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Discussion => Off topic => Topic started by: moonbear on January 09, 2012, 03:50 am

Title: Spice messing up my brain?
Post by: moonbear on January 09, 2012, 03:50 am
Hello. I'm confused and have a problem that I don't understand. When I got off probation the other day, I smoked a bowl of chronic. It was obviously legit weed because spice never smells like real weed. I expected it to be way better than the spice I've had to use as a substitute for two long, agonizing years. But it was only slightly more euphoric, I might not have even noticed the difference if not for the smell. Before I smoked spice, real weed felt a lot different to me than it does now. It feels similar to spice, but not exactly the same. Has anyone else ever had this problem because it concerns me.
Title: Re: Spice messing up my brain?
Post by: spacewasp on January 09, 2012, 04:15 am
are you talking about DMT?
Title: Re: Spice messing up my brain?
Post by: Kali Kross on January 09, 2012, 05:05 am
Sounds like you got some bad weed or some really good spice. I don't think weed and spice have cross tolerance among each other. I would guess that the weed wasn't as good as you expected. But there is the possibility that tolerance could grow. The active ingredient in spice acts on cannabinoid receptors.

However, when I sold spice I only had the best. My spice was known in the whole industry as one of the best kinds. I smoked spice for about 6 months straight. After that 6 months I was in a position to get some Alaskan Thunder Fuck. I got high like it was my first time. Completely out of it couldn't even get off the couch. Every show was the best show I ever watched.

If you are interested in good weed I would suggest:
TheUsualSuspect - Great Quarter/OZ price with good weed
mrouid M39 == This is priced like budget weed and its very good.
Anarcho47 - Amazing OZ price worst quarter price in the world, awsem service, cool guy
OSO - Sells GREAT liquid THC. Amazing quality professionally done

I can personally say each one of these guys is a good choice for bud/liquid thc
Title: Re: Spice messing up my brain?
Post by: moonbear on January 09, 2012, 01:46 pm
Sounds like you got some bad weed or some really good spice. I don't think weed and spice have cross tolerance among each other. I would guess that the weed wasn't as good as you expected. But there is the possibility that tolerance could grow. The active ingredient in spice acts on cannabinoid receptors.

However, when I sold spice I only had the best. My spice was known in the whole industry as one of the best kinds. I smoked spice for about 6 months straight. After that 6 months I was in a position to get some Alaskan Thunder Fuck. I got high like it was my first time. Completely out of it couldn't even get off the couch. Every show was the best show I ever watched.

If you are interested in good weed I would suggest:
TheUsualSuspect - Great Quarter/OZ price with good weed
mrouid M39 == This is priced like budget weed and its very good.
Anarcho47 - Amazing OZ price worst quarter price in the world, awsem service, cool guy
OSO - Sells GREAT liquid THC. Amazing quality professionally done

I can personally say each one of these guys is a good choice for bud/liquid thc
I know I smoked good weed. I was high as fuck, but it wasn't the right kind of high, if you get what I'm saying. I'm starting to think maybe my mind just perceived the high differently when I was 14.
Title: Re: Spice messing up my brain?
Post by: gharyeee on January 09, 2012, 05:52 pm
I haven't used spice (as in the weed alternative, not DMT) personally, but a few friends have been in a similar situation to you. The effects seem to be "fairly" similar with my friends reporting weed having a better euphoria and spice being much heavier, sleepier (even compared to indicas). However, after smoking only spice for awhile their tolerance for weed did drop like a rock.

I think I understand what you are saying though. For me personally, I feel long term use of any substance will lead to a definite change in feeling towards it. After smoking weed for about a decade I remember looking back at how the high was over the years. The first few years were filled with adventure, joy, laughter, and all those happy flowery things. But after having smoked it for years --- counting periods with no/low tolerance --- I do notice the high being much different than it was when I was younger. Maybe I'm just used to the high. Maybe I'm just more centered with myself. Maybe something else. No way to know for sure, I suppose. I've noticed similar experiences with other substances as well (cigarettes, alcohol, mdma, lsd). Though your experience is indeed different as it was spice and now weed.

I still find a good few hits of some THC wax or gold dust will take me to that intense, giggly, perception changing high of the good ol' days, so I'd suggest giving that whirl and seeing how it affects you.
Title: Re: Spice messing up my brain?
Post by: mrgrey on January 09, 2012, 06:18 pm
ahhh yes, this is a very interesting topic actually ... and yes smoking the synthetic cannabiniods will totally wreck your tolerance with weed.  i believe the problem is with how tight these synthetic cannabiniods are binding to the cb1 and cb2 receptors.  some of these super potent cannabinoids bind at like 10-50 times higher rates than thc. 

therefore after you have repeatedly used them for a long period to get high you need cbds that are a full agonist and bind very strongly to the cb1 and cb2 receptors.  and when you smoke weed it just wont cut it.

the good news is its reversible, after a week or so you will start getting baked on weed again, and after 2-4 tolerance is pretty much gone.

alot of people equate the potency to how tight the drug binds to your receptors but this is mistaken.   
Title: Re: Spice messing up my brain?
Post by: mrgrey on January 09, 2012, 06:22 pm
also with the spice you really start running into alot of the unwanted side effects of weed.  the paranoia, panic attacks, high blood pressure, tachychardia (i think is the medical term), etc...

also i have read of several people on the internet that had a pyschotic break while on a spice overdose.  where is THC is completely safe, some of these new RC Cannabinoids are not safe at all.  and it sucks that the safest of the bunch and one that binds at rates near thc is jwh-18, but of course they make that illegal which makes people go and use much less safe and unknown chemicals.
Title: Re: Spice messing up my brain?
Post by: moonbear on January 09, 2012, 07:08 pm
also with the spice you really start running into alot of the unwanted side effects of weed.  the paranoia, panic attacks, high blood pressure, tachychardia (i think is the medical term), etc...

also i have read of several people on the internet that had a pyschotic break while on a spice overdose.  where is THC is completely safe, some of these new RC Cannabinoids are not safe at all.  and it sucks that the safest of the bunch and one that binds at rates near thc is jwh-18, but of course they make that illegal which makes people go and use much less safe and unknown chemicals.
Thanks for your advice. I think the government is too ignorant and doesn't care about drug users health - they'd rather push me into using synthetics than let me smoke Gods gift. What a bunch of assholes.
Anyway, hopefully my tolerance will go back to normal and I can enjoy my good ol' highs :)
Title: Re: Spice messing up my brain?
Post by: moonbear on January 09, 2012, 07:11 pm
I haven't used spice (as in the weed alternative, not DMT) personally, but a few friends have been in a similar situation to you. The effects seem to be "fairly" similar with my friends reporting weed having a better euphoria and spice being much heavier, sleepier (even compared to indicas). However, after smoking only spice for awhile their tolerance for weed did drop like a rock.

I think I understand what you are saying though. For me personally, I feel long term use of any substance will lead to a definite change in feeling towards it. After smoking weed for about a decade I remember looking back at how the high was over the years. The first few years were filled with adventure, joy, laughter, and all those happy flowery things. But after having smoked it for years --- counting periods with no/low tolerance --- I do notice the high being much different than it was when I was younger. Maybe I'm just used to the high. Maybe I'm just more centered with myself. Maybe something else. No way to know for sure, I suppose. I've noticed similar experiences with other substances as well (cigarettes, alcohol, mdma, lsd). Though your experience is indeed different as it was spice and now weed.

I still find a good few hits of some THC wax or gold dust will take me to that intense, giggly, perception changing high of the good ol' days, so I'd suggest giving that whirl and seeing how it affects you.
Thanks for the advice. I believe that in a few days my highs will get back to how they used to be, it's probably my tolerance. I'll post in here again in a few days if this is not the case, though.
Title: Re: Spice messing up my brain?
Post by: Kali Kross on January 09, 2012, 10:57 pm
also with the spice you really start running into alot of the unwanted side effects of weed.  the paranoia, panic attacks, high blood pressure, tachychardia (i think is the medical term), etc...

also i have read of several people on the internet that had a pyschotic break while on a spice overdose.  where is THC is completely safe, some of these new RC Cannabinoids are not safe at all.  and it sucks that the safest of the bunch and one that binds at rates near thc is jwh-18, but of course they make that illegal which makes people go and use much less safe and unknown chemicals.

The problem with spice is that Chinese companies, for the most part, are producing a product without regard to safety. My spice came directly from a company in California. I cant tell you how many people bought my spice, 100s, maybe 1000 or more. The whole time I was in business my customers constantly said that they didnt get the unwanted effects they often got with other spices. Like weed you might get paranoid or something but good spice will never cause the crazy stuff like strokes, death, and other serious problems. I often had customers say that my spice was better because they had severe effects with other spice and not with mine. Keep in mind that I was selling large amounts of spice for a good price, so my customers were consuming more spice with less bad side effects and never anything serious. I sold 7 gram minimum bags at $30(and still making double my money or more with each sale) while the other top spice companies sold as little as one gram for $20. I sold a gram of my stuff for $5 + shipping so people could try it.

With that being said its clear that I speak from experience in the industry with a high quality product. While alot of people, especially doctors and anti-drug folks speak based on the most extreme cases and focus on unsafe brands and then judge the entire industry based on the worst and most dangerous brands they can find.

I dont think spice is a better alternative than weed but until weed is legal many people will choose spice over weed.
Title: Re: Spice messing up my brain?
Post by: onestopshop on January 09, 2012, 11:27 pm
It's a bit hard to say really mate..try different strains of weed before reaching a conclusion, next time you pickup see if you can get another strain.

I was kind of in a reverse/similar situation, I moved out of my local and was smoking moroccan and afghani hash for a year straight when my guy got busted (he was part of a large smuggling ring that all went down) area went completely dry like a nun's you-know-what..

anyway  I went through a period of smoking Spice and liked it but found my tolerance builds up way quicker then it does with weed...after the draught I picked up a oz of chronic and 1 spliff didn't get me stoned like it used to but after a few days off the spice everything was back to normal..

remember even though everybody's always like "we need moar THC!" there's around 40 chemicals in weed that get you high and 8 main ones, your habitual use of spice might have made your tolerance high to some/one of the compounds and lower to the other ones resulting in a "different" high...


on a side note is there more then one type of spice??? as far as I know Spice over here is that legal high with the picture of a eye on the front...are there other types as far as I know all the other brands/varieties were garbage ? :s
Title: Re: Spice messing up my brain?
Post by: moonbear on January 10, 2012, 01:24 pm
It's a bit hard to say really mate..try different strains of weed before reaching a conclusion, next time you pickup see if you can get another strain.

I was kind of in a reverse/similar situation, I moved out of my local and was smoking moroccan and afghani hash for a year straight when my guy got busted (he was part of a large smuggling ring that all went down) area went completely dry like a nun's you-know-what..

anyway  I went through a period of smoking Spice and liked it but found my tolerance builds up way quicker then it does with weed...after the draught I picked up a oz of chronic and 1 spliff didn't get me stoned like it used to but after a few days off the spice everything was back to normal..

remember even though everybody's always like "we need moar THC!" there's around 40 chemicals in weed that get you high and 8 main ones, your habitual use of spice might have made your tolerance high to some/one of the compounds and lower to the other ones resulting in a "different" high...


on a side note is there more then one type of spice??? as far as I know Spice over here is that legal high with the picture of a eye on the front...are there other types as far as I know all the other brands/varieties were garbage ? :s
Yes there are different types of spice. There are dozens of different chemicals, right now the most common are am-2201, jwh-210, and jwh-081. Different brands mix different chems, some use just one chem, etc. God knows that shit can't be too good for you... but they do all activate the cannabinoid receptors in their own ways.
Title: Re: Spice messing up my brain?
Post by: doublemint on January 12, 2012, 02:47 am
Good spice can be similar to weed. It's legit bad for your brain though, so stick to the real shit if you can. I haven't heard of weed being mistaken for spice though.
Title: Re: Spice messing up my brain?
Post by: lowberry on January 12, 2012, 05:47 am
I do believe they have a cross tolerance, when i was experimenting with "mojo" a few years back I noticed this
Title: Re: Spice messing up my brain?
Post by: Atticus on January 12, 2012, 07:54 pm
I smoke spice now and again when some friends are offering it or I've not got any weed available - never noticed anything like this personally though and I much prefer grass. A couple of friends really got into spice pretty recently and when I was smoking them in on some weed recently they said they got a really spice-like high and were wondering if I mixed it with spice.
Title: Re: Spice messing up my brain?
Post by: moonbear on January 12, 2012, 08:14 pm
I smoke spice now and again when some friends are offering it or I've not got any weed available - never noticed anything like this personally though and I much prefer grass. A couple of friends really got into spice pretty recently and when I was smoking them in on some weed recently they said they got a really spice-like high and were wondering if I mixed it with spice.
Interesting, so I wasn't the only one...
Title: Re: Spice messing up my brain?
Post by: Tryptamine on January 12, 2012, 08:42 pm
Using synthetic cannabinoids will cause some kind of 'cross-tolerance' since they do after all bind to some of the same proteins. It won't be as straight-forward as cannabis tolerance; certain aspects of the subjective experience will be attenuated or enhanced, which may explain why subsequently using cannabis may lead to an unusual experience.
I personally would not consume any synthetic cannabinoid product, that these substances mimic the subjective effects of cannabis does not mean they have anything near the safety profile (let alone the beneficial effects) of cannabis. They are not phytocannabinoid analogues; the relationship is not like that of Mescaline and 2CE, but more like that of fentanyl and morphine, where the molecule itself is very diferent despite the effects being described similarly. There may be 'safe' synthetic cannabinoids, but you should not assume that most (or any) of them are.
Title: Re: Spice messing up my brain?
Post by: doublemint on January 12, 2012, 09:13 pm
I smoke spice now and again when some friends are offering it or I've not got any weed available - never noticed anything like this personally though and I much prefer grass. A couple of friends really got into spice pretty recently and when I was smoking them in on some weed recently they said they got a really spice-like high and were wondering if I mixed it with spice.

I'm not a fan of the high, it feels like your watching over yourself... its odd (Spice).
Title: Re: Spice messing up my brain?
Post by: moonbear on January 12, 2012, 10:03 pm
I actually do enjoy spice, depending on what chemicals are used. No combination of them is better than real mary jane, but if made well it's still a nice high, at least to me.
Title: Re: Spice messing up my brain?
Post by: jookie on January 12, 2012, 11:24 pm
I've tried a few blends and they all sucked compared to good old bud. And it's definitely way worse for you than weed could ever be. It's a full agonist as opposed to marijuana and it WILL do damage to your cannabinoid receptors when done in excess which is regularly done by many who assume it's just as safe as marijuana. The creator of the JWH series was fucking appalled to hear that people was getting high off this stuff because he just did not perceive it as safe.
Title: Re: Spice messing up my brain?
Post by: moonbear on January 13, 2012, 03:12 am
I've tried a few blends and they all sucked compared to good old bud. And it's definitely way worse for you than weed could ever be. It's a full agonist as opposed to marijuana and it WILL do damage to your cannabinoid receptors when done in excess which is regularly done by many who assume it's just as safe as marijuana. The creator of the JWH series was fucking appalled to hear that people was getting high off this stuff because he just did not perceive it as safe.
Damages cannabinoid receptors? Thats plausible, please tell me more on this subject. How do you know? Or is that just your 2 cents?