Well, between the methadone and the morphine ER I would choose the methadone. But, if your doctor will prescribe it, for sure go for the Opana. When taken as prescribed, it has very little side effects. It takes away the pain and thats about it..Now, thats taken as prescribed. If you take it like most of us do, then not only does it take away the pain, but other effects... I am surprised that he wrote 2 IR meds to begin with. He must of had a problem. Someone got caught selling or OD'ed or something.. So, it looks like hes making you go to one ER and one IR. For personal pain use. I have always found it better that the 2 meds are different. IF you use the opana ER I would probably use oxycodone for breakthrough. Or use methadone for your ER and opana ir's for breakthrough...