+1 absolutely sage advice. The best method is to get a proper dose on the first one and re-dose once or twice. Personally, I like 180 mg oral followed by 120 mg insufflated about 2 hours later, but ymmv. After that you start fighting the hedonic treadmill and you're out of serotonin. It's a complete waste of time to take MDMA 2 nights in a row. I wouldn't recommend taking it once a week unless you're consuming 5-HTP to boost serotonin levels, but the best schedule is once a month. At that rate I don't need any supplements or boosters, and I get virtually no negative after effects.