Just a reminder.. Fentanyl (like oxymorphone and all other opiates) seem to raise one's tolerance fairly quickly. with opana, it just takes a couple pills and your tolerance seems to be a lot higher, some with fentanyl. just a few mg's and you need more for the same effect. Don't get me wrong, Fent is a great opioid, you just need to treat it with tender loving care and be knowledgeable and youll be fine...