In my thread I stated that a friend took an opana and put it in the barrel of a syringe (with water) then waited 24 hours and then shot it. He said it worked great. But, putting all those fillers into your system cant be good. The problem is patience. If you want a "quick" or "quicker" fix, then iso extraction is for that. But, im sure if you let it sit overnight in water and then filtered to get rid of the nasty fillers, you might be ok. I'm glad Im not into Iv'ing so for me its not an issue. I think that snorting one with a high fat meal is best..