Just like when they say the bioavailibiliy of opana is 10 percent. Some its 5 some its 20. Im basing it off what I have read in the package inserts. And personal experience.. (also adding a shot of booze will also help, but dont do it, lol) And no, its almost impossible to get above 100 percent. Although, I have seen studies when they brought thet new oxyconin out. They never named the substance, but said that they got 103 percent out of it, I wish someone knew what that product was, but im sure it wold be difficult to do. So, I guess its possible to get over 100 percent, but be happy with it, lol...