actuslly trying to fall asleep again, then same dream ensues again and it repeats most of the night, i may get two hours of real sleep from 5am to 7am when i wake for MMT clinic, then come home ad may sleep at most from 9a-11a. i dont know how to stop these shaking fits other then when I do a narcotic before bed, like heroin, then ill sleep with out any tremors, and VERY large doses exceeding 60mg of midazolam (usually 15mg IV, 45 oral), 4mg of klonpin and 2mg of xanax, 20mg valium and .25 triazolam, ill still have tremors!  is this aside effect of benzo use? im guessing i shiould cut back, but the dose i just wrote above gives me some relief, the less benzos the worse it is. also ill take hydroxyzine pamoate benzos with . but one thing that actual DOES help me sleep, is .2mg clonodine, but i dont have a constant access to them. should i ween off benzos?  i feel as it will get much worse before it gets better, maybe will ask my doc to prescribe clonodine, but then how long till those effects wear off...and the other odd thing is i can go all day with out benzos and may only take at bed time for relief from tremors, but even if i dont take them at night, i dont go through s withdrawal for a day or two, which seems odd to me....any advice would be appreciated, mainly for how to make tremors stop asap, and ill deal with the coming off
that on my own, if that is the advice you think is best,  but when taken in normal amounts like 4mg klonopin, it still totally eases my anxiety, i take large doses to sleep, i wont lie sometimes during the day to get high, but mainly at night, these tremors started before increase in usage and i dont know how to make them stop but every night is like nightmare combined with sleep paralysis, also my women is not in bed in my dreams, im alone trying to fall asleep, thats how i know its some type of dream, we sleep together every night and she always stops me from shaking as fast as she can, if you can PM me any advice it would be greatly appreciated
Thank you for your dedication and help to this community, any adivce is greatly appreciated, also PM me if you need to know more and think you can help
thanks, peace!
stay safe and healthy everyone
much love
psilo

Hi!
I think your case is too complicated to give you accurate information over the internet. First of all, it would be necessary to be sure about what is the cause of your tremors, and then search for the adequate, specific treatment. Your problem can be related to medication (by overdose or abrupt changes in dosages of prescription drugs), caused by a neurological or metabolic condition...Some of your symptoms (but not all) agree with a disease named "restless legs syndrome", that can be related to opiate/benzos use. Sometimes this disease is caused by low levels of iron in blood or thyroid hormones. But there are other diseases that could give similar symptoms and it is very important to know the cause before deciding a treatment. It is important to make test (a complete interview, a complete neurological exploration, blood tests...) to know what is happening and then decide the treatment. Your symptoms must be very umconfortable so I think the best is to speak with your doctor and not to try to auto-medicate you.

Thank you Doc. I think i may get a blood test down and some kind of sleep study or brain scan. my MMT clinic wants me to get a peak and trough test done to test my serum levels because im still getting sick in the am before i go. i want to increase 5mg from 115mg and have never exceeded 120mg but that was two or 3 years ago when i was using a gram of heroin a day, this time my habit never exceeded splitting a half gram with my girl, so about 250mg of strong heroin, i live in a heroin hot spot. its all high quality, people travel from hours away to cop H from here. but i only use once or twice max now and have been on methadone for almost a year daily now for this time. i dont think i have restless leg syndrome, ive detoxed from 120mg of methadone in 21 days, and have detoxed of H many times so i know that feeling, this feels much more nuerological. my benzo use, although daily, the amounts can be very sporadic, always combined with hyroxyzine pam(100-200mg) and carisoprodol (500mg) and occasionaly ketamine, but usually only a few day binge in a month or two months, as i said not often, but sometimes Heroin. but the newest one to the mix has been clonodine and is the only thing to keep me from tremors/sleep paralysis, which is odd because its a blood pressure/heart medication i believe.  I think i will go have a brain scan done and try control my benzo use to same amounts of same type at certain times of day, instead of 2 or 3 cocktails of all different kinds.  i want to tell my doctor, but i know he willickeput me on a benzo taper and i cant have that, i truly do need them, and although i can buy as many as i want on this glorious website of ours   i for now, need a legal script for MMT and probation. and even if i cut back, i cant imagine NEVER being able to take one without risk of getting kicked out off MMT or go to prison for a few years for facing my probate charges. even if he writes me .25mg of lorazepam once a day. ill be happy because i can still have it in my urine tests. but that would be unlikely if he knew i was taking them in the amounts i am, also knowing im on methadone hes putting himself at risk, although im taking them so i can get some actual rest, i can hardly do anything im always exhausted from never reaching REM sleep. he told me when i start to come off the methadone hes going to taper my clonazepam and add clonodine, but im not ready to taper from methadone again yet, ill go back to being a junk fiend and i dont want that. also i dont see my doc again for about 2months so it will be sometime before i could even voice my concerns to him..i suppose after i get some type of brain scan done if it shows abnormalities ill PM the details to you for future reference of anyone having similar problems. also will get peak and trough blood test for meth and will add all the extras to the lab paper to have them tested for, if theres anything else you think i should get blood tested for impaticular your advice is very much appreciated. thank you for your help thus far. if theres anything i feel i cant tell doctors without being totally weened off benzos, ill PM you for advice on how to gio about it with all details i have at that point of finding out what is going with me if you dont mind me following up with you, even just for you to archive if anything if you feel you cant properly advise me  based on what i tell you but just staying in touch with a doc i can tell anything too keeps my mind a little more at ease. i will also in the mean time try to stop using heroin ketamine or cocaine at all (use coke very seldomly, but cant hurt to not do it all) and get my benzo dosing pattern in a normal manner

anyway, thank you so much
what you provide for our community is SO very useful and i feel pertinent in helping to advise some of us to stay healthy, or even for your to write a paper about junkies, just please, dont quote me if so
thanks again doc
stay healthy and keep giving your great advice to those of us who feel need medical attention/advise without being able to get it, your work is very noble
peace out, if you can tell anything from my extra details for what to have looked at impaticularly for either blood testing or certain brain scan, please let me know. i really need for this to stop its affect on me is detremental and is also ruining my ladys sleep pattern from being awoke twice every hour to hold me down and keep me calm.
sorry for rambling, hope to talk again soon
Adios Doc

[DoctorX]

Spontaneous recovery from hepatitis C happen in 15-20% of patients, but only in the first six months/one year of evolution. 30-40% do not develop significant hepatic lesions after 20-30 years of infection. Another 30-40% develop hepatic fibrosis (that can lead to hepatic cirrhossis). A 1-5% develop hepatic cancer.
Evolution is impredictible although a healthy live (and medical controls) are the best way to be safe. So it is possible to live with Hep C without problems. And interferon and similars are umconfortable treatments, but very effective also.
The risk of sexual transmission is very low. VHC is not transmitted by semen, but by blood. The risk of the situation you are thinking is theoretically possible, but extremely rare in real conditions.

Hi Doc

In 2003 i became infected with Hep C, caused by my IV drug abuse. Since than i didnt use a syringe, even once.
Im using hard drugs very rare, im working out a lot and i live very healthy.

My questions to you are two.

Is it possible to cure myself naturaly, cause i never use interferon and simillar and i feel great ?
And the most important question - Can i transmit my virus to my son, via his mother when i impregnate her ? She is not Hep C positive and she never used narcotics .

Thank you in advance !

[DoctorX]

Hey!

I've been wondering about a combination of two drugs and if it would get me the full "stoned" experience while suppressing my appetite.

The two drugs I wanted to combine would be an appetite-suppressant (piracetam) and marijuana.

My goal is to get all the effects of marijuana without getting obsessively hungry right after.

Thanks!

There is no evidence that piracetam is effective in diminishing appetite. This is not considered in the indications of the drug (and it is not even a common adverse effect). Maybe using cannabis with a full stomach can help better.

[bodnostrokulum]

Thank you very much DoctorX !
Do you know any alternative forms of cures for HVC ?
like Monolaurin or Crocodile blood serum 

[37]

Hey!

I've been wondering about a combination of two drugs and if it would get me the full "stoned" experience while suppressing my appetite.

The two drugs I wanted to combine would be an appetite-suppressant (piracetam) and marijuana.

My goal is to get all the effects of marijuana without getting obsessively hungry right after.

Thanks!

There is no evidence that piracetam is effective in diminishing appetite. This is not considered in the indications of the drug (and it is not even a common adverse effect). Maybe using cannabis with a full stomach can help better.

Tried that, I suppress my appetite for a good hour and a half or so, but right after I'm back hungry.

If you're not sure on that, is there any medicine you think would work best in appetite suppression while not affecting the marijuana's high?

99% of stimulants are out of the picture, for the obvious reason of being influenced by both at the same time, the two drugs will take away from the other.

That's my problem lol.

If anyone has insight on this, would be greatly appreciated.

[cleansober]

37,

My sense is the increase in appetite you are describing might be  the self-fulfilling process.  When you believe something will do something, sometimes it will do something. For me I have lost significant weight lately after regular weed smoking sessions for a good month.  My plan was not to become a heavy grass user but it happened until my stash vanished in a puff of smoke.  About two weeks into my study of the effects of cheap boarder weed I hit something of a low point when I started vomiting after going to bed and sleeping several hours.  A quick google of my symptoms and cannabinoid hyperemesis syndrome looked a somewhat like what I experienced.  My symptoms were different than described in the wiki on it but still similar.

On X's site there was a reference to some drug in weed that had been trialed for weight loss.  I could not find the reference when I went to his site using chrome and translating the pages into English.  The drug was taken off the European market after some suicides or some other nasty side effect, I think anyway. 

Not sure this is what you are asking, nor am I sure it's right.

CS

[DoctorX]

Thank you very much DoctorX !
Do you know any alternative forms of cures for HVC ?
like Monolaurin or Crocodile blood serum 

I am suspicious about alternative cures. Some treatments can be complementary in certain conditions but, in HVC I would reccomend orthodox, conventional medicine.

[DoctorX]

Hey!

I've been wondering about a combination of two drugs and if it would get me the full "stoned" experience while suppressing my appetite.

The two drugs I wanted to combine would be an appetite-suppressant (piracetam) and marijuana.

My goal is to get all the effects of marijuana without getting obsessively hungry right after.

Thanks!

There is no evidence that piracetam is effective in diminishing appetite. This is not considered in the indications of the drug (and it is not even a common adverse effect). Maybe using cannabis with a full stomach can help better.

Tried that, I suppress my appetite for a good hour and a half or so, but right after I'm back hungry.

If you're not sure on that, is there any medicine you think would work best in appetite suppression while not affecting the marijuana's high?

99% of stimulants are out of the picture, for the obvious reason of being influenced by both at the same time, the two drugs will take away from the other.

That's my problem lol.

If anyone has insight on this, would be greatly appreciated.

Appetite stimulation is an adverse effect of cannabis. Cannabis acts on cerebral receptors that make you feel "high" and in receptors that make you feel "hungry". It is impossible to achieve only the first effect without the second one.

[DoctorX]

Yoyu are talking abut rimonabant, a antagonist of cannabinoids receptor that was patented as an adjunctive to weight loss. But it was retired because of severe adverse effects. As I said in previous post, hunger is the consequence of action of cannabis in specific cerebral receptors. You could use theoretically rimonabant to avoid this effect, but you would neither get stoned (cannabinoid receptors would be blocked and cannabis could not act on them)

37,

My sense is the increase in appetite you are describing might be  the self-fulfilling process.  When you believe something will do something, sometimes it will do something. For me I have lost significant weight lately after regular weed smoking sessions for a good month.  My plan was not to become a heavy grass user but it happened until my stash vanished in a puff of smoke.  About two weeks into my study of the effects of cheap boarder weed I hit something of a low point when I started vomiting after going to bed and sleeping several hours.  A quick google of my symptoms and cannabinoid hyperemesis syndrome looked a somewhat like what I experienced.  My symptoms were different than described in the wiki on it but still similar.

On X's site there was a reference to some drug in weed that had been trialed for weight loss.  I could not find the reference when I went to his site using chrome and translating the pages into English.  The drug was taken off the European market after some suicides or some other nasty side effect, I think anyway. 

Not sure this is what you are asking, nor am I sure it's right.

CS

[cleansober]

I would rather be skinny than stoned, disregarding rimonabant's side effects of course.

X, do you think cannabinoid hyperemesis syndrome is a real problem and if so how does it present?

CS

[Gravitax-UK]

Hi Doc - Great to see you here giving some excellent advice!

I have a question about SSRIs and cocaine. I have been on 100mg of Sertraline (Lustral) since April. I am over the problem that caused me to start this course of medication but plan to stay on it until winter has passed then wean myself off slowly. I know MDMA has little effect whilst on SSRIs so have picked up some high quality cocaine instead. Are there any issues I should be aware of when mixing these two (psychological risks aside)?

Thanks!

[knuckles]

Hey Doctor,

My friend keeps getting muscle spasms & burning feel in his left leg whenever he takes 2cb. No matter if the dosage is low or high. Is there anything he can do or take to minimalize the pain?

[stranger]

hi DoctorX.

are there anydangerous interactions between nitrous oxide and other drugs? especially i couldn't find any info about if it dilates blood vessels and should be not used with other drugs that dilates or constricts blood vessels? (i am well aware of the interactions with psychedelics and how it affects the experience, i'm talking about psychical interactions)

thanks!

[DoctorX]

I would rather be skinny than stoned, disregarding rimonabant's side effects of course.

X, do you think cannabinoid hyperemesis syndrome is a real problem and if so how does it present?

CS

Cannabinoid hyperemesis is a rare syndrome characterized by recurrent vomiting, intense nausea and abdominal pain. It is reported that hot baths improved symptoms during these episodes. It was first described in 2005 and there are some 25 scientific reports on this issue to the date. In my oppinion, cannabis has been consumed for many centuries and is currently used by millions of people in many countries. It is hard to believe that a distinctive syndrome caused by cannabis has never been noted before by users or clinicians. If it exists, cannabis hyperemesis syndrome should be considered as an extremely rare circumstance.

[DoctorX]

Hi Doc - Great to see you here giving some excellent advice!

I have a question about SSRIs and cocaine. I have been on 100mg of Sertraline (Lustral) since April. I am over the problem that caused me to start this course of medication but plan to stay on it until winter has passed then wean myself off slowly. I know MDMA has little effect whilst on SSRIs so have picked up some high quality cocaine instead. Are there any issues I should be aware of when mixing these two (psychological risks aside)?

Thanks!

Pharmacological interactions are unlikely at that level. No organic complications have been reported by combination of SSRIs and cocaine. Psychological and personal circunstances are the most important issue here

[Cornelius23]

Cannabinoid hyperemesis is a rare syndrome characterized by recurrent vomiting, intense nausea and abdominal pain. It is reported that hot baths improved symptoms during these episodes. It was first described in 2005 and there are some 25 scientific reports on this issue to the date. In my oppinion, cannabis has been consumed for many centuries and is currently used by millions of people in many countries. It is hard to believe that a distinctive syndrome caused by cannabis has never been noted before by users or clinicians. If it exists, cannabis hyperemesis syndrome should be considered as an extremely rare circumstance.

I wonder if it might be related to the relatively recent emergence of 'skunk' strains depleted of CBD.

[cleansober]

I wonder if it might be related to the relatively recent emergence of 'skunk' strains depleted of CBD.

Good question C, but in my case it was shitty weed, potent, yes, but not the highest quality known to mankind, such as is available here, on the line.

KB, kindness bud, is the name one person, of the female persuasion, gave to this weed strain. Under pressure, she indicated, with complete confidence, that three hours after smoking kb, vomitation would commence post haste.  Her knowledge of genealogy was limited, as we all are, but in her case, more limited than those of us here.  I think she also mentioned "skunk", but I could be wrong or not, who knows.  Another thing

We talked in low tones close to ear, but loud enough for one of us to hear the others words. She blames drugs for her squandered youth; drugs, drugs and more, 'my bads'.  Do you think zaftigism is caused by too much eating? or, on the other hand, just plain bad luck, or, on the other other hand,too little excersize?  Is excessive coffee consumption an effective treatment plan?  What is excessive?

Thanks again, keep up the faith brother,

CS maximus

clean

If I keep asking the same questions over and over I hope to trick you into agreeing with me.  Very sorry for misspelling "excersize", no matter how many times I use the word I constantly get it wrong.  mea culpa.

[DoctorX]

Hey Doctor,

My friend keeps getting muscle spasms & burning feel in his left leg whenever he takes 2cb. No matter if the dosage is low or high. Is there anything he can do or take to minimalize the pain?

I don´t know. But that is not a typical adverse effect of 2C-B. Sometimes psychedelics intensify corporal sensations or perceptions. Maybe there could be some problem in his leg (not neccesarily severe) that only manifests on 2C-B but it is only an hypothesis. 2C-B does not produce this kind of symptoms or at least it has not been communicated in science.

[DoctorX]

hi DoctorX.

are there anydangerous interactions between nitrous oxide and other drugs? especially i couldn't find any info about if it dilates blood vessels and should be not used with other drugs that dilates or constricts blood vessels? (i am well aware of the interactions with psychedelics and how it affects the experience, i'm talking about psychical interactions)

thanks!

There are not described cases of nitrous oxide interactions with other recreational drugs resulting in significant health problems. Problems with its use come primarily from a bad administration route or dosage. When used as an anaesthetic, nitrous is always administered in combination with oxygen. Nitrous oxide should never be used in a gas mask, plastic bag or other situations that can limit oxigen intake. Heavy and frequent nitrous use can deplete vitamin B12 in the body and lead to serious and unpleasant neurological problems. Headache, palpitations or nausea are possible adverse effects. Problems with vasoconstrion are theoreticaly possible but very uncommon in real life (at least using psychedelics that have been used widely in humans). Interactions with classical psychedelics like psilocibin or LSD should be very rare. Anyway I would advice against using it in combination with substances like DOB, bromo-dragonfly or NBOMEs

[collarbones]

Hi Doc, love your work. I have a question along the lines of another user a few pages back, about the interaction between MDMA and anti-depressants.

A friend is on 300mg Efexor (venlafaxine, SNRI), so quite a strong dose. He still tries to party like in the old days, prior to taking the anti-depressants, so when we're all taking MDMA he lines up to take just as much as we do (between 100mg and 300mg a night, usually in 100mg-150mg doses). But inevitably he gets frustrated by not feeling the effects, for obvious reasons, which brings his mood down.

My question for you: is the 300mg venlafaxine completely inhibiting the psychoactive effects of the MDMA, thus rendering my friend taking the drug completely useless?

If the answer is yes, I'm going to have to find a way to gently break it to him that he's wasting his time with that drug. Thanks DrX.

[knuckles]

Hey Doctor X,

Would Anavar interfere with any psychs such as 2cb, lsd,al-lad, mushrooms, dmt?

My friend wants to take some , but he told me he was on Anavar and I can't find too much info on if its ok to to take any psychs while on cycle.

[DoctorX]

Cannabinoid hyperemesis is a rare syndrome characterized by recurrent vomiting, intense nausea and abdominal pain. It is reported that hot baths improved symptoms during these episodes. It was first described in 2005 and there are some 25 scientific reports on this issue to the date. In my oppinion, cannabis has been consumed for many centuries and is currently used by millions of people in many countries. It is hard to believe that a distinctive syndrome caused by cannabis has never been noted before by users or clinicians. If it exists, cannabis hyperemesis syndrome should be considered as an extremely rare circumstance.

I wonder if it might be related to the relatively recent emergence of 'skunk' strains depleted of CBD.

It might be. But nausea and vomiting are not effects of high dosage THC in any animal species. It could be an infrequent effect or related to some change in pattern of use or quality of the substance, as you say. Or it could be a consequence of the obsession of some investigators to discover new syndromes

[DoctorX]

Hello DoctorX,

Muchas gracias for being here! I will make a btc donation when I have some spare coins.

My question: I was using MDMA once a month and decided to start alternating with methylone (one month MDMA, the next month methylone), in order to reduce the serotonine depletion, because I understand methylone works relatively more on dopamine than on serotonine. My methylone dosage on the other hand is always quite a bit higher than my MDMA dosage (250mg MDMA vs 400mg methylone, spread over the night)

I realize methylone is not as well studied as MDMA, but I have never experienced any adverse reactions or bad comedowns or after effects, so I am not worried about that.

My main concern is whether this theory of alternating MDMA and methylone makes any sense, or if I am just fooling myself. Maybe 2c-b would be a better alternative?

Cheers!

TBD

According to available data, the impact of 250 mg/month or 250 mg/ twice a month of MDMA in terms of neurotoxicity would be little (if any) and adverse effects and risk of organic toxicity, moderate. Methylone has a short story of human use, data on humans are very little and risks of toxicity are unknown and difficult to estimate. Anyway 400 mg seems a quite high dosage.
There are some reports of methylone associated severe toxicity, probably caused by overdosage:
http://www.ncbi.nlm.nih.gov/pubmed/23403480
http://www.ncbi.nlm.nih.gov/pubmed/22967774
http://www.ncbi.nlm.nih.gov/pubmed/22582221
http://www.ncbi.nlm.nih.gov/pubmed/22589523
In terms of relative toxicity and human experience of use, 2C-B seems more adequate than methylone.

[DoctorX]

Hi Doc, love your work. I have a question along the lines of another user a few pages back, about the interaction between MDMA and anti-depressants.

A friend is on 300mg Efexor (venlafaxine, SNRI), so quite a strong dose. He still tries to party like in the old days, prior to taking the anti-depressants, so when we're all taking MDMA he lines up to take just as much as we do (between 100mg and 300mg a night, usually in 100mg-150mg doses). But inevitably he gets frustrated by not feeling the effects, for obvious reasons, which brings his mood down.

My question for you: is the 300mg venlafaxine completely inhibiting the psychoactive effects of the MDMA, thus rendering my friend taking the drug completely useless?

If the answer is yes, I'm going to have to find a way to gently break it to him that he's wasting his time with that drug. Thanks DrX.

The dosage of venlafaxine is probably enough to kill effects of MDMA. Or maybe is a combination between the antideppressant and his mood but the pharmacological interaction is very likely. He is probably wasting time, money and energy with this combination in this moment of his life. T

[DoctorX]

Hey Doctor X,

Would Anavar interfere with any psychs such as 2cb, lsd,al-lad, mushrooms, dmt?

My friend wants to take some , but he told me he was on Anavar and I can't find too much info on if its ok to to take any psychs while on cycle.

There are not described pharmacological interactions between oxandrolone and psychedelics. At dosages used in human therapeutics (not above 20-30 mg/day) adverse effects of oxandrolone are mild and possibilities of interactions are low. In case of high oxandrolone dosages and comnbination with potentially hepatotoxic drugs (alcohol, cocaine, MDMA...) caution should be recommended.

[Mindfun]

Thanks DoctorX for all info good read

[cambridgei]

Dear DoctorX,

first of all thank you for doing this thread. So here' my question:
I have hypothyroidism (I am not on any medication right now, i used to take 100 mg so I would last through the day, now I just do a nap) and now i want to take ritalin for studying. I've read that there could be adverse effects if someone has problems with its thyroid. But it is only meant for hyperthyroidism or also for hypothyroidism?

Best Regards,
cambridgei

[brainbank]

Hey Doc,

Vasoconstriction is a problem with many recreational drugs. Do you have any advice to lessen or prevent this? Also, do you know of any vasodilators that would be accessible to most people over the counter?

[Unclaimed]

Any info on mdpv + Amitriptyline to come down?

[DoctorX]

Dear DoctorX,

first of all thank you for doing this thread. So here' my question:
I have hypothyroidism (I am not on any medication right now, i used to take 100 mg so I would last through the day, now I just do a nap) and now i want to take ritalin for studying. I've read that there could be adverse effects if someone has problems with its thyroid. But it is only meant for hyperthyroidism or also for hypothyroidism?

Best Regards,
cambridgei

There are no contraindications or pharmacological interactions between hypothyroidism or drugs used in its treatment and methylphenidate. Combination is pharmacologically safe

[DoctorX]

Hey Doc,

Vasoconstriction is a problem with many recreational drugs. Do you have any advice to lessen or prevent this? Also, do you know of any vasodilators that would be accessible to most people over the counter?

Well...I don´t agree that is a problem with "many" recreational drugs...it is a known complication of some substances (DOB, mephedrone, bromo-dragonfly. 25I-NBOMe). The best way to avoid these risks is not using them (in case of psychedelics there are safer alternatives with minimum physical risks as LSD or psilocibin). In case of significative vasoconstriction it is always necessary use of intravenous medication in clinical setting. "Over the counter" drugs would be not effective

[downlight]

Hi DoctorX

I've read several times in this thread about SSRi's inhibiting the effects
of mdma.

My question is what change would a very small dose of mirtazapine ( 7.5mg per night )
have on mdma use ?

Thanks, keep up the great work !

[DoctorX]

Any info on mdpv + Amitriptyline to come down?

There are only a few studies on MDPV effects in humans. Amitriptyline is an old antidepressant., with some uncomfortable adverse effects. So I do not think these drugs and combination are a good option to "come down"

[TrackBall]

Hi Doc,

First of all thanks for your work.

My partner is currently on Lovan 20mg and smokes roughly 3.5g of weed a week. We have recently found out she is pregnant so her doctor has started cutting back her lovan by 5mg every 2 weeks. After the first 2 weeks she has found it tough to do this whilst also reducing her weed intake, she was thinking of coming of one drug at a time to lessen the impact on her. Is this safe to do so, and if so, which one should she come off first?

Thanks,
TrackBall

[DoctorX]

Hi DoctorX

I've read several times in this thread about SSRi's inhibiting the effects
of mdma.

My question is what change would a very small dose of mirtazapine ( 7.5mg per night )
have on mdma use ?

Thanks, keep up the great work !

There are no studies combinating MDMA and mirtazapine in humans. Animal studies show that mechanisms of action are antagonism of serotoninergic receptors 5-HT2A. So I think it is very likely that use of mirtazapine will lead to a diminish of MDMA effects. Common dosages start on 15 mg, so this effect will be theoretically smaller using 7.5 mg
https://www.ncbi.nlm.nih.gov/pubmed/21621587

[cleansober]

DoctorX,

The illegal drug lifestyle is alternative. Living on the edges of society brings on psychological pressures.  Other than quitting and joining the mainstream, do you see any branch of professional help more able to integrate this fringe societal element with the majority culture element of non-drug users?

cs

[Purity]

How long would u have to abuse street-amphetamines (not meth the normal amps) and how often until you damage your neurons`?

[DoctorX]

Hi Doc,

First of all thanks for your work.

My partner is currently on Lovan 20mg and smokes roughly 3.5g of weed a week. We have recently found out she is pregnant so her doctor has started cutting back her lovan by 5mg every 2 weeks. After the first 2 weeks she has found it tough to do this whilst also reducing her weed intake, she was thinking of coming of one drug at a time to lessen the impact on her. Is this safe to do so, and if so, which one should she come off first?

Thanks,
TrackBall

Use of cannabis during pregnancy has not been related to birth defects. There is some evidence that it can cause a lower weight of newborn (although this may be biased by the use of tobacco). Some investigators have also found can subtle neurocognitive effects that persist for several weeks. But there is no risk of malformation.
In relation with fluoxetine, it has been shown to be associated with a small increased risk of heart defects in the unborn child if used during the first three months of pregnancy. Incidence of this problem is 1% in general population; use of fluoxetine in early pregnancy may slightly increase this risk to around 2 per 100 pregnancies.
Use of psychoactive drugs during pregnancy should always be avoided during pregnancy. In real life this can be sometimes difficult. The first three months (where organs develop) is the most risky period. Risks of both fluoxetine and cannabis seem relatively low, but, in any case, administration of drugs in a person who is not deciding by himself should be avoided if possible. Risks on the mother should be considered, also.

[0b3]

Hello,

I happened to eat a pair of lines of coke. They tasted a whole lot like caffeine.

I don't have much experience with coke, but I think I can tell that it did contain real cocaine by how it anesthetized my tongue. But I know caffeine really well, and that tasted a lot like it. Is that normal for cocaine? Do all extracted crystalline alkaloids taste like that?

The coke wasn't bought off SR.

[DoctorX]

How long would u have to abuse street-amphetamines (not meth the normal amps) and how often until you damage your neurons`?

Amphetamine can produce neurotoxic effects. There are clear evidences about this both in animals and humans. But it is very difficult to know the toxic dosage and pattern of use. Amphetamine has been used as therapeutic drug up to 40 mg/daily dosage (oral route) without evidence of neurotoxicity in long time. Intranasal or intravenous route probably enhance the possibility of neurotoxicity. The purity (or presence of toxic adulterants) of street amphetamine is unknown but it is also an important factor. It is possible, also, that a occasional high dosage of amphetamine can produce a direct neurotoxic effect or other cerebrovascular problems.
In conclusion, it is unlikely that occasional, sporadic, recreational use of common dosages of amphetamine will produce neurotoxic effects but high dosages or intensive (daily or very common) patterns of use will be probably exposed to this risk.

[DoctorX]

Hello,

I happened to eat a pair of lines of coke. They tasted a whole lot like caffeine.

I don't have much experience with coke, but I think I can tell that it did contain real cocaine by how it anesthetized my tongue. But I know caffeine really well, and that tasted a lot like it. Is that normal for cocaine? Do all extracted crystalline alkaloids taste like that?

The coke wasn't bought off SR.

An anesthetic effect is not indicative of cocaine purity. Other local anaesthetics (lidocaine, benzocaine, tetracaine...) produce this effect and these are common adulterants of cocaine (exactly for that reason). Scott test (cobalt thiocyanate reagent) is the easiest way to distinguish between cocaine and other local anaesthetics. It is impossible to estimate cocaine purity by taste

[bodnostrokulum]

Thanks Doc ! You are doing amazing job helping us !

[Ketamonster]

I would like to know more about the adverse effects of ketamine.  How much is too much?  How often is too often?

[OpPop]

Been thinking about asking this, so here goes.

I'm a 55 year old male who, over the course of about 35 years has had 3 lower back laminectomys and finally, about 18 years ago, a lower back fusion. Now don't get me wrong, that lower back fusion was one of the best things I've ever done. It allowed me to go back to work full time as an automotive mechanic for 15 years. However, a few years ago, the lower back pain started getting progressively worse to the point where I could no longer work. I am now in constant chronic pain and am able to control it fairly well with opioids. Usually Percocet or vicodin, and the like.

My problem is where I live there is currently a big push in the medical community, backed by the goverment, to stop the prescribing of any type of opioid or narcotic pain killers. It's getting harder and harder to find a doctor or pain clinic that will prescribe them or even see chronic pain patients as they are somewhat afraid to prescribe the meds anymore.

I currently am prescribed Percocet 5/325. 1 or 2, 4 times a day along with Flexeril. This only barely works. I've been going to the emergency room once a week or so because the pain gets unbearable. They give me a shot, usually Diluadid,   to break the pain and then send me home. I cannot get the current doc to prescribe anything stronger, so I've recently taken matters into my own hands and searched out stronger stuff. I am currently, on occasion, able to buy some morphine sulphate er 60mg tablets. When I can get these, about 4 tablets, 240mg, spread out through 24 hours, keeps me pretty much completely out of pain and able to function as a normal human being. (Yes, I am quite opioid tolerant.) I do not take any other meds with the morphine and I don't drive anymore because of my back anyway, so that is not a concern.

My question is about switching medications. I will not be able to get the morphine for very long and the supply is expensive and erratic. I was considering going to opium. Either making opium tea or using the paste-like stuff that is captured from the pods that they used to make all opioid narcotics. Considering it contains all the opioid alkaloids, I was wondering if it might be a lower-cost alternative?

The only other option offered by the medical community is a "spinal cord stimulator" implant. It's extremely expensive, I would have to have government help to pay for it and even then I doubt if I could afford the part I would have to pay. Several specialists have told me they wouldn't do another surgery on me for any reason because it would just further aggravate the situation. One of the larger medical universities in the area are the ones who want to put the spinal cord stimulator in and even then, they cannot guarantee the results. The surgeon that did my fusion warned me repeatedly before he did it that I would never be able to have another back surgery after the fusion. To be honest, I don't really want to have another surgery. I know they can't really see what's wrong because every time they send me for imaging (xray, MRI, ect) the radiologist always complains that the metal in my back whites out everything and they can't see any detail.

If possible, I'd like to hear your opinion, Dr.
Thanks mush for taking the time to read this if you can.
OpPop 

[Energo]

My little brother has started using meth daily, not daily but at least 5 days a week. Not a huge amount, he literally weighs out about 50-60mg and uses an oral dose.

He still eats, mainly protein shakes but does manage one full meal a day. He also drinks about 3-5 litres of water a day and lift weights five days a week. He says he gets between 5 and 7 hours sleep a night as well.

He uses multi-vitamins and all the other vitamins suggested to go along with the use of Methamphetamine. 3 times a week he use L-Dopa as well for dopamine depletition.

He's using 7-keto as well for cortisol control as he is doing this for bodybuilding purposes. To burn extra fat, I've told him its stupid but his mind is set on it.

He says he is only going to do it for a month. He is very motivated in to bodybuilding so I believe him when he says he will only do it for a month as he is trying to burn fat before he bulks up again.

I just wanted to know if you think he is doing any serious damage? Other than addiction potential? Any advice for him?

This is generally about my little brother, I bodybuild as well but on a different level than him I have been cycling steroids for at least 10 years now and wouldn't consider Meth to be part of bodybuilding.

[funky dingus]

Is it generally a good idea to stick drugs up your butt?

this is a serious question

[DoctorX]

I would like to know more about the adverse effects of ketamine.  How much is too much?  How often is too often?

Ketamine should not be used combinated with other depressants (alcohol, GHB, benzos...). Changes in body perception and anaesthetic effect can lead to problems when someone is under its effects. If you get burn (by a cigarrette, for example) or suffer some wound under K effects it is possible that you don´t notice it. Loss of motor coordination is a common adverse effect depending on dosage

There has been some concern about ketamine and neurotoxicity but there is no evidence of this in humans and probably, it is not a problem. "Ketamine bladder" is the most important problem related to its use. Frequent ketamine use can injure the bladder, causing ulcers (wounds) and fibrosis (stiffening of the bladder walls and shrinkage). Patients refer urinary frequency, urgency, pressure, pain, incontinence and/or bleeding from the bladder. Treatments are not very effective. In general, this problem appears in intensive, dependent persons who take several grams a day/week, although there are exceptions to this rule.

Dependence potential of ketamine is another important problem. It is clear that some people are unable to control their ketamine use, and develop a desadaptative pattern of use where control is lost (similar to cocaine or heroin).

It is very difficult to decide how much is too much and how often is too often. If we make this question for alcohol (as an example of a common drug) we would have very different answers. In general, ocassional use in recreative contexts of moderate dosages is much less risky than daily or even weekly use. Risks increase with frequency and dosage but these are not the unique factors. As a general rule, regular use of drugs increases risks of problems. Less is more.

More reliable information on K effects and problems:
http://www.erowid.org/chemicals/ketamine/ketamine.shtml

[cleansober]

@OpPop

Curious if you have had any luck with cannabis for pain relief?  For years my back caused me chronic pain until I discovered the pain is primarily a shoulder problem. Now the back is ok but there is still shoulder pain on occasion. The one time I studied a friends back Xrays after his fusion, the most notable memory I have is that we both were looking at the film upside down.

How about cannabis combined with touch therapy, any luck or experience with this or any other alternative pain relief therapies?  A recent advert I saw involved Chakra Tuneups. Given your mechanical background, perhaps a chakra tuneup is in order?   

CS

[DoctorX]

Been thinking about asking this, so here goes.

I'm a 55 year old male who, over the course of about 35 years has had 3 lower back laminectomys and finally, about 18 years ago, a lower back fusion. Now don't get me wrong, that lower back fusion was one of the best things I've ever done. It allowed me to go back to work full time as an automotive mechanic for 15 years. However, a few years ago, the lower back pain started getting progressively worse to the point where I could no longer work. I am now in constant chronic pain and am able to control it fairly well with opioids. Usually Percocet or vicodin, and the like.

My problem is where I live there is currently a big push in the medical community, backed by the goverment, to stop the prescribing of any type of opioid or narcotic pain killers. It's getting harder and harder to find a doctor or pain clinic that will prescribe them or even see chronic pain patients as they are somewhat afraid to prescribe the meds anymore.

I currently am prescribed Percocet 5/325. 1 or 2, 4 times a day along with Flexeril. This only barely works. I've been going to the emergency room once a week or so because the pain gets unbearable. They give me a shot, usually Diluadid,   to break the pain and then send me home. I cannot get the current doc to prescribe anything stronger, so I've recently taken matters into my own hands and searched out stronger stuff. I am currently, on occasion, able to buy some morphine sulphate er 60mg tablets. When I can get these, about 4 tablets, 240mg, spread out through 24 hours, keeps me pretty much completely out of pain and able to function as a normal human being. (Yes, I am quite opioid tolerant.) I do not take any other meds with the morphine and I don't drive anymore because of my back anyway, so that is not a concern.

My question is about switching medications. I will not be able to get the morphine for very long and the supply is expensive and erratic. I was considering going to opium. Either making opium tea or using the paste-like stuff that is captured from the pods that they used to make all opioid narcotics. Considering it contains all the opioid alkaloids, I was wondering if it might be a lower-cost alternative?

The only other option offered by the medical community is a "spinal cord stimulator" implant. It's extremely expensive, I would have to have government help to pay for it and even then I doubt if I could afford the part I would have to pay. Several specialists have told me they wouldn't do another surgery on me for any reason because it would just further aggravate the situation. One of the larger medical universities in the area are the ones who want to put the spinal cord stimulator in and even then, they cannot guarantee the results. The surgeon that did my fusion warned me repeatedly before he did it that I would never be able to have another back surgery after the fusion. To be honest, I don't really want to have another surgery. I know they can't really see what's wrong because every time they send me for imaging (xray, MRI, ect) the radiologist always complains that the metal in my back whites out everything and they can't see any detail.

If possible, I'd like to hear your opinion, Dr.
Thanks mush for taking the time to read this if you can.
OpPop

It is very difficult to assess only through Internet in a case like this but I will give you my opinion. Opiates are one of the best available option for treatment of  pain that not responds to other treatments (analgesics, NSAID...). Its efficacy is well stablished in the case of short time pain, but not so clear in long-time pain. Risk of dependence but also pharmacological tolerance are the limitations of opioids. I also agree with you that moral prejudices are a important part, and sometimes life  with dependence than life with pain. Depending on the characteristics of pain some other treatments (amytriptiline, gabapentine...) can be very useful, although I can´t reccomend them only based in Internet information.
ER morphine sulphate should be used each 12 hours. It is better to use a higher dosage twice a day than four dosages during the day. Morphine and fentanyl are, among all prescription opiates, the ones with proved efficacy in control of long-time pain (more than 6 months). The proofs of efficacy of oxicodone or hydrocodone are much more limited in this sense.
Opium contains morphine and other analgesic alkaloids. Using it for control of long-time pain would have two specific problems added to general opiate risks: morphine would act ast "fast release" (intense effects but short time) and contain of morphine in opium could have big differences between different plants.
Cannabinoids could help to improve opiates analgesic effects but I don´t think should be enough in this case by themselves.
 

[DoctorX]

My little brother has started using meth daily, not daily but at least 5 days a week. Not a huge amount, he literally weighs out about 50-60mg and uses an oral dose.

He still eats, mainly protein shakes but does manage one full meal a day. He also drinks about 3-5 litres of water a day and lift weights five days a week. He says he gets between 5 and 7 hours sleep a night as well.

He uses multi-vitamins and all the other vitamins suggested to go along with the use of Methamphetamine. 3 times a week he use L-Dopa as well for dopamine depletition.

He's using 7-keto as well for cortisol control as he is doing this for bodybuilding purposes. To burn extra fat, I've told him its stupid but his mind is set on it.

He says he is only going to do it for a month. He is very motivated in to bodybuilding so I believe him when he says he will only do it for a month as he is trying to burn fat before he bulks up again.

I just wanted to know if you think he is doing any serious damage? Other than addiction potential? Any advice for him?

This is generally about my little brother, I bodybuild as well but on a different level than him I have been cycling steroids for at least 10 years now and wouldn't consider Meth to be part of bodybuilding.

50-60 mg methamphetamine daily can lead to psychiatric or cardiovascular problems, even more with physical exercise. Prescription methamphetamine rarely exceeds 10-15 mg daily. I can´t say that he will irremediably have a problem but risk is increased. I also think it will not be very effective to control fat, and even less to gain weight. A combination of a hypocaloric-hyperproteic diet with an adequate aerobic physical exercise seems more logical and effective to achieve his goals.

[DoctorX]

Is it generally a good idea to stick drugs up your butt?

this is a serious question

In general, rectal administration of drugs implies some changes in its distribution and effects. A higher proportion of the drug reaches brain without passing through liver an it produces a faster onset, shorter peak, and shorter duration than the oral route. The absorption can be conditioned by the presence and quantity of faeces in rectum and colon, but in general dosages should be 10-20% lesser than oral route. In moderate use and using hygienic measures risks should not be different to oral route and there are no communicated cases of serious adverse effects using this route (although it is not very common). Not every drug is suitable for this method, but morphine, cocaine and amphetamine derivatives work.

This is a serious answer 

[Ketamonster]

Is there anything a ketamine user can do to try and keep the bladder as healthy as possible besides obviously limiting and spacing out usage?

[Pablo]

Hey Doc, just a question about MDMA.
I have taken a fair few doses before and whenever I take ~150mg at once I get extremely cold, especially when people touch me they say I feel like ice.
Is this feeling dangerous at all or just an effect of vasoconstriction to my extremities? also is there any way I can stop this feeling? obviously I try to stay away from these doses but sometimes in the moment my judgement is flawed. but when I do feel like this I try to drink some water and sit down for a bit to give myself a bit of a break.
cheers
P

[collarbones]

Hey DrX, can you please explain the mechanism behind the 'Tuesday blues' that can accompany MDMA abuse?

Example: last Saturday I took ~250mg orally and ~50mg insufflation over the course of a night. Sunday and Monday my mood was normal, but on Tuesday I took a big dive - completely unproductive, uninspired, took the day off work.

Also: are there any supplements or products that can be used to curtail those after-effects? I have read that 5HTP is useful to take during comedown...

[DoctorX]

Is there anything a ketamine user can do to try and keep the bladder as healthy as possible besides obviously limiting and spacing out usage?

There are only a few cases of ketamine bladder in non-intensive users of ketamine. Most of them are dependent people using several grams a day. So, limiting and spacing out usage seems to be a very useful strategy. There are other measures, although their efficacy is theoretical and not based in evidences. Drinking enough water while on K and a day after could help to keep bladder cleaner. It is possible that a simple urine test could detect early symptoms (microscopic blood and other alterations). Probably, very frequent users should take a simple urine test to rule out problems, and go to the doctor if urinary symptoms are present..

[DoctorX]

Hey Doc, just a question about MDMA.
I have taken a fair few doses before and whenever I take ~150mg at once I get extremely cold, especially when people touch me they say I feel like ice.
Is this feeling dangerous at all or just an effect of vasoconstriction to my extremities? also is there any way I can stop this feeling? obviously I try to stay away from these doses but sometimes in the moment my judgement is flawed. but when I do feel like this I try to drink some water and sit down for a bit to give myself a bit of a break.
cheers
P

"Vasoconstriction" implies a spasm in arteries, leading to decreased blood flow. It can cause cold, but also intense pain, change of color in extremities and, sometimes, necrosis (death of tissues). It is a very severe condition associated to some psychedelic amphetamines (DO-X) , bromodragonfly, NBOMe...
Vasoconstriction, in this sense, is not a MDMA adverse effect. A common situation under MDMA is that body can become very sensitive to environment temperature, and sensations of cold and hot are common. These situations are, in general, common and no indicative of severe problems (like heat stroke). If you feel cold, just protect and take some shelter. 

[DoctorX]

Hi DoctorX,

Some days ago I went to donate blood in my local community center (they do this several times a year). However, when I said I had used MDMA two weeks earlier, they told me they could NOT use my blood.

Does this make any sense to you? It was this really old fashioned looking rectal-exam type head nurse who looked "not amused", so it could very well be prejudice on her part. Should I simply not mention it next time?

TBD


(Edited: missed the word NOT!)

Half-life of MDMA is 6-10 hours. Aproximately in 50 hours there is no rest of substance in your body. That is a reasonable time to donate blood. There are a lot of prejudices to drug users, and the nurse probably did not distinguish between MDMA and injected heroin    If you want to donate you´d better wait at least a week after MDMA and not mentioning

[Hilary]

I have a problem with blocked up nostrils within hours of snorting heroin. It never used to happen, but it happens pretty well all the time now within a few hours and it can last a few days, even up to a week.

Is there any cure of do I have to lay off snorting?

I also take it by plugging, which works, but isn't very glamorous. I can smoke it on foil, but that always seems wasteful and I'm sure it's not good for my lungs. I don't like IVing - I've done it a few times and had it done to me by an expert so I'm sure I don't really like it.

Maybe I should go for pills? I know heroin doesn't work orally, but how about morphine or one of the others that come in pill form?

[Foxy]

I've recently used Cocaine and found it to only give me a numbing sensation in the nose (becomes a little runny as expected) and throat (after it settles in) there isn't a strong stimulate feeling whatsoever. I've had more of a buzz from large doses of coffee even, is this normal or would higher purity coke cause a lack of speediness?

I was a regular user of Ritalin as a child (about 5 years or so) if that matters.

[nobodyenduser]

Greeting and Salutations Dr. X,

I have resumed doing methamphetamine on a limited basis after a long 10 year break. I am a 50 year old male that can be classed as morbidly obese with no other problems except for severe osteoarthritis in both knees. Part of the reason for resuming meth use is because of the weight I have gained and my overall lethargic lifestyle. I have no energy for anything anymore. 

The last time I used meth for a couple days in a row my urine had a horrible smell. It is hard to describe but it was very bad and very strong and a very dark color. I remember the dark color when I used to use a long time ago but never the bad smell.

It lasted maybe a day or two after I got some sleep and stopped using which I felt was longer than it should have been. Is this just from dehydration? I know meth is a diuretic but should I be concerned with the smell? I try to increase my fluid intake but probably not enough considering I do not each much for up to two days. Sometimes time will pass and I'll forget to drink until I have the urge to urinate badly which sneaks up on me.

Should I be concerned about bladder or kidney infections? Should I drink cranberry juice?

Any help would be gladly appreciated.

Thank you kindly

 

[DoctorX]

I have a problem with blocked up nostrils within hours of snorting heroin. It never used to happen, but it happens pretty well all the time now within a few hours and it can last a few days, even up to a week.

Is there any cure of do I have to lay off snorting?

I also take it by plugging, which works, but isn't very glamorous. I can smoke it on foil, but that always seems wasteful and I'm sure it's not good for my lungs. I don't like IVing - I've done it a few times and had it done to me by an expert so I'm sure I don't really like it.

Maybe I should go for pills? I know heroin doesn't work orally, but how about morphine or one of the others that come in pill form?

Intranasal damage is a common problem of drugs used by this route of administration. Dosage, frequency and technique of use are important factors that have influence in severity. Heroin itself (and impurities associated) can irritate nasal tissues and block it up.  It is recommendable to pulverize the substance to a very thin dust before sniffing. Do not use always the same nostril for sniffing, but alternate both. Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better. Saline irrigation can be used several days (better using a syringe) twice a day. If these measures are not enough and blocking is permanent you should ask for doctor advice.
Each route of adminstration has its own pros and cons. For heroin, intranasal is probably the safest and IV the most risky. Heroin is active by oral route, but "rush" is little and effects less noticeable. The same is for morphine

[DoctorX]

I've recently used Cocaine and found it to only give me a numbing sensation in the nose (becomes a little runny as expected) and throat (after it settles in) there isn't a strong stimulate feeling whatsoever. I've had more of a buzz from large doses of coffee even, is this normal or would higher purity coke cause a lack of speediness?

I was a regular user of Ritalin as a child (about 5 years or so) if that matters.

There is no cross tolerance between caffeine and cocaine, so the fact of large doses of coffee does not affect effects of cocaine. Previous use of methylphenidate (years ago) does not cause tolerance, neither.
"Numbing sensations" are not indicative of cocaine purity. In fact other topic anaesthetics (lidocaine, tetracaine, benzocaine...) are among the usual adulterants of cocaine and they are used because of this sensations. Probably a low quality of cocaine is the cause of these feelings without stimulation.

[collarbones]

Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better

Hey Doc, can you please explain this in a bit more detail? I think what you're getting at is to point the straw toward the outside (fleshy bit) of the nostril rather than toward the hole, is that correct?

Also, I posted a question earlier on this page that you might have missed. Thank you

[DoctorX]

Hey DrX, can you please explain the mechanism behind the 'Tuesday blues' that can accompany MDMA abuse?

Example: last Saturday I took ~250mg orally and ~50mg insufflation over the course of a night. Sunday and Monday my mood was normal, but on Tuesday I took a big dive - completely unproductive, uninspired, took the day off work.

Also: are there any supplements or products that can be used to curtail those after-effects? I have read that 5HTP is useful to take during comedown...

Sorry...you are right...I missed this question...
The neurobiological mechanisms of "Tuesday blues" are not clear but, as far as we know, are probably linked to serotonin deplection. Hangover of other drugs (e.g. alcohol) are almost immediate but probably, effects of MDMA serotonin deplection do not manifest before 48-72 hours. Some users refer taking 5-HTP or L-tryptophan to releive these symptoms. This has not been studied in clinical trials and there are no proofs of evidence. But both 5-HTP and L-tryptophan have little toxicity and adverse effects and mechanism sounds pharmacologically logic.

[Cornelius23]

Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better

Hey Doc, can you please explain this in a bit more detail? I think what you're getting at is to point the straw toward the outside (fleshy bit) of the nostril rather than toward the hole, is that correct?

Yep, that's it. Toward the outer fleshy part rather than the inner cartilage between the nostrils

[DoctorX]

Greeting and Salutations Dr. X,

I have resumed doing methamphetamine on a limited basis after a long 10 year break. I am a 50 year old male that can be classed as morbidly obese with no other problems except for severe osteoarthritis in both knees. Part of the reason for resuming meth use is because of the weight I have gained and my overall lethargic lifestyle. I have no energy for anything anymore. 

The last time I used meth for a couple days in a row my urine had a horrible smell. It is hard to describe but it was very bad and very strong and a very dark color. I remember the dark color when I used to use a long time ago but never the bad smell.

It lasted maybe a day or two after I got some sleep and stopped using which I felt was longer than it should have been. Is this just from dehydration? I know meth is a diuretic but should I be concerned with the smell? I try to increase my fluid intake but probably not enough considering I do not each much for up to two days. Sometimes time will pass and I'll forget to drink until I have the urge to urinate badly which sneaks up on me.

Should I be concerned about bladder or kidney infections? Should I drink cranberry juice?

Any help would be gladly appreciated.

Thank you kindly

Urinary infections usually have additional symptoms more than bad smell and colour. Urge to urinate, pain and frequent urinating are common symptoms and, without them, a diagnosis of urinary tract infection is unlikely.
With available information I think of three possibilities:
1) Your urine has been too concentrated because of reversible deshydration
2) The problem may be caused by another factor different to meth use
3) In some persons, meth can damage skeletal muscle tissue.  Products of damaged muscle cells are released into the bloodstream. Urine is tainted with the protein myoglobin. This problem (rhabdomyolysis) can be severe and cause significant problems.
A simple urine test would be very useful to rule out possibility 3) and give a lot of information about cause and treatment (if necessary). In the case you have had a rhabdomyolysis episode, use of meth should be contraindicated.

[DoctorX]

DoctorX,

Thank you for your services, they're priceless. 

So I enjoy using cocaine.  But I would be lieing if I told you I wasn't scared to use it because of the dangers ie. heart attack, seizure, etc.  I only purchase higher quality cocaine that is usually about 80% and the main cut in the rest is ephedrine.  I insufflate it every time.  What is a safe dosage to use if I only use it a few times a week?  I usually do 75 mg at a time and wait 60-90 minutes before insufflating roughly the same amount and after about 300-600 mg I stop (more often its about 300 mg, maybe once or twice a month I'll consume 600mg in a session). This is over a 4-5 hour period.   I've never had my heart rate pass 145 bpm and I usually don't consume anymore until it's back down to about 110-120 to keep it in what I deem a safer heart rate than allowing it to get out of control and reaching 160 or more.  Also, do you have any recommendations to change what I do to minimize the risk of danger.

I'm a healthy male, 20s, just over 200 lbs., 25% body fat (I carry much of it from the waist down, visceral fat is average) and am not in bad shape but I've stopped exercising due to other obligations for about 4 months now with the exception of a 2 hour walk/hike 2-3 times a week.  Any insight you can offer would be extremely helpful as I haven't been able to find guidelines through clearnet on safe limits for my quality of coke and my personal shape, age, etc.

Again, thank you DoctorX....

There are no studies or guidelines to assess about "safe" use of cocaine. "Risk zero" only exists with complete abstinence, and risk increases with dosage and frequency of use. Probably the dosage you are using (75 mg each 45-60 min up to 300 mg) does not mean an excessive risk. But if you repeat this pattern of use "a few times a week" risk can be more significative in long-time. There is no way to accurately estimate the exact risk you are exposed. The less you use, the risk decreases. That is the only information I can offer.
You say that your cocaine cut is "only ephedrine". Ephedrine is a  sympathomimetic amine related to amphetamines with similar effects, adverse effects and risks. A 20% ephedrine is a high dosage that can have its own problematic effects.

[DoctorX]

Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better

Hey Doc, can you please explain this in a bit more detail? I think what you're getting at is to point the straw toward the outside (fleshy bit) of the nostril rather than toward the hole, is that correct?

Also, I posted a question earlier on this page that you might have missed. Thank you

I have uploaded this image, I hope it is more clear like this
http://i44.tinypic.com/2nv9gsk.jpg

[Cornelius23]

I have uploaded this image, I hope it is more clear like this
http://i44.tinypic.com/2nv9gsk.jpg

[cracknback]

Sorry If someones asked this DocX but I dont like reading pages of peoples medical issues.  My question is, have you experimented with drugs or used them regularly or chroically? if so which drug and how much were you taking etc.  cheers doc... great work.   

[cleansober]

People should gamble everyday.  Imagine walking around being lucky and not know it.

crackn',

Lucky people can walk around knowing they are lucky without needing to gamble to prove it. Are you suggesting to take advantage of good luck by gambling?

I dont like reading pages of peoples medical issues.  My question is, have you experimented with drugs or used them regularly or chroically?

So you only want to know one person's history, X's?


Cheers,

CS

[haydenp]

What are the effects of xanax overdose on the body such as heart rate, blood pressure and blood sugar?
And what are the effects of narcan ( aka the chemical used to reverse opiate overdose) on the same (heart, blood pressure and blood sugar)?
The reason i'm asking is because someone i know overdosed on xanax (100 mg worth) and his family called the ambulance on him because he had very shallow breathing (6 breaths per minute) and in the ambulance they thought it was an opiate overdose and they gave him a narcan shot. When he got to the hospital, his heart rate was almost triple its usual rate at 160 (instead of 60) and his blod pressure was through the roof, and his bood sugar was 400something or 500something even though he had not eaten in 24 hours. So can xanax overdose cause this or can narcan caue this or is this something else? they already figured out tht its not diabetes bec it went bck to normal within 24 hours..

Oh and one last question, is xanax overdose, even a huge amount ever fatal by itself (asuming it was ONLY benzos and NO alcohol or opiates)?

Thanks!

EDIT: I believe the blood pressure was actually 150 over 40, not through the roof like i previously stated. Everything else on these hospital records are the same as what i wrote above

[DoctorX]

Sorry If someones asked this DocX but I dont like reading pages of peoples medical issues.  My question is, have you experimented with drugs or used them regularly or chroically? if so which drug and how much were you taking etc.  cheers doc... great work.

So you only want to know one person's history, X's?

I understand your curiosity but this thread is about "people medical issues"
If I were a pop star and you were Oprah Winfrey or Larry King maybe the question could make sense, but I don't think my personal use of drugs is relevant...

[DoctorX]

What are the effects of xanax overdose on the body such as heart rate, blood pressure and blood sugar?
And what are the effects of narcan ( aka the chemical used to reverse opiate overdose) on the same (heart, blood pressure and blood sugar)?
The reason i'm asking is because someone i know overdosed on xanax (100 mg worth) and his family called the ambulance on him because he had very shallow breathing (6 breaths per minute) and in the ambulance they thought it was an opiate overdose and they gave him a narcan shot. When he got to the hospital, his heart rate was almost triple its usual rate at 160 (instead of 60) and his blod pressure was through the roof, and his bood sugar was 400something or 500something even though he had not eaten in 24 hours. So can xanax overdose cause this or can narcan caue this or is this something else? they already figured out tht its not diabetes bec it went bck to normal within 24 hours..

Oh and one last question, is xanax overdose, even a huge amount ever fatal by itself (asuming it was ONLY benzos and NO alcohol or opiates)?

Thanks!

In the context you refer, changes in blood pressure and heart rate can be explained by drugs (the history is compatible with a benzodiacepine intoxication and use of naloxone). Neither benzos or naloxone cause changes in glucose. It is possible that this is simply a stress reaction of the body. If glucose levels are normal in normal conditions and only have changed in this situation, probably it is something without importance.

Lethal intoxications with benzos (with no other drugs) are very unlikely. They have a very wide security range and it should be necessary to take a huge-huge amount to kill one person

[cracknback]

People should gamble everyday.  Imagine walking around being lucky and not know it.

crackn',

Lucky people can walk around knowing they are lucky without needing to gamble to prove it. Are you suggesting to take advantage of good luck by gambling?

I dont like reading pages of peoples medical issues.  My question is, have you experimented with drugs or used them regularly or chroically?

So you only want to know one person's history, X's?


Cheers,

CS

umm no, the gambling thing is a quote from a famous poker player. I saw it, I liked it so I pasted it on my signature. 

Again no.  I'm  not interested in anyones personal history. I asked DrX if he had personal real life experience with drugs..thats all.  I guess I though it was appropriate cause he is here giving advice and medical opinion on drugs to drug users.   ? 
.
But hey I wasn't sure anyone read my posts so you did confirm that you do........ for some reason.   

[4TheeLow]

My friend had been using heroin IV Wednesday and Thursday, maybe 8 stamp bags each day of okay H.  He is 27years old 190pound and in good health.  If he stopped using at 5am friday morning, would he pass a lab UA the following tuesday evening? Making it almost 4 1/2 days since he used.  Thanks!

[DoctorX]

My friend had been using heroin IV Wednesday and Thursday, maybe 8 stamp bags each day of okay H.  He is 27years old 190pound and in good health.  If he stopped using at 5am friday morning, would he pass a lab UA the following tuesday evening? Making it almost 4 1/2 days since he used.  Thanks!

Time detection for urine test analysis for heroin depend on the method use and sensibility of the test. Normal times are 3-5 days so is probable (but not sure) that he will test negative. Drinking a lot of water, sweating, doing exercise or using diuretic are useless measures to eliminate heroin from urine.

[haydenp]

What are the effects of xanax overdose on the body such as heart rate, blood pressure and blood sugar?
And what are the effects of narcan ( aka the chemical used to reverse opiate overdose) on the same (heart, blood pressure and blood sugar)?
The reason i'm asking is because someone i know overdosed on xanax (100 mg worth) and his family called the ambulance on him because he had very shallow breathing (6 breaths per minute) and in the ambulance they thought it was an opiate overdose and they gave him a narcan shot. When he got to the hospital, his heart rate was almost triple its usual rate at 160 (instead of 60) and his blod pressure was through the roof, and his bood sugar was 400something or 500something even though he had not eaten in 24 hours. So can xanax overdose cause this or can narcan caue this or is this something else? they already figured out tht its not diabetes bec it went bck to normal within 24 hours..

Oh and one last question, is xanax overdose, even a huge amount ever fatal by itself (asuming it was ONLY benzos and NO alcohol or opiates)?

Thanks!

In the context you refer, changes in blood pressure and heart rate can be explained by drugs (the history is compatible with a benzodiacepine intoxication and use of naloxone). Neither benzos or naloxone cause changes in glucose. It is possible that this is simply a stress reaction of the body. If glucose levels are normal in normal conditions and only have changed in this situation, probably it is something without importance.

Lethal intoxications with benzos (with no other drugs) are very unlikely. They have a very wide security range and it should be necessary to take a huge-huge amount to kill one person

Thanks for your quick reply! How much is considered a standard donation for this kind of medical advice on the forums here?
And one last question, can an overdose on xanax slow down the breathing to 6 breaths per minute? (I thought that was a symptom of opiate overdose?) and if xanax does slow down breathing this much, is this considered dangerous?

[Energo]

What are the effects of xanax overdose on the body such as heart rate, blood pressure and blood sugar?
And what are the effects of narcan ( aka the chemical used to reverse opiate overdose) on the same (heart, blood pressure and blood sugar)?
The reason i'm asking is because someone i know overdosed on xanax (100 mg worth) and his family called the ambulance on him because he had very shallow breathing (6 breaths per minute) and in the ambulance they thought it was an opiate overdose and they gave him a narcan shot. When he got to the hospital, his heart rate was almost triple its usual rate at 160 (instead of 60) and his blod pressure was through the roof, and his bood sugar was 400something or 500something even though he had not eaten in 24 hours. So can xanax overdose cause this or can narcan caue this or is this something else? they already figured out tht its not diabetes bec it went bck to normal within 24 hours..

Oh and one last question, is xanax overdose, even a huge amount ever fatal by itself (asuming it was ONLY benzos and NO alcohol or opiates)?

Thanks!

In the context you refer, changes in blood pressure and heart rate can be explained by drugs (the history is compatible with a benzodiacepine intoxication and use of naloxone). Neither benzos or naloxone cause changes in glucose. It is possible that this is simply a stress reaction of the body. If glucose levels are normal in normal conditions and only have changed in this situation, probably it is something without importance.

Lethal intoxications with benzos (with no other drugs) are very unlikely. They have a very wide security range and it should be necessary to take a huge-huge amount to kill one person

Thanks for your quick reply! How much is considered a standard donation for this kind of medical advice on the forums here?
And one last question, can an overdose on xanax slow down the breathing to 6 breaths per minute? (I thought that was a symptom of opiate overdose?) and if xanax does slow down breathing this much, is this considered dangerous?

I'm no doctor but I Xanax is a CNS depressant meaning it can slow down your heart/breathing etc.

So an overdose could bring you down to 6 breaths per minute, which is dangerous to say the least.

[haydenp]

What are the effects of xanax overdose on the body such as heart rate, blood pressure and blood sugar?
And what are the effects of narcan ( aka the chemical used to reverse opiate overdose) on the same (heart, blood pressure and blood sugar)?
The reason i'm asking is because someone i know overdosed on xanax (100 mg worth) and his family called the ambulance on him because he had very shallow breathing (6 breaths per minute) and in the ambulance they thought it was an opiate overdose and they gave him a narcan shot. When he got to the hospital, his heart rate was almost triple its usual rate at 160 (instead of 60) and his blod pressure was through the roof, and his bood sugar was 400something or 500something even though he had not eaten in 24 hours. So can xanax overdose cause this or can narcan caue this or is this something else? they already figured out tht its not diabetes bec it went bck to normal within 24 hours..

Oh and one last question, is xanax overdose, even a huge amount ever fatal by itself (asuming it was ONLY benzos and NO alcohol or opiates)?

Thanks!

In the context you refer, changes in blood pressure and heart rate can be explained by drugs (the history is compatible with a benzodiacepine intoxication and use of naloxone). Neither benzos or naloxone cause changes in glucose. It is possible that this is simply a stress reaction of the body. If glucose levels are normal in normal conditions and only have changed in this situation, probably it is something without importance.

Lethal intoxications with benzos (with no other drugs) are very unlikely. They have a very wide security range and it should be necessary to take a huge-huge amount to kill one person

Thanks for your quick reply! How much is considered a standard donation for this kind of medical advice on the forums here?
And one last question, can an overdose on xanax slow down the breathing to 6 breaths per minute? (I thought that was a symptom of opiate overdose?) and if xanax does slow down breathing this much, is this considered dangerous?

I'm no doctor but I Xanax is a CNS depressant meaning it can slow down your heart/breathing etc.

So an overdose could bring you down to 6 breaths per minute, which is dangerous to say the least.

but not fatal? dangerous in what way?

[DoctorX]

What are the effects of xanax overdose on the body such as heart rate, blood pressure and blood sugar?
And what are the effects of narcan ( aka the chemical used to reverse opiate overdose) on the same (heart, blood pressure and blood sugar)?
The reason i'm asking is because someone i know overdosed on xanax (100 mg worth) and his family called the ambulance on him because he had very shallow breathing (6 breaths per minute) and in the ambulance they thought it was an opiate overdose and they gave him a narcan shot. When he got to the hospital, his heart rate was almost triple its usual rate at 160 (instead of 60) and his blod pressure was through the roof, and his bood sugar was 400something or 500something even though he had not eaten in 24 hours. So can xanax overdose cause this or can narcan caue this or is this something else? they already figured out tht its not diabetes bec it went bck to normal within 24 hours..

Oh and one last question, is xanax overdose, even a huge amount ever fatal by itself (asuming it was ONLY benzos and NO alcohol or opiates)?

Thanks!

In the context you refer, changes in blood pressure and heart rate can be explained by drugs (the history is compatible with a benzodiacepine intoxication and use of naloxone). Neither benzos or naloxone cause changes in glucose. It is possible that this is simply a stress reaction of the body. If glucose levels are normal in normal conditions and only have changed in this situation, probably it is something without importance.

Lethal intoxications with benzos (with no other drugs) are very unlikely. They have a very wide security range and it should be necessary to take a huge-huge amount to kill one person

Thanks for your quick reply! How much is considered a standard donation for this kind of medical advice on the forums here?
And one last question, can an overdose on xanax slow down the breathing to 6 breaths per minute? (I thought that was a symptom of opiate overdose?) and if xanax does slow down breathing this much, is this considered dangerous?

Although bradypnea (decreased respiratory rate) is more typical of opiate overdose, it is a possible symptom of benzos overdose. Opiate overdose can kill a person by respiratory depression, this is very unlikely overdosing benzos.
Amount of donations is up to you, no rules

[TwistedNine]

idk if this has been asked. but im on a new anxiolytic called buspar (buspirone), and i was wondering if it'll have any interactive effects with marijuana, MDMA, DMT, or LSD???

[wolfhat110]

idk if this has been asked. but im on a new anxiolytic called buspar (buspirone), and i was wondering if it'll have any interactive effects with marijuana, MDMA, DMT, or LSD???

Just a heads up there aren't any drugs that interact with marijuana that you would ever have to worry about taking. From personal experience both my sister and friend take buspar and dab (marijuana concentrate) all the time and are fine. Same goes for lsd... it just doesn't interact, and the dosage is far to small there are 0 worries there. As for the MDMA, I am not positive but at least you aren't on an SSRI. Dmt is again a drug that reacts with basically nothing and since it is already in your system all the time you shouldn't worry about interactions except buspar might make the experiences a bit more toned down since it is a anxiolytic.



I also have a question... MDMA + Bupropion = Just a slower come up? or danger?

Thank you

[TwistedNine]

idk if this has been asked. but im on a new anxiolytic called buspar (buspirone), and i was wondering if it'll have any interactive effects with marijuana, MDMA, DMT, or LSD???

Just a heads up there aren't any drugs that interact with marijuana that you would ever have to worry about taking. From personal experience both my sister and friend take buspar and dab (marijuana concentrate) all the time and are fine. Same goes for lsd... it just doesn't interact, and the dosage is far to small there are 0 worries there. As for the MDMA, I am not positive but at least you aren't on an SSRI. Dmt is again a drug that reacts with basically nothing and since it is already in your system all the time you shouldn't worry about interactions except buspar might make the experiences a bit more toned down since it is a anxiolytic.

thanks, and yeah MDMA and SSRIs just doesnt work.. i used to take prozac, zoloft, and celexa, and when i was on zoloft i went on a molly binge at a friends house, stayed up all night snorting it, and could barely feel anything.. also did LSD on zoloft and it did barely anything as well

[wolfhat110]

idk if this has been asked. but im on a new anxiolytic called buspar (buspirone), and i was wondering if it'll have any interactive effects with marijuana, MDMA, DMT, or LSD???

Just a heads up there aren't any drugs that interact with marijuana that you would ever have to worry about taking. From personal experience both my sister and friend take buspar and dab (marijuana concentrate) all the time and are fine. Same goes for lsd... it just doesn't interact, and the dosage is far to small there are 0 worries there. As for the MDMA, I am not positive but at least you aren't on an SSRI. Dmt is again a drug that reacts with basically nothing and since it is already in your system all the time you shouldn't worry about interactions except buspar might make the experiences a bit more toned down since it is a anxiolytic.

thanks, and yeah MDMA and SSRIs just doesnt work.. i used to take prozac, zoloft, and celexa, and when i was on zoloft i went on a molly binge at a friends house, stayed up all night snorting it, and could barely feel anything.. also did LSD on zoloft and it did barely anything as well

Ya zoloft sucked for me, wellbutrin has been great and tends to intensify most drugs. Especially stims (obviously) and dissociative since they are broken down by the same enzyme.

[Cornelius23]

Thanks for your quick reply! How much is considered a standard donation for this kind of medical advice on the forums here?

Personally, I tax myself around 10% of what I spend on SR

thanks, and yeah MDMA and SSRIs just doesnt work.. i used to take prozac, zoloft, and celexa, and when i was on zoloft i went on a molly binge at a friends house, stayed up all night snorting it, and could barely feel anything.. also did LSD on zoloft and it did barely anything as well

I find this curious as the effect of MDMA on myself was just as strong when I'd been on 200mg/day of sertraline (Zoloft) for many years as it does now, having not taken any SSRIs since the start of the year. Mind you, the sertraline seemed to have little effect upon me generally and after a recent rediagnosis the psychiatrist has suggested to my doctor that he stop prescribing it to me.

[TwistedNine]

thanks, and yeah MDMA and SSRIs just doesnt work.. i used to take prozac, zoloft, and celexa, and when i was on zoloft i went on a molly binge at a friends house, stayed up all night snorting it, and could barely feel anything.. also did LSD on zoloft and it did barely anything as well

I find this curious as the effect of MDMA on myself was just as strong when I'd been on 200mg/day of sertraline (Zoloft) for many years as it does now, having not taken any SSRIs since the start of the year. Mind you, the sertraline seemed to have little effect upon me generally and after a recent rediagnosis the psychiatrist has suggested to my doctor that he stop prescribing it to me.
[/quote]

huh, thats interesting.. i could be mistaken and it mighta been prozac (this was like 1-2 years ago when i first started taking anti-depressants, prozac was my first and zoloft my second).. life for me was a bit hazy back then

[patar]

Instead of tobacco, what should I put into my weed, which is less destructive, but doesn't smell/taste like shit?

I know I know, ppl should be smoking pure green, but I don't have the wallet for that.

[UnfinishedSentenc]

Hi Doctor X,

First of all I want to thank you for doing this I've read through most of this thread and it's fasinating

I have a friend who has/suffers from Supra ventricular tachycardia. He's had a few attacks in his life and is in the process of seeing experts about his heart. The recent scans he has had have actually shown that his heart is fine and healthy apart from some 'faulty wiring' (which I don't quite understand) and an ablation could be done to fix that. It's worth noting he suffers from quite bad anxiety at times and I personally believe this could be the possible cause but doctors don't seem to accept or address that.

Anyway to the question, for someone who has/has had SVT attacks (around once a year but could be two in a year then not one for another two years) but no known abnormalities scructurally what are the risks of doing say MDMA or LSD? He would love to try MDMA but obviously heart conditions and MDMA are generally a no go but I'm wondering if MDMA would actually be potentially dangerous?

Another point is he gets a bit anxious while smoking weed solely because of his heart and can feel it beating faster and worries him a bit (he generally feels like there's something really wrong with his heart but I believe it's the way he actually views it making the problem worse).

Thanks in advance!

[DoctorX]

idk if this has been asked. but im on a new anxiolytic called buspar (buspirone), and i was wondering if it'll have any interactive effects with marijuana, MDMA, DMT, or LSD???

There are no studies available about clinical interactions between buspirone and psychedelic drugs. Buspirone acts partially on serotoninergic receptors 5-HT1A and decreases effects of serotonin-releasing drugs as fluoxetine. So it is possible that effects of MDMA, DMT or LSD should be diminished. In theory, effects of marijuana should not change.

[TwistedNine]

alright thanks! ill quit taking it a couple days before i trip

[DoctorX]

I also have a question... MDMA + Bupropion = Just a slower come up? or danger?

Thank you

A few words about bupropion and drug interactions
https://silkroad5v7dywlc.onion.to/index.php?topic=314.msg13160;topicseen#msg13160
https://silkroad5v7dywlc.onion.to/index.php?topic=314.msg51559;topicseen#msg51559

[DoctorX]

Instead of tobacco, what should I put into my weed, which is less destructive, but doesn't smell/taste like shit?

I know I know, ppl should be smoking pure green, but I don't have the wallet for that.

Combustion of all vegetals leads to toxic substances that can alter respiratory airway. There is discussion about if tobacco is more or less toxic than cannabis but, in any case, smoking plants is always unhealthy. The healthiest alternative is vaporizing. There are certified vaporizers for cannabis therapeutic use but the problem is that they are expensive. But there are also models cheaper, and benefits are clear compared to smoking.

[DoctorX]

Hi Doctor X,

First of all I want to thank you for doing this I've read through most of this thread and it's fasinating

I have a friend who has/suffers from Supra ventricular tachycardia. He's had a few attacks in his life and is in the process of seeing experts about his heart. The recent scans he has had have actually shown that his heart is fine and healthy apart from some 'faulty wiring' (which I don't quite understand) and an ablation could be done to fix that. It's worth noting he suffers from quite bad anxiety at times and I personally believe this could be the possible cause but doctors don't seem to accept or address that.

Anyway to the question, for someone who has/has had SVT attacks (around once a year but could be two in a year then not one for another two years) but no known abnormalities scructurally what are the risks of doing say MDMA or LSD? He would love to try MDMA but obviously heart conditions and MDMA are generally a no go but I'm wondering if MDMA would actually be potentially dangerous?

Another point is he gets a bit anxious while smoking weed solely because of his heart and can feel it beating faster and worries him a bit (he generally feels like there's something really wrong with his heart but I believe it's the way he actually views it making the problem worse).

Thanks in advance!

Amphetamines and amphetamine derivatives can trigger tachycardia episodes. In a person suffering from SVT antecedents this effect is more likely. Both amphetamine and methamphetamine are contraindicated in persons with cardiac problems, and clinical trials with MDMA exclude also persons with this antecedents. It is difficult to estimate the risk (SVT are more umconfortable than dangerous, in general) but there are reported cases of severe problems:
http://www.mc.fju.edu.tw/userfiles/file/Med%20Journal/Vol.6No.1/%E8%BC%94%E5%A4%A76%E5%8D%B71%E6%9C%9F-04.pdf
Theoretically, risk of LSD should be less important than MDMA or amphetamines.

[nobodyenduser]

Greeting and Salutations Dr. X,

The last time I used meth for a couple days in a row my urine had a horrible smell. It is hard to describe but it was very bad and very strong and a very dark color. I remember the dark color when I used to use a long time ago but never the bad smell.

Should I be concerned about bladder or kidney infections? Should I drink cranberry juice?

Any help would be gladly appreciated.

Thank you kindly

Urinary infections usually have additional symptoms more than bad smell and colour. Urge to urinate, pain and frequent urinating are common symptoms and, without them, a diagnosis of urinary tract infection is unlikely.
With available information I think of three possibilities:
1) Your urine has been too concentrated because of reversible deshydration
2) The problem may be caused by another factor different to meth use
3) In some persons, meth can damage skeletal muscle tissue.  Products of damaged muscle cells are released into the bloodstream. Urine is tainted with the protein myoglobin. This problem (rhabdomyolysis) can be severe and cause significant problems.
A simple urine test would be very useful to rule out possibility 3) and give a lot of information about cause and treatment (if necessary). In the case you have had a rhabdomyolysis episode, use of meth should be contraindicated.

Thank you for answering my question. It was my first time asking a question and I thought it may be possible not to get an answer. I was surprised to see that you eventually answer every question that is asked. I am sure you are a very busy person but yet you somehow find the time to answer our questions.

Yes I do think the work you do is worthy. Not many people would take the time to answer endless questions from a community of people that have been deemed nothing better than criminals and junkies by LE, media and society in general.

The only reason I waited this long to thank you is because I wanted to send you something but did not have the money.

I wish I could give more but I only have .015 btc to give which at this moment is around $13 USD.

Though I bet if everyone who ever asked you a question gave you $13 as well you would be doing this full time. (well maybe not)

So listen up people! spare whatever you can and reward Dr. X for what he does.

Being a freeloader is not a desirable trait.  I would like anyone that is 21 years or older and still living with their mom to disregard the freeloader remark. You obviously have bigger problems and need serious help

[DoctorX]

Thank you for answering my question. It was my first time asking a question and I thought it may be possible not to get an answer. I was surprised to see that you eventually answer every question that is asked. I am sure you are a very busy person but yet you somehow find the time to answer our questions.

Yes I do think the work you do is worthy. Not many people would take the time to answer endless questions from a community of people that have been deemed nothing better than criminals and junkies by LE, media and society in general.

The only reason I waited this long to thank you is because I wanted to send you something but did not have the money.

I wish I could give more but I only have .015 btc to give which at this moment is around $13 USD.

Though I bet if everyone who ever asked you a question gave you $13 as well you would be doing this full time. (well maybe not)

So listen up people! spare whatever you can and reward Dr. X for what he does.

Being a freeloader is not a desirable trait.  I would like anyone that is 21 years or older and still living with their mom to disregard the freeloader remark. You obviously have bigger problems and need serious help

I try to answer all questions. Thanks for support

[Foxy]

Thank you good doctor you're work here is priceless. I was wondering if you knew of any long term effects (postive or negative) from DMT use (heavy or not).

[repairguy]

Fantastic work doctor. If you have a spare moment, do take a minute to answer my question which I've been asking to professionals in the fields of medicine and biology: Do you believe in evolution as the only source of all life forms today? Otherwise, please ignore.

[TwistedNine]

hey, me again.. this time im wondering about mescaline and buspar (buspirone)? i read somewhere that cocaine mixed with buspar can cause seizures.. and since mescaline is a semi-stimulant, i was wondering about it.

[cleansober]

All,

If I may weigh in on the issue of worthiness.  From my perspective it is not about being worthy or being unworthy, rather it is how much would the same advice cost me from traditional medical providers?  Over the last week I have had two physicals from qualified Md's.  Why did I see two is a long story but a good test since only the second doctor knew about the first.  What my costs for two doctor visits right at the end of the year will I think be significant, for a poor drug user like myself.  This question is a raging one now in the USA given the health care initiative.  We pay a lot, that much seems clear.  There are, so I hear, lawyers and doctors who have troubles, habits, or conditions like us but few are surfing SR looking for their next high. 

What I do find amazing is that only one doctor in the world has commented on this thread.  We did have a speed, adder/ritalin, med student stop by for a quick comment but, sadly he never returned, to my knowledge anyway.  He stated med school has a large stimulant use population.  A fast question to a couple of med students finds his observations wanting, coffee was all they would admit to seeing.  He may have gone the way of supersaures neologic chap who started a drug thread promising to clear the drug air but refused to discuss his background at all.  He dropped down into the deep deep hole of non-active threads.  This is a similar state to my feeble efforts at completing my resume, the mountain to Mohammed, or something like that.

How about that 32 year old writer who wrote clever stories about young people who jumped from his parent's two flat or brownstone or whatever?  Apparently writing may clear the conscious but may be other ways to calm the beast within us.  Why go to your parent's house to kill yourself?  This may indicate how bad the depression causing the suicide was. Time and time again the victim is described as vulnerable but able to function well, everyone thought anyway.   He fooled those around him but did he himself know how serious his problem was?

 I'm glad to discover my height is more now than 40 years ago.  Not only am I not shrinking but I'm getting taller.  Always nice to gain an inch or two now and then.  One with shoes, one without shoes, both significant gains.  Which brings me to my question.

@X
Is it possible for someone to grow after completing puberty?  Are there any illnesses that cause growth to start after it normally would be completed?   Are there any drugs or genetic therapies that could start up the growth cycle using advanced techniques?  This may well be deemed a general question but maybe not too.  I'm wondering about my specific case, do people always shrink when we age, specifically me, should I expect to shrink?  Regardless whether or not I do shrink could I expect to get smaller over time if I live a long time?  Either linear shrinkage or more volatile size changes should be considered normal or inevitable? 


CS

[DoctorX]

Thank you good doctor you're work here is priceless. I was wondering if you knew of any long term effects (postive or negative) from DMT use (heavy or not).

As many other "classical psychedelics" organic toxicity of DMT is practically nonexistent. There are no reported cases of intoxication resulting in acute death. Lethal dosage is calculated based in animal models and it seems a reasonably secure drug. There are no reports about neurotoxicity, cardiotoxicity, hepatotoxicity or damage to other human organs, not even in animal administration.
Problems of long-term or acute DMT are of psychological nature. For some people it can be difficult to integrate psychedelic experiences. In people using it very often it can be difficult to distinguih between normal and modified states of consciousness, or difficulties to integrate these experiences in normal life. In a classical, psychiatric point of view, this could lead to anxiety or other affective disorders. It is also possible (uncommon, but possible) to trigger a psychotic episode.
A complete review about DMT effects:
http://www.moishv.com/works/iceers-org/docs/science/ayahuasca/ayahuasca-paper-addiction-ja07.pdf

[DoctorX]

Fantastic work doctor. If you have a spare moment, do take a minute to answer my question which I've been asking to professionals in the fields of medicine and biology: Do you believe in evolution as the only source of all life forms today? Otherwise, please ignore.

I am sorry but this is out of my fields of knowledge...

[DoctorX]

hey, me again.. this time im wondering about mescaline and buspar (buspirone)? i read somewhere that cocaine mixed with buspar can cause seizures.. and since mescaline is a semi-stimulant, i was wondering about it.

There are not many data about this particular. Buspirone does not act as an stimulant. Effects, adverse effects, toxicity and effects of overdosing are not that from stimulants. Anyway, there is little research about combination between psychedelic and prescription drugs. I do not recommend to use psychedelics while on therapeutic drugs. If you are doing so it is important to be very careful with dosages.

[TwistedNine]

hey, me again.. this time im wondering about mescaline and buspar (buspirone)? i read somewhere that cocaine mixed with buspar can cause seizures.. and since mescaline is a semi-stimulant, i was wondering about it.

There are not many data about this particular. Buspirone does not act as an stimulant. Effects, adverse effects, toxicity and effects of overdosing are not that from stimulants. Anyway, there is little research about combination between psychedelic and prescription drugs. I do not recommend to use psychedelics while on therapeutic drugs. If you are doing so it is important to be very careful with dosages.

alright, better safe than sorry. thanks

[AdamSmith]

Dear DoctorX,

First of all I love what you're doing here 

My question:
Is it a good idea to stop a bad trip on mushroom or LSD with benzo's (I have Xanax and Valium)?
Do you have better ideas?
What would you do?

Thanks ahead and keep up the good work!

[TwistedNine]

Dear DoctorX,

First of all I love what you're doing here 

My question:
Is it a good idea to stop a bad trip on mushroom or LSD with benzo's (I have Xanax and Valium)?
Do you have better ideas?
What would you do?

Thanks ahead and keep up the good work!

im not the doctor, nor am i attempting to speak for him, but in my opinion (and timothy leary's), the bad trips are just as important and healthy as the good ones. timothy leary explains it in his book The Psychedelic Experience. and from everything ive gained over the years, im pretty sure its safe to use trip killers as long as you dont OD with them (but that should be common sense)

[AdamSmith]

im not the doctor, nor am i attempting to speak for him, but in my opinion (and timothy leary's), the bad trips are just as important and healthy as the good ones. timothy leary explains it in his book The Psychedelic Experience. and from everything I've gained over the years, I'm pretty sure its safe to use trip killers as long as you dont OD with them (but that should be common sense)

Yeah I know what you mean I've had my share of good and bad trips.
My first bad trip was really more of a prophecy I don't remember everything but during my trip I went outside to the forest and tossed all my weed.
Guess what happened the next day.

I got my weed back.
Then I went drinking at a friends place and took the half ounce with me.
My friend said lets party and of course I did.
So I took it to the party, the police raided and I got nicked with a half ounce.
pretty freaky ain't it

I didn't give me a lot of problems but still

Some bad trips are to dangerous though I had one friend screaming he wanted to kill himself so in those cases it would come in handy

[TwistedNine]

Some bad trips are to dangerous though I had one friend screaming he wanted to kill himself so in those cases it would come in handy

yeah i agree. at that point its probably too terrifying to introspect and figure out anything

[GGGreenbud]

             A Beta-2 Adrenal blocker in conjunction with a Benzodiazepine is more effective than either alone for ending a bad trip.   I am hesitant to use the word "end", the word "mellow out" is more appropriate, as ending a trip completely is not really possible.  You really need to talk someone down after administering any emergency medication, and help them overcome the extreme depersonalization by playing familiar music, talking about good times you had, telling jokes, etc.  be sensitive, but don't let them go to far with any of their seemingly brilliant manic ideation that usually occurs with an ill-integrated trip.  This is what we are really talking about, bad trips don't just happen, it is a combination of set and setting, and the purpose of talking someone down, is to re-integrate the person with their baseline level of consciousness, not to judge or make the person feel bad, nor is it to pander to whatever thought loop they may be stuck on.  Stay safe, leave no person behind!(I really mean that...)
           

[vince]

How bad is it that I do a looooootttttttt of benzos?

[LeapOfFaith]

How many ignorant mother fuckers do you find asking questions on here??

[DoctorX]

Dear DoctorX,

First of all I love what you're doing here 

My question:
Is it a good idea to stop a bad trip on mushroom or LSD with benzo's (I have Xanax and Valium)?
Do you have better ideas?
What would you do?

Thanks ahead and keep up the good work!

If symptoms of a bad trip are mild it is possible to manage them using simply psychological measures (talking quietly to the person, remember him/her that he is under the effect of a drug, that he is not going to be crazy forever, offer some physical contact, try to alleviate hallucinations...). If symptoms are very severe (extreme anxiety, paranoid ideas, aggresivity) it is possible to use any benzo or even some neuroleptics (there are some experiences with haloperidol, olanzapine and risperidone).

I am hesitant to use the word "end", the word "mellow out" is more appropriate, as ending a trip completely is not really possible.  You really need to talk someone down after administering any emergency medication, and help them overcome the extreme depersonalization by playing familiar music, talking about good times you had, telling jokes, etc.  be sensitive, but don't let them go to far with any of their seemingly brilliant manic ideation that usually occurs with an ill-integrated trip.  This is what we are really talking about, bad trips don't just happen, it is a combination of set and setting, and the purpose of talking someone down, is to re-integrate the person with their baseline level of consciousness, not to judge or make the person feel bad, nor is it to pander to whatever thought loop they may be stuck on.  Stay safe, leave no person behind!(I really mean that...)

I agree with these advices

A Beta-2 Adrenal blocker in conjunction with a Benzodiazepine is more effective than either alone for ending a bad trip. 

But i don´t agree with this. I don´t understand what you mean with a "beta-2 adrenal blocker" and I don´t think there is evidence of the efficacy of this combination

[Cornelius23]

Thank you again for all you do here and I hope you're having a very happy Christmas, DoctorX

[DoctorX]

How bad is it that I do a looooootttttttt of benzos?

I don´t know what you exactly mean with doing "a looooootttttttt" of benzos. If ""a looooootttttttt" means a very high dosage, intoxication of benzos can lead to heavy sleep, even coma. If "a looooootttttttt" means "with high frequency" common adverse effects of benzos include drowsiness, amnesia, tolerance and dependence. In general, doing "a looooootttttttt" of almost everything is bad for health

[patashnik]

Hi Doc, thanks for sharing your expertise. I was hoping you could answer a question about regular ketamine use and nasal health.

I started using early this year and got comfortable with 100mg (insufflated) per week. This continued for about five months with a gap in between. I've not used for a few months after I became concerned about my insides and my nose, even though by all accounts I was within safe limits. I noticed no side effects and obviously had no problem with tolerance, but decided to play it safe and stop using for the time being.

Do you know what kind of level of usage of K is possible while avoiding long-term problems resulting from either the drug itself or snorting on a weekly basis?

Cheers

[DoctorX]

Effects and risks of 5-MeO-DMT have been studied during decades. In fact, 5-MeO-DMT  is a common constituent of many different plants and has been used traditionally in psychoactives snuffs such as Yopo from the Anadenanthera colubrina seeds, Epena from Virola sap, and some ayahuasca-type brews. Risks are basically psychological and, as many other classical psychedelics, physical toxicity is considered to be very low.  Short term (1-10 minute) non-responsiveness or unconsciousness has been reported with smoked doses over 8-10 mg or insufflated doses over 15-20 mg, so sitters are extremely important. I think breathing problems are probably related to psychological stress, as there are no reported cases in science of organic toxicity associated to 5-MeO-DMT ( with the exception of intoxication from large doses and/or combinations with MAOIs)

 

Hi Doctor X,

I sent you this as a private message before finding out how to get out of the newbyzone and post publically, so i figured I'd ask the question for all to be able to read. Anyway, I am very interested in exploring 5-MEO-DMT as an entheogen. However, I am apprehensive about whether there are any dangers. I have never read about any reported deaths or serious complications, but the many trip reports mention breathing irregularities, having to remember to breath, people turning a bit blue in the face, extremely elevated heart rate or blood pressure, feeling like an elephant in sitting on you or you blood is turning to concrete, etc.  I read the LD50 is very high though, far higher than the active dose.  So my question, are these physical effects all in peoples' heads? Is 5-MEO-DMT just as safe as N-N-DMT or are there any real dangers involved?

Would greatly appreciate your input! Thanks, and have a happy holidays!

[bigone]

with the above post in mind do you know of any complications with taking DMT and methadone maintenance? Or what about complications with taking MAOIs like Caapi vine or syrian rue in ayahuasca when on methadone maintenance?

[DoctorX]

Hi Doc, thanks for sharing your expertise. I was hoping you could answer a question about regular ketamine use and nasal health.

I started using early this year and got comfortable with 100mg (insufflated) per week. This continued for about five months with a gap in between. I've not used for a few months after I became concerned about my insides and my nose, even though by all accounts I was within safe limits. I noticed no side effects and obviously had no problem with tolerance, but decided to play it safe and stop using for the time being.

Do you know what kind of level of usage of K is possible while avoiding long-term problems resulting from either the drug itself or snorting on a weekly basis?

Cheers

Long-term problems of ketamine use are ketamine-associated cistopathy and dependence. Cistopathy appears generally in long-term, heavy-dosage users and your dosages seem to be low risk in this sense. Potential of addiction depends on dosage, but also in psychological and personal circumstances. It is impossible to estimate a 100% safe dosage, obviously risks increase with dosage and frequency. 100 mg/week seems a reasonable dosage, although there are many risk factors some of which are unpredictable.

In relation with snorting, it is recommendable to pulverize the substance to a very thin dust before sniffing. Do not use always the same nostril for sniffing, but alternate both. Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better. Saline irrigation can be used several days (better using a syringe) twice a day.

[DoctorX]

with the above post in mind do you know of any complications with taking DMT and methadone maintenance? Or what about complications with taking MAOIs like Caapi vine or syrian rue in ayahuasca when on methadone maintenance?

There are no known interactions between methadone and DMT.
But methadone is a phenylpiperidine derivative and these molecules have serotoninergic activity. At least in theory, it is possible an interaction between methadone and MAOIs, at least in large doses or susceptible individuals. MAOIs used in ayahuasca are not, in general, very potent. But MAOIs have important interactions with other psychoactives and this combination should be avoided or managed with extreme caution.
http://bja.oxfordjournals.org/content/95/4/434.full

[TwistedNine]

the above posts got me wondering. what if i mixed St Johns Wort with smoked DMT?

[Oculus]

How about steroid usage.  Any advice.   Given I would take about 1/4th of a 50mg D-Bol every 4-5 hours 3 times a day. (37.5mg)  Ontop of the average bidaily exercise.  I would do this for 3 weeks, then 1 week of clomid.  Starting with 50mg clomid, then 25mg a day for the remainder (6 days).  What would you advise I change (add or detract from) about this routine?  I've only learned these usages and doses from the remainder of the internet and I'm sure you could shed a little more light.  Is dbol even that effective as a standalone steroid?



Thank you,
Oc

[DoctorX]

the above posts got me wondering. what if i mixed St Johns Wort with smoked DMT?

Hypericum perforatum (St John´s Wort) acts as an antidepressant. There are many drugs that can interact with this plant, and some of these interactions are relevant. Hypericum elevates serotonin levels and may contribute to serotonin syndrome. As far as I know there are no reported cases of this problem as a result of the combination of St John´s Wort and tryptamines or phenethylamines. But there are cases with drugs with similar mechanism of action.
http://www.ncbi.nlm.nih.gov/pubmed/17868285
http://www.ncbi.nlm.nih.gov/pubmed/15666281
http://www.ncbi.nlm.nih.gov/pubmed/12649774
http://www.ncbi.nlm.nih.gov/pubmed/12503845
So I strongly would advice against this kind of experiments...

[TwistedNine]

alrighty lol thanks

[DoctorX]

How about steroid usage.  Any advice.   Given I would take about 1/4th of a 50mg D-Bol every 4-5 hours 3 times a day. (37.5mg)  Ontop of the average bidaily exercise.  I would do this for 3 weeks, then 1 week of clomid.  Starting with 50mg clomid, then 25mg a day for the remainder (6 days).  What would you advise I change (add or detract from) about this routine?  I've only learned these usages and doses from the remainder of the internet and I'm sure you could shed a little more light.  Is dbol even that effective as a standalone steroid?



Thank you,
Oc

Dianabol (methandrostenolone) is an old steroid. It was marketed during the fifties in USA and retired from market quickly. The original prescribing guidelines for Dianabol called for a daily dosage of 5 mg.This was to be administered on an intermittent basis, with the drug taken for no more than 6 consecutive weeks. Although a low dose of 5 mg daily may be effective for improving performance, athletes typically take much higher amounts. A daily dosage of three to six 5 mg tablets (15-30 mg) is most common. The problem with this dosages is that adverse effects are very common. In a study on 13 athletes using 10-25 mg of dianabol during 6 weeks, 8/13 suffered adverse effects and 3/13 didn´t finish the study because of adverse effects.
http://bjsm.bmj.com/content/9/2/78.long
Hepatotoxicity is a frequent problem. In my opinion Dianabol is not a good option. Considering health,in a risk reduction perspective and based in clinical trials, if you are looking for an oral steroid oxandrolone 20 mg / daily /6 weeks would be a safer option. Anyway, steroid use should be monitorized by a doctor. I know in real life this happens rarely but quality of information about steroids in Internet is really low.

[Morthand]

Hello doctor!

My question concerns GBL/GHB and using prescription drugs. I use a (Seroxat or Optibar are the brand names.) SSRI 40mg in the morning and
Seroquel 300mg in the evening for mental illnesses. Very randomly I use klonazepam 2mg in the evening to relax. I know this is dodgy, using drugs while using depression/anxiety medication, but this is my situation.

The question is, if/when I make GHB from GBL and start using it, does it interfere with SSRI, Seroquel or random benzos? Or do I even make bigger risks with this combination and I shouldn't use it at all?

In any case I will use proper instructions on GHB and be very careful with the dosage. That is unless the combination is so risky I should just leave the stuff alone.

Thanks,
Morthand

[Oculus]

How about steroid usage.  Any advice.   Given I would take about 1/4th of a 50mg D-Bol every 4-5 hours 3 times a day. (37.5mg)  Ontop of the average bidaily exercise.  I would do this for 3 weeks, then 1 week of clomid.  Starting with 50mg clomid, then 25mg a day for the remainder (6 days).  What would you advise I change (add or detract from) about this routine?  I've only learned these usages and doses from the remainder of the internet and I'm sure you could shed a little more light.  Is dbol even that effective as a standalone steroid?



Thank you,
Oc

Dianabol (methandrostenolone) is an old steroid. It was marketed during the fifties in USA and retired from market quickly. The original prescribing guidelines for Dianabol called for a daily dosage of 5 mg.This was to be administered on an intermittent basis, with the drug taken for no more than 6 consecutive weeks. Although a low dose of 5 mg daily may be effective for improving performance, athletes typically take much higher amounts. A daily dosage of three to six 5 mg tablets (15-30 mg) is most common. The problem with this dosages is that adverse effects are very common. In a study on 13 athletes using 10-25 mg of dianabol during 6 weeks, 8/13 suffered adverse effects and 3/13 didn´t finish the study because of adverse effects.
http://bjsm.bmj.com/content/9/2/78.long
Hepatotoxicity is a frequent problem. In my opinion Dianabol is not a good option. Considering health,in a risk reduction perspective and based in clinical trials, if you are looking for an oral steroid oxandrolone 20 mg / daily /6 weeks would be a safer option. Anyway, steroid use should be monitorized by a doctor. I know in real life this happens rarely but quality of information about steroids in Internet is really low.

Thank you very much doctor.  What about post cycle therapy based on the oxandrolone 20mg/daily/6 weeks, I have clomid atm but I'm willing to buy other medications if there are obvious safer routes.

[Cornelius23]

… I use a SSRI 40mg in the morning

You might want to be more specific about the SSRI, as different SSRIs require different dosages.

[Morthand]

Thanks for the heads up. I updated the brand names (Seroxat and Optibar, same med different brands).

Quote from: Morthand on Today at 01:52:43 am

    … I use a SSRI 40mg in the morning

You might want to be more specific about the SSRI, as different SSRIs require different dosages.

[DoctorX]

Hello doctor!

My question concerns GBL/GHB and using prescription drugs. I use a (Seroxat or Optibar are the brand names.) SSRI 40mg in the morning and
Seroquel 300mg in the evening for mental illnesses. Very randomly I use klonazepam 2mg in the evening to relax. I know this is dodgy, using drugs while using depression/anxiety medication, but this is my situation.

The question is, if/when I make GHB from GBL and start using it, does it interfere with SSRI, Seroquel or random benzos? Or do I even make bigger risks with this combination and I shouldn't use it at all?

In any case I will use proper instructions on GHB and be very careful with the dosage. That is unless the combination is so risky I should just leave the stuff alone.

Thanks,
Morthand

GHB has depressant effects on Central Nervous System. Little increases in dosage can lead to dramatic effects and it is important to be very careful with dosage. Using other depressants on the same time can multiply sedative effects. This is particularly important in the case of benzos. Use of GHB with any benzo can be extremely dangerous. Quetiapine (Seroquel) has antihistaminic properties and may increase risk of deep sleep. So combination with this two drugs (and particularlly benzos) is dangerous.

[DoctorX]

How about steroid usage.  Any advice.   Given I would take about 1/4th of a 50mg D-Bol every 4-5 hours 3 times a day. (37.5mg)  Ontop of the average bidaily exercise.  I would do this for 3 weeks, then 1 week of clomid.  Starting with 50mg clomid, then 25mg a day for the remainder (6 days).  What would you advise I change (add or detract from) about this routine?  I've only learned these usages and doses from the remainder of the internet and I'm sure you could shed a little more light.  Is dbol even that effective as a standalone steroid?



Thank you,
Oc

Dianabol (methandrostenolone) is an old steroid. It was marketed during the fifties in USA and retired from market quickly. The original prescribing guidelines for Dianabol called for a daily dosage of 5 mg.This was to be administered on an intermittent basis, with the drug taken for no more than 6 consecutive weeks. Although a low dose of 5 mg daily may be effective for improving performance, athletes typically take much higher amounts. A daily dosage of three to six 5 mg tablets (15-30 mg) is most common. The problem with this dosages is that adverse effects are very common. In a study on 13 athletes using 10-25 mg of dianabol during 6 weeks, 8/13 suffered adverse effects and 3/13 didn´t finish the study because of adverse effects.
http://bjsm.bmj.com/content/9/2/78.long
Hepatotoxicity is a frequent problem. In my opinion Dianabol is not a good option. Considering health,in a risk reduction perspective and based in clinical trials, if you are looking for an oral steroid oxandrolone 20 mg / daily /6 weeks would be a safer option. Anyway, steroid use should be monitorized by a doctor. I know in real life this happens rarely but quality of information about steroids in Internet is really low.

Thank you very much doctor.  What about post cycle therapy based on the oxandrolone 20mg/daily/6 weeks, I have clomid atm but I'm willing to buy other medications if there are obvious safer routes.

There are many clinical studies on oxandrolone 20 mg/6-8 weeks and there is no need to use clomid or any other PCT. In terms of safety oxandrolone seems far much safer than dianabol.

[Morthand]

Hello doctor!

My question concerns GBL/GHB and using prescription drugs. I use a (Seroxat or Optibar are the brand names.) SSRI 40mg in the morning and
Seroquel 300mg in the evening for mental illnesses. Very randomly I use klonazepam 2mg in the evening to relax. I know this is dodgy, using drugs while using depression/anxiety medication, but this is my situation.

The question is, if/when I make GHB from GBL and start using it, does it interfere with SSRI, Seroquel or random benzos? Or do I even make bigger risks with this combination and I shouldn't use it at all?

In any case I will use proper instructions on GHB and be very careful with the dosage. That is unless the combination is so risky I should just leave the stuff alone.

Thanks,
Morthand

GHB has depressant effects on Central Nervous System. Little increases in dosage can lead to dramatic effects and it is important to be very careful with dosage. Using other depressants on the same time can multiply sedative effects. This is particularly important in the case of benzos. Use of GHB with any benzo can be extremely dangerous. Quetiapine (Seroquel) has antihistaminic properties and may increase risk of deep sleep. So combination with this two drugs (and particularlly benzos) is dangerous.

Thanks for the answer. I will definetly not take it with benzos. Is it possible to take GHB during the day and after 12 hours use the Seroquel though? Or does GHB affect so long that I cant take the Seroquel afterwards during 24h at all?

Regards,
Morthand

[DoctorX]

Duration of GHB effects are 4-5 hours. If you take Seroquel 12 hours after GHB there is no problem at that level

[staind]

Good morning DoctorX!

At first, I'd like to thank you for all the effort you have put into this project. I admire your commitment towards our community!

I have a general question regarding the combination of GHB and cocaine, my research has yielded quite contradictory results.
The common stance seems to be that any combination of a cns depressant and stimulant will put undue strain on the cardio-vascular system, but I also found information that would consider this combination health-beneficial.

Some characteristics of GHB found on Erowid:  low toxicity, relatively few contraindications, slowing of the heart rate without loss of blood pressure, muscle relaxation, absence of respiratory depression, reduction of body temperature, and various protective and anti-shock actions. -  These properties seem to antagonise some cocaine related health issues.

Here is another opinion on that particular combination:
"Coke is a very powerful systemic vasoconstrictor (reduces blood flow). GHB is a very power systemic vasodilator (increases blood flow). Apart from the obvious enhancement to both sexual function and sexual pleasure, it also protects the major organs (such as the heart and liver) from reduced blood flow in response to coke's vasoconstricting qualities. So it serves a health protective function additionally."

As an ordinary person, I have a hard time to assess the risks of this combination. One could even assume that the combination is safer as opposed to cocaine on it's own.

I would greatly appreciate your expertise in this matter.

[DoctorX]

Good morning DoctorX!

At first, I'd like to thank you for all the effort you have put into this project. I admire your commitment towards our community!

I have a general question regarding the combination of GHB and cocaine, my research has yielded quite contradictory results.
The common stance seems to be that any combination of a cns depressant and stimulant will put undue strain on the cardio-vascular system, but I also found information that would consider this combination health-beneficial.

Some characteristics of GHB found on Erowid:  low toxicity, relatively few contraindications, slowing of the heart rate without loss of blood pressure, muscle relaxation, absence of respiratory depression, reduction of body temperature, and various protective and anti-shock actions. -  These properties seem to antagonise some cocaine related health issues.

Here is another opinion on that particular combination:
"Coke is a very powerful systemic vasoconstrictor (reduces blood flow). GHB is a very power systemic vasodilator (increases blood flow). Apart from the obvious enhancement to both sexual function and sexual pleasure, it also protects the major organs (such as the heart and liver) from reduced blood flow in response to coke's vasoconstricting qualities. So it serves a health protective function additionally."

As an ordinary person, I have a hard time to assess the risks of this combination. One could even assume that the combination is safer as opposed to cocaine on it's own.

I would greatly appreciate your expertise in this matter.

It is very difficult to predict the effects and risk of a combination of drugs based in theoretical information about their characteristics. The fact that a drug is a "vasodilator" or "vasoconstrictor" in a very general and basic idea: pharmacological mechanisms, duration of effects, selective effect on arteries or veins, central vs. peripheral effects...should be considered. In the case of GHB+cocaine we can consider "theoretical-potential positive effects" but also "theoretical-potential risks". For example, both GHB and cocaine reduce the threshold for seizures, so it is possible that this combination could trigger a seizure.

Dosage and timing are also very important aspects to be considered. Little increments in GHB dosage produce dramatic changes in effects and cocaine is a short-acting drug, so effects and risks are very dependent on these factors. Combining moderate common recreational dosages of GHB and cocaine does not seem to be a high risk mixture. At least there are not many scientific case reports involving this combinaton . But I think there are not enough data to consider a "health protective function"

[staind]

Thank you very much DoctorX, your evaluation is of great value to me.

[Fckabich]

What is the best and least harmful way to come down from benzo depdence without rehab or detox? Say the person has been taking for about 2 weeks now, more than 4mg a day. Thank you for the info.

[DoctorX]

What is the best and least harmful way to come down from benzo depdence without rehab or detox? Say the person has been taking for about 2 weeks now, more than 4mg a day. Thank you for the info.

The best strategy is planning a gradual discontinuation schedule in 6-12 weeks. It is possible to reduce your  withdrawal symptoms by tapering the drug in small increments over a long period of time, letting your body adjust to each taper before tapering down again and not dropping off completely until you are down to a minimal dosage. Sometimes it is necessary a transition to other benzodiazepines that are eliminated more slowly from the body such as diazepam (Valium), clonazepam (Klonopin), or chlordiazepoxide (Librium). It is also important to know what is the benzo you have been using...there are very important differences and it is not the same 4 mg of tetrazepam than 4 mg of alprazolam...

[Fckabich]

What is the best and least harmful way to come down from benzo depdence without rehab or detox? Say the person has been taking for about 2 weeks now, more than 4mg a day. Thank you for the info.

The best strategy is planning a gradual discontinuation schedule in 6-12 weeks. It is possible to reduce your  withdrawal symptoms by tapering the drug in small increments over a long period of time, letting your body adjust to each taper before tapering down again and not dropping off completely until you are down to a minimal dosage. Sometimes it is necessary a transition to other benzodiazepines that are eliminated more slowly from the body such as diazepam (Valium), clonazepam (Klonopin), or chlordiazepoxide (Librium). It is also important to know what is the benzo you have been using...there are very important differences and it is not the same 4 mg of tetrazepam than 4 mg of alprazolam...

Thank you Doc, it was 4mg of alprazolam

[Foxy]

What in your opinion is the medical status of GHB use for recreation and for Human Growth Hormone increases/releases? (This could be anything from positive/negative/neutral)
Speaking directly about the powder variety which is dissolved into a liquid like juice or water.

[crabbs69]

Fantastic!... a virtual professional health adviser!... what can't be virtual this day in age?

Glad your here Doc a great service indeed.

[DoctorX]

What is the best and least harmful way to come down from benzo depdence without rehab or detox? Say the person has been taking for about 2 weeks now, more than 4mg a day. Thank you for the info.

The best strategy is planning a gradual discontinuation schedule in 6-12 weeks. It is possible to reduce your  withdrawal symptoms by tapering the drug in small increments over a long period of time, letting your body adjust to each taper before tapering down again and not dropping off completely until you are down to a minimal dosage. Sometimes it is necessary a transition to other benzodiazepines that are eliminated more slowly from the body such as diazepam (Valium), clonazepam (Klonopin), or chlordiazepoxide (Librium). It is also important to know what is the benzo you have been using...there are very important differences and it is not the same 4 mg of tetrazepam than 4 mg of alprazolam...

4 mg of alprazolam is equal to 60-80 mg of diazepam or 90-150 mg of chlordiazepoxide. That should be the total daily dosage to taper down

Thank you Doc, it was 4mg of alprazolam

[GreatLancet]

I took too many pills for like 10 years and stopped at the end of 2011. I feel like I have to urinate a lot more now and it frequently comes out very 'frothy' like a head of foam on a beer.

I knocked all that crap off but should I worry?

Nothing hurts, nothing else weird besides that...

[DoctorX]

What in your opinion is the medical status of GHB use for recreation and for Human Growth Hormone increases/releases? (This could be anything from positive/negative/neutral)
Speaking directly about the powder variety which is dissolved into a liquid like juice or water.

There is some evidence that GHB increases the release of GH (Growth Hormone).
http://www.sciencedirect.com/science/article/pii/S0306453097000553
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508244/
But these studies are done in experimental conditions, and only give a few doses of GHB. It is not clear if this effect is sustained in time or not, and what should be the dosage to achieve a noticeable physical effects. In fact long term administration studies have failed in demonstrate an effect related to this theoretical GH release, at least in some populations:
http://www.ncbi.nlm.nih.gov/pubmed/10530806
So the significance of this increase in GH release is unclear to the moment...

[DoctorX]

I took too many pills for like 10 years and stopped at the end of 2011. I feel like I have to urinate a lot more now and it frequently comes out very 'frothy' like a head of foam on a beer.

I knocked all that crap off but should I worry?

Nothing hurts, nothing else weird besides that...

It is not possible to give advice without knowing the exact "class of pills" you´ve been taking. Anyway, a simple urine test should help to find the diagnosis

[Cornelius23]

Hello, Doctor

A friend is interested in trying DMT after I recently introduced her boyfriend to it. There is a history of schizophrenia in her family while she herself has been diagnosed as being on the autistic spectrum. She is also currently diagnosed with depression and an anxiety disorder. Do you think DMT might be particularly hazardous for her and, if reasonably safe, are there any special precautions that should be taken?

[CAGIVA25001]

Hello Doctor,

I brought some MDMA a while ago and have since not took it again I am not sure if I OD or not but basically I was starting to come up which was aboustely amazing but then as soon as I got in the taxi on the way to the clubs i started excessive sweating where my light blue shirt was literally soaked and i was going hot and cold by the time I got to the club I just couldn't handle it my heart was beating very hard was struggle to get my breath so I decided to head back and have a cold shower but I was like this for around a hour and half where I thought I felt like I was literally going to Die.

I want to do MDMA again was this cause to OD ?

[TorXic]

how much MDMA did you took?

feel excessive hot or cold is normal cause on MDMA body temperature is altered.

[GreatLancet]

Hey again!

For someone who hasn't used Ecstasy in 8 years and has never taken pure MDMA, what would you suggest as a dosage? What if this person wants to mix it with an NBOMe? Is that stupid? How much of each?

Sounds iffy to me but thought I'd ask...

[ShogunMarcus]

Does anyone know where i can find a European pill identifier ? Can't find one anywhere...

[CAGIVA25001]

how much MDMA did you took?

feel excessive hot or cold is normal cause on MDMA body temperature is altered.

In my eyes it was very excessive my top was literally dark Bluee lol

[Apple7]

Hi Doctor,

So, I'm a occasional cocaine user and I've recently learned how bad Levamisole (the substance used to cut the coke) is for the human body. What I want to know is, how much Levamisole can the human body intake before any severe damage is done?

[jibjab]

DoctorX,

First, a big thank you for donating your time.

I noticed that you recommended oxandrolone over dianabol in what appears to be the only question that I've seen posed to you regarding anabolic steroids.

Do you have any opinions on oral primobolan?  In my own research, I've been led to believe that primobolan is an effective anabolic steroid; yet, it has little to no side-effects typically associated with steroid use.

I am interested in eating well and putting in the time working out - but after years of having done that, with less than stellar results, I would like something that would help me out to not be a monster; but get that Men's Health look.  However, not at the expense of some of the more horrific side effects that I have read about and heard of -- and I am also not excited about the idea of injection.

Last - I do have children and want to have more children, so my primary concern would be effects in that area. 

Thanks again for your willingness to help give out information in an area where the government has made it very difficult to obtain real information.

[DoctorX]

Hello, Doctor

A friend is interested in trying DMT after I recently introduced her boyfriend to it. There is a history of schizophrenia in her family while she herself has been diagnosed as being on the autistic spectrum. She is also currently diagnosed with depression and an anxiety disorder. Do you think DMT might be particularly hazardous for her and, if reasonably safe, are there any special precautions that should be taken?

Yes, in this case, the use of DMT or other psychedelics is formally contraindicated. Use of these substances is not recommended in persons with a diagnosis of mental health diseases and /or familiar history of schizophrenia. Risk of triggering an episode of mental disease is much higher than general population

[DoctorX]

Hello Doctor,

I brought some MDMA a while ago and have since not took it again I am not sure if I OD or not but basically I was starting to come up which was aboustely amazing but then as soon as I got in the taxi on the way to the clubs i started excessive sweating where my light blue shirt was literally soaked and i was going hot and cold by the time I got to the club I just couldn't handle it my heart was beating very hard was struggle to get my breath so I decided to head back and have a cold shower but I was like this for around a hour and half where I thought I felt like I was literally going to Die.

I want to do MDMA again was this cause to OD ?

I suppose you mean "out of date" with OD. But I do no think this is a logic explanation. MDMA keeps its properties during decades and it is very difficult to degrade. In any case it would lose some of its potency and not cause these symptoms. I can´t be sure about what has happened, but sounds to me as overdose. If you are to try it again, do with a lesser dosage ( 80 mg, for example)

[digitaldong]

DoctorX,

First, a big thank you for donating your time.

I noticed that you recommended oxandrolone over dianabol in what appears to be the only question that I've seen posed to you regarding anabolic steroids.

Do you have any opinions on oral primobolan?  In my own research, I've been led to believe that primobolan is an effective anabolic steroid; yet, it has little to no side-effects typically associated with steroid use.

I am interested in eating well and putting in the time working out - but after years of having done that, with less than stellar results, I would like something that would help me out to not be a monster; but get that Men's Health look.  However, not at the expense of some of the more horrific side effects that I have read about and heard of -- and I am also not excited about the idea of injection.

Last - I do have children and want to have more children, so my primary concern would be effects in that area. 

Thanks again for your willingness to help give out information in an area where the government has made it very difficult to obtain real information.

primobalan oral? its a waste of good steroid... its already  a weak steroid but good for keeping gains.. get some injectable primo and shoot in your leg... injectables are actually less toxic than the oral.. its when its methylated that it messes up the liver

[digitaldong]

and do some research.. oxandralone is the shittiest steroid on the market.. dbol kicks its ass in every aspect... but dont take my word for it
look it up..

[DoctorX]

Hey again!

For someone who hasn't used Ecstasy in 8 years and has never taken pure MDMA, what would you suggest as a dosage? What if this person wants to mix it with an NBOMe? Is that stupid? How much of each?

Sounds iffy to me but thought I'd ask...

Clinical trials with MDMA in humans use dosages between 80-150 mg. In healthy persons with no medical contraindications, that should be considered the reasonable dosage.
On the other hand, there are no clinical trials with NBOMEs in humans. In fact there are only a few studies on cloned neurorreceptors of rabbits and pigs (no joking). Using NBOMEs is potentially far more dangerous than MDMA or classical psychedelics. There is no "safe dosage", even less in combination

[DoctorX]

Does anyone know where i can find a European pill identifier ? Can't find one anywhere...

You can try here:
http://www.energycontrol.org   "Analisis sustancias" >>> "Resultados"
It is necessary to register to access the pdf files

[DoctorX]

Hi Doctor,

So, I'm a occasional cocaine user and I've recently learned how bad Levamisole (the substance used to cut the coke) is for the human body. What I want to know is, how much Levamisole can the human body intake before any severe damage is done?

In general, levamisole toxicity depends on dosage and it should be necessary daily use of several grams of cocaine to be in a significative risk. The problem is that, some persons are much more susceptible to these negative effects, based in genetic causes. 5-10% of users should be these "high risk" persons that would develop problems with lower dosages. But in general levamisole-cocaine problems appear more frequently in daily cocaine users.

[qwerty92]

Doc X

Do you think extensive use (but not abuse) of Mdma and other stimulant could cause a build up of cortisol . causing severve pain in my shoulders?

Im 21 years old and my body has the aches and pains of someone ten years older.


Thanks

[Cornelius23]

Yes, in this case, the use of DMT or other psychedelics is formally contraindicated. Use of these substances is not recommended in persons with a diagnosis of mental health diseases and /or familiar history of schizophrenia. Risk of triggering an episode of mental disease is much higher than general population

That's a pity but she's content to live without the experience.

Many thanks for your help. A donation is on it's way

I suppose you mean "out of date" with OD.…

'OD' in this context generally means 'overdose'

[GreatLancet]

Doc, youre the coolest! Can I bug you with one more thing? I'm having some sort of chest/throat problem the past few days, but also vomiting. I wrote it up on another thread, I'll just link it as I don't want to clutter yours too much...

I thought it was a bad reaction from being talked into insufflating powdered Adderall (yes, I realize that's a poor thing to do and won't be doing it again regardless) but at this point I'm really not sure...

This is actually starting to worry me, any pro info is WAY appreciated!

http://silkroad5v7dywlc.onion/index.php?topic=16417.0

[CAGIVA25001]

Hello Doctor,

I brought some MDMA a while ago and have since not took it again I am not sure if I OD or not but basically I was starting to come up which was aboustely amazing but then as soon as I got in the taxi on the way to the clubs i started excessive sweating where my light blue shirt was literally soaked and i was going hot and cold by the time I got to the club I just couldn't handle it my heart was beating very hard was struggle to get my breath so I decided to head back and have a cold shower but I was like this for around a hour and half where I thought I felt like I was literally going to Die.

I want to do MDMA again was this cause to OD ?

I suppose you mean "out of date" with OD. But I do no think this is a logic explanation. MDMA keeps its properties during decades and it is very difficult to degrade. In any case it would lose some of its potency and not cause these symptoms. I can´t be sure about what has happened, but sounds to me as overdose. If you are to try it again, do with a lesser dosage ( 80 mg, for example)

Hello Doctor,

Thank you very much I did mean Overdose

[jorgecassio]

Hello Doctor,

I have somewhat of a pressing issue regarding medication that I could use some advice on. I've been recently diagnosed with schizoaffective disorder, and take seroquel to manage the schizo-type symptoms and also klonopin, as it calms me down both mentally and physically, a great distraction from the delusions and grand conspiracy theories that keep me awake and extremely distressed when I should be resting. I feel though, that I'm becoming more and more reliant on klonopin just to function. If I go a few days without it, I'm quick to snap to anger at people's shortcomings and will find just about any excuse to pick a fight with someone, anytime, anywhere. I enjoy the power rush of getting riled up and putting my hands on someone with 0 remorse more than the klonopin itself,which scares me. I never been addicted to anything before but with the way I act lately, I feel like this stuff is starting to get the better of me and is turning me into a loose cannon.

What can I do in the meantime, to reduce my dependency on klonopin and still maintain a good sleep cycle & healthy anxiety-free mood? I would tell all this to my regular doc, but it would break my heart if he started treating me like a 2nd-class junkie patient, she's got quite a handful of them and I don't want to be lumped in that category,she's a good doctor so I pretend around her like everything's alright to stay in her good graces but I hate having to pretend when I really a reality check and solid advice on how not to screw myself up. I'm currently prescribed 0.5mg and am only suppose to take 1mg max a day, but I'll take anywhere from 2mg - 4mg a day, especially days where I have no choice but to deal with people face-to-face at work and keep my poker face on. I also supplement my script with, well duh, we're on SR soI won't go into that. The generic stuff here isn't as good as the real deal, but keeps me out of the doctor's office so I can maintain my facade of normalcy intact. What should I be doing at this point to avoid becoming dependent and everything nasty that comes with it? 

[DoctorX]

DoctorX,

First, a big thank you for donating your time.

I noticed that you recommended oxandrolone over dianabol in what appears to be the only question that I've seen posed to you regarding anabolic steroids.

Do you have any opinions on oral primobolan?  In my own research, I've been led to believe that primobolan is an effective anabolic steroid; yet, it has little to no side-effects typically associated with steroid use.

I am interested in eating well and putting in the time working out - but after years of having done that, with less than stellar results, I would like something that would help me out to not be a monster; but get that Men's Health look.  However, not at the expense of some of the more horrific side effects that I have read about and heard of -- and I am also not excited about the idea of injection.

Last - I do have children and want to have more children, so my primary concern would be effects in that area. 

Thanks again for your willingness to help give out information in an area where the government has made it very difficult to obtain real information.

Methenolone acetate is a non-c17-alpha alkylated oral steroid, one of only a few commercially available oral agents that presents limited liver toxicity to the user. There are enough clinical data about safety and efficacy, although most studies are old. This steroid has been used to promote weight gain in underweight premature infants and children in clinical studies, and was able to do so effectively and without signs of toxicity or undesirable effects.

Methenolone is not aromatized by the body and is not measurably estrogenic. Estrogen-linked side effects (gynecomastia, water retention, hypertension) should not be seen when administering this steroid.Androgenic effects (oily skin, acne, and body/facial hair growth, alopecia) are possible but uncommon.  Cardiovascular effects ( changes in cholesterol and lipids) are more common than other steroids like testosterone or nandrolone.

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Testosterone levels should return to normal within 1-4 months of drug secession. Primobolan® is generally described as having a low impact on endogenous testosterone production. But it depends on dosage too. Probably using low dosages (25-50 mg/daily, less than 8 weeks) effects on sexual function are limited and quickly reversible. Using higher dosages or combination will intensify effects on testicular atrophy and will cause a significant increase in recovery time.

[DoctorX]

Doc X

Do you think extensive use (but not abuse) of Mdma and other stimulant could cause a build up of cortisol . causing severve pain in my shoulders?

Im 21 years old and my body has the aches and pains of someone ten years older.


Thanks

I don´t know what can be the cause of your pain but is highly unlikely that this is produced by cortisol and MDMA. You should ask your doctor and get complete tests. Relation with MDMA/stimulants is not expected

[DoctorX]

Many thanks for your help. A donation is on it's way

Thank you very much! Highly appreciated!!!

[bigdaddyx]

I occasionally inject i.v. drugs (from sterile ampules from a trusted hospital source.)  Though I use a sterile syringe/needle each time and swab the area first..etc., every time I shoot I get a big needle bruise at the injection site.  Is there any way to prevent this/attenuate it or should I just find other ways to take my drugs?

I normally use either 30 or 31 gauge needles 8mm.

[DoctorX]

Doc, youre the coolest! Can I bug you with one more thing? I'm having some sort of chest/throat problem the past few days, but also vomiting. I wrote it up on another thread, I'll just link it as I don't want to clutter yours too much...

I thought it was a bad reaction from being talked into insufflating powdered Adderall (yes, I realize that's a poor thing to do and won't be doing it again regardless) but at this point I'm really not sure...

This is actually starting to worry me, any pro info is WAY appreciated!

https://silkroad5v7dywlc.onion.to/index.php?topic=16417.0

I think there are two possibilities: an adverse effect caused by the amphetamine or an adverse effect related to the excipients of the pill. In general, pharmaceutical drugs susceptible of abuse (amphetamines, opiates...) include some chemical compounds to make difficult the administration by different routes to oral.

[DoctorX]

Hello Doctor,

I have somewhat of a pressing issue regarding medication that I could use some advice on. I've been recently diagnosed with schizoaffective disorder, and take seroquel to manage the schizo-type symptoms and also klonopin, as it calms me down both mentally and physically, a great distraction from the delusions and grand conspiracy theories that keep me awake and extremely distressed when I should be resting. I feel though, that I'm becoming more and more reliant on klonopin just to function. If I go a few days without it, I'm quick to snap to anger at people's shortcomings and will find just about any excuse to pick a fight with someone, anytime, anywhere. I enjoy the power rush of getting riled up and putting my hands on someone with 0 remorse more than the klonopin itself,which scares me. I never been addicted to anything before but with the way I act lately, I feel like this stuff is starting to get the better of me and is turning me into a loose cannon.

What can I do in the meantime, to reduce my dependency on klonopin and still maintain a good sleep cycle & healthy anxiety-free mood? I would tell all this to my regular doc, but it would break my heart if he started treating me like a 2nd-class junkie patient, she's got quite a handful of them and I don't want to be lumped in that category,she's a good doctor so I pretend around her like everything's alright to stay in her good graces but I hate having to pretend when I really a reality check and solid advice on how not to screw myself up. I'm currently prescribed 0.5mg and am only suppose to take 1mg max a day, but I'll take anywhere from 2mg - 4mg a day, especially days where I have no choice but to deal with people face-to-face at work and keep my poker face on. I also supplement my script with, well duh, we're on SR soI won't go into that. The generic stuff here isn't as good as the real deal, but keeps me out of the doctor's office so I can maintain my facade of normalcy intact. What should I be doing at this point to avoid becoming dependent and everything nasty that comes with it?

Sometimes a forum in Internet is not the best option to help. I think your situation is one of them. I understand perfectly your fears, contradictions and worries. But I think you should discuss this with your doctor. The drugs you are taking are probably adequate to your condition and will help to make your live better. It is also true that clonazepam can be addictive (although the dosages you are taking are right and I don't think you should be obsessed with this). But, in your case, I think your personal doctor is the adequate person to give the best advice (and even a change of medication). You say "she's a good doctor", so you should discuss these things with her, including your fear "to be treated like a 2nd-class junkie patient".

[GreatLancet]

Doc, youre the coolest! Can I bug you with one more thing? I'm having some sort of chest/throat problem the past few days, but also vomiting. I wrote it up on another thread, I'll just link it as I don't want to clutter yours too much...

I thought it was a bad reaction from being talked into insufflating powdered Adderall (yes, I realize that's a poor thing to do and won't be doing it again regardless) but at this point I'm really not sure...

This is actually starting to worry me, any pro info is WAY appreciated!

https://silkroad5v7dywlc.onion.to/index.php?topic=16417.0

I think there are two possibilities: an adverse effect caused by the amphetamine or an adverse effect related to the excipients of the pill. In general, pharmaceutical drugs susceptible of abuse (amphetamines, opiates...) include some chemical compounds to make difficult the administration by different routes to oral.

Thanks, it's slowly going away. No more noon nausea and the chest tightness hasn't been so frequent or intense. Still a little every now and then but the albuterol nebulizer seems to help.

No more nose fun for me, dammit!

[TwistedNine]

Doc, youre the coolest! Can I bug you with one more thing? I'm having some sort of chest/throat problem the past few days, but also vomiting. I wrote it up on another thread, I'll just link it as I don't want to clutter yours too much...

I thought it was a bad reaction from being talked into insufflating powdered Adderall (yes, I realize that's a poor thing to do and won't be doing it again regardless) but at this point I'm really not sure...

This is actually starting to worry me, any pro info is WAY appreciated!

https://silkroad5v7dywlc.onion.to/index.php?topic=16417.0

I think there are two possibilities: an adverse effect caused by the amphetamine or an adverse effect related to the excipients of the pill. In general, pharmaceutical drugs susceptible of abuse (amphetamines, opiates...) include some chemical compounds to make difficult the administration by different routes to oral.

Thanks, it's slowly going away. No more noon nausea and the chest tightness hasn't been so frequent or intense. Still a little every now and then but the albuterol nebulizer seems to help.

No more nose fun for me, dammit!

im no doctor, but i can share my experience with snorting adderall.. in highschool i didnt realize or even think about the fillers in pharmaceutical pills. one day i got some adderall and decided to snort it. thing is, it was the tiny ball kind. the small little balls of amino acids that contain the amphetamine on the inside. like a fucking retard, i snorted a small "bump" (like 5 of those balls). and nothing happened. my nostril was clogged for a month after that, and my friend that knew more about drugs than me told me a couple days later that the sinus passages cant break down amino acids. and since the ball was made out of amino acids, i couldnt break it down to get to the amphetamine. it made me feel like i had a cold for a couple weeks.. i probably still have some of those balls in my sinuses to this day, unless i sneezed them out or something (lets hope). but im never doing that again..

[GreatLancet]

Uggh, I saw a guy do that on New Years.

At least I crushed em up real finely!

[TwistedNine]

Uggh, I saw a guy do that on New Years.

At least I crushed em up real finely!

lol, his mistake.. you live and you learn though

[GreatLancet]

The thing is, he KNEW it too! He came in drunk and wouldn't even give me a second to crush it up! Just SHOOSH, up the nose! It hurt just to watch.

[becks2013]

Hello Doctor X

A friend of mine is diagnosed with schizophrenia probably triggered by marijuana abuse.  (13-15 years ago)
He then stopped abusing substances for a while. He recovered, which by that i mean his social life got better, he could control voices he heard on his head, not being paranoid, etc. Few years ago he started using mj again and some mdma now and then. He did not show any signs of schizophrenia and his social life remained as is.

Now that he found his way into sr he want to try other substances too. He ordered 25(i,c or both, i am not sure) nbome, LSD and some opiates. Searching the web did not reveal anything about nbomes and schizophrenia but i found lots of reports that LSD triggered schizophrenia on some people.

Do you think a single trip on lsd or any other psychedelic could bring back effects of the schizophrenia? Do you think psychedelics should be avoided at all costs? What would be your advice on such situation?

Many many thanks in advance doc.
Your work is brilliant and you deserve all the good of the world.

[qwerty92]

Doc X

Do you think extensive use (but not abuse) of Mdma and other stimulant could cause a build up of cortisol . causing severve pain in my shoulders?

Im 21 years old and my body has the aches and pains of someone ten years older.


Thanks

I don´t know what can be the cause of your pain but is highly unlikely that this is produced by cortisol and MDMA. You should ask your doctor and get complete tests. Relation with MDMA/stimulants is not expected

Thanks doc x

[mr420mn420]

Doc, is mixing benzo's with Quaaluudes dangerous?

[mr420mn420]

Also I am on methadone maintenance 110mg/day for two years now, is there anything I can take to break through the methadone block so I can feel the pain meds

[cleansober]

DoctorX,

Any legal drug purchased at the local pharmacy has an insert about potential dangers and correct use.  Even over-the-counter remedies have correct usage labels on them. Take 2 before bed, take after eating, or call a doctor after two weeks if symptoms don't disappear, etc.

Given the increase in recreational cannabis usage, more users are making guesses about what the correct dosages and timing might be.  If you where asked to write a warning label for recreational cannabis products, what would it say? Or, can you recommend a document or site that you think provides reasonable and reliable directions on the safe use of recreational weed?  Erowid still has info from 1995 up on its site.  Illegal drugs are the ones without the guidance of MSDS and dealers seldom put warning labels on their products.


The following is editorializing and unrelated to my question regarding warnings above:

Hello Doctor X

A friend of mine is diagnosed with schizophrenia probably triggered by marijuana abuse.  (13-15 years ago)

Are you suggesting that cannabis use 13-15 years ago can be the cause of present day mental problems? This would explain why I want to kill five or six people.




Like masturbation, just because it feels good, doesn't mean it's the best idea to do cannabis two or three or four times a day, although I have tried both practices on exactly such schedules, at various times in my young 82 years of age. The passage of time cured the first habit while the later is still in play at times. Yesterday Obama finally talked about his weed use and he calls it a "vice" but no worse than alcohol. Why is it there is general agreement that using alcohol to excess on a daily basis is bad, but some people say using weed as a daily hobby is good? Is one beer at dinner time really the same thing as getting high on weed once per day?


Regards all,

CleanSober

[DoctorX]

I occasionally inject i.v. drugs (from sterile ampules from a trusted hospital source.)  Though I use a sterile syringe/needle each time and swab the area first..etc., every time I shoot I get a big needle bruise at the injection site.  Is there any way to prevent this/attenuate it or should I just find other ways to take my drugs?

I normally use either 30 or 31 gauge needles 8mm.

I recommend you this manual ,  I hope you can find some information useful for you:
http://harmreduction.org/wp-content/uploads/2011/12/getting-off-right.pdf

[DoctorX]

Hello Doctor X

A friend of mine is diagnosed with schizophrenia probably triggered by marijuana abuse.  (13-15 years ago)
He then stopped abusing substances for a while. He recovered, which by that i mean his social life got better, he could control voices he heard on his head, not being paranoid, etc. Few years ago he started using mj again and some mdma now and then. He did not show any signs of schizophrenia and his social life remained as is.

Now that he found his way into sr he want to try other substances too. He ordered 25(i,c or both, i am not sure) nbome, LSD and some opiates. Searching the web did not reveal anything about nbomes and schizophrenia but i found lots of reports that LSD triggered schizophrenia on some people.

Do you think a single trip on lsd or any other psychedelic could bring back effects of the schizophrenia? Do you think psychedelics should be avoided at all costs? What would be your advice on such situation?

Many many thanks in advance doc.
Your work is brilliant and you deserve all the good of the world.

Mental health problems as schizophrenia can be triggered by psychedelics. For most people use of psychedelics does not have consequences like this but for a minority, susceptible persons this is possible. People who have suffered a psychotic episode related with drugs are more sensitive to have new episodes if they continue or restart using them. This does not mean that this will an irremediable consequence, but there are more probabilities compared with other persons.
Cannnabis and psychedelics are drugs related with this kind of problems and are formally contraindicated in persons who have suffered a psychotic episode. There are no data about NBOMe because they have very little experience on humans, but according to mechanism of action and effects, the same risk is highly probable.
Opiates do not trigger psychotic episodes. In fact many opiates have antipsychotic properties. Unfortunatelly, opiates have their own problems and risks (overdose, dependence,adverse effects, etc...)

[bigdaddyx]

I occasionally inject i.v. drugs (from sterile ampules from a trusted hospital source.)  Though I use a sterile syringe/needle each time and swab the area first..etc., every time I shoot I get a big needle bruise at the injection site.  Is there any way to prevent this/attenuate it or should I just find other ways to take my drugs?

I normally use either 30 or 31 gauge needles 8mm.

I recommend you this manual ,  I hope you can find some information useful for you:
http://harmreduction.org/wp-content/uploads/2011/12/getting-off-right.pdf

Thank you very much, I appreciate it!

[becks2013]

Mental health problems as schizophrenia can be triggered by psychedelics. For most people use of psychedelics does not have consequences like this but for a minority, susceptible persons this is possible. People who have suffered a psychotic episode related with drugs are more sensitive to have new episodes if they continue or restart using them. This does not mean that this will an irremediable consequence, but there are more probabilities compared with other persons.
Cannnabis and psychedelics are drugs related with this kind of problems and are formally contraindicated in persons who have suffered a psychotic episode. There are no data about NBOMe because they have very little experience on humans, but according to mechanism of action and effects, the same risk is highly probable.
Opiates do not trigger psychotic episodes. In fact many opiates have antipsychotic properties. Unfortunatelly, opiates have their own problems and risks (overdose, dependence,adverse effects, etc...)

Thank you for taking the time to answer my question doctor. Your service here is priceless.

[jokerman2002]

Hello DoctorX thanks for helping us with your assistance:

First off I am 27 year old male 6"1 215lbs healthy. I have been using drugs pretty common recreationaly since I was about 15 years old. I mainly smoke marijuana on a daily basis as I was diagnosed with ADHD and Bipolar given drugs like depakote,  neurontin, adderall, it felt horrible. Then I found Cannabis, my main love. It helped me graduate High School and get a degree in Oganic Chemistry with a minor of Pharmacology from a prestigious University. However with this use also came other drug use. First it started with pills (benzos & opiates) and then cocaine, MDMA, Shrooms,  LSD, 2c-x, nbomes, the list goes on and on. It scares me sometimes. However I have tried every preventitive meassure to reverse any negative effects of the drug use and this has been since even when I was young and doing drugs. I always wanted to know exactly what I was taking, how much I was taking and what it would counteract with. I would make sure and take vitamin suppliments after the use of drugs and eat healthy foods. I have also been taking Noopept (nootropic) in 3 months stack and then 1 month off for the last 3 years. I noticed it has helped my memory and brain function a bit, and made my senses a lot more defined. I never have had any reprucutions of drug use other than the occasional time when they run out. Do you agree that preventable measures and controlled drug abuse (never physically addicted to a drug) can be fully negated of most negative effects from the drugs ingested during a life period?

[DoctorX]

Doc, is mixing benzo's with Quaaluudes dangerous?

Methaqualone is a drug sedative–hypnotic activity. This can be enhanced by the use of benzos. The risk of excessive sedation, respiratory depression or coma is higher mixing these methaqualone and benzos, obviously depending on dosage and potency

[DoctorX]

Also I am on methadone maintenance 110mg/day for two years now, is there anything I can take to break through the methadone block so I can feel the pain meds

I don't think this pharmacologically possible

[Pillow]

sub

[DoctorX]

Yes, I think Erowid is still the best reliable page with information about drugs in all the Web:
http://www.erowid.org/plants/cannabis/

DoctorX,

Any legal drug purchased at the local pharmacy has an insert about potential dangers and correct use.  Even over-the-counter remedies have correct usage labels on them. Take 2 before bed, take after eating, or call a doctor after two weeks if symptoms don't disappear, etc.

Given the increase in recreational cannabis usage, more users are making guesses about what the correct dosages and timing might be.  If you where asked to write a warning label for recreational cannabis products, what would it say? Or, can you recommend a document or site that you think provides reasonable and reliable directions on the safe use of recreational weed?  Erowid still has info from 1995 up on its site.  Illegal drugs are the ones without the guidance of MSDS and dealers seldom put warning labels on their products.


The following is editorializing and unrelated to my question regarding warnings above:

Hello Doctor X

A friend of mine is diagnosed with schizophrenia probably triggered by marijuana abuse.  (13-15 years ago)

Are you suggesting that cannabis use 13-15 years ago can be the cause of present day mental problems? This would explain why I want to kill five or six people.




Like masturbation, just because it feels good, doesn't mean it's the best idea to do cannabis two or three or four times a day, although I have tried both practices on exactly such schedules, at various times in my young 82 years of age. The passage of time cured the first habit while the later is still in play at times. Yesterday Obama finally talked about his weed use and he calls it a "vice" but no worse than alcohol. Why is it there is general agreement that using alcohol to excess on a daily basis is bad, but some people say using weed as a daily hobby is good? Is one beer at dinner time really the same thing as getting high on weed once per day?


Regards all,

CleanSober

[Warnerve]

Hey Doc,

I've been following your thread since it was small on the old SR forum. I seem to remember at one point you posting this website where you could copy the url of a PubMed article and end up getting the full text of the article for free. I looked all over this thread and can't seem to find it. Must be in the old forum... Anyways, if you could give me the name of such a website again I'd sure appreciate it.

Sorry this isn't a drug safety related question, but if you could hook me up I'd be happy to send you some coin. Thanks.

[cleansober]

http://www.sci-hub.org/ but is says it's closed and this is the archived site: http://libgen.org/scimag/

[Warnerve]

Aw shucks. Thank you based cleansober.

[JustMe]

Hi Dr,

Big UPS for all of your responses! I have removed my last message as I believe it wasn't exactly harm reduction.

Cheers

JM

[DoctorX]

Hello DoctorX thanks for helping us with your assistance:

First off I am 27 year old male 6"1 215lbs healthy. I have been using drugs pretty common recreationaly since I was about 15 years old. I mainly smoke marijuana on a daily basis as I was diagnosed with ADHD and Bipolar given drugs like depakote,  neurontin, adderall, it felt horrible. Then I found Cannabis, my main love. It helped me graduate High School and get a degree in Oganic Chemistry with a minor of Pharmacology from a prestigious University. However with this use also came other drug use. First it started with pills (benzos & opiates) and then cocaine, MDMA, Shrooms,  LSD, 2c-x, nbomes, the list goes on and on. It scares me sometimes. However I have tried every preventitive meassure to reverse any negative effects of the drug use and this has been since even when I was young and doing drugs. I always wanted to know exactly what I was taking, how much I was taking and what it would counteract with. I would make sure and take vitamin suppliments after the use of drugs and eat healthy foods. I have also been taking Noopept (nootropic) in 3 months stack and then 1 month off for the last 3 years. I noticed it has helped my memory and brain function a bit, and made my senses a lot more defined. I never have had any reprucutions of drug use other than the occasional time when they run out. Do you agree that preventable measures and controlled drug abuse (never physically addicted to a drug) can be fully negated of most negative effects from the drugs ingested during a life period?

I think it is a very delicate question. Using drugs means facing some risks. These risks depend not only in the substance, but also in the personal characteristics of oneself, context and other factors. Risk reduction measures are useful to reduce risks, but they not eliminate them completely. It is always better to use risk reduction measures, but this does not mean that you are a 100% safe.

[DoctorX]

Yes. it was sci-hub.org...although now is closed. Thx cleansober

Hey Doc,

I've been following your thread since it was small on the old SR forum. I seem to remember at one point you posting this website where you could copy the url of a PubMed article and end up getting the full text of the article for free. I looked all over this thread and can't seem to find it. Must be in the old forum... Anyways, if you could give me the name of such a website again I'd sure appreciate it.

Sorry this isn't a drug safety related question, but if you could hook me up I'd be happy to send you some coin. Thanks.

[giancarlo]

subbed

[alepx]

Ok op, what could happen if someone consums dayli over 4 years gamma butyrolacton ? for sure dissolved with enough water. any inquiries you will have ?

[DoctorX]

GHB and precursors (GBL, BDO) are pharmacologically safe and have not shown significant toxicity to any human organ or system. The main problem of daily use is the risk of physical dependence. With regular use, it is posible to develop tolerance and severe withdrawal symptoms with abstinence. Risk of dependence to GHB is important in daily use.
http://www.ncbi.nlm.nih.gov/pubmed/24001290
http://www.ncbi.nlm.nih.gov/pubmed/21040601
http://www.ncbi.nlm.nih.gov/pubmed/24380737

[creditemaildust]

sub

[june7godfly]

Many thanks for your contributions here dear sir.

Quick question for you - Erowid.org classifies 5-meo-mipt as a research chemical with little history of human use.

Having looked around in this forum I couldn't uncover much about it either.

What is known about the toxicity of the drug and what would you advise about using it please?

Thank you.

[cleansober]

X,

Steroids help increase muscle growth, from what little I know about them. Does any steroid, or other potion such as hydrolyzed collagen, help increase range of motion in normally functioning joints? For example, if a young (62 yo) yoga student desperately wants to move up to the advanced yoga class, but is unable to manage the advanced positions, would, might, or could, a course of steroid (?) help increase muscle and ligament  range of motion when used in combination with active daily stretching? It is my understanding that once elongated, ligaments stay longer, so this would be a permanent change?

Cs

Footnote: Link to discussion about marijuana users being skinnier than non-users.

http://www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/

Full study published July 2013, The American Journal of Medicine:

http://www.amjmed.com/article/S0002-9343%2813%2900200-3/abstract

[DoctorX]

Many thanks for your contributions here dear sir.

Quick question for you - Erowid.org classifies 5-meo-mipt as a research chemical with little history of human use.

Having looked around in this forum I couldn't uncover much about it either.

What is known about the toxicity of the drug and what would you advise about using it please?

Thank you.

There is very little information about 5-MeO-MIPT. It is an analogue of the more popular drug 5-MeO-DiPT. Some users report activity as low as 1 mg while others report no activity up to 20 mg, this compound seems to be highly sensitive to the individual. Activity seems mediated by serotoninergic agonism (5HT2A), as other classical psychedelics, but probably involves other mechanisms also.

5-MeO-MIPT should be considered as a "research chemical" and general precautions about careful dosing with a scale, not mixing with other substances, etc...should be considered. Anyway, considering history of use and chemical structure similar to classical tryptamines, it is probably safer than other RCs as bromo-dragonfly or NBOMEs

[june7godfly]

careful dosing with a scale

Of course, it's not fun 'eye-balling' doses in the mg range!

Thanks for the information Doc.

[AlbertHoffman]

I just wanted to say thank you Doctor X for your continued efforts and ask one simple question. What do you know about ibogaine being used to "cure" addiction? I read somewhere that ibogaine use can lead to heart failure so I was turned off by this, but a cure for addiction is something I am definitely interested in. I have been addict as early as 12 years of age and Im in my 30s now. Thanks in advance for your time and efforts.

[Nertrix]

I really respect what you are doing here, i have been a member of a forum which main purpose is harm reduction for many years and when i saw your topic it warmed my heart.

Do you know if there is any harmful effects if you have taken amphetamine(~100 mg) and 1 hour after last dose(line) about 1 mg of remeron (mirtazapine) ?

I just want to avoid serotonin syndrome. And i know serotonin antagonists and SSRI's can be dangerous, Remeron is a NaSSA however.
The amphetamine was weighed out before administering it and there was certainly no more than 100 mg. I suffer from clinical depression and i know amphetamine is one of the worst drugs to take if my serotonin levels are allready low. I have really paid for this the last days.

[hellwind]

Hi DoctorX, thank you for your amazing work here.

I had stomach issues lately and after a CT Scan, doctor confirmed I have a Diverticulitis.
Now I'm taking antibiotics (Amoxicillin) and painkillers and waiting to get better.

My question is, taking drugs like amphetamines or mdma (not during antibiotics treatment) is still safe for me?
I'm not talking of daily (ab)use, but 2-3 times in a month.

Thanks for your time!

[DoctorX]

X,

Steroids help increase muscle growth, from what little I know about them. Does any steroid, or other potion such as hydrolyzed collagen, help increase range of motion in normally functioning joints? For example, if a young (62 yo) yoga student desperately wants to move up to the advanced yoga class, but is unable to manage the advanced positions, would, might, or could, a course of steroid (?) help increase muscle and ligament  range of motion when used in combination with active daily stretching? It is my understanding that once elongated, ligaments stay longer, so this would be a permanent change?

Cs

Footnote: Link to discussion about marijuana users being skinnier than non-users.

http://www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/

Full study published July 2013, The American Journal of Medicine:

http://www.amjmed.com/article/S0002-9343%2813%2900200-3/abstract

Steroids are useful to increase muscle growth and/or definition. I don't know about any medication or drug useful to improve flexibility

[DoctorX]

I just wanted to say thank you Doctor X for your continued efforts and ask one simple question. What do you know about ibogaine being used to "cure" addiction? I read somewhere that ibogaine use can lead to heart failure so I was turned off by this, but a cure for addiction is something I am definitely interested in. I have been addict as early as 12 years of age and Im in my 30s now. Thanks in advance for your time and efforts.

There is some evidence (both from animal data and humans) that ibogaine can be useful in reducing withdrawal symptoms and reducing craving. Because of ibogaine´s status as a Schedule I substance, the development of its use in the treatment of drug addiction has taken place outside conventional clinical and medical settings. I have reports of people whose life has changed after ibogaine. I also know people in which it has had no effects.
In my opinion, addiction problems are complex and it is difficult to solve them completely with the use of a psychedelic.It can work for some people but I don't believe it can be considered as a magic bullet, effective for everyone.
 There are also reports of adverse and toxic effects, even deaths (well...this happens with conventional medication sometimes, too...). People with cardiological medical background should be specially aware about this

[AlbertHoffman]

Thank you for your time and efforts here.

[mito]

What exactly is substance tolerance?
How does it work?

Does the brain shutdown some receptors?


For example, why does the same dose today have a weaker effect if taken tomorrow?

[DoctorX]

I really respect what you are doing here, i have been a member of a forum which main purpose is harm reduction for many years and when i saw your topic it warmed my heart.

Do you know if there is any harmful effects if you have taken amphetamine(~100 mg) and 1 hour after last dose(line) about 1 mg of remeron (mirtazapine) ?

I just want to avoid serotonin syndrome. And i know serotonin antagonists and SSRI's can be dangerous, Remeron is a NaSSA however.
The amphetamine was weighed out before administering it and there was certainly no more than 100 mg. I suffer from clinical depression and i know amphetamine is one of the worst drugs to take if my serotonin levels are allready low. I have really paid for this the last days.

I have not found clinical reports of serotonin syndrome associated to amphetamine and mirtazapine combination. Probably, the risk of serotonin syndrome is more theoretical than real. There is one clinical trial searching about this interaction but the study was withdrawn prior to enrollment patients
http://clinicaltrials.gov/show/NCT00600145
So, you pointed in your message the main reason for avoiding this combination. If you are suffering from clinical depression amphetamine is no good for you, regardless of mirtazapine use or risk of (unlikely) serotonin syndrome. On the other hand, typical dosage of oral pure amphetamine as therapeutic drug is up to 60 mg, so 100 mg seems a dosage that can be harmful on its own.

[DoctorX]

Hi DoctorX, thank you for your amazing work here.

I had stomach issues lately and after a CT Scan, doctor confirmed I have a Diverticulitis.
Now I'm taking antibiotics (Amoxicillin) and painkillers and waiting to get better.

My question is, taking drugs like amphetamines or mdma (not during antibiotics treatment) is still safe for me?
I'm not talking of daily (ab)use, but 2-3 times in a month.

Thanks for your time!

If medical treatment works correctly,you are free from symptoms and you can have a normal life, it is unlikely that common recreational dosages of MDMA or amphetamines will have a negative impact in your disease. Theoretically, it is possible some effects of MDMA in immune system that could prejudice or reactivate a latent infection, but I think in real world this risk is unlikely. Anyway, it should be important to wait until complete recovery and having a normal life before trying drugs.

[Prevan]

Hello,
I was recently diagnosed as being bipolar.
My psychiatrist put me on Oxycarbazepine / Trileptal.
My question is: How does Oxycarbazepine affect LSD, MDMA, psilocybin? and does it make it unsafe for me to use them?

[hellwind]

Thanks Doctor! Sent you a little reward Keep up the good work.

[justonefix]

Hey doc I got a question for you.,
How safe is it to IV suboxone??
I am doing for about one year and a half very small doses, 2mg per day.
I heard that its pretty bad for your health , but it keeps me off heroin and satisfies my "needlemania"
Any info???
thnx

[Ghost]

Hey Doctor,

Ive used ambien and or xanax to help me sleep for a long time, but Im wanting to stop getting it off the road and actually get prescribed from a real doctor. I know it sends red flags to a doctor when you specify what I want, but I know what works well with me, how can I approach this?

[DoctorX]

What exactly is substance tolerance?
How does it work?

Does the brain shutdown some receptors?


For example, why does the same dose today have a weaker effect if taken tomorrow?

Drug tolerance is a commonly encountered effect in pharmacology, it is a progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration., requiring an increase in concentration to achieve the desired effect.
 Tolerance is reversible, and its rate depends on the characteristics of each particular drug. Some drugs create tolerance more quickly than other. LSD develops tolerance to psychoactive effects very quickly (1-2 days), and cocaine or opiates in a week. There is also different rates of tolerance development for different effects of the same drug. For example, tolerance to anxiolytic effect of benzodiacepines develops in a few days but tolerance to anticonvulsivant effects develops in months.

The pharmacological mechanisms involved are complex. Sometimes depends on the ability of the organism to better metabolize and degrade the substance and other there is a decreased sensitivity of cerebral receptors.

[DoctorX]

Hello,
I was recently diagnosed as being bipolar.
My psychiatrist put me on Oxycarbazepine / Trileptal.
My question is: How does Oxycarbazepine affect LSD, MDMA, psilocybin? and does it make it unsafe for me to use them?

There are not known interactions between oxycarbazepine and common recreational psychedelics. In your case, using LSD, MDMA or psilocybin can be more harmful than other people. This is not related to the pharmacological combination but you may have an increased sensitivity to adverse effects because of your diagnosis.

[DoctorX]

Thanks Doctor! Sent you a little reward Keep up the good work.

Thanks...highly appreciated!

[DoctorX]

Hey doc I got a question for you.,
How safe is it to IV suboxone??
I am doing for about one year and a half very small doses, 2mg per day.
I heard that its pretty bad for your health , but it keeps me off heroin and satisfies my "needlemania"
Any info???
thnx

There is little experience about effects of intravenous buprenorphine, although there are some data:
http://www.ncbi.nlm.nih.gov/pubmed/15349002
But subuxone contains naloxone in addition to buprenorphine, so pharmacological effects of buprenorphine should be counteracted or eliminated. It is possible that this can satisfy your "needlemania" but, in a strictly pharmacological point of view the effects should be unnoticeable or very little.
I think this guideline can be useful to you:
http://harmreduction.org/wp-content/uploads/2011/12/getting-off-right.pdf

[DoctorX]

Hey Doctor,

Ive used ambien and or xanax to help me sleep for a long time, but Im wanting to stop getting it off the road and actually get prescribed from a real doctor. I know it sends red flags to a doctor when you specify what I want, but I know what works well with me, how can I approach this?

Hi...I´m sorry but I don´t see how could I help you...I think you should speak clearly to your doctor...

[justonefix]

Hey doc I got a question for you.,
How safe is it to IV suboxone??
I am doing for about one year and a half very small doses, 2mg per day.
I heard that its pretty bad for your health , but it keeps me off heroin and satisfies my "needlemania"
Any info???
thnx

There is little experience about effects of intravenous buprenorphine, although there are some data:
http://www.ncbi.nlm.nih.gov/pubmed/15349002
But subuxone contains naloxone in addition to buprenorphine, so pharmacological effects of buprenorphine should be counteracted or eliminated. It is possible that this can satisfy your "needlemania" but, in a strictly pharmacological point of view the effects should be unnoticeable or very little.
I think this guideline can be useful to you:
http://harmreduction.org/wp-content/uploads/2011/12/getting-off-right.pdf

Yeah I know that naloxone supposed to counteract the effects, but it doesnt.
I dont know why but naloxone doesnt work on me.
Thanks for your time.

[haydenp]

Is it  myth that MDMA can help people suffering from PTSD? And if not, what other illegal drugs can help people with PTSD symptoms?
the subject i am asking about is kinda reluctant to ask their doctor about using illegal narcotics, but noting thry are prescribing is helping at all. In fact, they are making it worse. She currently self medicates with xanax, but is looking for a less addictive alternative, such as psylocybin mushrooms (once a month) or maybe MDMA once or twice a month. Do you have any other recommendations?
thx

[flaxceed]

Would you consider a thread over on Hub, doctor?  That would allow you to hit many different darknet drug market buyers and sellers on one forum.  It is growing very rapidly.

[mojorising]

Hi Doc,

Thank you very much for coming on to the forums and offering your time. I was hoping to utilize your services and ask a couple questions that have been on my mind for awhile now.

Comparatively, how bad would you say psychedelic phenethylamines are compared to MDMA? I've been reading a lot about phenethylamines lately and how they can boost the body's metabolism, induce the feeling of love, and possibly improve cognitive function and mood. On a personal level, I can say that after consuming a variety of different 2C-x compounds at lower doses, I've never had adverse after-effects, which I cannot say for MDMA. 2C-I, 2C-E, and other 2C-x compounds seem to utilize a more of a pay-it-forward approach, where you feel like shit on the come-up (not unlike mescaline), but then just feel amazing through the trip and without any sort of ill-effects in the come-down. Can psychedelic phenethylamines potentially cause damage akin to what MDMA does to Nigral cells? Could you start burning holes in to your brain if you took psychedelic phenethylamines a few too many times, or are they fairly safe when compared to MDMA?

[Foxy]

Good doctor I've been having chest pain for a few days now (left side/pectoral and in the back too, under my shoulder blade) I've perhaps pulled something while working but I also noticed it the most when coming down from cocaine use. I also heard that GHB withdrawal causes chest pains and muscle tightness I've tried a few things to fix it including benzos but alas it continues to bother me heavily. What is your advice I would rather avoid seeing my doctor unless needed but if it continues to bother me I wil have no choice...

[Nertrix]

Thank you for the help Doctor 

[DoctorX]

I will be out of office until February 20th. Will go back then

[knuckles]

Is it good to stay off of psychdelics if one is going under anesthesia for a surgery?

[DoctorX]

There are some studies that suggest MDMA can be a useful tool in treatment of PTSD. In general, MDMA is administered in a therapeutic context, in one or two sessions, and into a programmed protocol. I think MDMA is more adequate for this use than any other psychedelic, but this use implies a therapeutic context. It is not a question of only taking the drug, but doing it as a part of a psychotherapeutic plan.
Extensive information here:
http://www.maps.org/research/mdma/

Is it  myth that MDMA can help people suffering from PTSD? And if not, what other illegal drugs can help people with PTSD symptoms?
the subject i am asking about is kinda reluctant to ask their doctor about using illegal narcotics, but noting thry are prescribing is helping at all. In fact, they are making it worse. She currently self medicates with xanax, but is looking for a less addictive alternative, such as psylocybin mushrooms (once a month) or maybe MDMA once or twice a month. Do you have any other recommendations?
thx

[DoctorX]

Would you consider a thread over on Hub, doctor?  That would allow you to hit many different darknet drug market buyers and sellers on one forum.  It is growing very rapidly.

Yes, great idea...but my time is very limited and there is too much work here. Opening a thread in The Hub would imply closing this...But I don´t know...I will think about it, thank you

[DoctorX]

Hi Doc,

Thank you very much for coming on to the forums and offering your time. I was hoping to utilize your services and ask a couple questions that have been on my mind for awhile now.

Comparatively, how bad would you say psychedelic phenethylamines are compared to MDMA? I've been reading a lot about phenethylamines lately and how they can boost the body's metabolism, induce the feeling of love, and possibly improve cognitive function and mood. On a personal level, I can say that after consuming a variety of different 2C-x compounds at lower doses, I've never had adverse after-effects, which I cannot say for MDMA. 2C-I, 2C-E, and other 2C-x compounds seem to utilize a more of a pay-it-forward approach, where you feel like shit on the come-up (not unlike mescaline), but then just feel amazing through the trip and without any sort of ill-effects in the come-down. Can psychedelic phenethylamines potentially cause damage akin to what MDMA does to Nigral cells? Could you start burning holes in to your brain if you took psychedelic phenethylamines a few too many times, or are they fairly safe when compared to MDMA?

There is no evidence that occasional, moderate use of MDMA can cause permanent neurologic damage. Studies that show neurotoxic effects for MDMA are based in animal models or extremely intensive human users. So, in this sense, MDMA is a more studied molecule than 2C-X, in which there is a lack of human investigation.
Some 2C-X (-B, -I, -E) have been used during decades without knowledge of significant negative effects and are probably safe. Other are newer and potentially dangerous (2C-Bfly) or contain atoms rarely seen in human pharmacology (2C-C. 2C-F, 2C-SE).
Anyway, it is true that after-effects or "comedown" related to MDMA is harder than 2C-X for most people. But it does not necessarily mean that reasonable use of MDMA leads to neurotoxicity

[DoctorX]

Good doctor I've been having chest pain for a few days now (left side/pectoral and in the back too, under my shoulder blade) I've perhaps pulled something while working but I also noticed it the most when coming down from cocaine use. I also heard that GHB withdrawal causes chest pains and muscle tightness I've tried a few things to fix it including benzos but alas it continues to bother me heavily. What is your advice I would rather avoid seeing my doctor unless needed but if it continues to bother me I wil have no choice...

I'm sorry if I am answering your question too late, as I have been out of office. If your chest pain is related to cocaine it should be important to rule out cardiological problems. It is necessary to see your doctor.

[DoctorX]

Is it good to stay off of psychdelics if one is going under anesthesia for a surgery?

Interactions between classical psychedelics and anaesthetic medications is unlikely. Anyway,as a general rule, it is recommendable to stay off of any psychoactive drug (and any other non-necessary drug or treatment) a few days (2-3) before undergoing anaesthesia

[GreatLancet]

Hi Doc!

I posted on here around the beginning of the year about a bad time I had with some pure amphetamine and unknowingly potentiating it with baking soda, which I take regularly for heartburn.

I'm not having breathing issues anymore, but I've noticed my pulse is remaining consistantly high during the day. According to my cheap BP meter, it's around 100-120bpm. My blood pressure is pretty much normal, avg. 135 over 85. I've stopped using all amphetamines and stimulants, no more decongestant in the morning or caffeinated soda or coffee (i have a tea once in awhile). I do use cannabis daily.

I'm slightly overweight, smoke maybe 8 cigarettes a day (honestly), but my father has had a history of high BP and his father died of heart failure. I'm not that damned old but this is really starting to worry me.

I'm trying to get into a doctor now, hopefully a local free clinic as I have no insurance and very little income.

Any info would REALLY be appreciated right now! I really appreciate what you do on here, as I'm sure everyone else does!

[AJ4CKS]

Hi Doctor X,

I'm still relatively new to MDMA.. well, I shouldn't say MDMA - I should say Party Pills as I guess I really don't know what I'm taking (I'm buying a test kit soon).

I love taking party pills because it's much better to spend $50 - $75 (on pills) on a night out rather than $200 - $300 (on alcohol). But, my only worry is health risks. The only health risks I know about are, anxiety/paranoia from taking too much (only happened once to me), and over heating - which I avoid by drinking water every 1-2 hours. Is there any other health risks that I should be worried about? 

I guess you could say memory loss, but I have much more memory loss when drinking alcohol.

[bla-ljus]

I'm not the doctor, but chiming in. Major MDMA, err. party pill risks:
- If not verified with testkit, you may get anything, including stuff that can kill you if taken just 1 pill. (Have a look at PMA, have a look at pillreports.com)
- neurotoxicity with higher dosages and/or prolonged use
- The "crash" - severe depression due to depleted serotonin / abuse of the substance - Have a look at http://www.bluelight.ru/vb/forums/22-MDMA-amp-Empathogenic-Drugs for example cases _AND_ also very good harm reduction information

I would recomend by starting with http://www.bluelight.org/vb/threads/657228-Six-Simple-Rules-To-MDMA
If you are too lazy, then follow these two rules:
1) TEST your stuff with testkit prior using it. It may save your health or life
2) Don't abuse the stuff: Avoid constant redosing, give your body enough time to recover between uses (1month)

[DoctorX]

Tachycardia can be a symptom of different diseases.Before giving advice it is indispensable to perform tests (radiology, electrocardiography and blood test)  in order to know where is the problem. It is not necessarily something very important or a severe disease, but it is not possible to give an advice without a correct diagnosis. So the only info I can offer is the necessity of talking with a real-world doctor

Hi Doc!

I posted on here around the beginning of the year about a bad time I had with some pure amphetamine and unknowingly potentiating it with baking soda, which I take regularly for heartburn.

I'm not having breathing issues anymore, but I've noticed my pulse is remaining consistantly high during the day. According to my cheap BP meter, it's around 100-120bpm. My blood pressure is pretty much normal, avg. 135 over 85. I've stopped using all amphetamines and stimulants, no more decongestant in the morning or caffeinated soda or coffee (i have a tea once in awhile). I do use cannabis daily.

I'm slightly overweight, smoke maybe 8 cigarettes a day (honestly), but my father has had a history of high BP and his father died of heart failure. I'm not that damned old but this is really starting to worry me.

I'm trying to get into a doctor now, hopefully a local free clinic as I have no insurance and very little income.

Any info would REALLY be appreciated right now! I really appreciate what you do on here, as I'm sure everyone else does!

[DoctorX]

Hi Doctor X,

I'm still relatively new to MDMA.. well, I shouldn't say MDMA - I should say Party Pills as I guess I really don't know what I'm taking (I'm buying a test kit soon).

I love taking party pills because it's much better to spend $50 - $75 (on pills) on a night out rather than $200 - $300 (on alcohol). But, my only worry is health risks. The only health risks I know about are, anxiety/paranoia from taking too much (only happened once to me), and over heating - which I avoid by drinking water every 1-2 hours. Is there any other health risks that I should be worried about? 

I guess you could say memory loss, but I have much more memory loss when drinking alcohol.

Common side effects of MDMA include loss of appetite, visual distortions, nystagmus (involuntary eye movement), increased heart rate and blood pressure, edginess, body temperature changes, vomiting, anxiety, perspiration, motion sicknesses, confusion, dry mouth, jaw tension and difficulty to concentrate.

Hyperthermia is extremely severe but extremely rare also. It is more likely to occur in close spaces when intense physical activity is engaged (for example, dancing for many hours) and when people don’t hydrate properly. To avoid this, it’s recommended to take breaks from dancing and restore liquids (with water and juices, or preferably with isotonic beverages, with moderation, approximately half a liter each hour if experiencing intense physical activity and less if resting), avoiding, if possible, alcohol because it increases dehydration and body heat.

MDMA produces an increase on heart beat and arterial pressure. Therefore people with heart conditions or hypertension should be cautious with its use.

High and continuous doses of MDMA in frequent users can potentiate in the future loss memory and mood alterations. The basic rule of MDMA’s use is “Less is more”. Bad side effects tend to decrease, as well as long time sequels, if one takes more time between consumptions. It is estimated that using MDMA more than once a month can be excessive. To moderate its use is the golden rule to enjoy the experience in all its fullness and prevent undesirable long time sequels.

It’s impossible to know a pill’s concentration of MDMA unless it’s analyzed in a laboratory. The team I work with is developing an International Drug Testing Service for Deep Web users that will be introduced in following weeks.

[haydenp]

Is it possible to get physically addicted (and get withdrawals when discontinued) from ketamine?

[Foxy]

What method of inhalation would you advise to a person with chronic bronchitis, would it be possible to increase dosage to make up for the inability/reduced ability to absorb smoke/vapor?

[DoctorX]

Is it possible to get physically addicted (and get withdrawals when discontinued) from ketamine?

Yes. Ketamine dependence is one of the problems associated with this drug. Some ketamine users become dependent on the drug in a manner resembling cocaine dependence, with craving , high tolerance and loss of ability to manage the use of the drug. Some users take 5-6 grams of ketamine daily and abuse of ketamine becomes the priority in their lives. There is no evidence of a physiological withdrawal syndrome, but this does not mean that dependence is not possible. A minority (estimated 5-8%) of users develop ketamine dependence.
An extensive review about this issue can be found here (pages 166-203)
https://www.maps.org/books/K-DreamsKJansenMAPS.pdf

[DoctorX]

What method of inhalation would you advise to a person with chronic bronchitis, would it be possible to increase dosage to make up for the inability/reduced ability to absorb smoke/vapor?

Smoking is not recommended in persons who suffer chronic bronchitis.. The most reasonable option would be using a vaporizator. With this device it is possible to inhale many substances without the problems of combustion

[TheChain]

Is it possible to get physically addicted (and get withdrawals when discontinued) from ketamine?

Yes. Ketamine dependence is one of the problems associated with this drug. Some ketamine users become dependent on the drug in a manner resembling cocaine dependence, with craving , high tolerance and loss of ability to manage the use of the drug. Some users take 5-6 grams of ketamine daily and abuse of ketamine becomes the priority in their lives. There is no evidence of a physiological withdrawal syndrome, but this does not mean that dependence is not possible. A minority (estimated 5-8%) of users develop ketamine dependence.
An extensive review about this issue can be found here (pages 166-203)
https://www.maps.org/books/K-DreamsKJansenMAPS.pdf

I have read Karl Jansens K Dreams and would like to chime in a little bit of info (from personal experience). K doesn't seem to be physically addictive but psychological dependence is quite common. In my area we have seen a lot of K abuse some people get away with it for years others have bladder damage and cramps caused by norketamine.

Haydenp - If access is easy it's way too easy to do too much K. It's like psychedelic heroin, it just makes everything OK but I havent seen any physical dependance even after years of abuse.

[Aleoreneo]

Hi Doc,
If  I take Isotretinoin, it's safe to use LSD, Psylocibin, DMT, weed and alchool?
How often is to often to take LSD and DMT? What are harms of DMT? It's a problem if I take microdose of LSD (15ug) one or two times in a week?
Thanks!

[haydenp]

Is it possible to get physically addicted (and get withdrawals when discontinued) from ketamine?

Yes. Ketamine dependence is one of the problems associated with this drug. Some ketamine users become dependent on the drug in a manner resembling cocaine dependence, with craving , high tolerance and loss of ability to manage the use of the drug. Some users take 5-6 grams of ketamine daily and abuse of ketamine becomes the priority in their lives. There is no evidence of a physiological withdrawal syndrome, but this does not mean that dependence is not possible. A minority (estimated 5-8%) of users develop ketamine dependence.
An extensive review about this issue can be found here (pages 166-203)
https://www.maps.org/books/K-DreamsKJansenMAPS.pdf

Thank you kind sir.
I sent a donation your way. I highly encourage everybody to donate towards a better future
Dr.X is SAVING people's lives!

[newportboy123]

Is it possible to get physically addicted (and get withdrawals when discontinued) from ketamine?

Yes. Ketamine dependence is one of the problems associated with this drug. Some ketamine users become dependent on the drug in a manner resembling cocaine dependence, with craving , high tolerance and loss of ability to manage the use of the drug. Some users take 5-6 grams of ketamine daily and abuse of ketamine becomes the priority in their lives. There is no evidence of a physiological withdrawal syndrome, but this does not mean that dependence is not possible. A minority (estimated 5-8%) of users develop ketamine dependence.
An extensive review about this issue can be found here (pages 166-203)
https://www.maps.org/books/K-DreamsKJansenMAPS.pdf

This is quite accurate, i used to be addicted to ketamine and i would use up to 7 grams a day sometimes. I eventually was even IVing it to get high, it sounds strange but i have probably lost more in my life due to ketamine addiction than to opiate and benzo addiction.

[tjetPVYWF0]

Doc, I was prescribed 100mg of dextroamphetamine per day. How high is it safe to go?

[DoctorX]

Hi Doc,
If  I take Isotretinoin, it's safe to use LSD, Psylocibin, DMT, weed and alchool?
How often is to often to take LSD and DMT? What are harms of DMT? It's a problem if I take microdose of LSD (15ug) one or two times in a week?
Thanks!

Alcohol (and, with less probability psylocibin) is the only drug strictly contraindicated with isotretinoin. Rest of the substances listed are safe to use while in treatment with isotretinoin.

Using psychedelics is like going to Disneyworld (in case you like Disney characters, of course). First times are amazing but if you go to often you will get tired. Frequency (in both cases) depends on personal preferences. For some people it is twice a year, for others once a month but most people  find boring doing it every weekend. In general, the less frequent is the use, it is better.

DMT, as other classical psychedelics has no physical dangers. Harms are related to mental issues (anxiety, difficulty to integrate the experience) or, very rarely, persistent mental health problems

15 ug of LSD is below the level of psychoactivity of the substance. Body develops tolerance quickly to LSD and, in case of subtle effects, these would dissapear in a few days or weeks. I think this pattern of use is useless.

[Cornelius23]

Indeed, please donate. The doctor does a wonderful job here.

(My most recent donation was ฿0.1 although my largest was ฿0.5. I don't know how anyone would prove that, though).

[bigdaddyx]

Hey Doc, here's my 2-part question:

1)  I know sometimes cocaine is "cut" with levamisole.  Is there any way to tell if mine is cut with it, or is it just pure luck?

2)  Is there any additional risk of injecting it if it is cut with levamisole compared to the usual risks associated with i.v. drug injection?

[tjetPVYWF0]

Indeed, please donate. The doctor does a wonderful job here.

(My most recent donation was ฿0.1 although my largest was ฿0.5. I don't know how anyone would prove that, though).

You would post a TXID and sign a message with the sending address.

[DoctorX]

Is it possible to get physically addicted (and get withdrawals when discontinued) from ketamine?

Yes. Ketamine dependence is one of the problems associated with this drug. Some ketamine users become dependent on the drug in a manner resembling cocaine dependence, with craving , high tolerance and loss of ability to manage the use of the drug. Some users take 5-6 grams of ketamine daily and abuse of ketamine becomes the priority in their lives. There is no evidence of a physiological withdrawal syndrome, but this does not mean that dependence is not possible. A minority (estimated 5-8%) of users develop ketamine dependence.
An extensive review about this issue can be found here (pages 166-203)
https://www.maps.org/books/K-DreamsKJansenMAPS.pdf

Thank you kind sir.
I sent a donation your way. I highly encourage everybody to donate towards a better future
Dr.X is SAVING people's lives!

Thank you very much!

[DoctorX]

Doc, I was prescribed 100mg of dextroamphetamine per day. How high is it safe to go?

Sorry...I´m not sure that I understood correctly the question. Usual dosage of dextroamphetamine as a prescription pharmaceutical is in the rank 5-60 mg. Daily 100 mg seems too much,although it  personal,  idiosyncratic characteristics should be considered also.

[DoctorX]

Hey Doc, here's my 2-part question:

1)  I know sometimes cocaine is "cut" with levamisole.  Is there any way to tell if mine is cut with it, or is it just pure luck?

2)  Is there any additional risk of injecting it if it is cut with levamisole compared to the usual risks associated with i.v. drug injection?

Here is my 2-part answer:

1) The only way to know if cocaine is cut with levamisole is analyzing it. The presence of levamisole is not only important, but also concentration. Quantity of levamisole in cocaine is usually 2-10% but  can reach 30%. In following weeks the Spanish NGO I work with (www.energycontrol.org) will introduce an International Drug Testing Service designed to analyze drug samples and provide information to Deep Web users at affordable rates using high resolution and quantification techniques. You can see an advance here:
http://www.youtube.com/watch?v=_2VBxUDJna8

2) Injecting levamisole-tainted cocaine raises the possibility of levamisole associated complications (immunologic depression or dermatologic problems like vasculitis).Injection is the most risky administration route in relation to levamisole, as it goes directly to blood and tissues.
http://www.youtube.com/watch?v=_2VBxUDJna8

[DoctorX]

Indeed, please donate. The doctor does a wonderful job here.

(My most recent donation was ฿0.1 although my largest was ฿0.5. I don't know how anyone would prove that, though).

Donations are really uncommon as you can verify in my address. Cornelius23 is one of the few supporters who has been periodically donating BTCs several times during several months. He sent me a PM informing he had sent a donation the same day I received the only 0.5 BTC donation I have had.

[elitetherapy]

Hi Doc,

Thanks for your time and support. You are a highly regarded person in this community!

I wanted to ask if I should be worried about itchy nose after using cocaine.

At the time of snorting I had some nose bleed. It stopped fairly quickly within half an hour. Since then only once I had some blood coming out on a tissue but just once, two days after my first cocaine intake. Then, 5 days after the first intake I snorted again the same shit. This time I didn't have any nose bleeding. However, since then I have felt my nose fragile and sort of itchy. In the last few days it has become increasingly itchy and I would say it even hurts a tiny bit. No bleeding, however. I have also been sneezing a lot and having runny nose for the last two days, sort of flu symptoms.

Timespan:
1st snort 14th of Feb (with bleeding). Second bleeding 16 Feb.
2nd snort 18th Feb (no bleeding)
27th Feb until now - increased itchy-ness and flu sympthoms like sneezing, feeling down, runny nose (not sure if actual flu or just the nose)

Unfortunately, it wasn't the purest of cocaine...  Do you think I should be worried?

Thanks a lot and god bless ya : ))

[DoctorX]

Hi Doc,

Thanks for your time and support. You are a highly regarded person in this community!

I wanted to ask if I should be worried about itchy nose after using cocaine.

At the time of snorting I had some nose bleed. It stopped fairly quickly within half an hour. Since then only once I had some blood coming out on a tissue but just once, two days after my first cocaine intake. Then, 5 days after the first intake I snorted again the same shit. This time I didn't have any nose bleeding. However, since then I have felt my nose fragile and sort of itchy. In the last few days it has become increasingly itchy and I would say it even hurts a tiny bit. No bleeding, however. I have also been sneezing a lot and having runny nose for the last two days, sort of flu symptoms.

Timespan:
1st snort 14th of Feb (with bleeding). Second bleeding 16 Feb.
2nd snort 18th Feb (no bleeding)
27th Feb until now - increased itchy-ness and flu sympthoms like sneezing, feeling down, runny nose (not sure if actual flu or just the nose)

Unfortunately, it wasn't the purest of cocaine...  Do you think I should be worried?

Thanks a lot and god bless ya : ))

It is very unlikely that snorting occasional average amounts of cocaine causes severe problems. Your symptoms do not seem worrying in this moment. Persisting bleeding, complete and persisting nasal congestion, white and fetid nasal secretion, intense pain in cheeks or forehead are common alarm symptoms. Probably washing your nostrils with a saline solution twice a day at warm temperature using a syringe during 7-10 days should be enough to recovery.
In relation with snorting technique , it is recommendable to pulverize the substance to a very thin dust before sniffing. Do not use always the same nostril for sniffing, but alternate both. Sniffing straw should not point to nasal septum, but to nasal turbinates (lateral ) , where vascularization is greater and absorption better.

[bigdaddyx]

Hey Doc, here's my 2-part question:

1)  I know sometimes cocaine is "cut" with levamisole.  Is there any way to tell if mine is cut with it, or is it just pure luck?

2)  Is there any additional risk of injecting it if it is cut with levamisole compared to the usual risks associated with i.v. drug injection?

Here is my 2-part answer:

1) The only way to know if cocaine is cut with levamisole is analyzing it. The presence of levamisole is not only important, but also concentration. Quantity of levamisole in cocaine is usually 2-10% but  can reach 30%. In following weeks the Spanish NGO I work with (www.energycontrol.org) will introduce an International Drug Testing Service designed to analyze drug samples and provide information to Deep Web users at affordable rates using high resolution and quantification techniques. You can see an advance here:
http://www.youtube.com/watch?v=_2VBxUDJna8

2) Injecting levamisole-tainted cocaine raises the possibility of levamisole associated complications (immunologic depression or dermatologic problems like vasculitis).Injection is the most risky administration route in relation to levamisole, as it goes directly to blood and tissues.
http://www.youtube.com/watch?v=_2VBxUDJna8

Thanks for the great info, Doc!!  You're the best.  I'm sending a donation your way.  Muchos gracias.

Also, excellent video, thanks for that also.

[tjetPVYWF0]

Doc, I was prescribed 100mg of dextroamphetamine per day. How high is it safe to go?

Sorry...I´m not sure that I understood correctly the question. Usual dosage of dextroamphetamine as a prescription pharmaceutical is in the rank 5-60 mg. Daily 100 mg seems too much,although it  personal,  idiosyncratic characteristics should be considered also.

Well, I'm prescribed it for ADD. I was taking 2x30mg in the morning, then a 30mg and a 10mg in the afternoon. I was wondering at what point it would become neurotoxic.

EDIT: I should also add that I have low blood pressure due to postural orthostatic tachycardia syndrome, so that may be why my dose is so high.

[DoctorX]

Doc, I was prescribed 100mg of dextroamphetamine per day. How high is it safe to go?

Sorry...I´m not sure that I understood correctly the question. Usual dosage of dextroamphetamine as a prescription pharmaceutical is in the rank 5-60 mg. Daily 100 mg seems too much,although it  personal,  idiosyncratic characteristics should be considered also.

Well, I'm prescribed it for ADD. I was taking 2x30mg in the morning, then a 30mg and a 10mg in the afternoon. I was wondering at what point it would become neurotoxic.

EDIT: I should also add that I have low blood pressure due to postural orthostatic tachycardia syndrome, so that may be why my dose is so high.

As I said, general dosage is up to 60 mg but personal characteristics may have an influence when prescribing higher dosages. Neurotoxicity should not be a matter of concern in oral route and 100 mg/daily dosages. Anyway, I think you should better discuss personally with your doctor what is the best prescription drug for your disease and what are the problems and long time effects that can be expected.

[tjetPVYWF0]

Doc, I was prescribed 100mg of dextroamphetamine per day. How high is it safe to go?

Sorry...I´m not sure that I understood correctly the question. Usual dosage of dextroamphetamine as a prescription pharmaceutical is in the rank 5-60 mg. Daily 100 mg seems too much,although it  personal,  idiosyncratic characteristics should be considered also.

Well, I'm prescribed it for ADD. I was taking 2x30mg in the morning, then a 30mg and a 10mg in the afternoon. I was wondering at what point it would become neurotoxic.

EDIT: I should also add that I have low blood pressure due to postural orthostatic tachycardia syndrome, so that may be why my dose is so high.

As I said, general dosage is up to 60 mg but personal characteristics may have an influence when prescribing higher dosages. Neurotoxicity should not be a matter of concern in oral route and 100 mg/daily dosages. Anyway, I think you should better discuss personally with your doctor what is the best prescription drug for your disease and what are the problems and long time effects that can be expected.

Thanks, I was somewhat worried about killing brain cells, as my doctor said that was a high dose. However, it seemed to work quite well, although when I lost insurance, withdrawal was hell.

[Aleoreneo]

Hi Doc,
If  I take Isotretinoin, it's safe to use LSD, Psylocibin, DMT, weed and alchool?
How often is to often to take LSD and DMT? What are harms of DMT? It's a problem if I take microdose of LSD (15ug) one or two times in a week?
Thanks!

Alcohol (and, with less probability psylocibin) is the only drug strictly contraindicated with isotretinoin. Rest of the substances listed are safe to use while in treatment with isotretinoin.

Using psychedelics is like going to Disneyworld (in case you like Disney characters, of course). First times are amazing but if you go to often you will get tired. Frequency (in both cases) depends on personal preferences. For some people it is twice a year, for others once a month but most people  find boring doing it every weekend. In general, the less frequent is the use, it is better.

DMT, as other classical psychedelics has no physical dangers. Harms are related to mental issues (anxiety, difficulty to integrate the experience) or, very rarely, persistent mental health problems

Thanks!

15 ug of LSD is below the level of psychoactivity of the substance. Body develops tolerance quickly to LSD and, in case of subtle effects, these would dissapear in a few days or weeks. I think this pattern of use is useless.

It's called microdose (http://silkroad5v7dywlc.onion/index.php?topic=626.210) I have light effects withi it, increase my mood, concentration and other. Body develops tolerance quickly with only 15ug of LSD? If I take 15ug and the next day I take 200ug, how many is attenuate the 200ug trip?

[1200mics]

Hi Doc,

I got a quick question:

I've started taking St. John's Wort extract with amazing results (treating a mild - moderate depression).

Do you know how long before taking MDMA I have to discontinue St. John's in order not to get into a dangerous situation like serotonin syndrome or spoil the roll?

What about Amphetamines? Are they dangerous whilst on St. John's (I figured no because they are not acting on serotonin that much)?

Are you aware of any other drugs that might be dangerous with St. John's? Do just the same rules apply to St. John's as to any "regular" SSRI in regards to drug use?

I have done an extensive research on the internet but couldn't find an answer.

I highly appreciate your work. Thank you very much for your help!

[fragg3r]

There are not described cases of nitrous oxide interactions with other recreational drugs resulting in significant health problems. Problems with its use come primarily from a bad administration route or dosage. When used as an anaesthetic, nitrous is always administered in combination with oxygen. Nitrous oxide should never be used in a gas mask, plastic bag or other situations that can limit oxigen intake. Heavy and frequent nitrous use can deplete vitamin B12 in the body and lead to serious and unpleasant neurological problems. Headache, palpitations or nausea are possible adverse effects. Problems with vasoconstrion are theoreticaly possible but very uncommon in real life (at least using psychedelics that have been used widely in humans). Interactions with classical psychedelics like psilocibin or LSD should be very rare. Anyway I would advice against using it in combination with substances like DOB, bromo-dragonfly or NBOMEs

Hey Doc, thanks for your advice in this thread!

I have a more specific question concerning N2O (mixed with other substances like LSD).
Over the last couple of months it has become somewhat if a ritual for me to induce myself into an LSD trip once or twice a month, very often with the assistance of short nitrous oxide "flashes".
Now I know the effects it creates: Next to light headedness, slight euphoria and halluzinogenic coloring, I get a strong visual and sonic "echoing". Visual in the case that it's like you are only able to see one still picture, and after the effects of the N2O slowly wear off, more and more of your surrounding increasingly starts to move again, but in an "echoey" way.
This lasts for around 1-2 minutes, as usual.

The last time I did such a LSD-N2O session though, one of these echoing "flashes" lasted worryingly long... I'm guessing well over half an hour!
Does anyone remember the movie Riddick, when the Lord Marshal had this ghosting effect on his body? Imagine that, but on everything that is moving in your viewing field, and at much stronger effect!
During that time you begin to panic because the effect isn't wearing off, until you settle down and consider that a) the LSD is prolonging the effect and it will slowly wear off with the drug, or b) you have caused yourself an irreversible amount of brain damage.

Thankfully it did wear off and I'm feeling fine again, but obviously it made me reconsider this practise of mixing both drugs to that extent. We're talking about 300-400ug LSD plus ten capsules of gas in a five hour time frame...

I know that neither LSD nor N2O have been tested scientifically to an extent, or even combined, and that a high amount of nitrous oxide can cause brain damage and B12 deficiency.
But I'm asking myself HOW dangerous this mix is, and if there have been reports of N2O effects lasting that long, and/or if the effects are "normal" and how dangerous they are...

Sorry for writing down the whole story, but it genuinely scared me and I wanted you to have a detailed picture of the situation, maybe you can help me out with some insight!


Thanks!

[DoctorX]

Hi Doc,

I got a quick question:

I've started taking St. John's Wort extract with amazing results (treating a mild - moderate depression).

Do you know how long before taking MDMA I have to discontinue St. John's in order not to get into a dangerous situation like serotonin syndrome or spoil the roll?

What about Amphetamines? Are they dangerous whilst on St. John's (I figured no because they are not acting on serotonin that much)?

Are you aware of any other drugs that might be dangerous with St. John's? Do just the same rules apply to St. John's as to any "regular" SSRI in regards to drug use?

I have done an extensive research on the internet but couldn't find an answer.

I highly appreciate your work. Thank you very much for your help!

St John´s Wort acts like a monoamine oxidase inhibitor. So, theoretically, it could induce severe adverse effects in combination with drugs whose mechanism of action is related to dopamine, norepinephrine and/or serotonin liberation. This includes MDMA, LSD, amphetamines, cocaine, psilocybin. The use of ketamine , GHB or cannabis is probably safe although not recommended. A 2-3 week period of clearance is enough to avoid problems

[DoctorX]

There are not described cases of nitrous oxide interactions with other recreational drugs resulting in significant health problems. Problems with its use come primarily from a bad administration route or dosage. When used as an anaesthetic, nitrous is always administered in combination with oxygen. Nitrous oxide should never be used in a gas mask, plastic bag or other situations that can limit oxigen intake. Heavy and frequent nitrous use can deplete vitamin B12 in the body and lead to serious and unpleasant neurological problems. Headache, palpitations or nausea are possible adverse effects. Problems with vasoconstrion are theoreticaly possible but very uncommon in real life (at least using psychedelics that have been used widely in humans). Interactions with classical psychedelics like psilocibin or LSD should be very rare. Anyway I would advice against using it in combination with substances like DOB, bromo-dragonfly or NBOMEs

Hey Doc, thanks for your advice in this thread!

I have a more specific question concerning N2O (mixed with other substances like LSD).
Over the last couple of months it has become somewhat if a ritual for me to induce myself into an LSD trip once or twice a month, very often with the assistance of short nitrous oxide "flashes".
Now I know the effects it creates: Next to light headedness, slight euphoria and halluzinogenic coloring, I get a strong visual and sonic "echoing". Visual in the case that it's like you are only able to see one still picture, and after the effects of the N2O slowly wear off, more and more of your surrounding increasingly starts to move again, but in an "echoey" way.
This lasts for around 1-2 minutes, as usual.

The last time I did such a LSD-N2O session though, one of these echoing "flashes" lasted worryingly long... I'm guessing well over half an hour!
Does anyone remember the movie Riddick, when the Lord Marshal had this ghosting effect on his body? Imagine that, but on everything that is moving in your viewing field, and at much stronger effect!
During that time you begin to panic because the effect isn't wearing off, until you settle down and consider that a) the LSD is prolonging the effect and it will slowly wear off with the drug, or b) you have caused yourself an irreversible amount of brain damage.

Thankfully it did wear off and I'm feeling fine again, but obviously it made me reconsider this practise of mixing both drugs to that extent. We're talking about 300-400ug LSD plus ten capsules of gas in a five hour time frame...

I know that neither LSD nor N2O have been tested scientifically to an extent, or even combined, and that a high amount of nitrous oxide can cause brain damage and B12 deficiency.
But I'm asking myself HOW dangerous this mix is, and if there have been reports of N2O effects lasting that long, and/or if the effects are "normal" and how dangerous they are...

Sorry for writing down the whole story, but it genuinely scared me and I wanted you to have a detailed picture of the situation, maybe you can help me out with some insight!


Thanks!

I am sorry I can´t provide information about this. LSD is definitely not neurotoxic and low, occasional dosages of N2O, neither. Maybe these kinds of combination can trigger panic attacks or unpleasant experiences in some people depending on dosages and personal characteristics. From a neurobiological point of view I don´t think this is a matter of concern, but it is important to be cautious when combining LSD and other substances

[fragg3r]

I am sorry I can´t provide information about this. LSD is definitely not neurotoxic and low, occasional dosages of N2O, neither. Maybe these kinds of combination can trigger panic attacks or unpleasant experiences in some people depending on dosages and personal characteristics. From a neurobiological point of view I don´t think this is a matter of concern, but it is important to be cautious when combining LSD and other substances

Okay great, thanks for the info! =)

[dateandrape]

how can i perform 'twilight sleep amenisa' with oral scolopamine and oral morphine  as all the doses are IV?

gracias

[DoctorX]

how can i perform 'twilight sleep amenisa' with oral scolopamine and oral morphine  as all the doses are IV?

gracias

Both scopolamine and morphine can be fatal in overdose. Positive (pleasure) effects of scopolamine are minimum (if any). I do not think it is a good idea to experiment with them and I have no idea how to reach that state.

[bigone]

Hi everyone,

I wanted some advice. I'm a regular injecting opiate user but tonight I had 70 mg of of ice IV for only the second time ever, just to try something different. I'd had my usual evening smack shots, probably around a point before I had the meth. Within a couple of minutes I had the most intense pain in my head, like a vice was on my head. It was an absolutely excruciating, unbearable pain. Then it started to wear off after half an hour until I power vomited. Now I'm well enough to write but still feel nauseous and have a painful headache.

Does anybody have any ideas about what went wrong? 

In another thread a respondent said that it was probably a blood clot and that i just dodged a stroke. They said to count myself extremely lucky and that i should start taking aspirin every day. They also said they were not a medical expert. I thought it time I get another opinion.

[DoctorX]

Hi everyone,

I wanted some advice. I'm a regular injecting opiate user but tonight I had 70 mg of of ice IV for only the second time ever, just to try something different. I'd had my usual evening smack shots, probably around a point before I had the meth. Within a couple of minutes I had the most intense pain in my head, like a vice was on my head. It was an absolutely excruciating, unbearable pain. Then it started to wear off after half an hour until I power vomited. Now I'm well enough to write but still feel nauseous and have a painful headache.

Does anybody have any ideas about what went wrong? 

In another thread a respondent said that it was probably a blood clot and that i just dodged a stroke. They said to count myself extremely lucky and that i should start taking aspirin every day. They also said they were not a medical expert. I thought it time I get another opinion.

You know I am not alarmist or exaggerator. But a extreme headache followed by nausea and vomiting after iv stimulants can be a symptom of subarachnoid hemorrhage. You should seek immediate medical help to rule out this possibility. And taking aspirin would only aggravate this problem, if it exists.

[knuckles]

For tooth pain, would it be safe to use a topical cream such as Orajel when taking LSD & 2cb?

[bigone]

Hi everyone,

I wanted some advice. I'm a regular injecting opiate user but tonight I had 70 mg of of ice IV for only the second time ever, just to try something different. I'd had my usual evening smack shots, probably around a point before I had the meth. Within a couple of minutes I had the most intense pain in my head, like a vice was on my head. It was an absolutely excruciating, unbearable pain. Then it started to wear off after half an hour until I power vomited. Now I'm well enough to write but still feel nauseous and have a painful headache.

Does anybody have any ideas about what went wrong? 

In another thread a respondent said that it was probably a blood clot and that i just dodged a stroke. They said to count myself extremely lucky and that i should start taking aspirin every day. They also said they were not a medical expert. I thought it time I get another opinion.

You know I am not alarmist or exaggerator. But a extreme headache followed by nausea and vomiting after iv stimulants can be a symptom of subarachnoid hemorrhage. You should seek immediate medical help to rule out this possibility. And taking aspirin would only aggravate this problem, if it exists.

So, even though I feel completely fine without any symptoms - I still need to see a doctor?

[DoctorX]

For tooth pain, would it be safe to use a topical cream such as Orajel when taking LSD & 2cb?

Topical creams should not interact with psychedelics. But psychedelics can have an impact in pain and body sensations. It may diminish them, change them, increase them or give another significance. If you have ever been on psychedelics you know what I mean. I think this factor should be considered in your case. If possible, it is better to use psychedelics in the best physical state possible.

[DoctorX]

Hi everyone,

I wanted some advice. I'm a regular injecting opiate user but tonight I had 70 mg of of ice IV for only the second time ever, just to try something different. I'd had my usual evening smack shots, probably around a point before I had the meth. Within a couple of minutes I had the most intense pain in my head, like a vice was on my head. It was an absolutely excruciating, unbearable pain. Then it started to wear off after half an hour until I power vomited. Now I'm well enough to write but still feel nauseous and have a painful headache.

Does anybody have any ideas about what went wrong? 

In another thread a respondent said that it was probably a blood clot and that i just dodged a stroke. They said to count myself extremely lucky and that i should start taking aspirin every day. They also said they were not a medical expert. I thought it time I get another opinion.

You know I am not alarmist or exaggerator. But a extreme headache followed by nausea and vomiting after iv stimulants can be a symptom of subarachnoid hemorrhage. You should seek immediate medical help to rule out this possibility. And taking aspirin would only aggravate this problem, if it exists.

So, even though I feel completely fine without any symptoms - I still need to see a doctor?

It is very difficult to offer accurate advice only through Internet. With the symptoms you described yesterday my advice was immediate medical attention. If symptoms have completely dissapeared today it is possible that it is not strictly needed now. But I can only offer my opinion based on the limited data we share here.

[GreatLancet]

Hey Doc!

I've posted a couple times about rapid heart palpitations I've been getting recently. I don't believe it's drug related, all I've been doing is LSD, psilocybin and DMT. I had been taking Adderall but cut it out when this started.

I got into a free clinic and was told my problem could be hyperthyroid. That also happens to run in my family (my mother had to get the radioactive iodine treatment to kill hers).  They said my thyroid was slightly englarged (no nodules though) and I HAVE been feeling a slight tightness in my neck right over the gland (didn't even put it together until I was at the docs office).

All they did was give me a beta blocker and ask me to come back in a month. The beta blocker IS slowing my heart and lowering my BP, but it's only addressing a symptom and not the problem, right?

I know there's no sure fire cure for hyperthyroid issues, but do you have any experience/suggestions on how to control it? I'd rather not take thyroid suppressing chems and definitely don't want to nuke my damn thyroid.

I've heard that bugleweed and motherwort can help lower thyroid function over time. Is there anything dietary I should/shouldnt be doing? I've also heard it can be due to low/high iodine levels but I wouldn't want to start meddling with that without knowing wether my iodine is high or low. Could applied kinesiology give me a clue? Do you even believe in that and should I?

I'm staying away from all stims, be it caffiene, decongestants or uppers. I'm still using psychedelics about 1x per week and the rapid heart beat is of course more noticable and worrying while in that state. It's becoming a real bummer on my life and my trips!

Again, I don't expect conclusive answers but anything you have to offer on hyperthyroidism is greatly appreciated!

[knuckles]

For tooth pain, would it be safe to use a topical cream such as Orajel when taking LSD & 2cb?

Topical creams should not interact with psychedelics. But psychedelics can have an impact in pain and body sensations. It may diminish them, change them, increase them or give another significance. If you have ever been on psychedelics you know what I mean. I think this factor should be considered in your case. If possible, it is better to use psychedelics in the best physical state possible.

Well when I first started psych's I never had a tooth pain. After some stomach problems I had anytime I do LSD,AL-LAD, Mushrooms or 2cb I end up with tooth pain usually on the left side of my mouth. Ever since then my diet has changed tremendously. Sodas,junk food, frozen foods,etc all out of my diet now.

A while ago you told me to take Vitamin D3, I take that , 5000iu daily with 90mcg k2. I also excersise, meditate, and so far not much luck.  Also, the tooth pain isn't from grinding, I never grind/clench my jaw when tripping.

Or I was going to see if maybe something more natural like a coconut water rinse during my trip may help or any type of herbal supplement?

I'd just like to enjoy 1 trip without constant pain for hours

[shinyhappypeople]

Hello doctor,

I had a very large session 3 weeks ago. Consumed 2grams of cocaine, 6-7 grams of mephedrone and 2 grams of MDMA, mostly snorting it. This was over a 2 day period.

During the period my nose was getting blocked, and I was using decongestant to unblock it, as well as cotton buds.

I have noticed after this session, my left nostril was bleeding. Now the graphic bit, which I'll try to explain, Most normal bogeys lie in the large cavity of the nose (which can be picked out), however after this session, it feels like I have a blocked nose, but if I blow very hard and with a lot of wiggling, HUGE solid, blood soaked bogeys fly out, which have come from the actual nasal passage (unable to pick, too high).

It was been 3 weeks now and every morning I need to clear my nose out. I am worried I have bored my nasal passages wide open and mucus is collected in my nasal passage, and not in my nose like most people.

[DoctorX]

Hey Doc!

I've posted a couple times about rapid heart palpitations I've been getting recently. I don't believe it's drug related, all I've been doing is LSD, psilocybin and DMT. I had been taking Adderall but cut it out when this started.

I got into a free clinic and was told my problem could be hyperthyroid. That also happens to run in my family (my mother had to get the radioactive iodine treatment to kill hers).  They said my thyroid was slightly englarged (no nodules though) and I HAVE been feeling a slight tightness in my neck right over the gland (didn't even put it together until I was at the docs office).

All they did was give me a beta blocker and ask me to come back in a month. The beta blocker IS slowing my heart and lowering my BP, but it's only addressing a symptom and not the problem, right?

I know there's no sure fire cure for hyperthyroid issues, but do you have any experience/suggestions on how to control it? I'd rather not take thyroid suppressing chems and definitely don't want to nuke my damn thyroid.

I've heard that bugleweed and motherwort can help lower thyroid function over time. Is there anything dietary I should/shouldnt be doing? I've also heard it can be due to low/high iodine levels but I wouldn't want to start meddling with that without knowing wether my iodine is high or low. Could applied kinesiology give me a clue? Do you even believe in that and should I?

I'm staying away from all stims, be it caffiene, decongestants or uppers. I'm still using psychedelics about 1x per week and the rapid heart beat is of course more noticable and worrying while in that state. It's becoming a real bummer on my life and my trips!

Again, I don't expect conclusive answers but anything you have to offer on hyperthyroidism is greatly appreciated!

The kind of treatment better for you depends on your age,sex, what is causing your hyperthyroidism, how much thyroid hormone your body is making, and other medical conditions you may have. In general, antithyroid drugs, radioactive iodine and surgery are the best options. In many times hyperthyroidism treatment leads to hypothyroidism, and then is necessary to administrate the hormone daily by oral route. This is not a problem for most people and it has less risks and complications than a sustained hyperthyroidism.
I do not know about the effectiveness of natural herbs or suplements.
I do not recommend using psychedelics in this state, ketamine is specially counter-indicated.

[Ketatmine]

Hi Doc, Doing ketamine after taking Paracetamol and/or Ibuprofen (recommended dosage)...Is it particularly dangerous? Can't imagine it's great for the liver? Not something to make a habit of but the ketamine distracts from the pain.
Many thanks.

[DoctorX]

I regret I can´t give you help without a physical examination. If you have snorted 10 gr of substances in a 2 day period it is possible to have some permanent damage in your nasal cavity. You should seek a doctor´s help to verify if there is a problem or not

Hello doctor,

I had a very large session 3 weeks ago. Consumed 2grams of cocaine, 6-7 grams of mephedrone and 2 grams of MDMA, mostly snorting it. This was over a 2 day period.

During the period my nose was getting blocked, and I was using decongestant to unblock it, as well as cotton buds.

I have noticed after this session, my left nostril was bleeding. Now the graphic bit, which I'll try to explain, Most normal bogeys lie in the large cavity of the nose (which can be picked out), however after this session, it feels like I have a blocked nose, but if I blow very hard and with a lot of wiggling, HUGE solid, blood soaked bogeys fly out, which have come from the actual nasal passage (unable to pick, too high).

It was been 3 weeks now and every morning I need to clear my nose out. I am worried I have bored my nasal passages wide open and mucus is collected in my nasal passage, and not in my nose like most people.

[DoctorX]

Hi Doc, Doing ketamine after taking Paracetamol and/or Ibuprofen (recommended dosage)...Is it particularly dangerous? Can't imagine it's great for the liver? Not something to make a habit of but the ketamine distracts from the pain.
Many thanks.

There are not known interactions between recommended dosages of paracetamol or ibuprofen and ketamine. The combination is safe

[candyflip]

If you are using moderate-normal dosages (not higher than 120-140 mg, 1.5-2 mg/kg), you both have experience with the substance and are in a general good health, there should not be excessive risks in a physical point of view. Having sex is no more risky than dancing in a rave (in a cardiovascular point of view), so adding MDMA does not imply many differences. General rules of risk reduction for MDMA are applicable.

There are different opinions about sex on MDMA, probably it is a question of personal preferences. Most people prefer sex 3-4 hours after MDMA intake. In that moment the important mental effects are diminishing but persist well being and tactile enhancement. MDMA difficults penile erection in many men, and 3-4 hours after this effect is less noticeable, at least for most people. It can be interesting to forget about penile erection and explore other aspects of sexuality. Retarded ejaculation is another frequent issue (this can be an adventage or disadventage, depending on persons and situations).  As I say, many people prefer sex after MDMA but, nevertheless, other prefer it during the peak experience.

Another aspect is psychological reactions and changes in communication with other persons. Depending on your personal implication with that person it is possible that your  thoughts about your partner arne different than usual (deeper, clearer, more emotional...). It is possible that he/she experiments the same. The consequences of this kind of situations can be very possitive, negative or neutral, depending on many factors. But taking in consideration MDMA psychological effects is also a risk reduction measure.

Look for an adequate, intimate space, be free of preocupations...a good set and settting, in definitive, is the best you can do. And leave some space for improvisation and do not expect too much of it.

Very interesting !

[RonBurgundy]

DoctorX,

I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I'm wondering how these will affect drug use. I've been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I've also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I'm on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E?

Thanks in advance for any advice.

[DoctorX]

DoctorX,

I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I'm wondering how these will affect drug use. I've been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I've also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I'm on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E?

Thanks in advance for any advice.

Antipsychotics and antideppressants diminish effects of all classical psychedelics, including 2C-x family. So this is normal. In theory, the unique way to counteract this effect is increasing the psychedelic dosage. I say "in theory" because in a practical point of view this is not recommended at all. First, because it will increase physical adverse effects from psychedelics and risk of intoxication (this is particularly important in 2C-x and 25-x-NBOMEs). Second, because it will increase the risks of bad psychedelic experiences. And this is particularly important if you are using psychiatric medication. This last question is not only about pharmacological interactions, but also about the cause you are using medication. It is probable that this cause (the reason that makes that you need to use this medication) makes not recommendable to use psychedelics. 

[RonBurgundy]

DoctorX,

I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I'm wondering how these will affect drug use. I've been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I've also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I'm on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E?

Thanks in advance for any advice.

Antipsychotics and antideppressants diminish effects of all classical psychedelics, including 2C-x family. So this is normal. In theory, the unique way to counteract this effect is increasing the psychedelic dosage. I say "in theory" because in a practical point of view this is not recommended at all. First, because it will increase physical adverse effects from psychedelics and risk of intoxication (this is particularly important in 2C-x and 25-x-NBOMEs). Second, because it will increase the risks of bad psychedelic experiences. And this is particularly important if you are using psychiatric medication. This last question is not only about pharmacological interactions, but also about the cause you are using medication. It is probable that this cause (the reason that makes that you need to use this medication) makes not recommendable to use psychedelics.

I'm on the medication for depression and anxiety, which certain psychedelic drugs seem to help a little bit. I'm not on antipsychotics for anything like bipolar disorder or schizophrenia so, correct me if I'm wrong, but I feel like it is safe for me to use psychedelics.

I have one more question.

On the part about counteracting the effects of the medication by increasing psychedelic dosage, is this safe to do with DMT? Also, is there any cross tolerance between 2C-X, NBOMe series, and DMT?

[DoctorX]

DoctorX,

I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I'm wondering how these will affect drug use. I've been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I've also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I'm on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E?

Thanks in advance for any advice.

Antipsychotics and antideppressants diminish effects of all classical psychedelics, including 2C-x family. So this is normal. In theory, the unique way to counteract this effect is increasing the psychedelic dosage. I say "in theory" because in a practical point of view this is not recommended at all. First, because it will increase physical adverse effects from psychedelics and risk of intoxication (this is particularly important in 2C-x and 25-x-NBOMEs). Second, because it will increase the risks of bad psychedelic experiences. And this is particularly important if you are using psychiatric medication. This last question is not only about pharmacological interactions, but also about the cause you are using medication. It is probable that this cause (the reason that makes that you need to use this medication) makes not recommendable to use psychedelics.

I'm on the medication for depression and anxiety, which certain psychedelic drugs seem to help a little bit. I'm not on antipsychotics for anything like bipolar disorder or schizophrenia so, correct me if I'm wrong, but I feel like it is safe for me to use psychedelics.

I have one more question.

On the part about counteracting the effects of the medication by increasing psychedelic dosage, is this safe to do with DMT? Also, is there any cross tolerance between 2C-X, NBOMe series, and DMT?

Increasing the dosage of DMT could increase the risk of bad psychological experiences, in a physical way is probably safe.
There are no studies of cross tolerance between 2C-X, DMT and NBOMEs, although probably there is some degree. Anyway, NBOMes have no studies and probably are more risky than other substances

[flightisnormal]

Thank you, DoctorX and +1!
Subbing.

[hippo]

Hi Doc,

My girlfriend has been in a panic lately about her contraceptive pill (mercilon). Previously she has always had a bar in her arm but switched 2 months ago to the pill. Do any of the following affect how well the pill works:

Mephedrone
Methylone
Cocaine
Mdma
Alcohol

or in any combination of the above?

[DoctorX]

Hi Doc,

My girlfriend has been in a panic lately about her contraceptive pill (mercilon). Previously she has always had a bar in her arm but switched 2 months ago to the pill. Do any of the following affect how well the pill works:

Mephedrone
Methylone
Cocaine
Mdma
Alcohol

or in any combination of the above?

There are not significative pharmacological interactions known between recreational drugs and hormonal anticonceptives. The only exception is tobacco, that, in combination with some hormones can raise the risk of some cardiovascular problems.

[AfricanCanadianBrotha]

Hello,
I am a Spanish Family Physician working in fields like risk reduction associated to drug use, club drugs, new synthetic drugs, cannabis therapeutic and steroids since 1999. I would like to contribute to this forum offering professional advice in topics related to drug use and health: pharmacological interactions, risks of drug use in particular conditions (specific diseases, problems of health…), contraindications, adverse effects and toxicity, risk reduction measures…
This advice cannot replace a complete face-to-face medical evaluation, but I know how difficult can be to talk frankly about these things. You can see my CV on my personal web-page http://www.doctorcaudevilla.com/
You can also use PM for personal questions or video-conference in my web (available only in Spanish).
I will try to answer all your questions (if I know the answers) but I have limited time
DoctorX

Please look over and follow these guidelines before posting:

1) Have a look into the thread or use the search engine. It is possible your question has been     asked and answered already.

2) Try to be as descriptive as possible, the more accurate your information (age, gender, health problems, prescription/illegal drug use...) the more specific my answer will be.

3) Information in this thread is general advice, but it can't replace a personal, medical evaluation. Health problems must be evaluated in person. No responsibility is assumed by misunderstanding of this information.

4) Answering questions entails dedicating time and personal effort. Consider supporting this service with a donation

(10/10/13) Continuing this thread from old SR forum

(03/05/13) Please only use PM and PGP for personal questions. Most of the questions can be answered in general forum and can be useful to other people

thank you for your contribution and i am intreasted in same feild of work in hard reduction of drugs and awareness of drugs like shedding light on untruthful rumors about drugs me being in united states there are some real myth on drug use and it lead to the abuse of drugs i really support spains drug policy thet seem so much more advance in that genreal area from what ive heard they have given up the war on drugs

also support spains youth in the occupy movement thosand times better then ares

[IshitBacon]

DoctorX,

I am currently taking abilify (not sure on the dose, maybe ~5mg),

   ahah I took abilfty but it made my pee pee not work well so I had to stop!!

sorry for you having to take all these meds. I was given the combo treatment a couple times also

[cleansober]

Many users (including myself) seem to get wrapped up in the many physical sensations drugs can bring about, losing sight of the normal physical sensation of everyday physical health. There is lip service paid to the notion of resetting one's body off of drugs, every so often, but I wonder if the psychological longing for altered states can be reset so easily? We must be our own physician and know ourself and any symptoms that may occur. To truly know oneself is a more subtle process than taking a week or two holiday from drug use to get to know our 'regular' physical being. The disease process sometimes requires we are completely focused on small, almost imperceptible changes in our physical conditions.

Finally for my question: Could cannabis possibly loosen the bond between the retina and choloid? I have no clue how this bond is made, but of course, we all know how important it is. Given the vasodilator  properties of weed, could there be some interaction?

cs

[DoctorX]

No, there are not known cases of choroid-retina pathology associated to cannabis use

[unknownx]

+1

[marasal2]

is it safe having sildenafil with lsd or mdma pills?
thank you

[haydenp]

is it safe having sildenafil with lsd or mdma pills?
thank you

Just wanted to add to the question.. My bf cant seem to "get it up" during sex  when he's on mdma. Is viagra or cialis helpful for this problem? Are there any serious problems to worry about when mixing mdma and cialis? Are there other (safer) alternatives?
And dr. X, sorry abt all the questions i always ask you, i know you are probably a busy person. let me know of you need anoher donation from me, and i'll happily give another generous one
thanks

[2fruits]

is it safe having sildenafil with lsd or mdma pills?
thank you

Just wanted to add to the question.. My bf cant seem to "get it up" during sex  when he's on mdma. Is viagra or cialis helpful for this problem? Are there any serious problems to worry about when mixing mdma and cialis? Are there other (safer) alternatives?
And dr. X, sorry abt all the questions i always ask you, i know you are probably a busy person. let me know of you need anoher donation from me, and i'll happily give another generous one
thanks

Sildenafil works on phosphodiesterase-5 (PDE-5) inhibition and is absolutely safe with most drugs (notable exceptions being things like amyl nitrates - "poppers" - or nitroglycerines, becasuse these are also vasodilators and the combo can stop your heart).

In fact it's often used to reverse the vasoconstriction associated with amphetamines. I use it for this purpose myself.

As for MDMA, it isn't just a vasoconstrictor (remember, it's an amphetamine)... it also happens to intefere with the "orgasm reflex" in the nervous system. This is why even if men CAN get it up, they often have problems reaching orgasm.

Viagra certainly helps, and it's not contraindicated with MDMA. Quite safe.

[marasal2]

i have got another questin. what are the risks of candyflipping (mixing lsd with mdma)? is it dangerous??
Thank you Doc.

[Xadnem]

Hey DoctorX
I have a 'friend' whom whilst tripping on 25I-Nbome started to come down and freaked out a bit.
My friend now suffers from anxiety and I don't know what to do about it, and would have to see a psycologist to get a prescription to get meds
This person suffers from crohn's disese and i'm worried that could have been a part of the problem. :/
Would there be any risk of them taking xanax to stop the anxiety attacks?

EDIT: Friend is around the age of 18 and female. Very short and skinny

[DoctorX]

is it safe having sildenafil with lsd or mdma pills?
thank you

There are no reported cases of severe toxicity mixing MDMA or LSD and sildelnafil. The combination is "probably" (but not "absolutely") safe. The risk of problems or adverse effects depends on dosage, timing, previous experience with both substances and personal characteristics. It is possible (at least theoretically) some "rebound" effect between vasoconstrictor properties of amphetamines and vasodilator of sildenafil. Moderate dosages of both substances diminish the risk of problems.
The most dangerous combination, as 2fruits said, is between PDE-5 inhibitors (Viagra, Cialis, Levitra...) and poppers.

[DoctorX]

is it safe having sildenafil with lsd or mdma pills?
thank you

(...)Are there other (safer) alternatives? (...)

The only alternative I can think about is to explore other aspects of sexuallity that do not involve penetration. MDMA is very interesting for that. And when you stop thinking about it, it works on its own

[DoctorX]

Hey DoctorX
I have a 'friend' whom whilst tripping on 25I-Nbome started to come down and freaked out a bit.
My friend now suffers from anxiety and I don't know what to do about it, and would have to see a psycologist to get a prescription to get meds
This person suffers from crohn's disese and i'm worried that could have been a part of the problem. :/
Would there be any risk of them taking xanax to stop the anxiety attacks?

EDIT: Friend is around the age of 18 and female. Very short and skinny

I can´t find a link between psychedelics and Crohn´s disease. I do not think that is part of the problem.
Xanax can be an option to cut a panic attack, but if they are recurrent it is not the best medication. Some SSRIs are more helpful long time. Anyway, there is little human experience with 25I-NBOMe. If her problem persist I think she should search for medical advice

[Xadnem]

Hey DoctorX
I have a 'friend' whom whilst tripping on 25I-Nbome started to come down and freaked out a bit.
My friend now suffers from anxiety and I don't know what to do about it, and would have to see a psycologist to get a prescription to get meds
This person suffers from crohn's disese and i'm worried that could have been a part of the problem. :/
Would there be any risk of them taking xanax to stop the anxiety attacks?

EDIT: Friend is around the age of 18 and female. Very short and skinny

I can´t find a link between psychedelics and Crohn´s disease. I do not think that is part of the problem.
Xanax can be an option to cut a panic attack, but if they are recurrent it is not the best medication. Some SSRIs are more helpful long time. Anyway, there is little human experience with 25I-NBOMe. If her problem persist I think she should search for medical advice

Thanks DoctorX I appreciate the advice, i've let her know and she's going to see a psycologist to get on medication

[marasal2]

is it safe having sildenafil with lsd or mdma pills?
thank you

There are no reported cases of severe toxicity mixing MDMA or LSD and sildelnafil. The combination is "probably" (but not "absolutely") safe. The risk of problems or adverse effects depends on dosage, timing, previous experience with both substances and personal characteristics. It is possible (at least theoretically) some "rebound" effect between vasoconstrictor properties of amphetamines and vasodilator of sildenafil. Moderate dosages of both substances diminish the risk of problems.
The most dangerous combination, as 2fruits said, is between PDE-5 inhibitors (Viagra, Cialis, Levitra...) and poppers.

Thank you Doctor, i am greatful. Have a nice day
Best regards

[The General]

Nice work you do DoctorX +1

I have a quick maybe dumb question, I have medical problems and in my early 30's (Getting old lol)

Kind of off topic but seems this is the place it will be awnsered. So a few weeks back I was totally stung out on coke, all honesty was buying ozzys local to resell but ended up snorting it all. When I was at the hight of addiction I was snorting an oz a week to myself, I am not proud or bragging its was horrible and would not wish it on anyone.

Now I cut back big time, but my nose is completely fucked always full of buggers even when I am not sniffing. Was just wondering could that be from lots of lev in the coke? Also is there any good shit to help it heal, or should I go see a doctor?

Any help would be greatly appreciated.

Have a good one.

The General.

[luckysocks420]

Hi, Dr. X
About 9 months ago I smoked some synthetic cannabis and had a really horrible time, about 5mins in my vision started to go all cartoony like on a psychedelic then that subsided quickly and a buzzing started in my head, a tiny bit similar to real cannabis, but it kept getting stronger and stronger until it felt like someone was shaking my brain from side to side really violently my vision was also shaking really strongly side to side. When I closed my eyes there were fairly weak CEV'S, I started to panic and was very close to going to the hospital but I just held back ,I can't tell how long it lasted but I'd guess an hour.

It shook me up a bit but I forgot about it until I started to notice 1-2 months later I wasn't really enjoying smoking cigarettes anymore, it wasn't a relaxing break anymore but just something I had to do. It then became quite nasty when I smoked; it tasted bad, it hurt my chest (it never used to) and if I smoked a full cigarette I'd get a bad headache and a tingling in my hands (like pins and needles) and would have to sit down for 5-10 mins.

Worse is that the same has happened to weed, It must have been about 4 months after the synthetic stuff that I tried real weed again. It started to kick in and felt OK for about 5mins then it started to get fuzzy and a bit confusing and it kept on getting worse and was just really not nice I fell asleep and woke up 3-4 hours later feeling really rough. I've tried 3 other strains since then with the same results every time. I tried some some cannabis oil I made myself but it was sort of the same feeling but a bit weaker.

Last night I tried DMT for the first time I took roughly 50mg probably less I had trouble vaporizing it ( first time ) but I didn't really feel anything so I took some more and I started to feel something but it wasn't nice and no real visuals it started to feel a tiny bit similar to when I smoke weed so I stopped.  I want to try again but I'm worried the same thing will happen.

I don't know if it's related but about a month after the synthetic weed I took MDMA everyday for 5 days in a row about 2g in total (I know this is really stupid) the week after I had some really bad symptoms. I generally felt ill, when I tried to sleep just before I would fall asleep I would get a feeling like an electric shock through my body and jump up, this would happen 4-5 times before I fell asleep this happened for a week before it stopped then a week later I started getting pins and needles all over my body, it was pretty unpleasant. I guessed it was something to do with the CNS so I started to drink a couple of beers when it started because alcohol is a CNS depressant I think? this did dull the tingling a bit, a week later this stopped too I took a 5 month break and now I'm fine with MDMA.

I've had cocaine, LSD, speed, MDMA and methylone several times since and had no problems ( the comedown on the coke was really bad but it was much better quality than I've ever had) I'm really starting to worry something permanent has happened to the way my brain reacts to these things any help would really be appreciated. Sorry for the long post and thanks a lot for reading

[alexander super-tramp]

Hey just wanted to ask kind of had a scare with one of my clients who get mdma off of me.

So 3 days prior to his surgery it was only minor thing serious. He bought some mdma and rolled. Did'nt touch it but when he went under he said they ran into complications with the anesthesia.

It made his heart rate spike when he was under. Everything was fine the procedure was only 25 min long.

But they did do a blood test after and found mdma in his system and said that was the cause of the adverse affects.

Could you please explain why this would have such an affect even when not on the drug by chance? It was just in his system.

Kind of scared me but thank god it was nothing to serious.

[DoctorX]

Nice work you do DoctorX +1

I have a quick maybe dumb question, I have medical problems and in my early 30's (Getting old lol)

Kind of off topic but seems this is the place it will be awnsered. So a few weeks back I was totally stung out on coke, all honesty was buying ozzys local to resell but ended up snorting it all. When I was at the hight of addiction I was snorting an oz a week to myself, I am not proud or bragging its was horrible and would not wish it on anyone.

Now I cut back big time, but my nose is completely fucked always full of buggers even when I am not sniffing. Was just wondering could that be from lots of lev in the coke? Also is there any good shit to help it heal, or should I go see a doctor?

Any help would be greatly appreciated.

Have a good one.

The General.

You could try irrigating your nostrils with saline water warm and a syringe twice a day. If it does not work in a week, buggers are stinky or bloody or nose remains closed, then you should visit a doctor

[DoctorX]

Hi, Dr. X
About 9 months ago I smoked some synthetic cannabis and had a really horrible time, about 5mins in my vision started to go all cartoony like on a psychedelic then that subsided quickly and a buzzing started in my head, a tiny bit similar to real cannabis, but it kept getting stronger and stronger until it felt like someone was shaking my brain from side to side really violently my vision was also shaking really strongly side to side. When I closed my eyes there were fairly weak CEV'S, I started to panic and was very close to going to the hospital but I just held back ,I can't tell how long it lasted but I'd guess an hour.

It shook me up a bit but I forgot about it until I started to notice 1-2 months later I wasn't really enjoying smoking cigarettes anymore, it wasn't a relaxing break anymore but just something I had to do. It then became quite nasty when I smoked; it tasted bad, it hurt my chest (it never used to) and if I smoked a full cigarette I'd get a bad headache and a tingling in my hands (like pins and needles) and would have to sit down for 5-10 mins.

Worse is that the same has happened to weed, It must have been about 4 months after the synthetic stuff that I tried real weed again. It started to kick in and felt OK for about 5mins then it started to get fuzzy and a bit confusing and it kept on getting worse and was just really not nice I fell asleep and woke up 3-4 hours later feeling really rough. I've tried 3 other strains since then with the same results every time. I tried some some cannabis oil I made myself but it was sort of the same feeling but a bit weaker.

Last night I tried DMT for the first time I took roughly 50mg probably less I had trouble vaporizing it ( first time ) but I didn't really feel anything so I took some more and I started to feel something but it wasn't nice and no real visuals it started to feel a tiny bit similar to when I smoke weed so I stopped.  I want to try again but I'm worried the same thing will happen.

I don't know if it's related but about a month after the synthetic weed I took MDMA everyday for 5 days in a row about 2g in total (I know this is really stupid) the week after I had some really bad symptoms. I generally felt ill, when I tried to sleep just before I would fall asleep I would get a feeling like an electric shock through my body and jump up, this would happen 4-5 times before I fell asleep this happened for a week before it stopped then a week later I started getting pins and needles all over my body, it was pretty unpleasant. I guessed it was something to do with the CNS so I started to drink a couple of beers when it started because alcohol is a CNS depressant I think? this did dull the tingling a bit, a week later this stopped too I took a 5 month break and now I'm fine with MDMA.

I've had cocaine, LSD, speed, MDMA and methylone several times since and had no problems ( the comedown on the coke was really bad but it was much better quality than I've ever had) I'm really starting to worry something permanent has happened to the way my brain reacts to these things any help would really be appreciated. Sorry for the long post and thanks a lot for reading

It is very difficult to give an explanation about what could have happened. I know a lot about cannabis, MDMA or cocaine because they are substances that have been studied during the last 100 years and there is enough scientific information about them.
This is not the same with synthetic cannabinoids. In this case it is true that users are behaving as guinea pigs, as there are no experiments with humans with these substances. They are far extremely more dangerous than cannabis. This is a idea that I have been repeating here always.
In your case, in general, and according to your symptoms, I think it is unlikely that it means a permanent-irreversible damage. But I should recommend several months of total abstinence of psychoactives in order to facilitate full recovery.

[DoctorX]

Hey just wanted to ask kind of had a scare with one of my clients who get mdma off of me.

So 3 days prior to his surgery it was only minor thing serious. He bought some mdma and rolled. Did'nt touch it but when he went under he said they ran into complications with the anesthesia.

It made his heart rate spike when he was under. Everything was fine the procedure was only 25 min long.

But they did do a blood test after and found mdma in his system and said that was the cause of the adverse affects.

Could you please explain why this would have such an affect even when not on the drug by chance? It was just in his system.

Kind of scared me but thank god it was nothing to serious.

I´m sorry but it all sounds me very strange. It is very unlikely that MDMA causes problems 3 days after. MDMA is not detected in blood test, but in urine...

[alexander super-tramp]

Ill have to get more info and be back to you. How long does mdma stay in your system well till you cant tell in a blood test?

[DoctorX]

MDMA is only detected in blood (up to 24 h ) with high complexity techniques that are only used in forensic or investigation. Standard tests for MDMA are in urine, and they are positive 48-72 hours after use.

Ill have to get more info and be back to you. How long does mdma stay in your system well till you cant tell in a blood test?

[IshitBacon]

     does SSRIs mess up a dmt trip?

 

[stranger]

hello again DoctorX!

i have few questions:

1. i read that ibuprofen countereacts short memory problems with weed - but when and in what dosage shall it be ingested? day before? during trip? day after?

also can you elaborate on what exactly are problems with short term memory when using weed? is it only meaning that anything done during trip will be not remembered? or that you cannot recall recent things? or that during trip and SOME TIME AFTER there will be problems with remembering things? to sum up: what kind of problems are known and when do they occur?

2. is using ibuprofen everyday produce any side effects? is it bad idea to use ibuprofen with GBL or GHB?

3. GBL - besides risk of dependency, are there any other health risks, especially from long term using (let's say two doses 1.3-1.5 ml in the evening for 3-4 days a week)? is there anything that shall be done when using GBL?

thanks again, i will make sure to send you some coins later today!

edit: i didn't made it yesterday, but i wired you something for your time today!

one more question:

4. is is safe to suplement yourself with 5-HTP everyday? i use it for mood lift and to stabilize serotonine levels (i sometimes use drugs that affect it - of course i don't use 5-HTP right before it) but was wondering if it is safe

thanks!

[cleansober]

Does anyone know why doc has one neg? I'm guessing I know but could be wrong, guesses?

cs

[DoctorX]

     does SSRIs mess up a dmt trip?

 

SSRI diminish in general effects of psychedelics acting in 5-HT receptors like DMT. This effect is only partial, this inhibition is rarely complete

[DoctorX]

hello again DoctorX!

i have few questions:

1. i read that ibuprofen countereacts short memory problems with weed - but when and in what dosage shall it be ingested? day before? during trip? day after?

also can you elaborate on what exactly are problems with short term memory when using weed? is it only meaning that anything done during trip will be not remembered? or that you cannot recall recent things? or that during trip and SOME TIME AFTER there will be problems with remembering things? to sum up: what kind of problems are known and when do they occur?

2. is using ibuprofen everyday produce any side effects? is it bad idea to use ibuprofen with GBL or GHB?

3. GBL - besides risk of dependency, are there any other health risks, especially from long term using (let's say two doses 1.3-1.5 ml in the evening for 3-4 days a week)? is there anything that shall be done when using GBL?

thanks again, i will make sure to send you some coins later today!

edit: i didn't made it yesterday, but i wired you something for your time today!

one more question:

4. is is safe to suplement yourself with 5-HTP everyday? i use it for mood lift and to stabilize serotonine levels (i sometimes use drugs that affect it - of course i don't use 5-HTP right before it) but was wondering if it is safe

thanks!

1.- That is a myth based in some basic experiments on animals and cells. There is no proof that this works in humans.
Acute use of cannabis leads to recent memory deficits (capacity for holding a small amount of information in mind in an active, readily available state for a short period of time). In daily cannabis users, the ability to learn and remember new concepts can be impaired, although this effect is in general of little magnitude and reversible after 2-4 weeks of abstinence.
http://www.cmcr.ucsd.edu/images/pdfs/Grant_2003.pdf

2.- Daily use of ibuprofen can lead to adverse effects of this drug. Gastrointestinal issues (from disconfort to ulcer) are the most common. Simultaneous use of GBL or GHB should not give more problems.

3.-  There are not known long-time risks of GBL, besides of dependence potential, that is relatively high. GBL abstinence can be problematic, in a medical point of view

4.- It is safe, long and short adverse effects are mild in normal dosages. But there are no proofs of efficacy, neither

[jword123]

DR.X
Can you point me in the right direction on beating a Hair Folicle Test? I am interested in products and methods on beating or lowing trace elements of  drugs in my system.
best regards,
jword123

[stranger]

hello DoctorX!

again many thanks for your help!

1.- That is a myth based in some basic experiments on animals and cells. There is no proof that this works in humans.
Acute use of cannabis leads to recent memory deficits (capacity for holding a small amount of information in mind in an active, readily available state for a short period of time). In daily cannabis users, the ability to learn and remember new concepts can be impaired, although this effect is in general of little magnitude and reversible after 2-4 weeks of abstinence.
http://www.cmcr.ucsd.edu/images/pdfs/Grant_2003.pdf

actually I was referring to this new research on the subject:

original article: [clearnet] http://www.cell.com/cell/abstract/S0092-8674%2813%2901360-3
some article about it: [clearnet] http://articles.latimes.com/2013/nov/21/science/la-sci-marijuana-ibuprofen-alzheimers-buzzkill-20131121

3.-  There are not known long-time risks of GBL, besides of dependence potential, that is relatively high. GBL abstinence can be problematic, in a medical point of view

okay, thanks for info. one more regarding this - is it recommended to convert it to GHB (myself) before consumption or the risks are the same?

5. and another issue - several times with cannabioids (both normal weed and syntetics) if i got too high i experienced OEVs much like those from LSD or other psychedelics. now when i think about it it is possible that - besides high dosage - i was taking 5-HTP earlier. given that many psychedelic drugs operate on serotonine, is it plausible in your opinion to connect 5-HTP as a factor that may increase chances of experiencing visual effects?

i know a friend that didn't do any psychedelics but took some 5-HTP and described her vision this day with "colors appearing much more beautiful/wonderful" - and this person didn't possibly know about pharmacology of psychedelics, it was just spontaneus comment after taking 5-HTP just for mood elevation, and she was referring to actual colors, not the methapore of good mood, so this again makes me wonder if 5-HTP can enable visual effects.

thanks again!

[haydenp]

received this question from a customer, told him i would ask for him, since he has less than 50 posts...

Hi, I really liked that vitamin K, but I am worried about my friend.  I told him not to, but he really wanted to try IM'ing it, but he pushed too far and touched bone, now it's hurting...  Any advice with what to do for that kind of thing? Thanks again

just to clarify, he was asking about ketamine in case i wasnt being clear..

[DoctorX]

DR.X
Can you point me in the right direction on beating a Hair Folicle Test? I am interested in products and methods on beating or lowing trace elements of  drugs in my system.
best regards,
jword123

There is no way to beat a Hair Folicle Test (unless you are able to use the hair from another person). Traces of drugs used during last months deposit on the folicle and there is no way to eliminate them from there

[DoctorX]

hello DoctorX!

again many thanks for your help!

1.- That is a myth based in some basic experiments on animals and cells. There is no proof that this works in humans.
Acute use of cannabis leads to recent memory deficits (capacity for holding a small amount of information in mind in an active, readily available state for a short period of time). In daily cannabis users, the ability to learn and remember new concepts can be impaired, although this effect is in general of little magnitude and reversible after 2-4 weeks of abstinence.
http://www.cmcr.ucsd.edu/images/pdfs/Grant_2003.pdf

actually I was referring to this new research on the subject:

original article: [clearnet] http://www.cell.com/cell/abstract/S0092-8674%2813%2901360-3
some article about it: [clearnet] http://articles.latimes.com/2013/nov/21/science/la-sci-marijuana-ibuprofen-alzheimers-buzzkill-20131121

3.-  There are not known long-time risks of GBL, besides of dependence potential, that is relatively high. GBL abstinence can be problematic, in a medical point of view

okay, thanks for info. one more regarding this - is it recommended to convert it to GHB (myself) before consumption or the risks are the same?

5. and another issue - several times with cannabioids (both normal weed and syntetics) if i got too high i experienced OEVs much like those from LSD or other psychedelics. now when i think about it it is possible that - besides high dosage - i was taking 5-HTP earlier. given that many psychedelic drugs operate on serotonine, is it plausible in your opinion to connect 5-HTP as a factor that may increase chances of experiencing visual effects?

i know a friend that didn't do any psychedelics but took some 5-HTP and described her vision this day with "colors appearing much more beautiful/wonderful" - and this person didn't possibly know about pharmacology of psychedelics, it was just spontaneus comment after taking 5-HTP just for mood elevation, and she was referring to actual colors, not the methapore of good mood, so this again makes me wonder if 5-HTP can enable visual effects.

thanks again!

1.- The study you mention is a basic investigation on cells, done in laboratory conditions. It reveals interesting information about underlying mechanisms of cannabinoids action in brain but it is not directly extrapolable to humans. There are big differences between basic experiments and real life. We don´t know if results are the same in human brain, what dosage should be necessary, if COX inhibitors reach brain in enough concentration, the metabolization, degree of tolerance...the info provided in newspapers is not scientific, but sensationalistics suppositions without a base.

2.- Risks of GBL and GHB are basically the same, as GBL is transformed to GHB in body. One adventage of GHB is that taste is much better than GBL. Anyway, if you are converting GBL to GHB is very important to verify the reaction (a correct pH), if this reaction is not well done it can lead to very toxic (acid or basic) products.

3.- OEV are possible with high dosages of cannabis. Synthetic cannabinoids are far more dangerous than cannabis, as they have never been tested in humans and risks are much higher (and unknown). Cannabis acts on its own receptor system (CB) and I do not think the use of 5-HTP could increase visuals. This is only a personal opinion based on pharmacology, but there is no too much investigation about this combination. 

[DoctorX]

received this question from a customer, told him i would ask for him, since he has less than 50 posts...

Hi, I really liked that vitamin K, but I am worried about my friend.  I told him not to, but he really wanted to try IM'ing it, but he pushed too far and touched bone, now it's hurting...  Any advice with what to do for that kind of thing? Thanks again

just to clarify, he was asking about ketamine in case i wasnt being clear..

If there is no nerve affection, pain will pass with some pain-killer (acetaminophen, ibuprofen...) and rest. For following occassions, use an adequate injection technique
http://www.cmft.nhs.uk/directorates/mentor/documents/InjectionTechnique.pdf
 

[psarxnds]

hi doc.

i have a problem with lsd. everytime i use, some sort of liquid discharges from my penis for hours. i dont have any genital sickness and this doesnt happen anytime except on lsd. is this something serious?

[DoctorX]

I have never heard about this and I can´t find a logical explanation.

[cleansober]

Yes, perhaps a steady tiny titanic orgasm lasting longer than four hours. Tantric methods reportedly  make mental orgasms possible.  Just pay so and so for whatever and walla.

[BigRoomBastards]

I received my order from FlatBushZombies , 2 real big Mandrax pills I've been over 6 years in a methadone program and now i was slightly fearful of interactions Can anyone help me with the dosage or other tips

PLEASE HELP ME in this situation !!!

thanks

[Whiteball]

Hi, Dr. X
About 9 months ago I smoked some synthetic cannabis and had a really horrible time, about 5mins in my vision started to go all cartoony like on a psychedelic then that subsided quickly and a buzzing started in my head, a tiny bit similar to real cannabis, but it kept getting stronger and stronger until it felt like someone was shaking my brain from side to side really violently my vision was also shaking really strongly side to side. When I closed my eyes there were fairly weak CEV'S, I started to panic and was very close to going to the hospital but I just held back ,I can't tell how long it lasted but I'd guess an hour.

It shook me up a bit but I forgot about it until I started to notice 1-2 months later I wasn't really enjoying smoking cigarettes anymore, it wasn't a relaxing break anymore but just something I had to do. It then became quite nasty when I smoked; it tasted bad, it hurt my chest (it never used to) and if I smoked a full cigarette I'd get a bad headache and a tingling in my hands (like pins and needles) and would have to sit down for 5-10 mins.

Worse is that the same has happened to weed, It must have been about 4 months after the synthetic stuff that I tried real weed again. It started to kick in and felt OK for about 5mins then it started to get fuzzy and a bit confusing and it kept on getting worse and was just really not nice I fell asleep and woke up 3-4 hours later feeling really rough. I've tried 3 other strains since then with the same results every time. I tried some some cannabis oil I made myself but it was sort of the same feeling but a bit weaker.

Last night I tried DMT for the first time I took roughly 50mg probably less I had trouble vaporizing it ( first time ) but I didn't really feel anything so I took some more and I started to feel something but it wasn't nice and no real visuals it started to feel a tiny bit similar to when I smoke weed so I stopped.  I want to try again but I'm worried the same thing will happen.

I don't know if it's related but about a month after the synthetic weed I took MDMA everyday for 5 days in a row about 2g in total (I know this is really stupid) the week after I had some really bad symptoms. I generally felt ill, when I tried to sleep just before I would fall asleep I would get a feeling like an electric shock through my body and jump up, this would happen 4-5 times before I fell asleep this happened for a week before it stopped then a week later I started getting pins and needles all over my body, it was pretty unpleasant. I guessed it was something to do with the CNS so I started to drink a couple of beers when it started because alcohol is a CNS depressant I think? this did dull the tingling a bit, a week later this stopped too I took a 5 month break and now I'm fine with MDMA.

I've had cocaine, LSD, speed, MDMA and methylone several times since and had no problems ( the comedown on the coke was really bad but it was much better quality than I've ever had) I'm really starting to worry something permanent has happened to the way my brain reacts to these things any help would really be appreciated. Sorry for the long post and thanks a lot for reading

It is very difficult to give an explanation about what could have happened. I know a lot about cannabis, MDMA or cocaine because they are substances that have been studied during the last 100 years and there is enough scientific information about them.
This is not the same with synthetic cannabinoids. In this case it is true that users are behaving as guinea pigs, as there are no experiments with humans with these substances. They are far extremely more dangerous than cannabis. This is a idea that I have been repeating here always.
In your case, in general, and according to your symptoms, I think it is unlikely that it means a permanent-irreversible damage. But I should recommend several months of total abstinence of psychoactives in order to facilitate full recovery.

@ lucksocks420: I totally empathise with you. Was your panic attack brought on by a sativa induced white out or green out? Looking everywhere for this info on the forums and now I found it. I'm going to let the doctor's words answer, but I want to add my little bit to the picture. It is not as uncommon as you might think. http://silkroad5v7dywlc.onion/index.php?topic=98.msg699701#msg699701

@ DoctorX: Thanks for this thread. I don't believe other markets are big enough to take drug safety seriously. Some are very business oriented with no concern over the customers, that's silly because a dead customer can't pay. No questions from me, just a thanks and a +1.

[BigRoomBastards]

no one can help me ??

[cleansober]

BB,

When I say eat your vegetables, respect your elders, and pray for redemtion, I'm serious not joking. Seems no matter the problems we have, if we follow some basic rules, we can  be productive members of society.

Whom among you have listened to hip hop rap/urban soul?

CS

why is my spell check messed up?

[DoctorX]

I received my order from FlatBushZombies , 2 real big Mandrax pills I've been over 6 years in a methadone program and now i was slightly fearful of interactions Can anyone help me with the dosage or other tips

PLEASE HELP ME in this situation !!!

thanks

Methaqualone has depressant effects on Central Nervous System, so it can enhance some methadone effects and, if used in combination, methaqualone dosage should be significantly lower to avoid problems

[BigRoomBastards]

I received my order from FlatBushZombies , 2 real big Mandrax pills I've been over 6 years in a methadone program and now i was slightly fearful of interactions Can anyone help me with the dosage or other tips

PLEASE HELP ME in this situation !!!

thanks

Methaqualone has depressant effects on Central Nervous System, so it can enhance some methadone effects and, if used in combination, methaqualone dosage should be significantly lower to avoid problems

how high the dosage should be? thanks doctor + karma for your help

[cleansober]

All,

Many folks have asked me why FC has one neg. It is the recognition that we are responsible for our behaviour, good and bad. Only we can make the changes necessary to be the person we want to be. Everyone here seems to understand maintaining our good health is up to ourselves, no one else. Sermon over, time to rest.

cs

ps, I'm at a loss to explain my 25-39 jump in +karma. Either my comment about the constant orgasm lasting longer than four hours, or my question about who likes Hip Hop rap urban/soul music, who knows?  Something touched a karma generation.

[fragg3r]

Hey Doc, I have a quick question for you...

Do Nootropics, like Piracetam, have any side effects when using DMT? Or are there any interactions between them at all?

With LSD there was no noticable difference. It had no negative impact, nor did it specifically boost the trip. But tryptamines are a different story, I presume...

[DoctorX]

I received my order from FlatBushZombies , 2 real big Mandrax pills I've been over 6 years in a methadone program and now i was slightly fearful of interactions Can anyone help me with the dosage or other tips

PLEASE HELP ME in this situation !!!

thanks

Methaqualone has depressant effects on Central Nervous System, so it can enhance some methadone effects and, if used in combination, methaqualone dosage should be significantly lower to avoid problems

how high the dosage should be? thanks doctor + karma for your help

Methadone interactions can be important. I do not recommend this combination but, if you are going to try it, I would start by half a dosage of methaqualone

[DoctorX]

Hey Doc, I have a quick question for you...

Do Nootropics, like Piracetam, have any side effects when using DMT? Or are there any interactions between them at all?

With LSD there was no noticable difference. It had no negative impact, nor did it specifically boost the trip. But tryptamines are a different story, I presume...

There are no interactions described between piracetam and tryptamines (as DMT) or tryptamine derivatives (as LSD). In fact the efficacy of piracetam in real life situations is questionable, but interactions are not expected.

[palmergbl]

Hello Doctor X,

I have been wondering is there any harm reduction advice about taking stimulants and physical exercise?

I am asking especially if after a weekend drug taking – stimulants like MDMA, MDA or especially mephedrone since it feels to be most burdening for cardiovascular system – does one have to cut down on physical exercise he regularly does during week ? Is that its better to stop with or limit the exercise and wait for the heart and cardio system to get back to norm after it has been “overstimulated” during the drug intake ?

I am asking because I sometimes have a feeling that after snorting mephedrone especially (2-3 days after that) I get tired faster, have short breath faster etc… I generally feel that I had been pushing too hard for my cardio system while abusing.

[DoctorX]

This could be important depending on your age, pattern of use, kind of substance, physical condition and additional cardiovascular risk factors. I think these all factors should be analyzed in this case. Probably, if your heart rate is over 90 and/or blood pressure over 140/90 in basal conditions, you should not train.

[palmergbl]

Thank you very much for your answer Doc!

[Apple7]

Hi Doc,

What would the consequence of using MDMA and Cocaine in the same night be?

[SensiJackSilver]

Greetings doc,

Are there any drug interactions between cannabis and the antidepressant Mirtazapine? I can't find a definitive answer on the clearnet.

Also, have you got a view on cannabis and mental health? Especially in terms of someone with mild anxiety and mild depression. 

[RedSky]

Hey doc,

How to I dost speed paste? I've never actually tried this stuff before. I tend to be a high tolerance person. How should I take it?

Thanks

[TwistedNine]

hey doc, me again,

ive been switched to wellbutrin (buPROPion) recently and was wondering of the effects of mixing it with marijuana? im getting mixed answers from google. also, what about smoking DMT on it? (i feel i already know the answer to this last question since its a psychedelic)

[DoctorX]

Hi Doc,

What would the consequence of using MDMA and Cocaine in the same night be?

The consequences would depend in many factors: timing, total dosage, frequence and personal and environmental factors. In general a variable degree of hyperstimulation could be expected. For most people this is not a pleasant combination, as cocaine reduces empathic effects of MDMA. But it also a matter of personal taste...high dosages of both substances make unpleasant effects (tachicardia, hypertension, anxiety...) more likely

[sledgehammer]

Hi Doc,

What would the consequence of using MDMA and Cocaine in the same night be?

The consequences would depend in many factors: timing, total dosage, frequence and personal and environmental factors. In general a variable degree of hyperstimulation could be expected. For most people this is not a pleasant combination, as cocaine reduces empathic effects of MDMA. But it also a matter of personal taste...high dosages of both substances make unpleasant effects (tachicardia, hypertension, anxiety...) more likely

Great Work DoctorX

[DoctorX]

Greetings doc,

Are there any drug interactions between cannabis and the antidepressant Mirtazapine? I can't find a definitive answer on the clearnet.

Also, have you got a view on cannabis and mental health? Especially in terms of someone with mild anxiety and mild depression.

There are not known pharmacological interactions between mirtazapine and cannabis. Anyway, if you are suffering from mental health problems, cannabis could trigger anxiety attacks.
In relation with cannabis and mental health, please review or search in this thread or SR1 forum DoctorX thread, this issue has been covered before:
http://web.archive.org/web/20131015051405/https://dkn255hz262ypmii.onion/index.php?topic=147607.0

[greenehorn]

Hi Doc,

I'm considering taking human growth hormone (i think hypertropin) or testosterone ethanate to help me with the gym. I'm not sure about dosage or cycles or anything like that and there seems to be a lot of contradictory advice on forums. For T.E. some say 400mg a month, some say 500mg a week! Could you offer any advice on how to safely use these drugs?

Love herewith

[TheChain]

Greetings doc,

Are there any drug interactions between cannabis and the antidepressant Mirtazapine? I can't find a definitive answer on the clearnet.

Also, have you got a view on cannabis and mental health? Especially in terms of someone with mild anxiety and mild depression.

It's bad because you will eat all your food and then die of cardiovascular disease... Death by super munchies

[Whiteball]

Greetings doc,

Are there any drug interactions between cannabis and the antidepressant Mirtazapine? I can't find a definitive answer on the clearnet.

Also, have you got a view on cannabis and mental health? Especially in terms of someone with mild anxiety and mild depression.

Precisely the reason I'm interested in high CBD/low THC strains. I can tolerate high THC providing they are not super strong edibles, but low CBD is good for anxiety or a decrease in the risk of suffering a panic attack while tripping. A vendor was thinking of sourcing seeds if I remember correctly to grow them. I haven't checked the thread in a while.

[SensiJackSilver]

Greetings doc,

Are there any drug interactions between cannabis and the antidepressant Mirtazapine? I can't find a definitive answer on the clearnet.

Also, have you got a view on cannabis and mental health? Especially in terms of someone with mild anxiety and mild depression.

There are not known pharmacological interactions between mirtazapine and cannabis. Anyway, if you are suffering from mental health problems, cannabis could trigger anxiety attacks.
In relation with cannabis and mental health, please review or search in this thread or SR1 forum DoctorX thread, this issue has been covered before:
http://web.archive.org/web/20131015051405/https://dkn255hz262ypmii.onion/index.php?topic=147607.0

Thanks Doc, much appreciated.

[rankings]

Hello Doctor X,

I have a friend that will be undergoing general anesthesia in a week for a procedure.  They were wondering if taking a single dose of 130mg MDMA (it's been tested) in a couple of days would have any adverse effects on them in regards to the anesthesia.  I would rather them be safe than sorry so any information would be helpful.  Thank you!

[DoctorX]

Hi Doc,

I'm considering taking human growth hormone (i think hypertropin) or testosterone ethanate to help me with the gym. I'm not sure about dosage or cycles or anything like that and there seems to be a lot of contradictory advice on forums. For T.E. some say 400mg a month, some say 500mg a week! Could you offer any advice on how to safely use these drugs?

Love herewith

Yes, reliable information about steroids it is hard to find in the web. Information about recreational drugs oriented in harm reduction is available, but this is not true for steroids. You will find the classic anti-drug hysteric information ("you will get bold, impotent and violent if you touch steroids") but, on the other side, some forums recommend patterns of use that are objectively very dangerous.
In general, testosterone enanthate is much safer, cheaper and less adulterated than hGH. Potential adverse effects, if properly used, are lesser also.
I have some general information about responsible user of steroids in my web. Unfortunately it is only available in Spanish, I don´t know if authomatic translators work...
http://doctorcaudevilla.com/index.php/las-sustancias/92-uso-responsable-de-esteroides-anabolizantes
According to clinical trials, dosages between 200-400 mg/week/6-8 weeks provide a reasonable relation between positive and adverse effects.
http://www.ncbi.nlm.nih.gov/pubmed/8774299
http://www.ncbi.nlm.nih.gov/pubmed/22396515
http://www.ncbi.nlm.nih.gov/pubmed/18795988
http://www.ncbi.nlm.nih.gov/pubmed/17530941
 

[DoctorX]

Hey doc,

How to I dost speed paste? I've never actually tried this stuff before. I tend to be a high tolerance person. How should I take it?

Thanks

The main problem with speed is purity. Active dosage of pure intranasal amphetamine should be around 10-20 mg, but in general speed paste purity is 10-15%, although in some samples purity is 2% or 80%.
I strongly recommend using International Drug Testing Service from Energy Control: http://silkroad5v7dywlc.onion/index.php?topic=36015.0
Anyway it is important to evaporate speed paste, as it sometimes contain toxic solvents. You can dry it just putting in a plate and waiting several hours, until it is completely dry.

[DoctorX]

hey doc, me again,

ive been switched to wellbutrin (buPROPion) recently and was wondering of the effects of mixing it with marijuana? im getting mixed answers from google. also, what about smoking DMT on it? (i feel i already know the answer to this last question since its a psychedelic)

There are not known pharmacological interactions between bupropion and DMT or cannabis. It is possible that bupropion will diminish some of the DMT psychedelic properties. Anyway, if you are suffering from mental health problems, cannabis could trigger anxiety attacks.

[DoctorX]

Hello Doctor X,

I have a friend that will be undergoing general anesthesia in a week for a procedure.  They were wondering if taking a single dose of 130mg MDMA (it's been tested) in a couple of days would have any adverse effects on them in regards to the anesthesia.  I would rather them be safe than sorry so any information would be helpful.  Thank you!

It is unlikely that taking MDMA 48 hours before anaesthesia can produce severe, life threatening effects. But psychological negative after effects of MDMA tipically appears 48 hours after using it, and a surgical intervention is not, in general, a pleasant experience. I would recommend waiting for a better moment

[Aphos]

Evening DoctorX, I'm concerned about how certain drugs could have a long term effect on my psychological state. I've been a heavy pot user for about a year now, just quiting two weeks ago. I've tried LSD twice, and I've been on and off vicodin for about two months. For some time now, I've been struggling with really strange mental problems, which are difficult to describe but I'll put it like this: they feels like anxiety attacks, but I have no idea what I'm anxious about. I can tell myself over and over that everything is fine and nothing is wrong, but I still feel odd. It feels somewhat depressing, and whenever these problems occur I get suicidal thoughts, thinking if I off myself I won't have to deal with the problem anymore. I'm not insane, and I feel fine when I'm around other people. I'm still a perfectly rational person as far as I'm concerned. I'm not sure if these problems could be from a difficult LSD trip, heavy pot use, or the vicodin. (The vicodin was for an operation I had, I wasn't using it recreationally.) I've just been feeling really disinterested in life I suppose. I don't want an antidepressant as I'm aware that suicide rates for people who use them are higher than for those who don't.

I'm running out of people to ask. I greatly appreciate your time and any help you can provide. Thanks much.

-EDIT-

Also wanted to ask if it would be a good or really dumb idea to use LSD to try to figure out what's wrong with me, as I've heard some people having success from that.

[TwistedNine]

cool thanks. ive searched the internet far and wide for an answer and never found one. thanks for keeping us safe

[freakshow102]

Hello DoctorX imma keep it short and clear. I love stimualants speed to be precise ( usually metamphetamine but sometimes I find a cheap guy for dexedrines and adderall rare though), I was always an athelete and adrenaline was unconciously something I chased while playing basketball throughout numerous years of highschool and a bit of primary. I love speed and I did do alot , Id like to know if there is a risk of long term amphetamine/methamphetamine use? I know my heart rate is not that high I can handle alot , but I want to know if there is any long term tissue damage that would make it easier for me to be hit by heart attack , my heart is weaker then before Thats for sure , I never realized I was breathing hard I just breathed beacuse I was always running and sprinting and huffing , now im in the complete opposite , always sitting down on the computer doing numerous useless entertaining activies . I wanted to know if its important to excersie after doing speed(meth/amph) for some reason now I have an anxiety that while im running I will suddenly have a heart attack beacuse I cant control my heart beat , but I know its normal for it to beat that fast while im jogging but I still feel anxiety , this usually happens whenever I touch speed or any stimulant the same week . I Feel GREAT after im done jogging as im exhausted as shit , but I would like to also know if jogging is good for the heart of a stimulant user , im not sure if im a heavy user I dont go on binges anymore I eat everyday and can sleep just fine (I always sleep at least 7-8 hours) if I havnt done any in the 3 hours . Let me know if theres anything I should worry about doctorX , and also im very ignorant and long term physical amphetamine ''damage'' if there is any Id really love to know so please tell me , I hope someone else hasnt asked same questions lol I cant search posts for some reason on specific threads

[DoctorX]

Evening DoctorX, I'm concerned about how certain drugs could have a long term effect on my psychological state. I've been a heavy pot user for about a year now, just quiting two weeks ago. I've tried LSD twice, and I've been on and off vicodin for about two months. For some time now, I've been struggling with really strange mental problems, which are difficult to describe but I'll put it like this: they feels like anxiety attacks, but I have no idea what I'm anxious about. I can tell myself over and over that everything is fine and nothing is wrong, but I still feel odd. It feels somewhat depressing, and whenever these problems occur I get suicidal thoughts, thinking if I off myself I won't have to deal with the problem anymore. I'm not insane, and I feel fine when I'm around other people. I'm still a perfectly rational person as far as I'm concerned. I'm not sure if these problems could be from a difficult LSD trip, heavy pot use, or the vicodin. (The vicodin was for an operation I had, I wasn't using it recreationally.) I've just been feeling really disinterested in life I suppose. I don't want an antidepressant as I'm aware that suicide rates for people who use them are higher than for those who don't.

I'm running out of people to ask. I greatly appreciate your time and any help you can provide. Thanks much.

-EDIT-

Also wanted to ask if it would be a good or really dumb idea to use LSD to try to figure out what's wrong with me, as I've heard some people having success from that.

I think it is unlikely that your problems are directly caused by use of drugs. It may exist some relation, but panic attacks or anxiety disorders (that´s what I understand from your message) are usually the addition of different causes. Both psychological and pharmacological treatments can be useful (better if combined). If an antidepressant is properly selected and managed with care, there is generally no problem with them and suicide risk.

I do not recommend using LSD for psychotherapeutic purposes without a very trained guide. It is true that the experience could help you, but it could also worsen the problems.

[DoctorX]

Hello DoctorX imma keep it short and clear. I love stimualants speed to be precise ( usually metamphetamine but sometimes I find a cheap guy for dexedrines and adderall rare though), I was always an athelete and adrenaline was unconciously something I chased while playing basketball throughout numerous years of highschool and a bit of primary. I love speed and I did do alot , Id like to know if there is a risk of long term amphetamine/methamphetamine use? I know my heart rate is not that high I can handle alot , but I want to know if there is any long term tissue damage that would make it easier for me to be hit by heart attack , my heart is weaker then before Thats for sure , I never realized I was breathing hard I just breathed beacuse I was always running and sprinting and huffing , now im in the complete opposite , always sitting down on the computer doing numerous useless entertaining activies . I wanted to know if its important to excersie after doing speed(meth/amph) for some reason now I have an anxiety that while im running I will suddenly have a heart attack beacuse I cant control my heart beat , but I know its normal for it to beat that fast while im jogging but I still feel anxiety , this usually happens whenever I touch speed or any stimulant the same week . I Feel GREAT after im done jogging as im exhausted as shit , but I would like to also know if jogging is good for the heart of a stimulant user , im not sure if im a heavy user I dont go on binges anymore I eat everyday and can sleep just fine (I always sleep at least 7-8 hours) if I havnt done any in the 3 hours . Let me know if theres anything I should worry about doctorX , and also im very ignorant and long term physical amphetamine ''damage'' if there is any Id really love to know so please tell me , I hope someone else hasnt asked same questions lol I cant search posts for some reason on specific threads

Amphetamine and methamphetamine can raise up blood pressure and heart rate. Intense exercise can do this also, so it does not seem a good combination, as it could increase the risk of cardiac problems.

Along with the desired effects there are also other results of the stimulation, such as: increased heart rate, respiratory rhythm, blood pressure, body heat; troubles sleeping, jaw tension and uncontrollable movement of muscles. High doses con induce convulsions. Other side-effects that may appear are: head ache, dry mouth, trouble urinating and achieving erection; and there’s a possibility of one experiencing psychotic breaks with a regular use of this substance. Long-time repeated use of methamphetamine can lead to dopaminergic toxicity, that would express as movement problems.

[sweety]

Hello!

I have read most of the responses to this and I don't think anyone has asked this specific question (I hope!), though there have been similar ones.

I am just wondering if there are any drugs that you would advise against using for someone with possible Bipolar Disorder? Or, maybe even drugs that might help alleviate some of the symptoms - if only temporarily.

I have not been properly diagnosed (waiting periods and referrals, so I haven't seen the new psychiatrist yet) but I have treatment-resistent depression (~5 years) and lately I feel strongly that it really is bipolar. I don't want to do anything to possibly make this situation worse but I am not sure if I can make it through this waiting period easily, and might need some help (why I am here at SR2).

I am female and early 20's, if this is relevent, currently on 300mg a day Efexor. I use cannabis sometimes but not too often, and other than that I don't really have much experience with drug use. I have a tendency for self-harm and I know that my drug use can influence this sometimes, so I want to know if I can find a balance between these things and if any drug can help me do this while I am waiting??

Thank you and sorry about the life story dump.

You are doing a good thing here.

[hippo]

Hi Doc,

Had a search around but couldnt find the answers i was looking for.
When taking MDMA i've noticed some of my friends always feel very nauseous. All of them have stopped taking it now as they say it just doesnt agree with them anymore. Some just feel sick, others are getting sick constantly for several hours. Some drink alcohol, others dont, so i dont think its alcohol related. The mdma is also clean and of high quality

I've read about special nausea drugs, which are prescribed to cancer patients, working for people who have this common problem with taking mdma, but acquiring these drugs seem a bit too far for the sake of wanting to be able to take mdma without being sick.

Maybe you can explain to me what it is that is causing some people to be sick and is there an easy or over the counter way of preventing this from happening?

Thanks!

[ZeroZeroZero]

Hi Doctor,

How long cocaine stays in my system (blood) ? Lets say after 0.5g of coke night session (snorting party) with some alcohol drinks.

Is it enough 7-8 days to get clean?

Medics will test/analyze my blood and urine. They will find a coke in it after 8 days or not?

Thank you. Best wishes.

[DoctorX]

I understand your situation. We do not know your diagnosis (maybe it is not so important, maybe it is just a "tag") but I think you are suffering.
Drugs are mind-altering substances. For most people this is not a problem, but maybe, for you, in this moment of your life, this is not adequate for you. Maybe for you it is more difficult to handle mind-altering substances, so I would not recommend you using them in general. If you have a tendence to self-harm, also, this could worsen the problem.
For some people, anti-inflammatory drugs are bad; I think in this moment, drugs, in general,are not adequate for you

Hello!

I have read most of the responses to this and I don't think anyone has asked this specific question (I hope!), though there have been similar ones.

I am just wondering if there are any drugs that you would advise against using for someone with possible Bipolar Disorder? Or, maybe even drugs that might help alleviate some of the symptoms - if only temporarily.

I have not been properly diagnosed (waiting periods and referrals, so I haven't seen the new psychiatrist yet) but I have treatment-resistent depression (~5 years) and lately I feel strongly that it really is bipolar. I don't want to do anything to possibly make this situation worse but I am not sure if I can make it through this waiting period easily, and might need some help (why I am here at SR2).

I am female and early 20's, if this is relevent, currently on 300mg a day Efexor. I use cannabis sometimes but not too often, and other than that I don't really have much experience with drug use. I have a tendency for self-harm and I know that my drug use can influence this sometimes, so I want to know if I can find a balance between these things and if any drug can help me do this while I am waiting??

Thank you and sorry about the life story dump.

You are doing a good thing here.

[DoctorX]

Feeling sick is a common, unpleasant adverse effect related to MDMA. This is related to serotoninergic receptors in stomach, and this is an effect inherent to the substance. As any other adverse effect, some people are more susceptible than others.
Taking MDMA with empty stomach works for some persons, for others a soft meal is better. In general, hard heavy meals make this symptom worse.
In general, alcohol combination worsens symptoms.
For some people, rectal administration is the best way to avoid this problems. It may seem funny or bizarre but, as far as I know, is one of the best ways to avoid feeling sick in sensitive persons.

Hi Doc,

Had a search around but couldnt find the answers i was looking for.
When taking MDMA i've noticed some of my friends always feel very nauseous. All of them have stopped taking it now as they say it just doesnt agree with them anymore. Some just feel sick, others are getting sick constantly for several hours. Some drink alcohol, others dont, so i dont think its alcohol related. The mdma is also clean and of high quality

I've read about special nausea drugs, which are prescribed to cancer patients, working for people who have this common problem with taking mdma, but acquiring these drugs seem a bit too far for the sake of wanting to be able to take mdma without being sick.

Maybe you can explain to me what it is that is causing some people to be sick and is there an easy or over the counter way of preventing this from happening?

Thanks!

[Apple7]

Hi doc,

So I took about 8-10mgs of xanax a couple weeks ago, and I'm worried that I'm currently going through I slight withdraw.

My question is: what are the beginning stages of xanax withdraw?

[DoctorX]

Hi Doctor,

How long cocaine stays in my system (blood) ? Lets say after 0.5g of coke night session (snorting party) with some alcohol drinks.

Is it enough 7-8 days to get clean?

Medics will test/analyze my blood and urine. They will find a coke in it after 8 days or not?

Thank you. Best wishes.

In case of cocaine, drug tests are normally performed in urine samples, although detection in blood is also possible. In general, cocaine can be detected 3-5 days after last use, depending on sensitivity of the method of detection. 7-8 days should be enough to get clean

[retardedcat]

Hey Doc!

I take 150mg Wellbutrin XR and 50mg Tresleen (Sertralin) every morning as treatment for depression.

My question: How many days ahead of an LSD trip do I have to stop taking these meds in order to experience decent effects?

[Oxytocin]

Hey Doc!

Is there any concern with taking MDMA if someone has a fractured bone and it is in a cast?

Cheers

[DoctorX]

Hi doc,

So I took about 8-10mgs of xanax a couple weeks ago, and I'm worried that I'm currently going through I slight withdraw.

My question is: what are the beginning stages of xanax withdraw?

Sleep disturbance, irritability, increased tension and anxiety, panic attacks, hand tremor, sweating, difficulty with concentration are common symptoms of benzodiacepines withdrawal. 2 weeks is not time enough to develop a total dependence, but there could be some symptoms. Tappering down during a few days will make it easier.

[DoctorX]

Hey Doc!

I take 150mg Wellbutrin XR and 50mg Tresleen (Sertralin) every morning as treatment for depression.

My question: How many days ahead of an LSD trip do I have to stop taking these meds in order to experience decent effects?

Effects of SSRIs are not immediate, it should be necessary 10-14 days to be completely clean. Anyway, I do not recommend stop taking your pills to use LSD. I think it should be better to wait to another moment

[DoctorX]

Hey Doc!

Is there any concern with taking MDMA if someone has a fractured bone and it is in a cast?

Cheers

In general there is no problem...but dancing with your cast can be uncomfortable 

[hitmann]

Hello. I have been a heavy cannabis user for the last 6-7 years, i am now been clean for 8 days, i train alot and have a healthy body, but now i have gotten a job and i need to pass a urine sample in 8 days, Is there anything i can use to get rid of this thc easier or do i have to wait ?, Wondering if i should take (Zydot Expellit) i was wondering what you mean about masking this urine sample.

[DoctorX]

Hello. I have been a heavy cannabis user for the last 6-7 years, i am now been clean for 8 days, i train alot and have a healthy body, but now i have gotten a job and i need to pass a urine sample in 8 days, Is there anything i can use to get rid of this thc easier or do i have to wait ?, Wondering if i should take (Zydot Expellit) i was wondering what you mean about masking this urine sample.

Cannabis elimination has a constant rate. Drinking too much water, urine cleaners or doing exercise are useless to mask urine sample. Diluting it with water does not work (density of urine is also tested in exams). The only way to mask the urine is change with other person's (if he or she does not use cannabis)

[blowmeplease]

Hey Doc!

Do you have any food supplement recommendation to reduce the bad effect of MDMA?

[DoctorX]

Hey Doc!

Do you have any food supplement recommendation to reduce the bad effect of MDMA?

As MDMA produces serotonin deplection, food rich in tryptophan (like peanuts, chocolate, banana...) is recommended by some people after taking MDMA. The basis of this is more theoretical than scientific, but at least is harmless

[haydenp]

Is it possible to get physical withdrawals from having a 2 glasses of wine (11-12%) every nite for over 18 months?

[EnigmaFish]

What is the Tolerance on LSD? How long should I go in between trips to get a full effect again?

Thanks doc <3

[DoctorX]

Is it possible to get physical withdrawals from having a 2 glasses of wine (11-12%) every nite for over 18 months?

In a technique, strict way, daily intake of 2 glasses of wine is equivalent to 2-3 units of alcohol (http://en.wikipedia.org/wiki/Unit_of_alcohol) Daily intake below 4 units of alcohol in men, and below 2 units in women is considered "low risk".

But these are theoretical considerations. Most people will not develop physical withdrawals from this pattern of use but there are also  psychological, behavioural, social and motivational aspects. It is also difficult to distinguish between "physical" and "psychological" symptoms of withdrawal. For most people quitting 2 glass of wine in the night should not be difficult, but for other people it can be more or less hard. Anyway, it is not an excessive quantity

[DoctorX]

What is the Tolerance on LSD? How long should I go in between trips to get a full effect again?

Thanks doc <3

LSD develops tolerance very quickly. It also dissapears quickly after daily administration. It is necessary a minimum of 5-7 days to get full effect. This does not mean that weekly use of LSD is recommended.

In this link of Google Books (pages 83-84) there is detailed information about tolerance in humans

http://books.google.es/books?id=KTyC-e7NmI8C&pg=PA82&lpg=PA82&dq=acute+tolerance+lsd&source=bl&ots=GufaJAFZLl&sig=Ax__eJTqT1OiWENTi-PIIw9v2YU&hl=es&sa=X&ei=cWyYU76sL9HY0QXoz4C4CA&ved=0CE0Q6AEwBA#v=onepage&q=acute%20tolerance%20lsd&f=false

[EnigmaFish]

Thanks, that was an interesting read.

How bad is it to roll on MDMA/bk-mdma once a week for 2 or 3 weeks? I know you are supposed to wait at least a month+.
Would you know which of mdma or bk-mdma is "safer"?

[add1ct]

What is a euphoria inducing and/or mood enhancing stimulant that has the least negative effect on sleep and is least likely to cause psychosis related problems?

I tried Provigil (modafinil) but it doesn't have much of a positive effect on me. Started out with 200mg with breakfast, didn't feel anything, 2 hours later another 200mg, then the energy kicked in around 3 hours later, felt pretty good for around an hour, then started making my stomach feel uncomfortable with general restlessness and tiredness

[DoctorX]

Thanks, that was an interesting read.

How bad is it to roll on MDMA/bk-mdma once a week for 2 or 3 weeks? I know you are supposed to wait at least a month+.
Would you know which of mdma or bk-mdma is "safer"?

MDMA is much safer than bk-MDMA. MDMA has been known for over a century, there are enough data to know its effects, risks and possible problems. Research on bk-MDMA is much lesser and its risks are potentially unknown. Structural differences of these two compounds is little but, in chemistry, a simple change of an atom can mean different properties and risks.
Recommendations on MDMA spacing are general. In general 3 months is better than 1, 1 month better than 2 weeks. But is a general recommendation and not a rule

[cleansober]

It is also difficult to distinguish between "physical" and "psychological" symptoms of withdrawal.

Doctor Caudevilla,

Disregarding the negative effects of smoking, would you say daily recreational cannabis use is harmless, as many legalization advocates contend, or do you think it can 'cause' more problems than suggested by some of its enthusiastic backers and users?
 

cs

[AJ4CKS]

I just made a thread (http://silkroad5v7dywlc.onion/index.php?topic=43572.msg786896#msg786896) but I think it's better to post here:

"Hey all, I'm alergic to Sulphar (in some medications) - and, I read a synthesis guide for cocaine I found on Tor and it said it could be made with either sulfuric acid or hydrochloric acid.

I don't know the difference between base/paste/flake (never heard of paste) however sulfuric acid or hydrochloric acid is only used when its converted from base to paste (what do you snort?)

I don't die from it immedietly, just a really shitty reaction where I get red and bumpy, and my esophagus ends up closing (enough time to rush to a hospital though).

Can anyone advise? Thanks. "

[bmaddd51]

Hey DoctorX! I have a question regarding MDMA and LSD use while on Nolvadex.

I've searched high and low for any possible information regarding this subject on both the clearnet and SR Forum and I really can't find much. I'm coming up on my 3rd week into Post Cycle Therapy (25mg Nolvadex daily) and next weekend I will be attending a music festival with friends. Due to a miscalculation with timing my cycle start date (Intra Muscular Testosterone-Enanthate 500mg/wk for 12 weeks) I didn't realize this festival would be cutting into my PCT time.

My question is- If I roll while taking Nolvadex, what are the potential issues? My concern is that both drugs are metabolized by cyp2d6. I'm preloading liver supplements just in case (Milk Thistle, Saw Palmetto, ALA, and Phytosterols) will that be enough? Will I still be able to roll? What is the potential damage?

Thank you!!!

[DoctorX]

It is also difficult to distinguish between "physical" and "psychological" symptoms of withdrawal.

Doctor Caudevilla,

Disregarding the negative effects of smoking, would you say daily recreational cannabis use is harmless, as many legalization advocates contend, or do you think it can 'cause' more problems than suggested by some of its enthusiastic backers and users?
 

cs

Cannabis has its own problems, as any other legal or illegal drug. Daily cannabis use can lead to short time memory problems, respiratory problems (related to smoked way of administration) and mental health problems (not in general population, but may trigger anxiety or other problems in predisposed persons). Legalization is not a question of health. Illegal drugs are not illegal because of health problems and legal drugs cause much more problems than illegal

[DoctorX]

I just made a thread (http://silkroad5v7dywlc.onion/index.php?topic=43572.msg786896#msg786896) but I think it's better to post here:

"Hey all, I'm alergic to Sulphar (in some medications) - and, I read a synthesis guide for cocaine I found on Tor and it said it could be made with either sulfuric acid or hydrochloric acid.

I don't know the difference between base/paste/flake (never heard of paste) however sulfuric acid or hydrochloric acid is only used when its converted from base to paste (what do you snort?)

I don't die from it immedietly, just a really shitty reaction where I get red and bumpy, and my esophagus ends up closing (enough time to rush to a hospital though).

Can anyone advise? Thanks. "

Clorhidrate of cocaine is the most common salt for cocaine. Sulphated compounds in cocaine are rare, but possible. The only way to be sure about the composition of a drug is submitting a sample to a Drug Testing Service, as Energy Control:
http://energycontrol.org/noticias/528-international.html

[DoctorX]

Hey DoctorX! I have a question regarding MDMA and LSD use while on Nolvadex.

I've searched high and low for any possible information regarding this subject on both the clearnet and SR Forum and I really can't find much. I'm coming up on my 3rd week into Post Cycle Therapy (25mg Nolvadex daily) and next weekend I will be attending a music festival with friends. Due to a miscalculation with timing my cycle start date (Intra Muscular Testosterone-Enanthate 500mg/wk for 12 weeks) I didn't realize this festival would be cutting into my PCT time.

My question is- If I roll while taking Nolvadex, what are the potential issues? My concern is that both drugs are metabolized by cyp2d6. I'm preloading liver supplements just in case (Milk Thistle, Saw Palmetto, ALA, and Phytosterols) will that be enough? Will I still be able to roll? What is the potential damage?

Thank you!!!

There are not known interactions between LSD and MDMA and tamoxifen. According to mechanisms of action, severe interactions are unlikely. I can´t say that the combination is harmless but there are no data to suspect severe problems.

[bmaddd51]

Thank you so much! I feel much better about next weekend. You're the best!!!

+1

[QKarunika]

I wanted to ask about damage caused by synthetic cannabinoids but I see you admit little knowledge so I'll share my experiences and hypotheses, since I see others here have also been injured by these new chemicals.

Subject bought some to sell, but ended up smoking it all himself. 20g AM-2201 and 10g UR-144 in a 6-month period. Subject probably inhaled generous amounts of acetone during this time as well (dipping cigarettes).

Subject said he felt as if the synthetic cannabinoids were re-crystallising after entering the lungs. The hypothesis is that, these tiny crystals were cutting the sensitive heart and kidney tissue, leaving scars from the micro-abrasions.

Subject reported a reduced sensitivity to harmaloids several months after quitting, indicating some changes to the serotonin receptor system.

One year after quitting, subject is still experiencing heart and kidney pains. Subject just started treatment with serrapeptase enzyme to heal the scar tissue. (Serrapeptase up to 1g per day, bought from a wholesaler @$250/kg (2500 IU/mg) rather than a brand-name capsulated product which generally cost between $3000-36000 per kilogram). Also DMSO. He will start taking MSM and liposomal vitamin C as soon as he can acquire it in bulk. And general dietary improvements, gradually moving toward a organic high-plant paleo diet (without any factory meat).

I'll let you know the results after a few months.

[DoctorX]

There is very little knowledge about risks and damages of synthetic cannabinoids. Most of these substances have never been tested in humans and users are really behaving as "guinea pigs". "Natural" cannabis is much safer than any of these substances

I wanted to ask about damage caused by synthetic cannabinoids but I see you admit little knowledge so I'll share my experiences and hypotheses, since I see others here have also been injured by these new chemicals.

Subject bought some to sell, but ended up smoking it all himself. 20g AM-2201 and 10g UR-144 in a 6-month period. Subject probably inhaled generous amounts of acetone during this time as well (dipping cigarettes).

Subject said he felt as if the synthetic cannabinoids were re-crystallising after entering the lungs. The hypothesis is that, these tiny crystals were cutting the sensitive heart and kidney tissue, leaving scars from the micro-abrasions.

Subject reported a reduced sensitivity to harmaloids several months after quitting, indicating some changes to the serotonin receptor system.

One year after quitting, subject is still experiencing heart and kidney pains. Subject just started treatment with serrapeptase enzyme to heal the scar tissue. (Serrapeptase up to 1g per day, bought from a wholesaler @$250/kg (2500 IU/mg) rather than a brand-name capsulated product which generally cost between $3000-36000 per kilogram). Also DMSO. He will start taking MSM and liposomal vitamin C as soon as he can acquire it in bulk. And general dietary improvements, gradually moving toward a organic high-plant paleo diet (without any factory meat).

I'll let you know the results after a few months.

[cleansober]

Dr. Fernando,

Do legal restrictions on cannabis prevent comprehensive scientific research from being done?  With nearly all governments against it, does this bias the funding of studies to make conclusions more likely to agree it should stay illegal? 


CS,

I believe your perfect record is at stake with reply #540.

[XCCDF]

Do Liver Pills really help your liver? Is there a such thing as a liver pill that works (herbal from stores such as GNC).

Thanks!

[DoctorX]

Dr. Fernando,

Do legal restrictions on cannabis prevent comprehensive scientific research from being done?  With nearly all governments against it, does this bias the funding of studies to make conclusions more likely to agree it should stay illegal? 


CS,

I believe your perfect record is at stake with reply #540.

Yes...that is how it exactly works...

[cleansober]

DoctorX,

Much more is known about traditional cannabis than the new synthetics. How much more needs to be known, and how many more studies need to be done, before judgement on the benefits or dangers of cannabis can be made? Until scientists and health professionals agree, as they seem to have with tobacco smoking and acetylsalicylic acid, are all drug users 'guinea pigs' in a grand chaotic unsupervised, but highly regulated, world wide drug experiment? Then again, low dose aspirin usage, despite many years of unhindered research, has yet to be "proven" beneficial. 

CS

[pixielover]

Doctor,

Thanks so much for this service!

I asked this question over in the cocaine forum and got some great feedback, thought I'd kick it in here for a medical perspective.

I'm new to cocaine use in my mid-50s but my love and I love it's effect during long, wonderful romantic sessions.

I find though that I need a fairly heavy administration of cocaine over an hour and  half or so before I can start to feel much besides annoying jittery feelings.

After an hour and a half of say 100-120mg every half hour then I can settle into 30mg every 45 minutes or so and feel phenomenal.

I worry about that initial high usage ... is there some biochemical reason some of us seem to get less from the low doses?

[eskibon]

Can I replace ghb instead of alcohol ?

[DoctorX]

Do Liver Pills really help your liver? Is there a such thing as a liver pill that works (herbal from stores such as GNC).

Thanks!

Most "liver pills" are useless. In medicine, there are almost no real situation in which these kind of drugs are used and their effectiveness is not proven. Most of them are based in "in vitro" or animal studies and they have not shown therapeutic properties in humans.

[cleansober]

DoctorX; You are not allowed to read this post, sorry.


Recommended for some, but optional for others, reading follows: no one under 21 should read this, if you are under 21 and made it here, congratulations but realize that many vendors will refuse to sell you drugs , they are very strict about this.  Also all you drug fans out there who are, like me, too lazy or too stupid to learn PGP understand this, only about 3/4 of the vendors will allow you to purchase something from them. I tread lightly on this subject as I believe PGP fluent followers are very likely to neg me when I voice my opinions on it.  So again, if you don't use PGP you are either stupid, lazy or both.


Dear Pixielover,

How big are you? By that I mean your height and weight, not the other thing. Curious what your take away from the other forum was. My personal decision is to stay away from anything with known addictive properties given  the trouble I have with self-control and deferred gratification. When I did the marshmallow test, I snorted the marshmallows before the tester left the room.  Apparently you have no such issue given your signature, "Judicious travel, wild control...", good one.  I'm practicing the wild part now. If I just gave up the caffine maybe my posts here would be less helter skelter willy nilly and much better.  On second thought "judicious travel" implies control, not necessarily "wild" but being judicious means being as controlled as required.

c

[egout]

Dr Fernando,
Thank you very much for this service, you are a hero. I'm being treated with Isotretinoin and I use multiple drugs as 2C-B, shrooms, weed, MXE, LSD, MDMA, 4-AcO-DMT, 6-APB, 4-FA which of these can I continue using? which ones should I avoid? Thanks in advance Doctor-

[stranger]

hi DoctorX,

i have some questions about some combinations:

1. is it good to use modafinil when using other stimulants (from MDMA to amphetamines)? i use it with depressants (GBL, alcohol) and it works perfectly, but i am not sure if using them with other stimulants does not put too much stress on the brain (i use a lot of antioxidants before, during and after every session with stimultants)

2. i heard that some people use sildenafil/tadalfil to reduce vasoconstriction that some stimulants induce - do you think it is a good idea? also, since alcohol also is a vasodilator would it be good to use a little alcohol to ease vasoconstriction? (i prefer to use GBL over alcohol since it has less side effects but if this vasodilatation would be worth it i could use it instead)

3. would sildenafil/tadalfil lower blood pressure after stims?

4. how long would it be best to wait after using different kind of drugs (mdma, amphetamines, opioids, weed etc.) to donate blood? i am talking about sporadic (once every week or two) use, not chronic. is waiting until drug test would turn out to be negative enough time or there are other guidelines? or is there any other time you would recommend, like 1 month/five years/never (of course i am talking about drugs taken only orally, smoked or sniffed, without any needles)

5. good option for person with diabetes to use GHB/GBL? searching on clearnet makes me think yes based on other people reports but just wanted to make sure there is no theoretical reason to worry

thanks again and i sent some coins your way again for your help!

[DoctorX]

Doctor,

Thanks so much for this service!

I asked this question over in the cocaine forum and got some great feedback, thought I'd kick it in here for a medical perspective.

I'm new to cocaine use in my mid-50s but my love and I love it's effect during long, wonderful romantic sessions.

I find though that I need a fairly heavy administration of cocaine over an hour and  half or so before I can start to feel much besides annoying jittery feelings.

After an hour and a half of say 100-120mg every half hour then I can settle into 30mg every 45 minutes or so and feel phenomenal.

I worry about that initial high usage ... is there some biochemical reason some of us seem to get less from the low doses?

Pharmacollogically, half-life of cocaine is shorter than other drugs. Effects appear and dissappear during the first hour, and it is necessary to redose to obtain effects. 100-120 mg is considered a high dosage and could lead to problems more easily than using lower dosages. Anyway, there are too many factors (tolerance, age, concurrence of other cardiovascular risk factors, context of use, experiences...) that can modify the dosage. Accumulation in the body of dosages and other neurochemical factors can explain the fact that you get less from the low dosages

[DoctorX]

Can I replace ghb instead of alcohol ?

GHB and alcohol are relatively similar in effects and risks. Both can lead to dependence with daily use and both can be very toxic in overdose. Alcohol is easier to handle for most people and accidents on overdose are less common. On the other hand, GHB is probably less toxic for liver and brain than alcohol. You can replace GHB instead of alcohol, but it is always important to take precautions

[DoctorX]

Dr Fernando,
Thank you very much for this service, you are a hero. I'm being treated with Isotretinoin and I use multiple drugs as 2C-B, shrooms, weed, MXE, LSD, MDMA, 4-AcO-DMT, 6-APB, 4-FA which of these can I continue using? which ones should I avoid? Thanks in advance Doctor-

You should avoid any drug with potential to harm liver or modify hepatic blood tests. From your list, 2C-B, shrooms, weed, LSD and 4-AcO-DMT are probably safe, although, as far as I know there are not clinical trials to say that combination is "absolutely" safe

[QKarunika]

Dr.X,

How about megadosing vitamin C to combat the side effects of drugs? Shouldn't all drug users be taking lots of vitamin C and vitamin B complex to counteract the depletion caused by recreational drugs? (not to mention all the pollution these days)

They say each tobacco cigarrette depletes 25mg of vitamin C from the system. They also say that megadoses of vitamin C can cure even hepatitis and antidote drug ODs, snake venom, radiation, etc.

"-40 grams ascorbic acid by vein and 1000 mg to 2000 mg vitamin B1 intramuscularly will neutralize the person intoxicated by alcohol."

"-For acute alcoholism Dr. Klenner has given 1000 mg of thiamin intramuscularly every two hours until recovery. Pyridoxine, 500 mg is given every six hours. 40 grams of C intravenously will detoxify the patient."

 -http://www.terrapapers.com/?p=39961

(Most 160 lb mammals produce 10-20g of vitamin C daily, and even more during times of stress or illness. Higher primates lost the enzyme 25 million years ago due to a viral mutation.)

[richie]

Hello Dr X

I was wondering if i could get some advice, I first brought half a  gram of methamphetamine from a vendor on Agora (Mini-Deal) about 2weeks ago give or take, i smoked it like i normally would and although nothing really stood out while i was smoking it i remember feeling rougher than i normally would, (i don't use it everyday i may smoke half a gram every 10-14 days roughly) at the time i thought nothing of it but it may have altered my behavior and made me react totally out of character and in a manor unlike me (i will come back to this in a moment).

I placed 2 new orders for a total of a gram, they where planed to arrive a few days apart however it turns out the vendor had not posted them as he should have done and they turned up a day apart. After smoking the first half i started to feel like shit, my nose is sore and scabby, my tongue is cut and bleeding, my lungs feel like they have the same residue that is caked inside of my nose on them and generally feel pretty rough, again im sitting here thinking about the past few days and about how i have handled a number of situations in a way im almost ashamed of, things i have said and taking actions that have no rhyme or reason.

So i took the half gram i have left and put it in to a lab beaker and using 50ml of acetone (previously dried so its water free) swirl it around with the meth and after a minute or so i carefully poor the acetone into an identical clean lab beaker leaving the meth behind as its not dissoluble in acetone. what is most shocking is the acetone has gone from clear to a bright pink color. After allowing the meth to dry it now tastes and feels clean and like the effect i would expect, before the wash it was very rushy and in your face and im sure it has effected my judgement a few weeks ago and over the last few days. im allowing the pink tone to evaporate so i can try and test the powder that is left over.

This is a really irresponsible thing to do with a product that is 9 times out of 10 smoked, the cut enters with the meth but cant leave your body in the same way, to say i feel rough is putting it lightly, even my windpipe feels like its got a coating...

Could this really effect my judgement in such a unpredictable way? It felt like i was doing the right thing in the moment only to realize my actions where so far from my normal self i find it hard to believe i did it!  like i say ive smoked meth on/off for 3yrs and not felt like i lost control of my judgement and acted like a prick like i have now on two separate occasions the only link is the meth!

What are you professional thoughts? i need to understand how it happened so i can stop it happening again in the future        

[cleansober]

DoctorX , optional reading material follows:


richie,

...how i have handled a number of situations in a way im almost ashamed of, things i have said and taking actions that have no rhyme or reason.

This quote I believe is a key problem with any drug use that changes rational perception.  Yesterday I was at a funeral.  The deceased had cancer and knew the situation was serious for some time.  He received the typical "he fought it bravely"  hero status at the service.  Before his death I saw him, after smoking weed, and made some seriously inappropriate comments about death.  In spite of my apologies and his forgiveness, I regret saying these things but I am sure these things would never have been said had I full control of my reasoning faculties. Preexisting stupidity set free while under the influence of cannabis.  For this reason I'm swearing off altered states until I become 100% certain I'm in full control of my sober actions and have no hidden flawed thinking waiting to unexpectedly surface.  Uncontrolled creative stupidness it might be called. Only then will I move into the realm of drug induced altered states.  In other words, not for a very long time, if ever.  Perhaps I'm overreacting but as another doctor told me while at the service, the unknown and unknowable effects of all drugs make avoidance of everything non essential the best and simplest policy for him.   Given my nom de plume these conclusion were all too predictable.  So much for my Sunday confession.

clean

If I could I'd neg myself for this post because I find this sort of "now I see the light" talk annoying.  This is only my conclusion, you all can come to your own point of equilibrium. 

[DoctorX]

hi DoctorX,

i have some questions about some combinations:

1. is it good to use modafinil when using other stimulants (from MDMA to amphetamines)? i use it with depressants (GBL, alcohol) and it works perfectly, but i am not sure if using them with other stimulants does not put too much stress on the brain (i use a lot of antioxidants before, during and after every session with stimultants)

2. i heard that some people use sildenafil/tadalfil to reduce vasoconstriction that some stimulants induce - do you think it is a good idea? also, since alcohol also is a vasodilator would it be good to use a little alcohol to ease vasoconstriction? (i prefer to use GBL over alcohol since it has less side effects but if this vasodilatation would be worth it i could use it instead)

3. would sildenafil/tadalfil lower blood pressure after stims?

4. how long would it be best to wait after using different kind of drugs (mdma, amphetamines, opioids, weed etc.) to donate blood? i am talking about sporadic (once every week or two) use, not chronic. is waiting until drug test would turn out to be negative enough time or there are other guidelines? or is there any other time you would recommend, like 1 month/five years/never (of course i am talking about drugs taken only orally, smoked or sniffed, without any needles)

5. good option for person with diabetes to use GHB/GBL? searching on clearnet makes me think yes based on other people reports but just wanted to make sure there is no theoretical reason to worry

thanks again and i sent some coins your way again for your help!

1.- Using modafinil in conjunction with stimulants can lead to increased adverse effects stimulant-related.
2.- Sildenafil/tadalafil are selective vasodilators. There is no evidence that they are useful to reduce vasoconstriction induced by drugs
3.- They may do it. But it is not possible to know the exact dosage necessary to lower blood pressure to normal levels. They may cause a "rebound effect" or adverse effects.
4.- 2-3 weeks seems a reasonable time
5.- On GHB, glucose levels remain stable, unlike alcohol.  From this limited perspective it could be an option for diabetics, although it is important to consider the risks and problems associated with GHB.

[stranger]

hi DoctorX,

many, many thanks for your answers!

i have some other questions:

1. beside modafinil what other drugs would you reccomend for chronic fatigue syndrome? i'm talking about something for everyday activities and to reduce sleepiness, not something with "recreational" qualities. modafinil helps a bit, but have some bad side effects when used longer (ultra dry mouth etc.) so i would like to find a replacement. i tried ritalin, but low doses seem to make me bit irritated, like too much coffee (and it's expensive!!). would oral amphetamine be safe? i don't want anything that would make you high, just something that would boost my energy through the day and not fry my brain.

i sometimes have good weeks when just coffee and a lot of sleep works, but sometimes have periods when i'm sleeping 12+ hours and would sleep more if not for work and other obligations. i use different kind of drugs (not only stims but psychedelics or downers as well) once a week or two for recreation and it doesn't seem to affect my alertness following days at all. when i don't do anything for three weeks or so i can still be tired, or i can have good weeks - there is no pattern.

i thought about atomoxetine - it is safe to try?

in my country there is no possibility to get proper prescription for tiredness as it is not recognized and there is huge stigma connected with any stimulants or controlled drugs.

i had mononucleosis sometime in the past and it seemed to have triggered this - before i would say had more energy than most of people i know, i could have days full of activities and learning and not be tired really, exact opposite of current situation.

2. when using stims i learned from clearnet sources that it is good to apply as much anti oxidants as possible - i use alpa lipoic acid, EGCG, melatonine and vitamine C, all in combination, in big amounts, as i read that they tend to act shortly, so one should take them every several hours and try to use many different kinds of antioxidants (since one kind is said to change oxidized form of the anti-oxidant to active again, thus increasing its efectiveness). is it safe and there is no risk of overdose or one shall limit intake of some type of anti oxidant? (most don't have RDA and on the labels it only says to not take more than one or two capsules per day).

many thanks again!

[DoctorX]

Megadoses of vitamin C are claimed by some alternative medicine doctors to have preventive or curative effects in many diseases. Nevertheless, there is no scientific evidence to support these ideas. Megadose recommendations for vitamin C are based mainly on theoretical speculation and observational studies but there are no large scale, formal clinical trials to support the idea of benefits using it.

A lack of vitamines can cause diseases but this does not mean that taking a lot you will get a health benefit. A car without fuel does not work, but filling the deposit above its limit won´t make it run faster (I hope you understand the simile, I don´t know how to explain it better in English)

http://www.quackwatch.com/01QuackeryRelatedTopics/pauling.html
http://www.ncbi.nlm.nih.gov/pubmed/384241?dopt=Abstract

Vitamin C and B are hydrosoluble and an excess is eliminated by kidney. It is unlikely that using megadoses of these vitamines will cause problems, but an excess of lipophilic vitamines (A, D, E, K) can be harmful.

Dr.X,

How about megadosing vitamin C to combat the side effects of drugs? Shouldn't all drug users be taking lots of vitamin C and vitamin B complex to counteract the depletion caused by recreational drugs? (not to mention all the pollution these days)

They say each tobacco cigarrette depletes 25mg of vitamin C from the system. They also say that megadoses of vitamin C can cure even hepatitis and antidote drug ODs, snake venom, radiation, etc.

"-40 grams ascorbic acid by vein and 1000 mg to 2000 mg vitamin B1 intramuscularly will neutralize the person intoxicated by alcohol."

"-For acute alcoholism Dr. Klenner has given 1000 mg of thiamin intramuscularly every two hours until recovery. Pyridoxine, 500 mg is given every six hours. 40 grams of C intravenously will detoxify the patient."

 -http://www.terrapapers.com/?p=39961

(Most 160 lb mammals produce 10-20g of vitamin C daily, and even more during times of stress or illness. Higher primates lost the enzyme 25 million years ago due to a viral mutation.)

[DoctorX]

Your problem can be caused by an idiosincratic reaction to meth, a different purity between drugs used or an adulteration with other substance. So the only advice I can offer in this kind of situations is submitting a sample to a center like the International Drug Testing Service of the Spanish NGO Energy Control

http://energycontrol.org/noticias/528-international.html
http://silkroad5v7dywlc.onion/index.php?topic=36015.0

They are offering a quick, reliable and affordable service to know exactly the composition and purity of drugs that are being sold in the Deep Web. Only with a drug test it is possible to know what has happened.

Hello Dr X

I was wondering if i could get some advice, I first brought half a  gram of methamphetamine from a vendor on Agora (Mini-Deal) about 2weeks ago give or take, i smoked it like i normally would and although nothing really stood out while i was smoking it i remember feeling rougher than i normally would, (i don't use it everyday i may smoke half a gram every 10-14 days roughly) at the time i thought nothing of it but it may have altered my behavior and made me react totally out of character and in a manor unlike me (i will come back to this in a moment).

I placed 2 new orders for a total of a gram, they where planed to arrive a few days apart however it turns out the vendor had not posted them as he should have done and they turned up a day apart. After smoking the first half i started to feel like shit, my nose is sore and scabby, my tongue is cut and bleeding, my lungs feel like they have the same residue that is caked inside of my nose on them and generally feel pretty rough, again im sitting here thinking about the past few days and about how i have handled a number of situations in a way im almost ashamed of, things i have said and taking actions that have no rhyme or reason.

So i took the half gram i have left and put it in to a lab beaker and using 50ml of acetone (previously dried so its water free) swirl it around with the meth and after a minute or so i carefully poor the acetone into an identical clean lab beaker leaving the meth behind as its not dissoluble in acetone. what is most shocking is the acetone has gone from clear to a bright pink color. After allowing the meth to dry it now tastes and feels clean and like the effect i would expect, before the wash it was very rushy and in your face and im sure it has effected my judgement a few weeks ago and over the last few days. im allowing the pink tone to evaporate so i can try and test the powder that is left over.

This is a really irresponsible thing to do with a product that is 9 times out of 10 smoked, the cut enters with the meth but cant leave your body in the same way, to say i feel rough is putting it lightly, even my windpipe feels like its got a coating...

Could this really effect my judgement in such a unpredictable way? It felt like i was doing the right thing in the moment only to realize my actions where so far from my normal self i find it hard to believe i did it!  like i say ive smoked meth on/off for 3yrs and not felt like i lost control of my judgement and acted like a prick like i have now on two separate occasions the only link is the meth!

What are you professional thoughts? i need to understand how it happened so i can stop it happening again in the future      

[DoctorX]

1.- First of all it should be important to be sure about your diagnosis. Many medical conditions can cause chronic fatigue and must be ruled out before a diagnosis of chronic fatigue syndrome can be given. Hypothyroidism, anemia, diabetes and certain psychiatric disorders are a few of the diseases that must be ruled out if the patient presents with these symptoms.

There is no evidence that stimulants are useful to treat chronic fatigue syndrome. Atomoxetine is used in hyperactive disorders but it does not have psychomotor stimulant properties as amphetamines or methylphenidate so, at least in theory, it should not be useful in chronic fatigue syndrom.

To the moment, cognitive behavioural therapy, graded exercise therapy and pacing are the most useful therapies for chronic fatigue syndrome.

2.- The answer is similar to the question about vitamine C megadoses (see above). Intoxication by overdose of melatonin or alpha lipoic acid are rare but possible.
http://www.ncbi.nlm.nih.gov/pubmed/23713820
http://www.ncbi.nlm.nih.gov/pubmed/9114843

hi DoctorX,

many, many thanks for your answers!

i have some other questions:

1. beside modafinil what other drugs would you reccomend for chronic fatigue syndrome? i'm talking about something for everyday activities and to reduce sleepiness, not something with "recreational" qualities. modafinil helps a bit, but have some bad side effects when used longer (ultra dry mouth etc.) so i would like to find a replacement. i tried ritalin, but low doses seem to make me bit irritated, like too much coffee (and it's expensive!!). would oral amphetamine be safe? i don't want anything that would make you high, just something that would boost my energy through the day and not fry my brain.

i sometimes have good weeks when just coffee and a lot of sleep works, but sometimes have periods when i'm sleeping 12+ hours and would sleep more if not for work and other obligations. i use different kind of drugs (not only stims but psychedelics or downers as well) once a week or two for recreation and it doesn't seem to affect my alertness following days at all. when i don't do anything for three weeks or so i can still be tired, or i can have good weeks - there is no pattern.

i thought about atomoxetine - it is safe to try?

in my country there is no possibility to get proper prescription for tiredness as it is not recognized and there is huge stigma connected with any stimulants or controlled drugs.

i had mononucleosis sometime in the past and it seemed to have triggered this - before i would say had more energy than most of people i know, i could have days full of activities and learning and not be tired really, exact opposite of current situation.

2. when using stims i learned from clearnet sources that it is good to apply as much anti oxidants as possible - i use alpa lipoic acid, EGCG, melatonine and vitamine C, all in combination, in big amounts, as i read that they tend to act shortly, so one should take them every several hours and try to use many different kinds of antioxidants (since one kind is said to change oxidized form of the anti-oxidant to active again, thus increasing its efectiveness). is it safe and there is no risk of overdose or one shall limit intake of some type of anti oxidant? (most don't have RDA and on the labels it only says to not take more than one or two capsules per day).

many thanks again!

[SpeedUp]

Hi doctor

I wonder, since MDMA and DOM(STP) or other acids, are both drugs that effect serotonin  receptors, if there's to wait some time between an assumption and another to feel properly the effects, also in the case i take DOM before and MDMA later, so it's not the same drug. in particular i would expect a week or two
I've to say it would be my first time for both the substances.

I know that it's not a common question in this thread (supposed to speak about health in using drugs) ahah but i didn't find anywhere an answer!
thank you very much 

[richie]

Your problem can be caused by an idiosincratic reaction to meth, a different purity between drugs used or an adulteration with other substance. So the only advice I can offer in this kind of situations is submitting a sample to a center like the International Drug Testing Service of the Spanish NGO Energy Control

http://energycontrol.org/noticias/528-international.html
http://silkroad5v7dywlc.onion/index.php?topic=36015.0

They are offering a quick, reliable and affordable service to know exactly the composition and purity of drugs that are being sold in the Deep Web. Only with a drug test it is possible to know what has happened.

Hello Dr X

I was wondering if i could get some advice, I first brought half a  gram of methamphetamine from a vendor on Agora (Mini-Deal) about 2weeks ago give or take, i smoked it like i normally would and although nothing really stood out while i was smoking it i remember feeling rougher than i normally would, (i don't use it everyday i may smoke half a gram every 10-14 days roughly) at the time i thought nothing of it but it may have altered my behavior and made me react totally out of character and in a manor unlike me (i will come back to this in a moment).

I placed 2 new orders for a total of a gram, they where planed to arrive a few days apart however it turns out the vendor had not posted them as he should have done and they turned up a day apart. After smoking the first half i started to feel like shit, my nose is sore and scabby, my tongue is cut and bleeding, my lungs feel like they have the same residue that is caked inside of my nose on them and generally feel pretty rough, again im sitting here thinking about the past few days and about how i have handled a number of situations in a way im almost ashamed of, things i have said and taking actions that have no rhyme or reason.

So i took the half gram i have left and put it in to a lab beaker and using 50ml of acetone (previously dried so its water free) swirl it around with the meth and after a minute or so i carefully poor the acetone into an identical clean lab beaker leaving the meth behind as its not dissoluble in acetone. what is most shocking is the acetone has gone from clear to a bright pink color. After allowing the meth to dry it now tastes and feels clean and like the effect i would expect, before the wash it was very rushy and in your face and im sure it has effected my judgement a few weeks ago and over the last few days. im allowing the pink tone to evaporate so i can try and test the powder that is left over.

This is a really irresponsible thing to do with a product that is 9 times out of 10 smoked, the cut enters with the meth but cant leave your body in the same way, to say i feel rough is putting it lightly, even my windpipe feels like its got a coating...

Could this really effect my judgement in such a unpredictable way? It felt like i was doing the right thing in the moment only to realize my actions where so far from my normal self i find it hard to believe i did it!  like i say ive smoked meth on/off for 3yrs and not felt like i lost control of my judgement and acted like a prick like i have now on two separate occasions the only link is the meth!

What are you professional thoughts? i need to understand how it happened so i can stop it happening again in the future      

Thanks for your reply, ive spent a lot of time thinking this over and i have come to the conclusion that i am better off not doing drugs! There was a period of time before this where i had done nothing for about 6weeks and the question i keep asking myself is "am i happier now or was i happier when i had nothing for weeks" and the answer? i was far happier being clean and life was starting to head in the right direction, i used again and everything changed! Although i thought i wanted it when i could not get it i was in a better place than i am now! i think i have found my own answers and cant send a sample as i flushed what was left away!

This is a very good service you offer here so keep up the good work!

[creditemaildust]

doctorx its been a really long time since ive read/visited this thread. 

question 1-is a 50/50 mix of l-glutamine and cocaine believed to be 80-84%pure safe?  if not what are some safe cuts that can be used. 

question 2-how long should the "high" of cocaine last for 80-85% purity.  the 50/50 cut leaves people wanting to redose every 30minutes.

thanks

[DoctorX]

As you say, 1-2 weeks seems a reasonable period

Hi doctor

I wonder, since MDMA and DOM(STP) or other acids, are both drugs that effect serotonin  receptors, if there's to wait some time between an assumption and another to feel properly the effects, also in the case i take DOM before and MDMA later, so it's not the same drug. in particular i would expect a week or two
I've to say it would be my first time for both the substances.

I know that it's not a common question in this thread (supposed to speak about health in using drugs) ahah but i didn't find anywhere an answer!
thank you very much 

[DoctorX]

doctorx its been a really long time since ive read/visited this thread. 

question 1-is a 50/50 mix of l-glutamine and cocaine believed to be 80-84%pure safe?  if not what are some safe cuts that can be used. 

question 2-how long should the "high" of cocaine last for 80-85% purity.  the 50/50 cut leaves people wanting to redose every 30minutes.

thanks

1.- Cuts can produce various health problems, depending on the nature of the substance and route of administration. Intravenous use is the most harmful in this way. Glutamine is not a common adulterant for cocaine and some effects are theoretically possible in intranasal or intravenous use. Lactose, manitol or other simple sugars should be an option

2.- The duration of the effect is related to the total amount of active substance in each dose, and not in proportions.

[QKarunika]

Megadose recommendations for vitamin C are based mainly on theoretical speculation and observational studies but there are no large scale, formal clinical trials to support the idea of benefits using it.

[/quote]

And there never will be any large scale clinical trials to prove it because those cost millions of dollars and there is no profit to be made in curing diseases with vitamin C. Observation has demonstrated the deadly effects of chemotherapy, methadone, and many (most?) other pharmaceuticals. There is no harm in trying liposomal vitamin C (etc), which as you point out, has been demonstrated beneficial in observational studies, before trying these other, guaranteed deadly, pharmaceuticals.

Iatrogenic disease is the leading cause of death in the USA today:
"They found that the iatrogenic death rate in the US (death caused by doctors and/or medical treatments) is 783,936 a year."
"Over a decade, the scientists predict that iatrogenic deaths will total about 7.8 million, a death rate equivalent to that caused by six jumbo jets falling out of the sky every day. "
"They also believe the numbers are actually much higher because most iatrogenic deaths aren’t reported as such: only 5 to 20% of iatrogenic deaths are reported for fear of lawsuits and because codes for reporting deaths due to drug side effects and other medical errors don’t even exist in many cases. The number of deaths due to conventional medicine may be 20 times higher than the numbers depicted...."

 

[QKarunika]

http://www.ncbi.nlm.nih.gov/pubmed/384241?dopt=Abstract

Quoted study gave the patients 10g per day orally, all at once, not an effective ROA. (compared to oral taken every couple hours, IV, or the best is liposomal C.)  Also, observational studies indicate that for serious illness like advanced cancer (in the study), for really effective benefits one must consume much more than 10g per day, i.e. "bowel tolerance" doses every 2-3 hours, or 100g of IV C or more.

The average 160lb mammal will have produce about 10-20g of vitamin C endogenously, so the "full tank" analogy should use that as a standard. Our RDA is ridiculously low, just enough to keep us from getting scurvy. It should be noted that we are no longer living in the verdant jungle like our primate ancestors, eating mostly fresh fruit all day, keeping us loaded on exogenous vitamin C.

Sorry, didn't mean to derail the thread.

I took some (poorly made) liposomal vitamin C yesterday and remembered more dreams than I can remember, even without my usual piracetam. I believe it was due to the choline in the lecithin. Given the choline-depleting effects of ganja and other drugs, I'd add lecithin to the earlier list of B and C.

[DoctorX]

Do you have any scientific evidence or proof about this? Any study in humans?

http://www.ncbi.nlm.nih.gov/pubmed/384241?dopt=Abstract

Quoted study gave the patients 10g per day orally, all at once, not an effective ROA. (compared to oral taken every couple hours, IV, or the best is liposomal C.)  Also, observational studies indicate that for serious illness like advanced cancer (in the study), for really effective benefits one must consume much more than 10g per day, i.e. "bowel tolerance" doses every 2-3 hours, or 100g of IV C or more.

[GreatLancet]

Hi Doc!

Not really a drug related question but I'd appreciate any help I can!

I've had hypertension with associated slight (like 90-100bpm) tachycardia at times for about 6 months now. The doctor started me on 100mg of metoprolol x2 per day and chlorthalidone 25mg (a diuretic) once a day.

This had the desired effect of treating the high BP and heart rate, but has had unfortunate sexual side effects. I guess there is a precedent of it with both these medications. I talked to my doc about it and they cut the diuretic and halved my metoprolol dosage.

However, since this change I'm experiencing the BP/tachycarida symptoms again.

My question to you is what other medications would control my fast heart rate or high BP without having adverse sexual side effects? Would an alpha blocker do the job?

Thanks for any info, I really appreciate what you do here!

[cleansober]

This thread from The Hub regarding the possible dangers of cannabis use makes me wonder how much it screws with my myelination... 

http://thehub7dnl5nmcz5.onion/index.php?topic=2434.0
 
The Hub is slow but you can be a Guest and just read. Able to use "Orweb" on my phone to edit this, nice.


Maybe I need something to increase my heart rate, rarely gets over 80 even when running short distances fast.

cs

[sputnik]

Great thread
+1 Doc

[SpeedUp]

Doctor, very important question:
I took MDMA with a friend, for each was the first time. I guess i may think that i have a strange natural tolerance to any drugs, since  I've tried speed, coke, also DOM, and less more than nothing came. And so i decided to use a quite large amount of the substance, it would has been 0,5 for me 0,4 for him. The fact is before we was pretty drunk too,  and after 10 minutes I drank it in a glass of water I was beginning to fell the effects, some time after I WAS NO LONGER MYSELF, i've never felt, like i said, something that before. my friend was having a great time too, we hugged, danced, even while there were moments in which I struggled my friend was ever felt good.
the day after him was acting in a strange way, kinder than usual, talkative with people who didn't know, and what fears me, a bit stupid, asking stupid question... and this not only the day after, but the second and the following
this is the fourth day, we have returned from holiday and I won't longer see him very often... ah, I am 80kg and him... mmh he's tall 2 metres so will be 90 kg or so.

my question is: I'm have to be afraid? or him are experiencing only longer side effect? i'm really worried...

I can definitely say that it was my first experience whit a drug, weed isn't ever comparable with this, that sensation to be out of mind... but what's the reason? why only md has affected me? it can be the setting of the moment, while I was in good mood by alchool? 
I didn't expect to fell sensations this great, I am a little afraid now although i don't fell particularly strange, only tired for lack of sleep, so I hope nothing happened at least to me

really thank you doctor

[DoctorX]

There are many different kinds of antihipertensive drugs.  Angiotensin-converting-enzyme (ACE) inhibitor, like enalapril, ramipril or captopril are widely used and can be useful if there are no contraindications. Other families of drugs include long-acting nitrates, calcium channel blockers (amlodipine, verapamil, diltiazem) or angiotensin II receptor antagonist (candesartan, irbesartan). The specific selection of drug depend on personal characteristics of the patient and profile of adverse effects. Some diuretics and beta-blockers are generally  not useful in young people because of negative effects on sexual functioning.

Hi Doc!

Not really a drug related question but I'd appreciate any help I can!

I've had hypertension with associated slight (like 90-100bpm) tachycardia at times for about 6 months now. The doctor started me on 100mg of metoprolol x2 per day and chlorthalidone 25mg (a diuretic) once a day.

This had the desired effect of treating the high BP and heart rate, but has had unfortunate sexual side effects. I guess there is a precedent of it with both these medications. I talked to my doc about it and they cut the diuretic and halved my metoprolol dosage.

However, since this change I'm experiencing the BP/tachycarida symptoms again.

My question to you is what other medications would control my fast heart rate or high BP without having adverse sexual side effects? Would an alpha blocker do the job?

Thanks for any info, I really appreciate what you do here!

[DoctorX]

Begginers should always start with a MDMA dosage not higher to 2 mg/kg (100-150 mg for a normal weight person). 400 or 500 mg is a very high dosage, and it can lead to adverse or toxic effects. Mixing with high dosages of alcohol can worsen the situation. The fact that you have tried other drugs (of unknown purity) and you need high dosages to achieve effect does not mean that this is the same for MDMA.

In real life conditions (at least in my experience) high doses of MDMA rarely lead to chronic toxic effects. So, probably, symptoms will diminish in following days until dissapear. If they last more than 7-10 days you should seek for medical advice although, in my experience, this is rare.

Doctor, very important question:
I took MDMA with a friend, for each was the first time. I guess i may think that i have a strange natural tolerance to any drugs, since  I've tried speed, coke, also DOM, and less more than nothing came. And so i decided to use a quite large amount of the substance, it would has been 0,5 for me 0,4 for him. The fact is before we was pretty drunk too,  and after 10 minutes I drank it in a glass of water I was beginning to fell the effects, some time after I WAS NO LONGER MYSELF, i've never felt, like i said, something that before. my friend was having a great time too, we hugged, danced, even while there were moments in which I struggled my friend was ever felt good.
the day after him was acting in a strange way, kinder than usual, talkative with people who didn't know, and what fears me, a bit stupid, asking stupid question... and this not only the day after, but the second and the following
this is the fourth day, we have returned from holiday and I won't longer see him very often... ah, I am 80kg and him... mmh he's tall 2 metres so will be 90 kg or so.

my question is: I'm have to be afraid? or him are experiencing only longer side effect? i'm really worried...

I can definitely say that it was my first experience whit a drug, weed isn't ever comparable with this, that sensation to be out of mind... but what's the reason? why only md has affected me? it can be the setting of the moment, while I was in good mood by alchool? 
I didn't expect to fell sensations this great, I am a little afraid now although i don't fell particularly strange, only tired for lack of sleep, so I hope nothing happened at least to me

really thank you doctor

[QKarunika]

Do you have any scientific evidence or proof about this? Any study in humans?

http://www.ncbi.nlm.nih.gov/pubmed/384241?dopt=Abstract

Quoted study gave the patients 10g per day orally, all at once, not an effective ROA. (compared to oral taken every couple hours, IV, or the best is liposomal C.)  Also, observational studies indicate that for serious illness like advanced cancer (in the study), for really effective benefits one must consume much more than 10g per day, i.e. "bowel tolerance" doses every 2-3 hours, or 100g of IV C or more.

Dr. Levy, in this talk, refers to scientific references to back up his points:
http://www.youtube.com/watch?v=GpptUsJFCEY
(Please overlook the blatant spelling error in the title by whoever posted this talk.)

I don't have the reference list but I believe it can be found in his book "Curing the Incurable: Vitamin C, Infectious Disease, and toxins":
http://www.amazon.com/Curing-Incurable-Vitamin-Infectious-Diseases/dp/1401069630

And there are a number of other talks on youtube easily found if anyone is interested.

I'm not too bothered with scientific studies because we all know that studies can be fudged to yield any desired result (like demonstrating that cannabis causes brain damage by asphyxiating monkeys). When I started taking lecithin I noticed immediate effects on cognition, making dreams more vivid and easier to recall, and making the mind clearer and more spacious in meditation;

We are building a centre here where, once all medicines are ready, we will find patients with "incurable" diseases and demonstrate that they can be easily cured by orthomolecular means. The results will be compiled and broadcast, but I have little interest in isolating variables or publishing in journals, etc.

Incidentally, ebola virus kills by rapidly depleting vitamin C and causing acute scurvy, therefore common sense says that vitamin C will protect against ebola.

[Bubbaabbub]

hey doc. x. I have this crazy weird phenomenon that I really can't figure out. So the back story is I have had petalla femoral pain syndrome for a long time now. and then one day my petalla dislocated while I was doing nothing, but sitting in a chair stoned. Ever since then every time I smoke pot it makes my knees hurt and in some cases dislocates my patella. I know its the pot because its the only time that happens to me. Ive quit now for a long time and my knee is a lot better, but I was wondering if you had any explanation for this? thank you very much.

Bubba

[Aleoreneo]

Hi doc,
how dangerous is 2CB and how often I can take it? Have you got some reliable information about dosage, duration, etc?
Really thanks for your work!

[DoctorX]

Scientific knowledge is sometimes biased and morally oriented. This is particularlly frequent in case of illegal drugs. But this fact does not mean that all scientific knowledge is so poor. Science has its own rules to detect fakes and in scientific literature you can find lots of references that say that the case you mention ( ("monkey axfyxiated with cannabis to prove neurotoxic effects") is a scam.

If you want to prove that megadoses of vitamin C can cure diseases you have to show science proofs. These proofs simply do not exist. Youtube videos are not science, in this case we should accept that Queen Elizabeth is a lizard.
https://www.youtube.com/watch?v=6yGpIwcuqpQ

If we talk with science we can continue this discussion. If not, I do not think it is worthy

Do you have any scientific evidence or proof about this? Any study in humans?

http://www.ncbi.nlm.nih.gov/pubmed/384241?dopt=Abstract

Quoted study gave the patients 10g per day orally, all at once, not an effective ROA. (compared to oral taken every couple hours, IV, or the best is liposomal C.)  Also, observational studies indicate that for serious illness like advanced cancer (in the study), for really effective benefits one must consume much more than 10g per day, i.e. "bowel tolerance" doses every 2-3 hours, or 100g of IV C or more.

Dr. Levy, in this talk, refers to scientific references to back up his points:
http://www.youtube.com/watch?v=GpptUsJFCEY
(Please overlook the blatant spelling error in the title by whoever posted this talk.)

I don't have the reference list but I believe it can be found in his book "Curing the Incurable: Vitamin C, Infectious Disease, and toxins":
http://www.amazon.com/Curing-Incurable-Vitamin-Infectious-Diseases/dp/1401069630

And there are a number of other talks on youtube easily found if anyone is interested.

I'm not too bothered with scientific studies because we all know that studies can be fudged to yield any desired result (like demonstrating that cannabis causes brain damage by asphyxiating monkeys). When I started taking lecithin I noticed immediate effects on cognition, making dreams more vivid and easier to recall, and making the mind clearer and more spacious in meditation;

We are building a centre here where, once all medicines are ready, we will find patients with "incurable" diseases and demonstrate that they can be easily cured by orthomolecular means. The results will be compiled and broadcast, but I have little interest in isolating variables or publishing in journals, etc.

Incidentally, ebola virus kills by rapidly depleting vitamin C and causing acute scurvy, therefore common sense says that vitamin C will protect against ebola.

[DoctorX]

Cannabis can amplify corporal sensations. This may explain the fact that you feel pain in your knee under pot effects but I can not find an explanation to the fact that it dislocates.

hey doc. x. I have this crazy weird phenomenon that I really can't figure out. So the back story is I have had petalla femoral pain syndrome for a long time now. and then one day my petalla dislocated while I was doing nothing, but sitting in a chair stoned. Ever since then every time I smoke pot it makes my knees hurt and in some cases dislocates my patella. I know its the pot because its the only time that happens to me. Ive quit now for a long time and my knee is a lot better, but I was wondering if you had any explanation for this? thank you very much.

Bubba

[DoctorX]

Hi doc,
how dangerous is 2CB and how often I can take it? Have you got some reliable information about dosage, duration, etc?
Really thanks for your work!

2C-B is a substance known during the last 40 years and there is no evidence of neurotoxic or long-lasting toxic effects. It should be used with caution, as any other psychedelic. Dosages between 5-10 mg produce stimulant empathogenic effects, these effects are more psychedelic in the rank of 20-30 mg. In my opinion it should not be used more than once a month.
Erowid is one of the best sources of information about drugs:
http://www.erowid.org/chemicals/2cb/2cb.shtml
I published a study on 2C-B a couple of years ago, it might interest you:
http://www.slideshare.net/fernandocaudevilla/2cb

[methylonnn]

When the topic is exactly on 2CB, i would need some explanations yesterday i took 2CB, i mostly snort drugs, it was first time for me and i didnt do much psychadelics mostly opiates in my life. However i snorted what i think it was about est.25 to 30mg line of 2CB. Trip started in about hour or hour and half, and lasted through whole day WHOLE fkcn day, i didnt expect that. Whole new situation for me. And time didnt go ANYWHERE. was reading all the forums, experiences with 2CB etc etc and thing just didnt END. There were times that it did and i felt totally sober, than again wave came around and i was again in some other body, disconnected from my body. its about 30 hours now, i was able to sleep with some anti depry pill taken, and i still feel effects, i am tired as hell, my muscles hurts (btw i went running as i wanted to get it out of my system + i made 3,4 times like 100 squats LOL ) and it helped a bit to concentrate me. The biggest problem was because i started asking myself when will this finish, will i be "dumb" and not able to remember focus for my life from now on etc, so i fell in bad trip. And than again i was able to get me out and there were times i felt like i am on top of the world.

So today i feel tired as hell, unable to concentrate, focus, i mean its much better but i still feel it. Is this normal ? How long does it take to go our of body totally ? What do i have to eat/drink to recover ? Phyisical training helps i guess ? I have problemss with concentration and memory how long doest that take ? Did i "fried my brains" ? :=) All in all, awsome experience, i found kinda inner peace what i needed after all these years i think...

Thanks for an answers DoctorX

[DoctorX]

When the topic is exactly on 2CB, i would need some explanations yesterday i took 2CB, i mostly snort drugs, it was first time for me and i didnt do much psychadelics mostly opiates in my life. However i snorted what i think it was about est.25 to 30mg line of 2CB. Trip started in about hour or hour and half, and lasted through whole day WHOLE fkcn day, i didnt expect that. Whole new situation for me. And time didnt go ANYWHERE. was reading all the forums, experiences with 2CB etc etc and thing just didnt END. There were times that it did and i felt totally sober, than again wave came around and i was again in some other body, disconnected from my body. its about 30 hours now, i was able to sleep with some anti depry pill taken, and i still feel effects, i am tired as hell, my muscles hurts (btw i went running as i wanted to get it out of my system + i made 3,4 times like 100 squats LOL ) and it helped a bit to concentrate me. The biggest problem was because i started asking myself when will this finish, will i be "dumb" and not able to remember focus for my life from now on etc, so i fell in bad trip. And than again i was able to get me out and there were times i felt like i am on top of the world.

So today i feel tired as hell, unable to concentrate, focus, i mean its much better but i still feel it. Is this normal ? How long does it take to go our of body totally ? What do i have to eat/drink to recover ? Phyisical training helps i guess ? I have problemss with concentration and memory how long doest that take ? Did i "fried my brains" ? :=) All in all, awsome experience, i found kinda inner peace what i needed after all these years i think...

Thanks for an answers DoctorX

First of all, it would be important to verify if the drug you took was 2C-B. 25-30 mg of intranasal 2C-B is a high, psychedelic dosage, but effects should last 6 hours more or less. A typical characteristic of intranasal route using 2C-B is that insufflation is extremely painful because of an irritative effect on nasal tissues. This is sometimes described as "sniffing chili". If you didn´t experience that, it is likely that the substance was other than 2C-B.
High doses of classical psychedelics can produce physical effects during some days that, normally, decrease until dissapearing. But I insist in the necessity of analyzing drugs before using them (as the Service provided by the Spanish NGO Energy Control: http://silkroad5v7dywlc.onion/index.php?topic=36015.0), carefully measure dosages with a scale, and start with low dosages when trying a new substance.

[methylonnn]

I am pretty sure it was 2CB. Dosage was however between 25 to 50 mg. i am much better today, not totally "back" to normal yet, still feeling sleepy here and there, but much more focused on things, memory also works normally etc....i read somewhere that one guy had problems for weeks after taking big dosage of it...anyway it was school for me But it has its awesome times during the high period..thanks for anwser

[CrystalBlue]

Hello,

I apparently share the common concern with the above fellas which is the effects of 2c-i. I've stumbled upon your thread yesterday and as I got one urgent question I decided to come back here. I've got a friend, quite a junkie who basically tries everything he gets his hands on. Lately he got interested in psychedelics and asked me if I could get him some Nbomes. I ordered 10x of 25i-NBOME blotters(Dosage:1000ug) from DahBome and recived 30 which was quite a bonus. Anyways, he had been doing these quite a while and got a tolerance(which already says he used them alot). Yet today we spoke again and he tells me that he's having severe epileptic seizures, he was to the hospital and got some medications. I Googled about epilepsy and Nbomes and there are some results to it, but mostly there's talked only about "causes seizures" which I don't really understand in the context if they mean epileptic seizures or something else. He hasn't had any epileptic seizures in years & they start immediately after using some 25i-nbomes. Maybe a coincidence, maybe not?

So the question in short - Is there any proven theories, rumors, forum posts or anything that would confirm my theory that these epileptic seizures were caused by 25I-NBOME? Or is it even considerable that NBOMEs are connected to the epiletic seizures?

[DoctorX]

NBOMEs can lead to seizures in overdose, there are some reports about this in the last 3 years:

http://www.ncbi.nlm.nih.gov/pubmed/24779864
http://www.ncbi.nlm.nih.gov/pubmed/23872917
http://www.ncbi.nlm.nih.gov/pubmed/23731373

NBOMEs have been present in the recreational drug market for only 3-4 years. There is no experience of human use and data from animal experiments are scarce. There are almost no data about toxicity and long term effects and risks. We know that can be lethal in overdose and are far more dangerous than classical psychedelics (LSD, DMT, psilocybin...)

Hello,

I apparently share the common concern with the above fellas which is the effects of 2c-i. I've stumbled upon your thread yesterday and as I got one urgent question I decided to come back here. I've got a friend, quite a junkie who basically tries everything he gets his hands on. Lately he got interested in psychedelics and asked me if I could get him some Nbomes. I ordered 10x of 25i-NBOME blotters(Dosage:1000ug) from DahBome and recived 30 which was quite a bonus. Anyways, he had been doing these quite a while and got a tolerance(which already says he used them alot). Yet today we spoke again and he tells me that he's having severe epileptic seizures, he was to the hospital and got some medications. I Googled about epilepsy and Nbomes and there are some results to it, but mostly there's talked only about "causes seizures" which I don't really understand in the context if they mean epileptic seizures or something else. He hasn't had any epileptic seizures in years & they start immediately after using some 25i-nbomes. Maybe a coincidence, maybe not?

So the question in short - Is there any proven theories, rumors, forum posts or anything that would confirm my theory that these epileptic seizures were caused by 25I-NBOME? Or is it even considerable that NBOMEs are connected to the epiletic seizures?

[girgis2000]

Hi Doc,

I've been taking Rubifen to keep me focused during work (long, laborious, and no time to fit it all in).  I also think that I might be suffering from the so called 'ADHD', because a day or two after starting, I noticed how productive and focused I was.  The problem has come that I'm now needing higher doses in order to get into the focus/buzz zone.

I say focus/buzz, because I find I'm my most productive when I'm experiencing a little high with it too.

At first I was taking 40-60mg per day.  But now I have no hesitancy to pop 60 when I wake up, and then to take another 40-80 throughout the rest of the day - the most I've taken in one day is around 180mg.  I didn't feel any side effects the next day. 

From this - it's obvious I've become tolerant to the drug, so I need to ask two questions:
1) How long should I abstain before I'm able to reduce the current state of my receptors?
2) Is it really dangerous to take more than 60mg/day? 

I ask 2) - because on the various online drug forums for ritalin/Methylphenidate, they say that thy're averaging 120mg per day (give or tajke) - they're also mixing concerta with ritalin, to boost the stimulation when the extended release drops.  I also ask 2), because I've been concerned about tolerance - so I looked up a few scientific papers, and one said that mice where subject to an equivalent (in humans) of x 60 the recomended dose - and there were no serious side effects, except for in the acute phase.

I'm also concerned, because I've never been addicted to any drug, but I'm starting to think that it's happening with this (reason being - I'm taking so much, and I'm not really caring about the effects.  Mainly due to pressures of work>health).

Any info would be great thanks, maybe you could send me over some ext release?   haha

All the best,
g

[DoctorX]

In general, 60 mg of immediate release methylphenidate is the maximum daily recommended dosage. In toxicological reports, 30% of people taking more than 120-150 mg daily developed at least "moderated adverse effects". Severe adverse effects are rare but possible. Psychotic episodes or cardiac problems are possible in long-time, high dosage.

Abuse potential and tolerance are the main problems of methylphenidate (as many other stimulants).  f you feel like you are taking too much and you feel that each time you need more (tolerance) it is possible that is time to stop or diminish it.

Although it is reatively common, it is not recommended mixing immediate and long-time release presentations, as it increases the risk of adverse effect and toxicity.

Hi Doc,

I've been taking Rubifen to keep me focused during work (long, laborious, and no time to fit it all in).  I also think that I might be suffering from the so called 'ADHD', because a day or two after starting, I noticed how productive and focused I was.  The problem has come that I'm now needing higher doses in order to get into the focus/buzz zone.

I say focus/buzz, because I find I'm my most productive when I'm experiencing a little high with it too.

At first I was taking 40-60mg per day.  But now I have no hesitancy to pop 60 when I wake up, and then to take another 40-80 throughout the rest of the day - the most I've taken in one day is around 180mg.  I didn't feel any side effects the next day. 

From this - it's obvious I've become tolerant to the drug, so I need to ask two questions:
1) How long should I abstain before I'm able to reduce the current state of my receptors?
2) Is it really dangerous to take more than 60mg/day? 

I ask 2) - because on the various online drug forums for ritalin/Methylphenidate, they say that thy're averaging 120mg per day (give or tajke) - they're also mixing concerta with ritalin, to boost the stimulation when the extended release drops.  I also ask 2), because I've been concerned about tolerance - so I looked up a few scientific papers, and one said that mice where subject to an equivalent (in humans) of x 60 the recomended dose - and there were no serious side effects, except for in the acute phase.

I'm also concerned, because I've never been addicted to any drug, but I'm starting to think that it's happening with this (reason being - I'm taking so much, and I'm not really caring about the effects.  Mainly due to pressures of work>health).

Any info would be great thanks, maybe you could send me over some ext release?   haha

All the best,
g

[girgis2000]

I forgot to mention that I take L-cartinine, L-tyrosine (I prefer NALT - seems more effective), sometimes I add noopept (co-stim of neurones via increased blood), Mg2+glycylate, Omega 3 (normal/double RDA), multivit (good one), CoenzymeQ (or whatever it's called), plus or minus Isoprenolate Choline (or whatever the first chem is in the mix).  every few days i take a componud b supplement, sometimes (once a week) i take vit D (but you make most from your melanocytes), also I go to the gym very often - intense cardio to keep my bp and hr down, and in general to keep my metabolism going (but i notice if i've taken some rubifen within 4 hours of the gym - I sweat proffusely)

Added supplements (if i'm not on a lot already ) - BCAAs (not every day, and not too many, usually the days i work out); guarrana tablets with gincko and some type of berry in it; sometimes i take creatinine also (small concentrate tablets - but not too many, usually one in the morning and if i work out, 2 1hr before)

Diet is extremely lean and healthy (i believe) - meat is minimal, and if I eat it (every other or 2 days) - it's usually chicken.  Fish i eat every other day (tuna/trout); Tofu is something i'm pretty much eating regularly, but not too much (I heard that selenium is carcinogenic these days - what isn't except the air we breathe? ); fruit (but i admitt most is via fresh juices, and where i live their mainly concentrate - which i'm not happy about); veg - i limit the veg that i eat - mainly green (salad, pepper, cucumber, etc) but i eat a lot of garlic (mixed with food/roasted/pickled); onions a lot (can't get enough); sweetcorn every day, beans every day (natural - harricot, falcone, red kidney, lentils, etc).

I know you're saying to taper it down - but the thing is, how long is long term use?  I usually take breaks twice a week ( so tomorrow I wont take any and also on sunday), then the next day i susspend the 1st dose until i start to feel tired.

With all the above - am i saving my self?

Also ddrink plenty of milk, water, and soya milk. - Don't drink alcohol often (All last year until two months ago I didn't have a single drop - too much work, it wouldve seriously hindered my productivity).

Sorry for all this, just my main concern was my liver, but now you're talking about the heart (I completely forgot about this!!) - sensitive data below - sorry again

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Thanks for your reply though,
all the best.

g

Freedom - one world, one unity!!!

[DoctorX]

There is no proven efficacy of most dietary supplements you mention, at least in healthy normal people. Most nutrients are in enough quantities in a varied, healthy diet and adding supplements is useless (but probably harmless, also). In order to avoid risk of tolerance and or abuse, you should try not to take regular amounts every day

I forgot to mention that I take L-cartinine, L-tyrosine (I prefer NALT - seems more effective), sometimes I add noopept (co-stim of neurones via increased blood), Mg2+glycylate, Omega 3 (normal/double RDA), multivit (good one), CoenzymeQ (or whatever it's called), plus or minus Isoprenolate Choline (or whatever the first chem is in the mix).  every few days i take a componud b supplement, sometimes (once a week) i take vit D (but you make most from your melanocytes), also I go to the gym very often - intense cardio to keep my bp and hr down, and in general to keep my metabolism going (but i notice if i've taken some rubifen within 4 hours of the gym - I sweat proffusely)

Added supplements (if i'm not on a lot already ) - BCAAs (not every day, and not too many, usually the days i work out); guarrana tablets with gincko and some type of berry in it; sometimes i take creatinine also (small concentrate tablets - but not too many, usually one in the morning and if i work out, 2 1hr before)

Diet is extremely lean and healthy (i believe) - meat is minimal, and if I eat it (every other or 2 days) - it's usually chicken.  Fish i eat every other day (tuna/trout); Tofu is something i'm pretty much eating regularly, but not too much (I heard that selenium is carcinogenic these days - what isn't except the air we breathe? ); fruit (but i admitt most is via fresh juices, and where i live their mainly concentrate - which i'm not happy about); veg - i limit the veg that i eat - mainly green (salad, pepper, cucumber, etc) but i eat a lot of garlic (mixed with food/roasted/pickled); onions a lot (can't get enough); sweetcorn every day, beans every day (natural - harricot, falcone, red kidney, lentils, etc).

I know you're saying to taper it down - but the thing is, how long is long term use?  I usually take breaks twice a week ( so tomorrow I wont take any and also on sunday), then the next day i susspend the 1st dose until i start to feel tired.

With all the above - am i saving my self?

Also ddrink plenty of milk, water, and soya milk. - Don't drink alcohol often (All last year until two months ago I didn't have a single drop - too much work, it wouldve seriously hindered my productivity).

Sorry for all this, just my main concern was my liver, but now you're talking about the heart (I completely forgot about this!!) - sensitive data below - sorry again

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Thanks for your reply though,
all the best.

g

Freedom - one world, one unity!!!

[gallileo]

DoctorX, I was wondering, is it potentially dangerous to mix Propranolol (Inderal) ~5-10mg instant release with other drugs that have racing heart to help prevent it?

[DoctorX]

DoctorX, I was wondering, is it potentially dangerous to mix Propranolol (Inderal) ~5-10mg instant release with other drugs that have racing heart to help prevent it?

Combination of beta-blockers like propranolol and stimulants is not recommended. Stimulants act on adrenergic receptors alpha and beta, and propranolol only blocks beta receptors. So it is possible a rebound effect on alpha receptors, leading to cardiovascular problems.
In fact, beta-blockers are formally contraindicated in treatment of acute intoxication of cocaine for this reason. So, combination of propranolol and stimulants (cocaine, and probably amphetamine derivatives) should be avoided. Labetalol (an alpha and beta blocker)or other cardiovascular drugs (verapamil, diltiazem...) should be considered safer alternatives.

[gallileo]

DoctorX, I was wondering, is it potentially dangerous to mix Propranolol (Inderal) ~5-10mg instant release with other drugs that have racing heart to help prevent it?

Combination of beta-blockers like propranolol and stimulants is not recommended. Stimulants act on adrenergic receptors alpha and beta, and propranolol only blocks beta receptors. So it is possible a rebound effect on alpha receptors, leading to cardiovascular problems.
In fact, beta-blockers are formally contraindicated in treatment of acute intoxication of cocaine for this reason. So, combination of propranolol and stimulants (cocaine, and probably amphetamine derivatives) should be avoided. Labetalol (an alpha and beta blocker)or other cardiovascular drugs (verapamil, diltiazem...) should be considered safer alternatives.

Amongst the derivates you mentionned (Labetalol, Verapamil, Diltiazem - which one would have the best similar quality to propranolol (strage fright type of anxiety, racing heart and high blood pressure from anxiety) and be the safest with stimulants (and preferably long-term daily usage) ? I only use propranol for its physical anti-anxiety properties - I have also shown high blood pressure in the past they put me on ramipril but I didnt like it at all.

P.S: Also are those safe when used with depressants like benzodiazepines and/or GHB/GBL

[DoctorX]

All of them could be used in this situation. Choosing one or another depends on many factors. Labetalol is structurally similar to propanolol so clinical effect should be very similar.But it has many adverse effects, mainly in daily use. Impotence, retarded ejaculation and other sexual problems are common in male. Labetalol is contraindacted in asthma. Verapamil and diltiazem are very similar in mechanism of action, diltiazem is probably more adeuquate for the purpose you want, although adverse effects are possible also

Anyway, it should be important to consider all factors (including the story of "high blood pressure" you mention). and evaluate possible benefits and potential risks to see if it is worthy or adequate the pharmacological combination you propose.

DoctorX, I was wondering, is it potentially dangerous to mix Propranolol (Inderal) ~5-10mg instant release with other drugs that have racing heart to help prevent it?

Combination of beta-blockers like propranolol and stimulants is not recommended. Stimulants act on adrenergic receptors alpha and beta, and propranolol only blocks beta receptors. So it is possible a rebound effect on alpha receptors, leading to cardiovascular problems.
In fact, beta-blockers are formally contraindicated in treatment of acute intoxication of cocaine for this reason. So, combination of propranolol and stimulants (cocaine, and probably amphetamine derivatives) should be avoided. Labetalol (an alpha and beta blocker)or other cardiovascular drugs (verapamil, diltiazem...) should be considered safer alternatives.

Amongst the derivates you mentionned (Labetalol, Verapamil, Diltiazem - which one would have the best similar quality to propranolol (strage fright type of anxiety, racing heart and high blood pressure from anxiety) and be the safest with stimulants (and preferably long-term daily usage) ? I only use propranol for its physical anti-anxiety properties - I have also shown high blood pressure in the past they put me on ramipril but I didnt like it at all.

P.S: Also are those safe when used with depressants like benzodiazepines and/or GHB/GBL

[kate]

finally out of n00bsville without spamming, so i can ask DoctorX:

hey all 

i might have to be put on mood stabilisers to treat BPD but i enjoy the occasional chemical binge every now and then (or 'weekend' as it's known to most people   :P).

i know SSRI's are a no-no when it comes to MDMA but can anyone tell me if lithium (or any other mood stabilisers they might give me) interact with:

Cocaine
MDMA
Benzos
Cannabis

i seriously doubt it has any effect on pot, but i am quite the stoner so thought i'd add it to the list.

currently tapering off a semi-serious Etizolam problem as well, hence benzos on the list (i know tiz is not strictly a benzo but i'm using other PAM's [flubro & diclaz - don't like valium] to come off them). i've searched this site and the interweb in general but can't find any definitive answers so thought i'd put the question where some people might actually know.

if anyone could repost this in drug safety i'd be very appreciative, or ask Doctor X for me if he's still around.

muchas gracias 

[DoctorX]

Pharmacollogically, interactions between lithium and recreational drugs (cocaine, MDMA, benzos or cannabis) are unlikely. But, in this case, the most important aspect is not pharmacollogical, but the influence of mind-altering , stimulant or psychedelic-like substances (cocaine, MDMA or cannabis) in a person suffering borderline personality disorder. Persons with this condition are more susceptible to negative reactions to these substances. This is the reason to recommend abstinence (or low dosages and frequencies) in persons with BPD.

finally out of n00bsville without spamming, so i can ask DoctorX:

hey all 

i might have to be put on mood stabilisers to treat BPD but i enjoy the occasional chemical binge every now and then (or 'weekend' as it's known to most people   :P).

i know SSRI's are a no-no when it comes to MDMA but can anyone tell me if lithium (or any other mood stabilisers they might give me) interact with:

Cocaine
MDMA
Benzos
Cannabis

i seriously doubt it has any effect on pot, but i am quite the stoner so thought i'd add it to the list.

currently tapering off a semi-serious Etizolam problem as well, hence benzos on the list (i know tiz is not strictly a benzo but i'm using other PAM's [flubro & diclaz - don't like valium] to come off them). i've searched this site and the interweb in general but can't find any definitive answers so thought i'd put the question where some people might actually know.

if anyone could repost this in drug safety i'd be very appreciative, or ask Doctor X for me if he's still around.

muchas gracias 

[kate]

thanks Dr! i think i should have made myself a bit clearer - by BPD i meant Bipolar Disorder (type II if that matters), not Borderline Personality Disorder. but i imagine the same answer still applies?

guess i'll have to start taking it easy then

still, thanks for the reply, i'll chuck something in your tip jar as soon as my coin appears

[sabrinafury]

Doctor X,

Are you aware of any negetive reactions between MDMA and aripiprazole, (Abilify)?

Not sure if I suffer from bipolar disorder or depression or even ptsd, but I haven't found any neg. effects yet.

[DoctorX]

thanks Dr! i think i should have made myself a bit clearer - by BPD i meant Bipolar Disorder (type II if that matters), not Borderline Personality Disorder. but i imagine the same answer still applies?

guess i'll have to start taking it easy then

still, thanks for the reply, i'll chuck something in your tip jar as soon as my coin appears

Yes...I regret the advice is valid for both Bipolar and Bordeline Disorder.

[ice9]

Hi Dr. X!

My question is about Modafinil.
It's been called a smart drug used to focus and excel but can it be used to excel in exercise?
Will it be able to help me push my body further for longer? Can I keep stamina up while focusing on my grabs as I rock climb?

The reason I ask is because the wikipage on it says that it's been used by athletes as a doping agent.
If this wouldn't help with workouts do you know a drug that will without the rapid muscle loss of post-steroid use?

I'm in good shape and good health.
I don't take any other prescriptions and just smoke pot sometimes.

Thanks your service is great.

 
 

[DoctorX]

Doctor X,

Are you aware of any negetive reactions between MDMA and aripiprazole, (Abilify)?

Not sure if I suffer from bipolar disorder or depression or even ptsd, but I haven't found any neg. effects yet.

There are no reported toxic effects or increment of adverse reactions of mixing MDMA and aripiprazole. But, as I said in the previous question, Bthe most important aspects are not pharmacollogical, but the influence of mind-altering , stimulant or psychedelic-like substances (cocaine, MDMA or cannabis) in a person suffering a mental health problem. I suposse this because aripiprazole is a drug used in these conditions. Persons with this condition are more susceptible to negative reactions to these substances. Some people are more susceptible to stomach problems taking antiinflammatory drugs and other can have mental problems if using psychedelic-like or empathogen drugs

[DoctorX]

Modafinil has shown to modify aerobic training power, enhancing the results in some laboratory parameters on short time.
http://www.ncbi.nlm.nih.gov/pubmed/15179180
Modafinil is also considered as a doping agent by anti-doping authorities.
Nevertheless, in my personal opinion it is unlikely that these effects are significative, at least in non-professional athletes. It is possible that it can make a difference in high trainig professional, but in normal people I do not think it is worthy using modafinil for this purpose. 

Hi Dr. X!

My question is about Modafinil.
It's been called a smart drug used to focus and excel but can it be used to excel in exercise?
Will it be able to help me push my body further for longer? Can I keep stamina up while focusing on my grabs as I rock climb?

The reason I ask is because the wikipage on it says that it's been used by athletes as a doping agent.
If this wouldn't help with workouts do you know a drug that will without the rapid muscle loss of post-steroid use?

I'm in good shape and good health.
I don't take any other prescriptions and just smoke pot sometimes.

Thanks your service is great.

[ice9]

Modafinil has shown to modify aerobic training power, enhancing the results in some laboratory parameters on short time.
http://www.ncbi.nlm.nih.gov/pubmed/15179180
Modafinil is also considered as a doping agent by anti-doping authorities.
Nevertheless, in my personal opinion it is unlikely that these effects are significative, at least in non-professional athletes. It is possible that it can make a difference in high trainig professional, but in normal people I do not think it is worthy using modafinil for this purpose. 

Interesting study. So it seems to prolong the endurance threshold a bit.
In your experience have you come across any mild performance enhancing drugs that would allow someone to work double-time without wearing out twice as fast?
One's that SR offers?

Thanks so much for your service. It is seriously valuable.

[XCCDF]

Live Detox

As a MD, have you ever heard of anything like this?


Lets say you drink a lot, and quit, and want to cleanse your liver and detox it and help it regrow.


Is this even legit? As far as something Dr. Group has on his site (clearnet site guys). ?


Thanks!

[DoctorX]

Modafinil has shown to modify aerobic training power, enhancing the results in some laboratory parameters on short time.
http://www.ncbi.nlm.nih.gov/pubmed/15179180
Modafinil is also considered as a doping agent by anti-doping authorities.
Nevertheless, in my personal opinion it is unlikely that these effects are significative, at least in non-professional athletes. It is possible that it can make a difference in high trainig professional, but in normal people I do not think it is worthy using modafinil for this purpose. 

Interesting study. So it seems to prolong the endurance threshold a bit.
In your experience have you come across any mild performance enhancing drugs that would allow someone to work double-time without wearing out twice as fast?
One's that SR offers?

Thanks so much for your service. It is seriously valuable.

I don´t know if you refer to physical performance (steroids, GH...) or psychological. There are no "magic" drugs , although it is possible to get benefits (more clear in physical performance) from some drugs or combinations, there are always also adverse effects and, sometimes, risk of severe toxicity.

In some cases, risk and intensity of adverse effects are reasonable. High dosages and high frequences of use are related to more risks. We would have to consider many factors (objectives, age, sex, health status, exercise, diet...) to choose an adequate option with a reasonable profile of adverse effects.

[DoctorX]

I do not see any clearnet link but  I suppose what are you are talking about...

Liver structure and function can be affected by alcohol and some drugs (both prescription and recreational-illegal). If you take too much alcohol and drugs your liver may experiment toxic effects. Liver has a quick (and also limited) ability to regenerate its cells. So if you stop taking too much alcohol and hepatotoxic drugs, your liver may "regenerate".

But in the case you are not abusing hepatotoxic compounds, or if you are taking moderate amounts, there is no need for "detoxification". And there is no need for abstaining from sugar, proteins or other stuff, as some of these "liver detox" diets say.
 

Live Detox

As a MD, have you ever heard of anything like this?


Lets say you drink a lot, and quit, and want to cleanse your liver and detox it and help it regrow.


Is this even legit? As far as something Dr. Group has on his site (clearnet site guys). ?


Thanks!

[mitsikid]

Bit of a random question but here goes...

I'm getting over a cold (green/yellow snot - gross I know!)

I clear my nose by blowing & spraying some saline up it to clear & unblock it before snorting & although I can feel the effects of the coke, would the coke feel stronger if I had a completely clear & dry nose???

I don't want to be wasting decent gear, I'd much rather save it for when my nose clears.

Any insight would be greatly appreciated.

Thanks 

[DoctorX]

Bit of a random question but here goes...

I'm getting over a cold (green/yellow snot - gross I know!)

I clear my nose by blowing & spraying some saline up it to clear & unblock it before snorting & although I can feel the effects of the coke, would the coke feel stronger if I had a completely clear & dry nose???

I don't want to be wasting decent gear, I'd much rather save it for when my nose clears.

Any insight would be greatly appreciated.

Thanks 

Yes...absorption by intranasal route depends on state of nasal mucous membrane. If the membrane is swollen because of a flu/cold, rate of absorption will be lower. And, even, it could be easier to have complications as nasal infection or sinusitis.

If symptoms are very mild, a pre-washing with saline can be useful. But in most cases I think there are no other alternatives than try other drug. In the case of cocaine rest of routes have a poor ratio of benefit/risks and intranasal route is the best one. Cocaine is active by oral route but you should need to double or triple the dosage to obtain a mild effect. Smoked or injected are possible routes, also, but risks are much higher than intranasal and are not recommended at all.

[-Darkroom]

Hello Dr.X:
I´m a follower of your blog, congratulations¡¡ I saw the interview with La Milá in cuatro, (always difficult vs with her)
My question is the next...
I usually go to a Techno festival once a year (due to my family situation) or if I were very lucky twice. I always take speed, but due the difficult to find nowadays a good amph, when I find a good batch i buy a little more for the next time, but the next time sometimes is even a year later.....I keep it in the fridge or in the freezer, well packed, Is safe to take it after a year? If the speed lost its properties, what does it mean? its power become low or could it become harmful?
Gracias y un saludo.

Greets

[DoctorX]

Amphetamine and amphetamine derivatives (meth, MDMA, MDA,2C-X, DO-X...) are simple, stable molecules. Their rate of degradation over time is very low, and they can keep their properties during years if they are kept in a dry, dark place, out of direct sunlight. There is no need to keep them in the fridge (in fact, moisture can facilitate degradation). They can be kept for years without problems

Hello Dr.X:
I´m a follower of your blog, congratulations¡¡ I saw the interview with La Milá in cuatro, (always difficult vs with her)
My question is the next...
I usually go to a Techno festival once a year (due to my family situation) or if I were very lucky twice. I always take speed, but due the difficult to find nowadays a good amph, when I find a good batch i buy a little more for the next time, but the next time sometimes is even a year later.....I keep it in the fridge or in the freezer, well packed, Is safe to take it after a year? If the speed lost its properties, what does it mean? its power become low or could it become harmful?
Gracias y un saludo.

Greets

[Pillow]

Amphetamine and amphetamine derivatives (meth, MDMA, MDA,2C-X, DO-X...) are simple, stable molecules. Their rate of degradation on time is very low, and they can keep their properties during years if they are kept in a dry, dark place, out of direct sunlight. There is no need to keep them in the fridge (in fact, moisture can facilitate degradation). They can be kept during years without problems

Hello Dr.X:
I´m a follower of your blog, congratulations¡¡ I saw the interview with La Milá in cuatro, (always difficult vs with her)
My question is the next...
I usually go to a Techno festival once a year (due to my family situation) or if I were very lucky twice. I always take speed, but due the difficult to find nowadays a good amph, when I find a good batch i buy a little more for the next time, but the next time sometimes is even a year later.....I keep it in the fridge or in the freezer, well packed, Is safe to take it after a year? If the speed lost its properties, what does it mean? its power become low or could it become harmful?
Gracias y un saludo.

Greets

put it inside a glass container and add dessicant and you'll be fine

[-Darkroom]

Amphetamine and amphetamine derivatives (meth, MDMA, MDA,2C-X, DO-X...) are simple, stable molecules. Their rate of degradation on time is very low, and they can keep their properties during years if they are kept in a dry, dark place, out of direct sunlight. There is no need to keep them in the fridge (in fact, moisture can facilitate degradation). They can be kept during years without problems

Hello Dr.X:
I´m a follower of your blog, congratulations¡¡ I saw the interview with La Milá in cuatro, (always difficult vs with her)
My question is the next...
I usually go to a Techno festival once a year (due to my family situation) or if I were very lucky twice. I always take speed, but due the difficult to find nowadays a good amph, when I find a good batch i buy a little more for the next time, but the next time sometimes is even a year later.....I keep it in the fridge or in the freezer, well packed, Is safe to take it after a year? If the speed lost its properties, what does it mean? its power become low or could it become harmful?
Gracias y un saludo.

Greets

put it inside a glass container and add dessicant and you'll be fine

Ok, thanks

[L.S.Dee]

A very close friend of mine has colon cancer and it's been in the 4th stage for 4 years.

After 2 years oc chemo, she decided to look at alternative treatments. The chemo did nothing but destroy her immune and digestive system.'

My friend is exterme pain but will not take durgs such as Dilaudid. Her nutritionist says the medication willl harm her liver.

Opium was suggested and so I got her 5 grams from a vendor here that looks legit. Great feedback and all.

Is there any reason why she would not feel  1/4 gram eaten? I have a feeling the vendor is legit. Could it be because her digestive system is working at around 1/3 of what it should be?

There's more to this and I'll get into more detail later.

Thanks.

[DoctorX]

The main active compounds in opium are morphine and codeine. Other opiates and substances can be present (tebaine, papaverine, noscapine...) but their activity is less important.

In general, opium contains a 10-15% of morphine althougfh there are important differences depending on the plant, extraction method and conditions of conservation.

Morphine or codeine can be very useful in management of some cancer symptoms, but they have no efficacy in the evolution (curation) of the disease.

The lack of efficacy can be related to the purity of the opium or tolerance issues if he has been using other opiates previously. Opium is not absorpted in colon, so it is unlikely that malfunction of digestive system is the cause.

There is no chemical difference between morphine obtained from opium or morphine in pills. Morphine pills have the advantage that concentration of the product is garantized.

Anyway, I insist that opiates can help in some cancer symptoms but they no cure any cancer.

A very close friend of mine has colon cancer and it's been in the 4th stage for 4 years.

After 2 years oc chemo, she decided to look at alternative treatments. The chemo did nothing but destroy her immune and digestive system.'

My friend is exterme pain but will not take durgs such as Dilaudid. Her nutritionist says the medication willl harm her liver.

Opium was suggested and so I got her 5 grams from a vendor here that looks legit. Great feedback and all.

Is there any reason why she would not feel  1/4 gram eaten? I have a feeling the vendor is legit. Could it be because her digestive system is working at around 1/3 of what it should be?

There's more to this and I'll get into more detail later.

Thanks.

[likemetoo9]

Hey Dr. X,
I've been reading alot of your posts and love the knowledge..
I'm currently very stoned and was wondering the truth about weed? How bad is it in reality? If we were talking about around 2-4 grams a day for a long time? And are the health differences big when you compare a bong versus a joint?

Thank you.

[DoctorX]

Most relevant consequences of heavy cannabis use are related to short time memory. Frequent cannabis users learn with more difficulty (and forget easily) new concepts. I´m talking about the memory we use to learn new things (studying) or remember a phone number. This effect depends on dosage (more frequent and intense in very heavy cannabis users) and dissapears with abstinence (aproximately after 3-4 weeks of abstinence).

Risk of lung problems (chronic bronchitis, lung cancer...) are probably similar to tobacco ones. Risk of joints and bongs are similar (as they produce combustion) but vaporizers avoid lung problems.

Other risks frequently related to cannabis (schizophrenia, infertility, chromosome damage...) are part of the anti-drug propaganda and are not real.

Hey Dr. X,
I've been reading alot of your posts and love the knowledge..
I'm currently very stoned and was wondering the truth about weed? How bad is it in reality? If we were talking about around 2-4 grams a day for a long time? And are the health differences big when you compare a bong versus a joint?

Thank you.

[likemetoo9]

Most relevant consequences of heavy cannabis use are related to short time memory. Frequent cannabis users learn with more difficulty (and forget easily) new concepts. I´m talking about the memory we use to learn new things (studying) or remember a phone number. This effect depends on dosage (more frequent and intense in very heavy cannabis users) and dissapears with abstinence (aproximately after 3-4 weeks of abstinence).

Risk of lung problems (chronic bronchitis, lung cancer...) are probably similar to tobacco ones. Risk of joints and bongs are similar (as they produce combustion) but vaporizers avoid lung problems.

Other risks frequently related to cannabis (schizophrenia, infertility, chromosome damage...) are part of the anti-drug propaganda and are not real.

Hey Dr. X,
I've been reading alot of your posts and love the knowledge..
I'm currently very stoned and was wondering the truth about weed? How bad is it in reality? If we were talking about around 2-4 grams a day for a long time? And are the health differences big when you compare a bong versus a joint?

Thank you.

Thank you very much for the answer 1+

[cleansober]

DoctorX,

A well written and entertaining, albeit rather lengthy argument against weed is here on the Hub "http://thehub7dnl5nmcz5.onion/index.php?topic=2434.0"  Just throwing this in to see if maybe you could find the time to read the thread and comment on it.

Sorry I' m using the word "albeit", "although" seemed too common, albeit more acceptable.  I'm unclear as to the meaning of "very moorish" in the next post.  Seems like a fantasitc word albeit "very" might be optional if I can ever figure out what "moorish" means in the context of coke usage.

Pax


Cleansober

[mitsikid]

Just out of curiosity.

How often a week doing coke up the nose will be heading for a serious habit?

I've found my cola usage is going up a bit now I have found some decent quality gear & I've been using 1mg Xanax to ease the comedown & help me fall asleep which it does perfectly.

I understand that everybody's different with regards addiction & tolerance levels but any imput from you would be really appreciated 

I'm going through about a gram per week, spread out from the weekend & a session midweek sometimes, would it be a good idea to slow down for a while as I find coke very moorish just lately which has got me thinking...

Thanks Doctor X, your a very worth while addition to the forum 

[DoctorX]

The question is very difficult to answer...how much sex is too much sex? how much drugs are too much drugs?. In some diseases (diabetes, hypertension...) there are objective parameters to measure normality from disease. But in drugs things do not work like this....

In my opinion, it is not the professional (doctor or whatever) who has to decide if someone is using or abusing drugs. It is the user who has to measure if his own use of drugs is appropiate for the personal, social, laboral or familiar activities he wants to develop. Of course there are patterns of use that are objectively harmful, but limits are difficult in many cases.

In general, routine or cyclic patterns of use of substances with high potential of addiction (in the case you mention, cocaine and benzodiacepines) are more risky or harmful than occasional, recreative uses. Anyway, if you think/feel that you should slow your pattern of use, follow your instinct....

Just out of curiosity.

How often a week doing coke up the nose will be heading for a serious habit?

I've found my cola usage is going up a bit now I have found some decent quality gear & I've been using 1mg Xanax to ease the comedown & help me fall asleep which it does perfectly.

I understand that everybody's different with regards addiction & tolerance levels but any imput from you would be really appreciated 

I'm going through about a gram per week, spread out from the weekend & a session midweek sometimes, would it be a good idea to slow down for a while as I find coke very moorish just lately which has got me thinking...

Thanks Doctor X, your a very worth while addition to the forum 

[mitsikid]

I understand & I thank you for your reply.

This forum is probably the best I have ever joined, especially when people such as yourself respond with good educated answers.

Thank you DoctorX 

[mitsikid]

Hello, firstly I would like to thank you for any educated answers on my question. I'm sorry to ask you another question which might seem a bit daft to most  people, but I would really like to know what would be the best way to store my products please? I'm not sure the best ways to store them.

So here we go.....I'm extremely wary of people or children/family/certain friends finding my secret drug substance stash so I keep all my substances & drug paraphernalia in a tough metal key locked safety box. It's out of general sight, placed up high & out of the reach of little ones that might go mooching about where they shouldn't be going. This is also kept in a private locked up room that nobody but me is allowed to enter for obvious reasons & because I work from this room, the room is mostly locked. Only I know where the key to the blue box is hidden. No one else knows where the key is kept.

MY MDMA is in a plastic bag then that  bag is placed in a darkened blacked out completely covered air tight glass container that no light can penetrate. I made this container myself for this reason.

My LSD is stored the same way as my MDMA, a sealed dark air tight glass container. Then that container is put in my blue locked up tin with everything else drug related.

Everything is in the lock box, & kept at room temperature which would fluctuate slightly during summer & winter months. Hopefully the temperature in the room would not fluctuate too much to cause a concern.

Is this the best way to store these substances for the long term? By that I mean possibly years to store them. With the slight temperature changes throughout the year & how they are stored inside my locked box, would they be affected any way?

I'm unsure how to store Xanax as well. I keep them in a clear plastic bag, inside my main big blue drug tin with everything else.  Some Xanax are in aluminum screw top pill tubes. Is the pill tube method of storage better than a clear plastic bag? Or doesn't it matter as long as they are in the blue tin & no light can get in to damage the tablets?

The same goes for coke storage. It is just sitting in a clear plastic bag, on it's own inside my locked blue tin. Is this good enough to store coke? I know coke attracts moisture so would it be a good idea to do the same to my coke supply as what I have done with my MDMA & LSD. Or is it just not worth all the effort to try & protect all my substances so I should just leave it all as it is in my locked up blue safety box?

Sorry if this random question has bored you, can't blame you for giving up reading half way through. Those of you that have read the whole thing, well thanks for reading it if you managed to get to the end.


Opinions on storing your own substances would really be appreciated 

[cleansober]

did you mean to double post this here and in the thread you started about long term storeage?

http://www.alfiekohn.org/teaching/edweek/marshmallows.htm

for those interested in the famous Stanford Marshmallow test the clearlink above is a thoughtful take on it.

[DoctorX]

(...) With the slight temperature changes throughout the year & how they are stored inside my locked box, would they be affected any way?

I'm unsure how to store Xanax as well. I keep them in a clear plastic bag, inside my main big blue drug tin with everything else.  Some Xanax are in aluminum screw top pill tubes. Is the pill tube method of storage better than a clear plastic bag? Or doesn't it matter as long as they are in the blue tin & no light can get in to damage the tablets?

The same goes for coke storage. It is just sitting in a clear plastic bag, on it's own inside my locked blue tin. Is this good enough to store coke? I know coke attracts moisture so would it be a good idea to do the same to my coke supply as what I have done with my MDMA & LSD. Or is it just not worth all the effort to try & protect all my substances so I should just leave it all as it is in my locked up blue safety box?

Sorry if this random question has bored you, can't blame you for giving up reading half way through. Those of you that have read the whole thing, well thanks for reading it if you managed to get to the end.


Opinions on storing your own substances would really be appreciated 

Most drugs are very stable and keep their properties during years if kept in good conditions. The conditions you describe seem reasonable enough to be able to keep them in good conditions during years. Amphetamine and amphetamine derivatives are the most stable drugs and will keep their activity during years, even decades if conserved in a dry, dark, ambient temperature space. LSD and cocaine are more sensible to sunlight and they lose potency if not properly stored or exposed to sunlight or extreme temperatures. Marijuana also suffers degradation (in months-years).
The conditions you describe seem enough. In general it is not a good idea to store drugs in the freezer, because of high humidity (unless they have been previously vacuum-sealed)

[cleansober]

DoctorX,

On May 2, 2013 you said this about weed,"...But I think, in general, some risks of cannabis are underestimated. In fact I consider it as a "minor psychedelic" with all the inconveniences (and properties) of these group." 

My question is as follows:

What would you tell someone 15-22 who came to see you and said they were thinking about using cannabis? "Everyone says it's great fun and safer than drinking. Enlightened governments are legalizing it around the world.  Some of my friends do it and they are still getting good grades."  What would you tell this fictional, curious, would be cannabis consumer?   My understanding of your opinion of psychedelics is to take them infrequently and integrate the experience into your life before dropping again.  Do you think the same applies to mota?

For over fifty years we have heard about cannabis and brain damage.  What does science and experience really tell us? 

The links below are to reports which indicate damage to developing brains from both heavy drinking and cannabis. It's too late for me, I'm quiting again(really this time, I even sent X the last fraction of my bitcoin treasure), but maybe some of the Tor savy youths on this site can gain from your perspective on intelligent cannabis use.  Maybe the intelligent thing to do is wait until the brain is done development before indulging, in spite of the modern day jongleurs who sing the praises of Kush, Chronic, etc. 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696957/
http://brain.oxfordjournals.org/content/135/7/2245.long
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052819/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479587/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345171/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644798/
et alii


Not sure exactly what all those studies mean, but they frighten me nevertheless.  If you read only one, read the last link, it's about addiction and choice. 

My next step is to work on my posting addiction.

Acutely,

cs


PS, Anyone having a working link to DoctorX's SR1 thread or the searchable archive please post here.  I lost and the wayback machine seems out of wack.

also, why do I seem to be the only person who feels the need to compulsively edit my posts? 

[stoney1980]

Dear DoctorX,

I´ve wanted to know if somebody has a depression on the base of drugs like speed nearly 2 till 3 gramm a day,
after a few years u can lose this drug- induced depression or it´s changed the hole personalitiy as u think you ´re the same as before?

Thanks for answering

[hypohype]

Hey Doc, i have a question about some (presumably) LSD i took:

So i got it from a reputable SR vendor (chased the forums, reddit etc and found no scam alerts on him, no NBOME calls or anything) and tried out a single 100-125 ug tab. Only experience with drugs before this (except alcohol and tobacco) was weed a single time. I ate probably both too much and the wrong things (meat) before the trip, but i haven't read that this could cause these pains.

Being a first time psychedelics user i had some scary moments under the trip, but mostly it went pretty well. However, i had for some time this persistent ache in my leftmost chest (felt like it was outside the heart, which i damn well hope it was). During the trip i took notes and described it as a warm feeling like my chest muscles/heart was slowly melting down across the chest. A little less than a week later i microdosed 25 ug and had that same feeling. This time around there was a single, short stab of pain in that area as well. Not too extreme but strong enough to worry me.

It tasted only slightly metalic, not bitter as i've read NBOMES do, but mostly sort of sour, and the taste lingered slightly throughout the trip.

I hope it was just have been panic attacks (the first time was just fuck-all overwhelming, and i accidentally swallowed the microdose after some time and thought it wouldn't work, so that trip wasn't entirely expected either), but i'd like to hear a qualified view on it.

[TheSlyFox]

Hey DoctorX,
What is the best method of storing pills (Xanax, Valium, ect)..?
Also how long does it take for them to start loosing thier potency..?

Cheers
~Fox

[ANUNNAKI]

How much Xanax and Oxycontin would be fatal when consumed together with alcohol and how much alcohol would cause problems? I know that drinking increases it greatly but I want to know if I can at least have a few, or does it all depend on height and weight?

[DoctorX]

Drug effects and risks depend on many factors. It is difficult to assess a 15-22 years old teenager without knowing his health status, mental condition, motivations, pattern of use of cannabis...In general, all drugs are less risky if used occasionally and in controlled conditions. Alcohol can be relatively harmless if used rationally or a very dangerous drug depending on all the factors previously mentioned. The same happens with cannabis. As a general rule, use of drugs in adults is better than in teenagers, not only by neurochemical-anatomical-cerebral factors but also because personality is more mature in adult people and capacity of control and decission is more developed. Nevertheless, most cannabis teenager users do not develop problems, although a minority can do it. In heavy users, personality disorders and/or very negative socioeconomical circumpstances these problems are more frequent. Cannabis is not a very high adictive substance (compared with others as alcohol, opiates or benzodiacepines) but some persons have difficulties to control their use.

In relation with neurotoxic potential, there is no proof that cannabis cause neurotoxic, long-lasting effects in humans. Most of the studies you show are retrospective, compare different populations or have methodological biases. The marketed spray of cannabinoids used in multiple sclerosis (a purified cannabis extract) has passed all FDA and European Union sanitary authorizations and there is no mention to "neurotoxic effects" in any of the technical sheets or clinical trials. This does not mean that "cannabis is good" , but definetly there are no proofs of neurotoxic cannabis effects (as these are described for alcohol or some amphetamine derivatives)

DoctorX,

On May 2, 2013 you said this about weed,"...But I think, in general, some risks of cannabis are underestimated. In fact I consider it as a "minor psychedelic" with all the inconveniences (and properties) of these group." 

My question is as follows:

What would you tell someone 15-22 who came to see you and said they were thinking about using cannabis? "Everyone says it's great fun and safer than drinking. Enlightened governments are legalizing it around the world.  Some of my friends do it and they are still getting good grades."  What would you tell this fictional, curious, would be cannabis consumer?   My understanding of your opinion of psychedelics is to take them infrequently and integrate the experience into your life before dropping again.  Do you think the same applies to mota?

For over fifty years we have heard about cannabis and brain damage.  What does science and experience really tell us? 

The links below are to reports which indicate damage to developing brains from both heavy drinking and cannabis. It's too late for me, I'm quiting again(really this time, I even sent X the last fraction of my bitcoin treasure), but maybe some of the Tor savy youths on this site can gain from your perspective on intelligent cannabis use.  Maybe the intelligent thing to do is wait until the brain is done development before indulging, in spite of the modern day jongleurs who sing the praises of Kush, Chronic, etc. 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696957/
http://brain.oxfordjournals.org/content/135/7/2245.long
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052819/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479587/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345171/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644798/
et alii


Not sure exactly what all those studies mean, but they frighten me nevertheless.  If you read only one, read the last link, it's about addiction and choice. 

My next step is to work on my posting addiction.

Acutely,

cs


PS, Anyone having a working link to DoctorX's SR1 thread or the searchable archive please post here.  I lost and the wayback machine seems out of wack.

also, why do I seem to be the only person who feels the need to compulsively edit my posts?

[DoctorX]

Long-time, high-dose of stimulants as speed can lead to psychological problems, both during use and also during next weeks/months of abstinence. Depression or other mental health problems are rarely the consequence of an unique cause, but the consequence of a group of factors. It is unlikely that a depression lasts for years, only caused by long-time use of stimulants. There are surely many other factors that have influence on this

Dear DoctorX,

I´ve wanted to know if somebody has a depression on the base of drugs like speed nearly 2 till 3 gramm a day,
after a few years u can lose this drug- induced depression or it´s changed the hole personalitiy as u think you ´re the same as before?

Thanks for answering

[sepeka]

Do you happen to know of a side effect from speed, when you come down you feel you need to yawn but you can't yawn, takes many tries before being able to successfully yawn

any idea what that is from? happens on stimulant come down, almost never while redosing, just when comedown

[DoctorX]

Hey Doc, i have a question about some (presumably) LSD i took:

So i got it from a reputable SR vendor (chased the forums, reddit etc and found no scam alerts on him, no NBOME calls or anything) and tried out a single 100-125 ug tab. Only experience with drugs before this (except alcohol and tobacco) was weed a single time. I ate probably both too much and the wrong things (meat) before the trip, but i haven't read that this could cause these pains.

Being a first time psychedelics user i had some scary moments under the trip, but mostly it went pretty well. However, i had for some time this persistent ache in my leftmost chest (felt like it was outside the heart, which i damn well hope it was). During the trip i took notes and described it as a warm feeling like my chest muscles/heart was slowly melting down across the chest. A little less than a week later i microdosed 25 ug and had that same feeling. This time around there was a single, short stab of pain in that area as well. Not too extreme but strong enough to worry me.

It tasted only slightly metalic, not bitter as i've read NBOMES do, but mostly sort of sour, and the taste lingered slightly throughout the trip.

I hope it was just have been panic attacks (the first time was just fuck-all overwhelming, and i accidentally swallowed the microdose after some time and thought it wouldn't work, so that trip wasn't entirely expected either), but i'd like to hear a qualified view on it.

It is impossible to know what has happened without knowing the substance purity.Chest pain is a possible symptom of a panic attack under psychedelics, but usually have also psychological symptoms (anxiety, fear...). LSD does not produce noticeable cardiovascular effects, but NBOMEs and other similar substances can do it.

LSD blotters or drops have fluorescence if put under a black light (the kind of  light used in some discos). Another alternative is a Drug Testing Service like the one provided by Energy Control
http://silkroad5v7dywlc.onion/index.php?topic=36015.0

[DoctorX]

Hey DoctorX,
What is the best method of storing pills (Xanax, Valium, ect)..?
Also how long does it take for them to start loosing thier potency..?

Cheers
~Fox

Benzodiacepines can be stored in "normal" conditions. There is no need for frigdes or special containers (unless you live in a ecuatorial or tropical country). In a environment of 10-25ºC, no extreme humidity and no direct sunlight, they will keep their quality for several years. A noticeable lose of potency will occur 5-10 years after production.

[krazy47]

Hey Dr X,

I was refferd to you by this post of mine right here http://silkroad5v7dywlc.onion/index.php?topic=57279.msg957701#msg957701.

Ive been doing coke at parties every weekend for the past 3 years (besides summer).

I can't say I've ever really had issues with my nose from cocaine. I've always had some pretty good product my whole life of doing coke, and I promise you I know the difference by looking at it, if I cant find fish scale rocks in it, I don't do it.

I went on a slight bender between April-June this year, and my bender I mean doing 1-3 lines every other day or so for those 2 months. I knew this was not a good habit to start if I wanted to keep using recreationally, so I quit (mainly because my good source moved away).

I found some good shit again, but I do not want fuck my nose up because 4 days after using like .5gs over the course of 2 days my nostril I used is hurting. It only hurts to touch/move. I have no bloody noses or blood in mucus or anything.

My health is more important then doing coke, but I feel like I really do not use enough to cause serious damage, but I think possibly the consistent use over 3 years like this might be taking a toll finally?

Do I have something to worry about or am I paranoid?

ADDED:

Again this is not serious pain or anything, it feels like there is a cut and everytime I move my nose it hurts and opens (again no blood though). The pain is located about half the length of a qtip head in, and on the middle part of the nose. When I have colds and am picking at/wiping my nose a lot I get this same type of pain.

2 weeks ago (when I did the .5g) I was also snorting MDMA crystal. I know... its just better not to ask questions, I was having to much fun that night haha. Im thinking this might still have some effect. I think this because in the summer after 2 months of no cocaine I blew like .2mg of mdma and had the same type of feeling in my nose.

[DoctorX]

How much Xanax and Oxycontin would be fatal when consumed together with alcohol and how much alcohol would cause problems? I know that drinking increases it greatly but I want to know if I can at least have a few, or does it all depend on height and weight?

Benzodiacepines (Xanax) are rarely mortal in overdose because they produce no respiratory depression. Alcohol and oxycodone can produce respiratory depression and combination of both and benzodiacepines, also. It is very difficult to exactly know what is the dangerous dosage of the combination (as there are three different drugs and factors as weight or tolerance should also be considered). Probably, combination of low dosages does not increase significantly the risk of death, but umconfortable adverse effects (as amnesia) are very likely. 

[DoctorX]

Do you happen to know of a side effect from speed, when you come down you feel you need to yawn but you can't yawn, takes many tries before being able to successfully yawn

any idea what that is from? happens on stimulant come down, almost never while redosing, just when comedown

Amphetamines act directly on facial musculature causing jaw contraction. This is a typical serotoninergic-amphetaminic effect and I suppose the difficulty for yawning you refer can be related to this.

[DoctorX]

Well...in relation with cocaine habit...I think you have expressed it well in your message...it is impossible to enjoy something that becomes a daily habit. So it is much better to leave it for special ocassions.

And in relation with nasal problems, as you imagine it is impossible to give an opinion without a physical exploration. There are some tricks very helpful with intranasal drug use:  to pulverize thoroughly the substance before using it, introduce the sniffing stick pointing not to the center (nasal septum) but to the ear (nasal turbinates) as these are more vascularized and absorption is better, to alternate both nostrils while sniffing and carefully washing both nostrils with saline water using a syringe after a session. With these tips it is possible to avoid problems but, if they persist, you should seek a doctor to directly evaluate if there is any problem.

Hey Dr X,

I was refferd to you by this post of mine right here http://silkroad5v7dywlc.onion/index.php?topic=57279.msg957701#msg957701.

Ive been doing coke at parties every weekend for the past 3 years (besides summer).

I can't say I've ever really had issues with my nose from cocaine. I've always had some pretty good product my whole life of doing coke, and I promise you I know the difference by looking at it, if I cant find fish scale rocks in it, I don't do it.

I went on a slight bender between April-June this year, and my bender I mean doing 1-3 lines every other day or so for those 2 months. I knew this was not a good habit to start if I wanted to keep using recreationally, so I quit (mainly because my good source moved away).

I found some good shit again, but I do not want fuck my nose up because 4 days after using like .5gs over the course of 2 days my nostril I used is hurting. It only hurts to touch/move. I have no bloody noses or blood in mucus or anything.

My health is more important then doing coke, but I feel like I really do not use enough to cause serious damage, but I think possibly the consistent use over 3 years like this might be taking a toll finally?

Do I have something to worry about or am I paranoid?

ADDED:

Again this is not serious pain or anything, it feels like there is a cut and everytime I move my nose it hurts and opens (again no blood though). The pain is located about half the length of a qtip head in, and on the middle part of the nose. When I have colds and am picking at/wiping my nose a lot I get this same type of pain.

2 weeks ago (when I did the .5g) I was also snorting MDMA crystal. I know... its just better not to ask questions, I was having to much fun that night haha. Im thinking this might still have some effect. I think this because in the summer after 2 months of no cocaine I blew like .2mg of mdma and had the same type of feeling in my nose.

[krazy47]

Thanks DrX!

Ive done a lot of research and I think my biggest issue was not so much abussing the drug, but I was not crushing it up very well.

This coke is very dense and dose not break up to powder easy. I was crushing it in a bag witha lighter and doing keybumps that was more chunky then powder!

I asked an old friend who used coke the same way I do for 4 years and quit due to a job. He said my issue is not breaking it up enough, and to never blow MDMA again... period.

[cleansober]

Ironic, the most viewed threads in the drug safety section are about sex but not much asked to DoctorX.  Why is this? Are we all drug chemists in training? Is drug production even part of the notion of drug safety?  How to make drugs safely is different from how to take them safely. Not a biggie, but does raise the issue of outline managment processes.

  I'm attempting to become actively engaged in sex (with partner).  In point of fact, I'm even willing become addicted to love, and for this a partner is absolutely necessary.  Changing one's diet to exclude meat is reportedly a way to increase sexual function.  There are many love potions, not to mention the well known advances in pharmacology that attempt to solve this conundrum.  It appears everyone on this drug site (other then me) has the business end of things working fine, another endoresment for legalization, or perhaps not, depending on what you what out of life.

Which reminds me of a joke. PM me if you care to hear it.





Clean (although oily) sober

[amphedup]

There is some really good info in this thread.

[DoctorX]

Thx

[mitsikid]

Hey there Dr.X

I'm not sure if this has been covered already but I was just wondering what would be considered as a dangerous heart rate when doing cocaine?

Thanks for everything you do.

[DoctorX]

It depends on age,health status, physical exercise and other factors, but a sustained long-lasting rate over 150-180 bpm should be considered dangerous. Sustained non-rythmic rates (even hours or days after using cocaine) should be considered dangerous also.

[boof bonzer]

Hola Doctor X.

I wish my written Spanish skills were better so I could ask you in that language. I have enjoyed reading your blog and like the way it increases my vocabulary. I can handle myself pretty well conversationally in your language, but almost all the internet and medical terms are new to me, as I learned to speak Spanish as a child, many years ago.

My question is about drugs consumed orally and the digestive process. On a couple of occasions I have consumed MDMA in sufficient quantity to cause vomiting. Please rest assured that I do not leave the house, or operate a car, or care for children when I get into this condition. I have noticed that when I became sick and threw up, it seemed like the food contents of my stomache had hardly digested at all, many (8+) hours after my last meal. I say this because the various things I had last eaten were all still clearly identifiable as such. Yet, when I have vomited due to regular (no-drugs) sickness, or motion sickness, even a few hours after eating, there was basically nothing identifiable in the vomit.

Am I imagining this, or is there something about the MDMA reacting in the stomache that slows the digestive process?

My friend reports that he has experienced a similar thing when eating magic mushrooms and throwing up, however I have never vomited from the consumption of mushrooms so I only mention this as hearsay, not observed personally like with the MDMA.

Thank you for the good work you are doing, here and elsewhere.

[DoctorX]

Stomach mucous membrane is rich in 5.HT serotonin receptors. This is one of the causes that make some people get sick after taking MDMA. In general is recommended a soft meal 1-2 hours before using it, avoiding very heavy or fatty foods. Some persons seem to be very susceptible to this effect and other do not notice it. There seems to be some degree of chronic tolerance and, some people diminish this emetic effect after a few times using it. During the days after using MDMA (in high dosages or frequencies) some people can suffer stomach problems and anorexia, that usually last a few days

[Aleoreneo]

Hey Doc, I take 30mg of Isotretinoin every day, my weight is 78kg.
Which drug I can't take? I mainly intersted in MDMA and 2CB, I never take MDMA but I would try it very soon at a party, 0.1g + 40ug LSD, there are problems?
I know that I can't drink alchool with isotretinoin but is fine to drink one or two beer every three month?

Thanks for service!

[DoctorX]

Isotretinoin can alter some blood test parameters related to liver, as aminotransferases. A raise in this count can be interpreted as indicative of toxicity. Some illegal or recreational drugs can alter aminotransferases too and increase the liver toxicity induced by isotretinoine.

Alcohol is the most non-recommendable drug in this sense and its use during isotretinoin treatment is formally contraindicated. Toxicity and risks are dosage-dependent, and probably very moderate sporadic use is not significative in terms of real harm.

For the rest of illegal drugs, risks depend on their potential to damage liver. LSD and 2C-B are probably safe. MDMA can in theory cause hepatotoxicity (at least is some dosages and circumpstances), although there are no data indicating that occassional use in combination with isotretinoin causes liver damage.

Anyway, in general, my recommendation is trying first substances alone, and then experiment with combinations. As isotretionin treatment is limited in time, you could also consider to wait until you have finished it, which is the safest option. In any case, as far as I know, there are no reported cases of toxicity with the mentioned combinations.

[cleansober]

DoctorX,


Any reason you can think of to avoid the combination of cannabis and one of these drugs sildenafil, vardenafil,  or tadalafil? For that matter, any reason you can think of to avoid any or all of the above?


cs

[DoctorX]

There are not pharmacollogical reasons to avoid this combination. There are no significative interactions described between use of cannabis and PDE-5 inhibitors as sildenafil, tadalafil or vardenafil. Poppers are, in fact, the only drug dangerous in combination with these prescription drugs.

DoctorX,


Any reason you can think of to avoid the combination of cannabis and one of these drugs sildenafil, vardenafil,  or tadalafil? For that matter, any reason you can think of to avoid any or all of the above?


cs

[cleansober]

DoctorX,

A long time ago, internet time anyway, you said Western medicine could learn things from Eastern practices.    What is it you think we should pay attention to that is being ignored from our friends to the East?  Given the current Ebola crisis it seems the West is the place to be, for now.  Yin Yan, qi, meridians and the all rest seems unlikely to do anything.  Of course you had a totally different point you were making.  Could you comment on this?  Thanks.


cs

[DoctorX]

DoctorX,

A long time ago, internet time anyway, you said Western medicine could learn things from Eastern practices.    What is it you think we should pay attention to that is being ignored from our friends to the East?  Given the current Ebola crisis it seems the West is the place to be, for now.  Yin Yan, qi, meridians and the all rest seems unlikely to do anything.  Of course you had a totally different point you were making.  Could you comment on this?  Thanks.


cs

Sorry...I do not remember having said that "Western medicine could learn things from Eastern practices"...The Ebola question is more related to rich and poor than West vs East. Anyway my field of expertise is drugs and I prefer to debate here only about this.

[Aleoreneo]

Isotretinoin can alter some blood test parameters related to liver, as aminotransferases. A raise in this count can be interpreted as indicative of toxicity. Some illegal or recreational drugs can alter aminotransferases too and increase the liver toxicity induced by isotretinoine.

Alcohol is the most non-recommendable drug in this sense and its use during isotretinoin treatment is formally contraindicated. Toxicity and risks are dosage-dependent, and probably very moderate sporadic use is not significative in terms of real harm.

For the rest of illegal drugs, risks depend on their potential to damage liver. LSD and 2C-B are probably safe. MDMA can in theory cause hepatotoxicity (at least is some dosages and circumpstances), although there are no data indicating that occassional use in combination with isotretinoin causes liver damage.

Anyway, in general, my recommendation is trying first substances alone, and then experiment with combinations. As isotretionin treatment is limited in time, you could also consider to wait until you have finished it, which is the safest option. In any case, as far as I know, there are no reported cases of toxicity with the mentioned combinations.

Do you think that MDMA can alter my blood test that I will do one week after?
Other question: I read that DMT can raise up blood pressure in the brain and the Isotretinoin do the same effect, there are problems to combine these two drugs?

Thanks!

[DoctorX]

Do you think that MDMA can alter my blood test that I will do one week after?
Other question: I read that DMT can raise up blood pressure in the brain and the Isotretinoin do the same effect, there are problems to combine these two drugs?

Thanks!

MDMA will probably not alter your blood test results. It is possible some alteration in aminotranspherases (parameters linked to liver activity) but very uncommon. MDMA and other amphetamines can be routinely detected in urine (if searched) but not in blood.

There are no known interactions or contraindications in combining DMT and isotretionin.

[tutenchamun]

thank you for this thread, subbed

[Copelandia]

Hello doctor X.
I have just a little question that might already have been answered.

My average consumption is on a pretty constant level since my teens. So lets say my habit was like this for about 20 years now:
I happen to smoke an average amount of 1g cannabis in different forms (hash and bud) through a bong.
A bowl is about .3g and I clear them in one hit. So yeah my lungs are filled.
I mix it in a ratio of 2g cannabis with 1g tobacco (sorry guys... in holland and france we mix our shit)
eventhough I don´t regularly smoke cigarettes. That makes about 1,5g of mix per day.
I rarely smoke joints or vaporize.

So my question is: How bad is this alone for my health. I know that there are interactions with alcohol and other drugs, but smoking cannabis is a staple in my diet, that I do not intend to eradicate, so I would just like to know what I am doing to myself and how it might/will end.

Thanks Doctor!

[kirby247]

Hello

I would just like to commend DoctorX on his great work, Just found this article floating around on the web and had to head over right away!

Many thanks Doc,

You are doing the world a whole lot of good!

http://www.smh.com.au/national/fernando-caudevilla-spanish-doctor-advises-drug-users-on-the-dark-webs-silk-road-20141020-118lfi.html#ixzz3GlLpLCDm

[DoctorX]

Hello doctor X.
I have just a little question that might already have been answered.

My average consumption is on a pretty constant level since my teens. So lets say my habit was like this for about 20 years now:
I happen to smoke an average amount of 1g cannabis in different forms (hash and bud) through a bong.
A bowl is about .3g and I clear them in one hit. So yeah my lungs are filled.
I mix it in a ratio of 2g cannabis with 1g tobacco (sorry guys... in holland and france we mix our shit)
eventhough I don´t regularly smoke cigarettes. That makes about 1,5g of mix per day.
I rarely smoke joints or vaporize.

So my question is: How bad is this alone for my health. I know that there are interactions with alcohol and other drugs, but smoking cannabis is a staple in my diet, that I do not intend to eradicate, so I would just like to know what I am doing to myself and how it might/will end.

Thanks Doctor!

Most relevant consequences of heavy cannabis use are related to short time memory. Frequent cannabis users learn with more difficulty (and forget easily) new concepts. I´m talking about the memory we use to learn new things (studying) or remember a phone number. This effect depends on dosage (more frequent and intense in very heavy cannabis users) and dissapears with abstinence (aproximately after 3-4 weeks of abstinence).

Risk of lung problems (chronic bronchitis, lung cancer...) are probably similar to tobacco ones. Risk of joints and bongs are similar (as they produce combustion) but vaporizers avoid lung problems.

Other risks frequently related to cannabis (schizophrenia, infertility, chromosome damage...) are part of the anti-drug propaganda and are not real, at least in general population and with most frequent patterns of use.

[OzFreelancer]

Hello

I would just like to commend DoctorX on his great work, Just found this article floating around on the web and had to head over right away!

Many thanks Doc,

You are doing the world a whole lot of good!

http://www.smh.com.au/national/fernando-caudevilla-spanish-doctor-advises-drug-users-on-the-dark-webs-silk-road-20141020-118lfi.html#ixzz3GlLpLCDm

I wrote that

And I'm super excited to be meeting the Good Doctor in the flesh next week in Portugal

[cleansober]

Ms. Freeloader,

You are lucky, talented who knows, but lucky, yes.  Will you meet in Madrid, at the fountain?  I pray you are a better roller skater than is X.


By the way, I'm Obama's personal physican, that's why the White House address.  Thought I should clarify this, many pm's have come my way asking about it.

clean

[DoctorX]

Hello

I would just like to commend DoctorX on his great work, Just found this article floating around on the web and had to head over right away!

Many thanks Doc,

You are doing the world a whole lot of good!

http://www.smh.com.au/national/fernando-caudevilla-spanish-doctor-advises-drug-users-on-the-dark-webs-silk-road-20141020-118lfi.html#ixzz3GlLpLCDm

I wrote that

And I'm super excited to be meeting the Good Doctor in the flesh next week in Portugal

I found Silk Road and the Deep Web through allthingsvice.com, so I am very excited to meet you too...!

[DoctorX]

Ms. Freeloader,

You are lucky, talented who knows, but lucky, yes.  Will you meet in Madrid, at the fountain?  I pray you are a better roller skater than is X.


By the way, I'm Obama's personal physican, that's why the White House address.  Thought I should clarify this, many pm's have come my way asking about it.

clean

You say I am a bad roller because of this:
http://www.msnbc.com/ronan-farrow/watch/a-different-type-of-drug-test-313349187622
But it is not my fault. It is the evil journalist who made me roll over an awful road surface.

[OzFreelancer]

Hello

I would just like to commend DoctorX on his great work, Just found this article floating around on the web and had to head over right away!

Many thanks Doc,

You are doing the world a whole lot of good!

http://www.smh.com.au/national/fernando-caudevilla-spanish-doctor-advises-drug-users-on-the-dark-webs-silk-road-20141020-118lfi.html#ixzz3GlLpLCDm

I wrote that

And I'm super excited to be meeting the Good Doctor in the flesh next week in Portugal

I found Silk Road and the Deep Web through allthingsvice.com, so I am very excited to meet you too...!

Seriously? I never knew that! 

[cleansober]

To the Great and wonderful Oz,

Can I make a movie of this?  It's too good to be true.  X and Z getting together.


cs

[jebemtistaru]

I just ordered some speed, only 3g, and I'm wondering how safe it is

It's not actually for me, but for my friends at a party, so I'm wondering how much is a "safe" dose for a person

We only used cannabis so far and I don't want anyone to get harmed

[Mulla Nasruddin]

Hello doctor, I'd like to ask you how to prevent a pretty annoying reaction that happens to me and a friend of mine, once every while after having taken MDMA.
As far as I've seen, it appears that it's something that happen only to certain people, and only sometimes...
In short, beside the usual toothache due to the jaw grinding, sometimes it happens that our mouth (usually the lips, but also throat and all the internal walls when it's really bad) get a serious inflammation. Some white spots appear making it difficult to eat, which take one week at least do disappear.
The worst case happened to that friend of mine who wasn't able to eat normally for a month (!) after having ingested 0.3 g of MDMA.
What is the reason to such reaction that I haven't seen on others? Is there a way to prevent it when taking MDMA?
Regards.

[josefiend]

Hi Doc!

Is there any drug I can take to slow my hear rate down while I am on meth so I can sleep? Benzos don't do the trick for me, I will feel the effects of the benzo but my heart still won't  slow down. Also when I take benzos to knock myself out after smoking meth I wake up within 5 hours feeling like I am still extremely high on meth.

[DoctorX]

I just ordered some speed, only 3g, and I'm wondering how safe it is

It's not actually for me, but for my friends at a party, so I'm wondering how much is a "safe" dose for a person

We only used cannabis so far and I don't want anyone to get harmed

Recreational dosage of intranasal amphetamine is in rank of 10-50 mg/dosage. It is very important to notice that "speed" is one of the most adulterated drugs in market. There are samples with 10% and samples with 80%, so is very important to know purity (or, at least to be very prudent if you are going to try a sample of unknown purity). Caffeine, acetaminophen, lactose or manitol are common adulterants of speed.
Another important point to consider is the fact that amphetamine effects last for 4-6 hours. So it is important not to redose frequently, and leave enough time between last dosage and sleep, to avoid sleep problems.
Erowid is an excellent source of information: http://www.erowid.org/chemicals/amphetamines/

[primey]

Hey doc,

First of all i just would like to thank you for what you do on here you help allot of people. Just wondering if you have any advice or tips for cutting back on Alprazolam i use to have them in pill form but i have been smoking on top of bongs lately because i could only get powder form. So i am not sure of my tolerance but i would say at least 15mg a day. Would really appreciate any advice. Should i stop smoking it? And get Valium instead? I am just not sure. Also i smoke about 5 grams of weed a day if that matters

Thank you for you're time

[DoctorX]

Hello doctor, I'd like to ask you how to prevent a pretty annoying reaction that happens to me and a friend of mine, once every while after having taken MDMA.
As far as I've seen, it appears that it's something that happen only to certain people, and only sometimes...
In short, beside the usual toothache due to the jaw grinding, sometimes it happens that our mouth (usually the lips, but also throat and all the internal walls when it's really bad) get a serious inflammation. Some white spots appear making it difficult to eat, which take one week at least do disappear.
The worst case happened to that friend of mine who wasn't able to eat normally for a month (!) after having ingested 0.3 g of MDMA.
What is the reason to such reaction that I haven't seen on others? Is there a way to prevent it when taking MDMA?
Regards.

Jaw clenching, dry mouth and bruxism (mandibular contraction) are common adverse effects of MDMA. These effects are characteristics of MDMA, are dose-dependent, but, as many other adverse effect of prescription or recreational drugs, some persons are more susceptible to them. On the other hand, some people have a natural tendency to oral sores, and little mechanical stimulus produce big erosions. This could be an explanation for your friend, or maybe some immune reaction.
Hydration of the mouth is the unique way to diminish this effect. Chewing gum while on MDMA is a good way to reduce this problems in susceptible persons, although some times it is impossible to prevent it completely. In case of oral sores, hydrocortisone buccal tablets for mouth ulcers are available OTC and effective.

[DoctorX]

Hi Doc!

Is there any drug I can take to slow my hear rate down while I am on meth so I can sleep? Benzos don't do the trick for me, I will feel the effects of the benzo but my heart still won't  slow down. Also when I take benzos to knock myself out after smoking meth I wake up within 5 hours feeling like I am still extremely high on meth.

The obvious answer for this is to use less meth in frequency and dosage. Occassional use of benzos or other prescription drugs after a stimulant session can be accepted in a risk reduction perspective. But using high potency or high dosages benzos if you are "too high" in a regular way, can lead to signifficative adverse effects, toxicity or severe harms because of the combination. On the other hand, drugs like neuroleptics or antipsychotics (that could be theoretically used in this sense) have a relevant profile of adverse effects and their toxicity can be high.
Some people use antihistaminics to sleep after stimulants (as they induce sleep and can be obtained OTC in many countries). This can be extremely dangerous, as some antihistaminics can trigger  arrythmias and other cardiac problems in combination with amphetamines or cocaine.

[Mulla Nasruddin]

Thank a lot doctor, swift answer too!
At the moment I'm suffering this very problem (not my worst inflamnation though, but it's the third time so far). Actually, I'm not the guy who suffers of excessive jaw clenching while on MDMA, but it's true that I lack a proper hydratation last Saturday night, and maybe that's the reason.
Next times I'll have at hand water bottle(s), chewing gum and eventually toothpaste and brush (washing the teeth is another tip I have been given).
I'll have a look to these hydrocortisone buccal tablets, hopefully they'll help me to ease the pain.
Thanks again.

[Mulla Nasruddin]

Yes, I've just verified... They are exactly mouth ulcers, the picture on the following link says it all.

http://www.webmd.boots.com/oral-health/guide/mouth-ulcers

It also says that it's a kind of disease that usually only 1 person out of 5 suffers, and that would explain why I haven't seen it on most of the other people ingesting the same amounts of MDMA.
Indeed these symptoms (but lighter) are also triggered when I eat way too much chocolate during the day (the only drug I'm addicted to... .
I'll try this hydrocortisone buccal tablets tomorrow straight away.

[josefiend]

Hi Doc!

Is there any drug I can take to slow my hear rate down while I am on meth so I can sleep? Benzos don't do the trick for me, I will feel the effects of the benzo but my heart still won't  slow down. Also when I take benzos to knock myself out after smoking meth I wake up within 5 hours feeling like I am still extremely high on meth.

The obvious answer for this is to use less meth in frequency and dosage. Occassional use of benzos or other prescription drugs after a stimulant session can be accepted in a risk reduction perspective. But using high potency or high dosages benzos if you are "too high" in a regular way, can lead to signifficative adverse effects, toxicity or severe harms because of the combination. On the other hand, drugs like neuroleptics or antipsychotics (that could be theoretically used in this sense) have a relevant profile of adverse effects and their toxicity can be high.
Some people use antihistaminics to sleep after stimulants (as they induce sleep and can be obtained OTC in many countries). This can be extremely dangerous, as some antihistaminics can trigger  arrythmias and other cardiac problems in combination with amphetamines or cocaine.

Thanks Doc! Guess I should slow down.

Silk Road loves you!

[DoctorX]

Hey doc,

First of all i just would like to thank you for what you do on here you help allot of people. Just wondering if you have any advice or tips for cutting back on Alprazolam i use to have them in pill form but i have been smoking on top of bongs lately because i could only get powder form. So i am not sure of my tolerance but i would say at least 15mg a day. Would really appreciate any advice. Should i stop smoking it? And get Valium instead? I am just not sure. Also i smoke about 5 grams of weed a day if that matters

Thank you for you're time

Alprazolam is a very addictive benzo, and the smoked route of administration enhances this potential. First of all I would suggest changing to oral route and calculate the exact amount you are using.

Then you should change to a benzo with a longer half-life, as diazepam. The conversion factor between alprazolam and diazepam is x10-20. So if you are using 10 mg of alprazolam daily you should start by 100-200 mg of diazepam (this is the daily total dosage, that should be distributed in three dosages during the day), and then tappering down 5-20 mg each week.

These are general rules, although there can be many factors to modify dosages, or using other benzos or drugs. In this kind of situations, in general I think is much better to consult with a specialist doctor instead of trying on your own.

[cleansober]

DoctorX,

Again the journalists publish a "new" report of brain issues from mota use. This is clearnet, of course:

 http://www.nytimes.com/2014/11/02/education/edlife/this-is-your-brain-on-drugs-marijuana-adults-teens.html

One of these days I may learn PGP, but for now, local deals are simple and unencombered by delay.  Negs away.  My PKR is in my upper range of acceptable.  In fact most of my negs are uninformed SRer's who have never read William Carlos Williams. At least this is what I tell myself.  Does it bother me?  Yes and no, more one than the other, sometimes for a long minute or two. I mostly ignored karma because I can't figure out what is wrong with me, although my wife has some good ideas.  I'm gonna leave soon cause I'm starting work on my PhD in astrophysics at MIT.  Loads of work to do. Cheers?

Why do men get married?

Punch line follows:
So they can have someone to tell them what's wrong with them.

So long,

cs

[OzFreelancer]

To the Great and wonderful Oz,

Can I make a movie of this?  It's too good to be true.  X and Z getting together.


cs

It was everything I dreamed, and more
https://twitter.com/fcaudevilla/status/528109703704768513