Im assuming that you are talking about Methadone, correct? I would say 100mg (its up to the user to know their own body) but, being opiate tolerant, that sounds about right. Normally, I can take 30-40mg orally and that will take me out of WD. The greatest thing about methadone is the long half-life. There have been times that I have gone 3 days between doses of methadone. I would use the narcotic dosage converter that is stickied on the harm reduction section. IF you are in doubt, its always safer to take less than more. Methadone has a very high oral bioavailability. It ranges between 50 percent to 90 percent. With me, Its about 75 percent. So, if it takes 100mg orally for me to get off, I would shoot 75mg.