There are ways to bypass the Timerx system. If you go to opiophile there is great "How to" for those that like the needle. Orally, its only about 10 percent, nasally it increases to almost 50 percent and if you eat a high fat meal, you can get nasally up to around 70 plus percent. to bypass the timerx for the needle just takes a bit of time, but is fairly easy.