I just started playing around with Qubes OS and am quite impressed by it. There's an option for full disk encryption during installation, which I had not realized. Some of the info I read about it were complaints that it didn't have full disk encryption, so those complaints are out of date. You can even install it on a thumb drive and run off that, so you can test your hardware before installing it on the hard drive. I will probably create a separate thread with a review of Qubes.