I would start taking it the morning after rolling, 100 mg 2 or 3 times a day, for a few days. I think it helps with MDMA up to a point. If you're rolling 4 times a week, 5-HTP won't help. I also don't think it helps with drugs like coke that don't deplete serotonin. The best thing you can do is take more time off between rolling, or any drug use for that matter.